ECSP16014324A - Compuestos espirociclicos como inhibidores de triptofano hidroxilasa - Google Patents

Compuestos espirociclicos como inhibidores de triptofano hidroxilasa

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Publication number
ECSP16014324A
ECSP16014324A ECIEPI201614324A ECPI201614324A ECSP16014324A EC SP16014324 A ECSP16014324 A EC SP16014324A EC IEPI201614324 A ECIEPI201614324 A EC IEPI201614324A EC PI201614324 A ECPI201614324 A EC PI201614324A EC SP16014324 A ECSP16014324 A EC SP16014324A
Authority
EC
Ecuador
Prior art keywords
tryptophan hydroxylase
spirocyclic compounds
hydroxylase inhibitors
inhibitors
diseases
Prior art date
Application number
ECIEPI201614324A
Other languages
English (en)
Inventor
Daniel R Goldberg
Eric Brian Sjogren
Kenneth Brameld
Stephane De Lombaert
Andrew Scribner
Original Assignee
Karos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51743540&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP16014324(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Karos Pharmaceuticals Inc filed Critical Karos Pharmaceuticals Inc
Publication of ECSP16014324A publication Critical patent/ECSP16014324A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos espirocíclicos que son inhibidores de triptófano hidroxilasa (TPH), particularmente la isoforma 1 (TPH1), que son útiles en el tratamiento de enfermedades o trastornos asociados con serotonina periférica, incluso, por ejemplo, enfermedades gastrointestinales, cardiovasculares, pulmonares, inflamatorias, metabólicas y de baja masa ósea, así como síndrome de serotonina y cáncer.
ECIEPI201614324A 2013-09-06 2016-04-06 Compuestos espirociclicos como inhibidores de triptofano hidroxilasa ECSP16014324A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361874545P 2013-09-06 2013-09-06
US201361899943P 2013-11-05 2013-11-05
US201462004385P 2014-05-29 2014-05-29

Publications (1)

Publication Number Publication Date
ECSP16014324A true ECSP16014324A (es) 2017-10-31

Family

ID=51743540

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201614324A ECSP16014324A (es) 2013-09-06 2016-04-06 Compuestos espirociclicos como inhibidores de triptofano hidroxilasa

Country Status (30)

Country Link
US (8) US9199994B2 (es)
EP (1) EP3041842B8 (es)
JP (1) JP6470290B2 (es)
KR (1) KR102336075B1 (es)
CN (1) CN105764902B (es)
AR (1) AR097571A1 (es)
AU (1) AU2014315109B2 (es)
CA (1) CA2922933C (es)
CL (1) CL2016000509A1 (es)
CY (1) CY1122652T1 (es)
DK (1) DK3041842T3 (es)
EA (1) EA032304B1 (es)
EC (1) ECSP16014324A (es)
ES (1) ES2780828T3 (es)
HR (1) HRP20200098T1 (es)
HU (1) HUE047574T2 (es)
IL (1) IL244315B (es)
LT (1) LT3041842T (es)
MX (1) MX371191B (es)
MY (1) MY186265A (es)
PE (1) PE20160648A1 (es)
PH (1) PH12016500416B1 (es)
PL (1) PL3041842T3 (es)
PT (1) PT3041842T (es)
RS (1) RS59871B1 (es)
SG (2) SG10201802118QA (es)
SI (1) SI3041842T1 (es)
TW (1) TWI652267B (es)
UA (1) UA119247C2 (es)
WO (1) WO2015035113A1 (es)

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KR20210139293A (ko) * 2019-03-15 2021-11-22 알타반트 사이언시스 게엠베하 폐동맥 고혈압 및 연관 폐동맥 고혈압 치료방법 및 매일 투여
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CN111007170B (zh) * 2019-12-13 2021-06-29 中国农业科学院农产品加工研究所 骨肽干预治疗骨质疏松中的生物标志物、筛选方法及用途
EP4096633A1 (en) * 2020-01-31 2022-12-07 Altavant Sciences GmbH Dosages and methods for treating pulmonary arterial hypertension with rodatristat
WO2023062595A1 (en) 2021-10-14 2023-04-20 Altavant Sciences Gmbh Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl
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