ECSP13012676A - Antagonistas del receptor del cgrp de piperidinona carboxamida azaindano - Google Patents
Antagonistas del receptor del cgrp de piperidinona carboxamida azaindanoInfo
- Publication number
- ECSP13012676A ECSP13012676A ECSP13012676A ECSP13012676A EC SP13012676 A ECSP13012676 A EC SP13012676A EC SP13012676 A ECSP13012676 A EC SP13012676A EC SP13012676 A ECSP13012676 A EC SP13012676A
- Authority
- EC
- Ecuador
- Prior art keywords
- cgrp
- piperidinona
- azaindano
- antigonists
- carboxamida
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a derivados de piperidinona carboxamida azaindano que son antagonistas de receptores del CGRP y útiles en el tratamiento o prevención de enfermedades en las que está implicado el CGRP, tales como migraña. La invención también se refiere a composiciones farmacéuticas que comprende estos compuestos y al uso de estos compuestos y composiciones en la prevención o tratamiento de dichas enfermedades en las que está implicado el CGRP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41307710P | 2010-11-12 | 2010-11-12 | |
| US201061425034P | 2010-12-20 | 2010-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP13012676A true ECSP13012676A (es) | 2013-08-30 |
Family
ID=45034191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP13012676 ECSP13012676A (es) | 2010-11-12 | 2013-06-12 | Antagonistas del receptor del cgrp de piperidinona carboxamida azaindano |
Country Status (43)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI501968B (zh) * | 2010-11-12 | 2015-10-01 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| WO2012129013A1 (en) | 2011-03-18 | 2012-09-27 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide spirohydantoin cgrp receptor antagonists |
| WO2013138418A2 (en) * | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Process for making cgrp receptor antagonists |
| US9174989B2 (en) * | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| WO2015038736A2 (en) * | 2013-09-16 | 2015-03-19 | Merck Sharp & Dohme Corp. | Formulations for cgrp receptor antagonists |
| US10117836B2 (en) * | 2014-02-05 | 2018-11-06 | Merck Sharp & Dohme Corp. | Tablet formulation for CGRP active compounds |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| FR3030521B1 (fr) * | 2014-12-23 | 2019-07-26 | Galderma Research & Development | Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| US20190374520A1 (en) * | 2018-06-08 | 2019-12-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| GB201908430D0 (en) * | 2019-06-12 | 2019-07-24 | Heptares Therapeutics Ltd | Cgrp antagonist compounds |
| GB201908420D0 (en) | 2019-06-12 | 2019-07-24 | Heptares Therapeutics Ltd | Cgrp antagonist compounds |
| CN110787163B (zh) * | 2019-12-05 | 2020-06-02 | 河北医科大学第二医院 | 一种用于神经保护和促进神经再生的药物组合物及其制剂 |
| MX2023001071A (es) | 2020-07-29 | 2023-05-12 | Allergan Pharmaceuticals Int Ltd | Tratamiento de la migraña. |
| CN116096361B (zh) * | 2020-08-07 | 2025-10-10 | 大鹏药品工业株式会社 | 新型环烯酮化合物或其盐 |
| CN112353767A (zh) * | 2020-11-16 | 2021-02-12 | 海南锦瑞制药有限公司 | 一种盐酸地尔硫卓和普瑞巴林组合物及其制备方法及其应用 |
| CN116456981A (zh) * | 2020-11-19 | 2023-07-18 | 辉瑞爱尔兰制药公司 | 用于改善的grp抑制剂递送的组合物 |
| CA3206184A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP2024509165A (ja) | 2021-03-02 | 2024-02-29 | シージーアールピー ダイアグノスティクス ゲーエムベーハー | 片頭痛の治療及び／又は発生の低減 |
| WO2023026205A1 (en) | 2021-08-24 | 2023-03-02 | Cgrp Diagnostics Gmbh | Preventative treatment of migraine |
| JP2024533756A (ja) | 2021-09-27 | 2024-09-12 | アラガン ファーマスーティカルズ インターナショナル リミテッド | アトゲパントを含む片頭痛の併用療法 |
| WO2023119327A1 (en) * | 2021-12-20 | 2023-06-29 | Msn Laboratories Private Limited, R&D Center | Process for the preparation of a pure amorphous form of ubrogepant |
| US20250353860A1 (en) * | 2022-04-29 | 2025-11-20 | Brise Pharmaceuticals Co., Ltd. | Piperidine carboxamide azaindane derivative, method for preparing same, and use thereof |
| US20260130901A1 (en) | 2022-10-11 | 2026-05-14 | Allergan Pharmaceuticals International Limited | Cgrp receptor antagonist for the treatment of migraine |
| WO2024134683A1 (en) * | 2022-12-21 | 2024-06-27 | Msn Laboratories Private Limited, R&D Center | Novel process for the preparation of intermediate compounds used in the treatment of migraine |
| WO2024218790A1 (en) * | 2023-04-15 | 2024-10-24 | Msn Laboratories Private Limited, R&D Center | A pharmaceutical composition of ubrogepant and their process for the preparation of solid dosage form for treating migraine |
| CN118834160B (zh) * | 2023-04-23 | 2025-12-19 | 中国医学科学院药物研究所 | Ubrelvy关键手性内酰胺中间体及其衍生物的不对称合成方法 |
| CN119431222B (zh) * | 2024-11-04 | 2025-10-17 | 杭州澳赛诺生物科技有限公司 | 一种不对称合成乌布吉泮手性中间体的方法 |
| CN119350337A (zh) * | 2024-12-24 | 2025-01-24 | 药康众拓(北京)医药科技有限公司 | 一类氘代哌啶酮酸酰胺氮杂茚满类cgrp抑制剂药物及用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| EP1606286B1 (en) | 2003-03-14 | 2011-05-11 | Merck Sharp & Dohme Corp. | Benodiazepine spirohydantoin cgrp receptor antagonists |
| US7288559B2 (en) | 2003-03-14 | 2007-10-30 | Merck + Co, Inc. | Carboxamide spirohydantoin CGRP receptor antagonists |
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| US8003792B2 (en) * | 2004-09-13 | 2011-08-23 | Merck Sharp & Dohme Corp. | Bicyclic anilide spirolactam CGRP receptor antagonists |
| EP1861399B1 (en) * | 2005-03-14 | 2011-12-14 | Merck Sharp & Dohme Corp. | Cgrp receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| CA2689217C (en) * | 2007-06-05 | 2016-02-16 | Merck & Co., Inc. | Carboxamide heterocyclic cgrp receptor antagonists |
| EP2225237A2 (de) * | 2007-11-22 | 2010-09-08 | Boehringer Ingelheim International GmbH | Organische verbindungen |
| US8044043B2 (en) * | 2008-04-11 | 2011-10-25 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| US8765763B2 (en) * | 2009-06-05 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Substituted piperazines as CGRP antagonists |
| WO2012064911A1 (en) * | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide indane cgrp receptor antagonists |
| TWI501968B (zh) * | 2010-11-12 | 2015-10-01 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| WO2012087777A1 (en) * | 2010-12-22 | 2012-06-28 | Merck Sharp & Dohme Corp. | Fused heterocyclic indane carboxamide cgrp receptor antagonists |
| EP2654423B1 (en) * | 2010-12-22 | 2016-12-07 | Merck Sharp & Dohme Corp. | Fused heterocyclic azaindane carboxamide cgrp receptor antagonists |
| WO2012129013A1 (en) * | 2011-03-18 | 2012-09-27 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide spirohydantoin cgrp receptor antagonists |
| EP2753640B1 (en) * | 2011-09-08 | 2016-03-09 | Codexis, Inc. | Biocatalysts and methods for the synthesis of substituted lactams |
| WO2013138418A2 (en) * | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Process for making cgrp receptor antagonists |
| WO2013138413A1 (en) * | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
| US9227972B2 (en) * | 2012-05-09 | 2016-01-05 | Merck Sharp & Dohme Corp. | Aliphatic spirolactam CGRP receptor antagonists |
| US9174989B2 (en) * | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| WO2013169563A1 (en) * | 2012-05-09 | 2013-11-14 | Merck Sharp & Dohme Corp. | Pyridine cgrp receptor antagonists |
| EP2846799B1 (en) * | 2012-05-09 | 2017-11-15 | Merck Sharp & Dohme Corp. | Spirolactam cgrp receptor antagonists |
| WO2015038736A2 (en) * | 2013-09-16 | 2015-03-19 | Merck Sharp & Dohme Corp. | Formulations for cgrp receptor antagonists |
| US10117836B2 (en) * | 2014-02-05 | 2018-11-06 | Merck Sharp & Dohme Corp. | Tablet formulation for CGRP active compounds |
| CN106456662A (zh) * | 2014-02-24 | 2017-02-22 | 奥利金制药公司 | 口服给药的戊聚糖多硫酸盐的组合物及其使用方法 |
| US20180092899A1 (en) * | 2016-09-30 | 2018-04-05 | Merck Sharp & Dohme Corp. | Method of treating acute migraine with cgrp-active compound |
-
2011
- 2011-11-09 TW TW104104474A patent/TWI501968B/zh active
- 2011-11-09 TW TW100140962A patent/TWI487706B/zh active
- 2011-11-09 TW TW104104475A patent/TWI522355B/zh active
- 2011-11-10 US US13/293,186 patent/US8481556B2/en active Active
- 2011-11-10 EP EP14185954.6A patent/EP2821407B1/en active Active
- 2011-11-10 SG SG2013034145A patent/SG190137A1/en unknown
- 2011-11-10 LT LTEP14185954.6T patent/LT2821407T/lt unknown
- 2011-11-10 PE PE2013000966A patent/PE20140240A1/es active IP Right Grant
- 2011-11-10 RS RS20140621A patent/RS53610B1/sr unknown
- 2011-11-10 SI SI201131014A patent/SI2821407T1/sl unknown
- 2011-11-10 ES ES14185954.6T patent/ES2604827T3/es active Active
- 2011-11-10 US US13/293,177 patent/US8912210B2/en active Active
- 2011-11-10 HU HUE14185954A patent/HUE031010T2/en unknown
- 2011-11-10 JP JP2013538871A patent/JP5642883B2/ja active Active
- 2011-11-10 WO PCT/US2011/060081 patent/WO2012064910A1/en not_active Ceased
- 2011-11-10 US US13/293,166 patent/US8754096B2/en active Active
- 2011-11-10 RS RS20160964A patent/RS55416B1/sr unknown
- 2011-11-10 MY MYPI2013001607A patent/MY165113A/en unknown
- 2011-11-10 ME MEP-2016-257A patent/ME02552B/me unknown
- 2011-11-10 SI SI201130327T patent/SI2638042T1/sl unknown
- 2011-11-10 PH PH1/2013/500958A patent/PH12013500958A1/en unknown
- 2011-11-10 AR ARP110104204A patent/AR083831A1/es active IP Right Grant
- 2011-11-10 KR KR1020137014960A patent/KR101537877B1/ko active Active
- 2011-11-10 PT PT141859546T patent/PT2821407T/pt unknown
- 2011-11-10 CA CA2817100A patent/CA2817100C/en active Active
- 2011-11-10 DK DK11787987.4T patent/DK2638042T3/en active
- 2011-11-10 HR HRP20141108AT patent/HRP20141108T1/hr unknown
- 2011-11-10 MX MX2013005246A patent/MX2013005246A/es active IP Right Grant
- 2011-11-10 ME MEP-2014-145A patent/ME01922B/me unknown
- 2011-11-10 BR BR112013011448A patent/BR112013011448B8/pt active IP Right Grant
- 2011-11-10 PL PL11787987T patent/PL2638042T3/pl unknown
- 2011-11-10 CN CN201180064736.XA patent/CN103328478B/zh active Active
- 2011-11-10 ES ES11787987.4T patent/ES2525021T3/es active Active
- 2011-11-10 EP EP11787987.4A patent/EP2638042B1/en active Active
- 2011-11-10 NZ NZ610468A patent/NZ610468A/en unknown
- 2011-11-10 EA EA201390683A patent/EA022850B1/ru not_active IP Right Cessation
- 2011-11-10 PL PL14185954T patent/PL2821407T3/pl unknown
- 2011-11-10 DK DK14185954.6T patent/DK2821407T3/da active
- 2011-11-10 SG SG10201509335VA patent/SG10201509335VA/en unknown
- 2011-11-10 AU AU2011326454A patent/AU2011326454B2/en active Active
- 2011-11-10 PT PT117879874T patent/PT2638042E/pt unknown
-
2013
- 2013-04-25 IL IL225978A patent/IL225978A/en active IP Right Grant
- 2013-05-06 MA MA35880A patent/MA34650B1/fr unknown
- 2013-05-09 CL CL2013001289A patent/CL2013001289A1/es unknown
- 2013-05-09 DO DO2013000103A patent/DOP2013000103A/es unknown
- 2013-05-10 GT GT201300122A patent/GT201300122A/es unknown
- 2013-05-10 NI NI201300043A patent/NI201300043A/es unknown
- 2013-05-10 CR CR20130214A patent/CR20130214A/es unknown
- 2013-05-30 CO CO13133033A patent/CO6801723A2/es active IP Right Grant
- 2013-06-12 EC ECSP13012676 patent/ECSP13012676A/es unknown
-
2014
- 2014-09-12 US US14/485,259 patent/US9499545B2/en active Active
-
2016
- 2016-10-14 US US15/293,569 patent/US9833448B2/en active Active
- 2016-12-05 HR HRP20161641TT patent/HRP20161641T1/hr unknown
- 2016-12-06 CY CY20161101255T patent/CY1118362T1/el unknown
-
2017
- 2017-12-04 US US15/830,131 patent/US10272077B2/en active Active
-
2019
- 2019-04-26 US US16/396,056 patent/US20190275024A1/en not_active Abandoned
-
2020
- 2020-07-28 US US16/940,943 patent/US20210008055A1/en not_active Abandoned
-
2023
- 2023-10-20 CY CY2023022C patent/CY2023022I1/el unknown
- 2023-10-20 NO NO2023040C patent/NO2023040I1/no unknown
- 2023-10-25 HU HUS2300037C patent/HUS2300037I1/hu unknown
- 2023-10-31 FR FR23C1039C patent/FR23C1039I2/fr active Active
- 2023-10-31 NL NL301248C patent/NL301248I2/nl unknown
- 2023-11-07 LU LU00321C patent/LUC00321I2/en unknown
- 2023-11-07 LT LTPA2023532C patent/LTC2638042I2/lt unknown
- 2023-11-10 FI FIC20230034C patent/FIC20230034I1/fi unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DOP2013000103A (es) | Antagonistas del receptor del cgrp de piperidinona carboxamida azaindano | |
| DOP2011000120A (es) | Antagonistas del receptor de orexina de isonicotinamida | |
| WO2013169574A3 (en) | Aliphatic spirolactam cgrp receptor antagonists | |
| CR20150296A (es) | Novedosos derivados de bencimidazol como antagonistas de ep4 | |
| CO6351717A2 (es) | Tripiridil carboxamida como antagonista del receptor de orexina | |
| MX342161B (es) | Compuestos antagonistas selectivos de receptor nk-3 novedosos, composicion farmaceutica y metodos para utilizarse en trastornos transmitidos por receptores nk-3. | |
| GT201200201A (es) | Moduladores alostéricos positivos de receptores m1 de la quinolina amida | |
| DOP2014000115A (es) | Uso de 4-fenil-piridinas sustituidas para la fabricación de medicamentos útiles en el tratamiento de enfermedades relacionadas con el receptor de nk1 | |
| EA201490037A1 (ru) | Антагонисты trpv4 | |
| EA201390821A1 (ru) | Антагонисты рецепторов лизофосфатидной кислоты и их применение | |
| CO6541545A2 (es) | Compuestos de espiropiperidina como antagonistas del receptor orl-1 | |
| ECSP12012270A (es) | Compuestos de pirazol como inhibidores del receptor sigma | |
| EA201100161A1 (ru) | Производные хинуклидина карбоната и их медицинские композиции | |
| UY35906A (es) | Novedosos derivados de bencimidazol como ligandos de ep4 | |
| CR20140257A (es) | Nuevos 2h-indazoles como antagonistas del receptor ep2 | |
| MX2015011536A (es) | Nuevos antagonistas de receptores trpa1 de sulfamidas. | |
| MX2015005312A (es) | Derivados de 1h-indazol-3-carboxamida y uso de los mismos como antagonistas de p2y12. | |
| TN2013000179A1 (en) | Piperidinone carboxamide azaindane cgrp receptor antagonists | |
| CL2010000998A1 (es) | Compuestos derivados de arilsulfonil pirazolin carboxamidina, antagonistas de 5-ht6; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y su uso para el tratamiento o profilaxis de enfermedades tales como psicosis, epilepsia, enfermedad de parkinson, migraña y enfermedad de alzheimer. | |
| UA109463C2 (xx) | Піперидинонкарбоксамідазаіндани - антагоністи рецептора cgrp | |
| CU20140058A7 (es) | Nuevos 2h-indizoles como antagonistas del receptor ep-2 |