ECSP17074645A - Azabenzimidazoles y su uso como moduladores del receptor ampa - Google Patents

Azabenzimidazoles y su uso como moduladores del receptor ampa

Info

Publication number
ECSP17074645A
ECSP17074645A ECIEPI201774645A ECPI201774645A ECSP17074645A EC SP17074645 A ECSP17074645 A EC SP17074645A EC IEPI201774645 A ECIEPI201774645 A EC IEPI201774645A EC PI201774645 A ECPI201774645 A EC PI201774645A EC SP17074645 A ECSP17074645 A EC SP17074645A
Authority
EC
Ecuador
Prior art keywords
azabenzimidazoles
receptor modulators
ampa receptor
compounds
formula
Prior art date
Application number
ECIEPI201774645A
Other languages
English (en)
Inventor
Devin M Swanson
Wei Zhang
Dongpei Wu
Bradley M Savall
Gang Chen
Cynthia G B Berry
Michael K Ameriks
David Wei Lin
Fabrice Loic Jourdan
Suchitra Ravula
Terry Patrick Lebold
Piñon Miguel Angel Pena
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP17074645A publication Critical patent/ECSP17074645A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En la presente invención se proporcionan compuestos de la Fórmula (I) y sales farmacéuticamente aceptables, N-óxidos o solvatos de estos. Además, en la presente invención se proporcionan composiciones farmacéuticas que comprenden compuestos de la Fórmula (I) y métodos para usar los compuestos de la Fórmula (I).
ECIEPI201774645A 2015-04-29 2017-11-10 Azabenzimidazoles y su uso como moduladores del receptor ampa ECSP17074645A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562154313P 2015-04-29 2015-04-29

Publications (1)

Publication Number Publication Date
ECSP17074645A true ECSP17074645A (es) 2018-02-28

Family

ID=56008859

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201774645A ECSP17074645A (es) 2015-04-29 2017-11-10 Azabenzimidazoles y su uso como moduladores del receptor ampa

Country Status (39)

Country Link
US (5) US11312712B2 (es)
EP (3) EP3288940B9 (es)
JP (2) JP6800886B2 (es)
KR (2) KR20170140382A (es)
CN (1) CN107835814B (es)
AR (1) AR104447A1 (es)
AU (2) AU2016255434C1 (es)
BR (2) BR122023023802A2 (es)
CA (1) CA2983826A1 (es)
CO (1) CO2017011017A2 (es)
CR (1) CR20170484A (es)
CY (1) CY1124059T1 (es)
DK (1) DK3288940T5 (es)
EA (1) EA033281B1 (es)
EC (1) ECSP17074645A (es)
ES (1) ES2865330T3 (es)
GT (1) GT201700231A (es)
HR (1) HRP20210403T1 (es)
HU (1) HUE053943T2 (es)
IL (1) IL254848B (es)
JO (1) JO3654B1 (es)
LT (1) LT3288940T (es)
MA (1) MA41988B1 (es)
MD (1) MD3288940T2 (es)
MX (1) MX376113B (es)
MY (1) MY194104A (es)
NI (1) NI201700129A (es)
PH (1) PH12017501816B1 (es)
PL (1) PL3288940T3 (es)
PT (1) PT3288940T (es)
RS (1) RS61688B1 (es)
SG (1) SG11201708190UA (es)
SI (1) SI3288940T1 (es)
SM (1) SMT202100222T1 (es)
TW (1) TWI706952B (es)
UA (1) UA120304C2 (es)
UY (1) UY36654A (es)
WO (1) WO2016176460A1 (es)
ZA (1) ZA201708065B (es)

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US20250230157A1 (en) 2025-07-17
EP3288940A1 (en) 2018-03-07
SMT202100222T1 (it) 2021-05-07
HRP20210403T1 (hr) 2021-10-29
EP4144736A1 (en) 2023-03-08
HUE053943T2 (hu) 2021-08-30
PL3288940T3 (pl) 2021-07-12
TW201708217A (zh) 2017-03-01
JO3654B1 (ar) 2020-08-27
WO2016176460A1 (en) 2016-11-03
EP3288940B9 (en) 2021-07-21
EA033281B1 (ru) 2019-09-30
US11312712B2 (en) 2022-04-26
MX376113B (es) 2025-03-07
MX2017013886A (es) 2018-03-12
SG11201708190UA (en) 2017-11-29
CN107835814B (zh) 2021-07-23
CA2983826A1 (en) 2016-11-03
EP3901153A1 (en) 2021-10-27
TWI706952B (zh) 2020-10-11
US20230114165A1 (en) 2023-04-13
UA120304C2 (uk) 2019-11-11
SI3288940T1 (sl) 2021-07-30
RS61688B1 (sr) 2021-05-31
AU2016255434B2 (en) 2020-05-14
US12304908B2 (en) 2025-05-20
MA41988A (fr) 2018-07-03
KR20240017991A (ko) 2024-02-08
GT201700231A (es) 2018-12-20
EA201792374A1 (ru) 2018-05-31
MA41988B1 (fr) 2021-03-31
AU2020210231A1 (en) 2020-08-20
US20210284641A1 (en) 2021-09-16
ZA201708065B (en) 2019-09-25
LT3288940T (lt) 2021-05-10
DK3288940T3 (da) 2021-05-25
NZ736057A (en) 2023-08-25
DK3288940T5 (da) 2021-09-20
AR104447A1 (es) 2017-07-19
BR112017023147A2 (pt) 2018-07-10
AU2016255434A1 (en) 2017-10-26
KR102782808B1 (ko) 2025-03-14
KR20170140382A (ko) 2017-12-20
AU2020210231B2 (en) 2021-07-22
AU2016255434C1 (en) 2021-09-23
US12145934B2 (en) 2024-11-19
BR112017023147B1 (pt) 2024-04-30
PT3288940T (pt) 2021-04-30
CN107835814A (zh) 2018-03-23
CR20170484A (es) 2018-02-26
BR122023023802A2 (pt) 2023-12-26
NZ774642A (en) 2024-09-27
PH12017501816B1 (en) 2023-07-19
JP2018518462A (ja) 2018-07-12
HK1252249A1 (en) 2019-05-24
US20180118740A1 (en) 2018-05-03
NI201700129A (es) 2019-05-10
JP6800886B2 (ja) 2020-12-16
JP2021042230A (ja) 2021-03-18
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US20230110576A1 (en) 2023-04-13
IL254848A0 (en) 2017-12-31
US12139485B2 (en) 2024-11-12
CO2017011017A2 (es) 2018-03-20
MD3288940T2 (ro) 2021-08-31
IL254848B (en) 2021-01-31
UY36654A (es) 2016-10-31
MY194104A (en) 2022-11-11
CY1124059T1 (el) 2022-05-27
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