ECSP18000844A - Anticuerpos de unión a tau - Google Patents

Anticuerpos de unión a tau

Info

Publication number
ECSP18000844A
ECSP18000844A ECIEPI2018844A ECPI201800844A ECSP18000844A EC SP18000844 A ECSP18000844 A EC SP18000844A EC IEPI2018844 A ECIEPI2018844 A EC IEPI2018844A EC PI201800844 A ECPI201800844 A EC PI201800844A EC SP18000844 A ECSP18000844 A EC SP18000844A
Authority
EC
Ecuador
Prior art keywords
tau
antibodies
union
binding
relates
Prior art date
Application number
ECIEPI2018844A
Other languages
English (en)
Inventor
Terence Seward Baker
Kerry Louise Tyson
Jean-Philippe Courade
Georges Mairet-Coello
David Edward Ormonde Knight
Patrick Downey
Original Assignee
Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of ECSP18000844A publication Critical patent/ECSP18000844A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4703—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a anticuerpos de unión a Tau y fragmentos de unión de los mismos.
ECIEPI2018844A 2015-07-06 2018-01-05 Anticuerpos de unión a tau ECSP18000844A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP15175519 2015-07-06

Publications (1)

Publication Number Publication Date
ECSP18000844A true ECSP18000844A (es) 2018-03-31

Family

ID=53524638

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI2018844A ECSP18000844A (es) 2015-07-06 2018-01-05 Anticuerpos de unión a tau

Country Status (23)

Country Link
US (4) US10344081B2 (es)
EP (1) EP3319984B1 (es)
JP (1) JP6937289B2 (es)
KR (1) KR102742965B1 (es)
CN (1) CN107849105B (es)
AR (1) AR105266A1 (es)
AU (1) AU2016289753C1 (es)
CA (1) CA2991264C (es)
CL (1) CL2018000042A1 (es)
CO (1) CO2017012974A2 (es)
EA (1) EA036821B1 (es)
EC (1) ECSP18000844A (es)
ES (1) ES3064846T3 (es)
IL (1) IL256687B (es)
MA (2) MA42380A (es)
MX (1) MX2017015908A (es)
PE (1) PE20180499A1 (es)
PH (1) PH12017502180A1 (es)
TN (1) TN2017000543A1 (es)
TW (1) TWI748954B (es)
UY (1) UY36774A (es)
WO (1) WO2017005732A1 (es)
ZA (1) ZA201708128B (es)

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Publication number Publication date
ES3064846T3 (en) 2026-04-29
MA42380A (fr) 2018-05-16
PH12017502180A1 (en) 2018-05-28
US10906966B2 (en) 2021-02-02
PE20180499A1 (es) 2018-03-09
AU2016289753A1 (en) 2017-12-14
MA41669A1 (fr) 2018-05-31
AR105266A1 (es) 2017-09-20
EP3319984C0 (en) 2026-03-11
TN2017000543A1 (en) 2019-04-12
ZA201708128B (en) 2019-05-29
US20190375829A1 (en) 2019-12-12
US11746145B2 (en) 2023-09-05
KR102742965B1 (ko) 2024-12-13
AU2016289753B2 (en) 2020-11-26
CO2017012974A2 (es) 2018-03-09
EA201890169A1 (ru) 2018-10-31
EA036821B1 (ru) 2020-12-23
NZ737843A (en) 2024-05-31
CA2991264C (en) 2023-10-10
US20230331833A1 (en) 2023-10-19
CA2991264A1 (en) 2017-01-12
US10344081B2 (en) 2019-07-09
KR20180027566A (ko) 2018-03-14
US20210139574A1 (en) 2021-05-13
CL2018000042A1 (es) 2018-06-01
BR112017028101A2 (en) 2018-09-04
AU2016289753C1 (en) 2021-08-05
CN107849105B (zh) 2021-09-17
IL256687B (en) 2022-02-01
US20180194832A1 (en) 2018-07-12
MX2017015908A (es) 2018-03-15
JP2018519833A (ja) 2018-07-26
WO2017005732A1 (en) 2017-01-12
UY36774A (es) 2017-01-31
EP3319984B1 (en) 2026-03-11
IL256687A (en) 2018-03-29
TW201713688A (zh) 2017-04-16
CN107849105A (zh) 2018-03-27
JP6937289B2 (ja) 2021-09-22
EP3319984A1 (en) 2018-05-16
TWI748954B (zh) 2021-12-11

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