ECSP12011843A - Arilindenopirimidinas sustituidas con arilo y su uso como antagonistas de receptores de adenosina a2a altamente selectivos - Google Patents

Arilindenopirimidinas sustituidas con arilo y su uso como antagonistas de receptores de adenosina a2a altamente selectivos

Info

Publication number
ECSP12011843A
ECSP12011843A ECSP12011843A ECSP12011843A EC SP12011843 A ECSP12011843 A EC SP12011843A EC SP12011843 A ECSP12011843 A EC SP12011843A EC SP12011843 A ECSP12011843 A EC SP12011843A
Authority
EC
Ecuador
Prior art keywords
arilindenopirimidinas
arilo
adenosine
antagonists
replaced
Prior art date
Application number
Other languages
English (en)
Inventor
Paul Jackson
Brian Christopher Shook
Mark Powell
Aihua Wang
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP12011843A publication Critical patent/ECSP12011843A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención se relaciona con una nueva arilindenopirimidina, A, y sus usos terapéuticos y profilácticos. Los trastornos tratados y/o prevenidos incluyen la enfermedad de Parkinson en donde, X, R2, R3 y R4 son como se definen en la especificación.
ECSP12011843 2009-10-29 2012-04-27 Arilindenopirimidinas sustituidas con arilo y su uso como antagonistas de receptores de adenosina a2a altamente selectivos ECSP12011843A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25593009P 2009-10-29 2009-10-29

Publications (1)

Publication Number Publication Date
ECSP12011843A true ECSP12011843A (es) 2012-06-29

Family

ID=43216987

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011843 ECSP12011843A (es) 2009-10-29 2012-04-27 Arilindenopirimidinas sustituidas con arilo y su uso como antagonistas de receptores de adenosina a2a altamente selectivos

Country Status (10)

Country Link
US (1) US20110105492A1 (es)
CN (1) CN102596918A (es)
AU (1) AU2010313576A1 (es)
BR (1) BR112012010131A2 (es)
CA (1) CA2779097A1 (es)
EC (1) ECSP12011843A (es)
IL (1) IL219340A0 (es)
MX (1) MX2012005002A (es)
PH (1) PH12012500808A1 (es)
WO (1) WO2011053509A1 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958328B2 (en) * 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
US20040127510A1 (en) * 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
JP4725963B2 (ja) * 2003-10-03 2011-07-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド アリールインデノピリジンおよびアリールインデノピリミジンならびにアデノシンＡ２ａ受容体アンタゴニストとしてのそれらの使用

Also Published As

Publication number Publication date
BR112012010131A2 (pt) 2019-09-24
US20110105492A1 (en) 2011-05-05
PH12012500808A1 (en) 2012-11-26
IL219340A0 (en) 2012-06-28
MX2012005002A (es) 2012-06-12
CN102596918A (zh) 2012-07-18
CA2779097A1 (en) 2011-05-05
WO2011053509A1 (en) 2011-05-05
AU2010313576A1 (en) 2012-05-24

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