ECSP17029203A - Inhibidor de cinasa aurora a - Google Patents

Inhibidor de cinasa aurora a

Info

Publication number
ECSP17029203A
ECSP17029203A ECIEPI201729203A ECPI201729203A ECSP17029203A EC SP17029203 A ECSP17029203 A EC SP17029203A EC IEPI201729203 A ECIEPI201729203 A EC IEPI201729203A EC PI201729203 A ECPI201729203 A EC PI201729203A EC SP17029203 A ECSP17029203 A EC SP17029203A
Authority
EC
Ecuador
Prior art keywords
kinase inhibitor
aurora
inhibitor aurora
cancer
useful
Prior art date
Application number
ECIEPI201729203A
Other languages
English (en)
Inventor
James Robert Henry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP17029203A publication Critical patent/ECSP17029203A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a un compuesto de aminopiridina, o una sal del mismo farmacéuticamente aceptable, que inhibe a Aurora A y, por lo tanto puede ser útil en el tratamiento de cáncer.
ECIEPI201729203A 2014-11-14 2017-05-12 Inhibidor de cinasa aurora a ECSP17029203A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462079742P 2014-11-14 2014-11-14

Publications (1)

Publication Number Publication Date
ECSP17029203A true ECSP17029203A (es) 2018-01-31

Family

ID=54697647

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201729203A ECSP17029203A (es) 2014-11-14 2017-05-12 Inhibidor de cinasa aurora a

Country Status (41)

Country Link
US (2) US9637474B2 (es)
EP (2) EP3218366B1 (es)
JP (1) JP6159029B2 (es)
KR (1) KR101930182B1 (es)
CN (1) CN107108567B (es)
AR (1) AR102463A1 (es)
AU (1) AU2015347043B2 (es)
BR (1) BR112017007239B1 (es)
CA (1) CA2963473C (es)
CL (1) CL2017001209A1 (es)
CO (1) CO2017004784A2 (es)
CR (1) CR20170158A (es)
CY (2) CY1121334T1 (es)
DK (2) DK3218366T3 (es)
DO (1) DOP2017000111A (es)
EA (1) EA032102B1 (es)
EC (1) ECSP17029203A (es)
ES (2) ES2716732T3 (es)
HR (2) HRP20190324T1 (es)
HU (2) HUE051530T2 (es)
IL (1) IL251406B (es)
JO (1) JO3488B1 (es)
LT (2) LT3473619T (es)
ME (1) ME03325B (es)
MX (1) MX377560B (es)
MY (1) MY188313A (es)
NZ (1) NZ730771A (es)
PE (1) PE20170898A1 (es)
PH (1) PH12017500881A1 (es)
PL (1) PL3218366T3 (es)
PT (2) PT3473619T (es)
RS (2) RS60999B1 (es)
SG (1) SG11201703394RA (es)
SI (2) SI3473619T1 (es)
SV (1) SV2017005418A (es)
TN (1) TN2017000116A1 (es)
TR (1) TR201902686T4 (es)
TW (1) TWI693218B (es)
UA (1) UA117983C2 (es)
WO (1) WO2016077161A1 (es)
ZA (1) ZA201702199B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7227968B2 (ja) * 2018-05-29 2023-02-22 大鵬薬品工業株式会社 抗腫瘍剤及び腫瘍治療方法
CN113038950A (zh) * 2018-11-30 2021-06-25 伊莱利利公司 用于治疗神经母细胞瘤的Aurora A激酶抑制剂
CN112239465A (zh) * 2019-07-16 2021-01-19 微境生物医药科技(上海)有限公司 极光激酶抑制剂及其用途
CN112898292A (zh) 2019-12-03 2021-06-04 微境生物医药科技(上海)有限公司 新型极光激酶抑制剂及其用途
TWI785474B (zh) * 2020-01-22 2022-12-01 大陸商北京加科思新藥研發有限公司 用作選擇性Aurora A抑制劑的新型雜環化合物
EP4349836A4 (en) 2021-05-24 2024-10-30 Jiangsu Hengrui Pharmaceuticals Co., Ltd. NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, ITS PREPARATION METHOD AND ITS APPLICATION IN DRUGS
TW202321215A (zh) * 2021-07-28 2023-06-01 大陸商北京加科思新藥研發有限公司 Aurora a 選擇性抑制劑的多晶型及其用途
EP4504209A1 (en) 2022-04-08 2025-02-12 Eli Lilly and Company Method of treatment including kras g12c inhibitors and aurora a inhibitors
WO2024109871A1 (zh) 2022-11-23 2024-05-30 江苏恒瑞医药股份有限公司 一种含氮杂环类化合物的可药用盐、晶型及制备方法
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2024230647A1 (zh) * 2023-05-05 2024-11-14 苏州信诺维医药科技股份有限公司 杂环类化合物、其药物组合物和其应用
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
TW202530228A (zh) 2023-10-12 2025-08-01 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1956982A (zh) * 2004-05-21 2007-05-02 万有制药株式会社 具有氨基噻唑骨架的Cdk4、6选择性抑制剂
EP1828165B1 (en) * 2004-10-29 2013-03-20 Msd K.K. Novel aminopyridine derivatives having aurora a selective inhibitory action
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
JP5411152B2 (ja) * 2008-02-22 2014-02-12 Ｍｓｄ株式会社 オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
KR20120004467A (ko) * 2009-03-24 2012-01-12 엠에스디 가부시키가이샤 오로라 ａ 선택적 억제 작용을 갖는 신규한 아미노피리딘 유도체
TWI485146B (zh) * 2012-02-29 2015-05-21 Taiho Pharmaceutical Co Ltd Novel piperidine compounds or salts thereof

Also Published As

Publication number Publication date
HRP20190324T1 (hr) 2019-04-19
DK3473619T3 (da) 2020-09-21
DK3218366T3 (en) 2019-04-01
EP3218366B1 (en) 2019-01-09
RS58347B1 (sr) 2019-03-29
IL251406A0 (en) 2017-05-29
TR201902686T4 (tr) 2019-03-21
CO2017004784A2 (es) 2017-08-31
JP2016539942A (ja) 2016-12-22
EP3473619A1 (en) 2019-04-24
ES2826448T3 (es) 2021-05-18
PH12017500881B1 (en) 2017-11-06
SI3473619T1 (sl) 2020-10-30
TN2017000116A1 (en) 2018-07-04
MX377560B (es) 2025-03-10
SV2017005418A (es) 2018-10-09
KR101930182B1 (ko) 2018-12-17
CA2963473A1 (en) 2016-05-19
EP3473619B8 (en) 2020-11-04
NZ730771A (en) 2018-07-27
LT3218366T (lt) 2019-04-10
AU2015347043A1 (en) 2017-05-04
KR20170066623A (ko) 2017-06-14
JP6159029B2 (ja) 2017-07-05
US20170119751A1 (en) 2017-05-04
EA032102B1 (ru) 2019-04-30
UA117983C2 (uk) 2018-10-25
PE20170898A1 (es) 2017-07-12
CL2017001209A1 (es) 2018-01-12
CY1123592T1 (el) 2022-03-24
EP3218366A1 (en) 2017-09-20
TW201629038A (zh) 2016-08-16
PT3218366T (pt) 2019-04-01
IL251406B (en) 2019-08-29
PH12017500881A1 (en) 2017-11-06
CY1121334T1 (el) 2020-05-29
CN107108567B (zh) 2020-01-10
PT3473619T (pt) 2020-11-11
RS60999B1 (sr) 2020-11-30
HUE051530T2 (hu) 2021-03-01
MY188313A (en) 2021-11-27
AR102463A1 (es) 2017-03-01
HRP20201681T1 (hr) 2020-12-25
CN107108567A (zh) 2017-08-29
LT3473619T (lt) 2020-11-10
SG11201703394RA (en) 2017-05-30
WO2016077161A1 (en) 2016-05-19
BR112017007239A2 (pt) 2017-12-19
US20160137628A1 (en) 2016-05-19
ZA201702199B (en) 2018-12-19
ME03325B (me) 2019-10-20
SI3218366T1 (sl) 2019-02-28
DOP2017000111A (es) 2017-06-15
EP3473619B1 (en) 2020-09-09
AU2015347043B2 (en) 2018-03-22
US10010540B2 (en) 2018-07-03
JO3488B1 (ar) 2020-07-05
MX2017006275A (es) 2017-08-14
ES2716732T3 (es) 2019-06-14
CA2963473C (en) 2018-12-18
EA201790838A1 (ru) 2017-12-29
CR20170158A (es) 2017-06-21
BR112017007239B1 (pt) 2023-01-31
HUE043759T2 (hu) 2019-09-30
US9637474B2 (en) 2017-05-02
TWI693218B (zh) 2020-05-11
PL3218366T3 (pl) 2019-06-28

Similar Documents

Publication Publication Date Title
ECSP17029203A (es) Inhibidor de cinasa aurora a
GT201500263A (es) Inhibidores de cdc7
CO2018013293A2 (es) Derivados de pirazolopirimidina como inhibidor de quinasa
JOP20190194A1 (ar) مركبات نيوكليوتيدات ثنائية حلقية لعلاج السرطان
MX2016009337A (es) Derivados de azepano y metodos para tratar infecciones por hepatitis b.
DOP2014000200A (es) Compuestos inhibidores de raf
CL2020001754A1 (es) Derivado de amino-fluoropiperidina como inhibidor de quinasa.
MX2019004626A (es) Compuesto de piridona como inhibidor de c-met.
CL2019000844A1 (es) Compuesto de piridina.
SG10201808940WA (en) Nox inhibitor and nfкb inhibitor containing methoxyflavone
MX2020000386A (es) Inhibidores heterociclicos de la cinasa atr.
MX2018006674A (es) Tratamiento de cancer usando 2-desoxi-2-fluoro-l-fucosa en combinacion con un inhibidor del punto de control.
AR098274A1 (es) Inhibidor de grelina o-acil transferasa
LT3534885T (lt) Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui
MX2017006110A (es) Carboxamidas de quinolina para usarse en el tratamiento de leucemia.
DOP2019000194A (es) Derivados de pirrolotriazina como inhibidor de cinasas
CL2018002930A1 (es) (+)-azasetron para uso en el tratamiento de desórdenes de oído.
PH12017501063A1 (en) Compounds for the treatment of cancer