ECSP18051972A - Nuevos derivados de fosfinanos y azafosfinanos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen - Google Patents
Nuevos derivados de fosfinanos y azafosfinanos, su procedimiento de preparación y las composiciones farmacéuticas que los contienenInfo
- Publication number
- ECSP18051972A ECSP18051972A ECSENADI201851972A ECDI201851972A ECSP18051972A EC SP18051972 A ECSP18051972 A EC SP18051972A EC SENADI201851972 A ECSENADI201851972 A EC SENADI201851972A EC DI201851972 A ECDI201851972 A EC DI201851972A EC SP18051972 A ECSP18051972 A EC SP18051972A
- Authority
- EC
- Ecuador
- Prior art keywords
- phosphinans
- aaphosphinans
- contain
- pharmaceutical compositions
- preparation procedure
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Compuestos de fórmula (I) (VER FORMULA EN LA MEMORIA TECNICA) en la que: Ak1 representa una cadena alquilo, X representa -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)-, N(R)-CH2- o -CH2-N(R)-CH2-, m y R son tales como se han definido en la descripción, R1 y R2 representan cada uno H cuando X representa -(CH2)m-, -CH(R)-, -N(R)-, -CH2-N(R)- o N(R)-CH2-, o bien forman juntos una unión cuando X representa -CH2-N(R)-CH2-, R3 representa NH2, Cy-NH2, Cy-Ak3-NH2 o piperidin-4-ilo, Cy y Ak3 son tales como se han definido en la descripción, R4 y R5, idénticos o diferentes, representan cada uno H o F, sus isómeros ópticos, así como sus sales de adición a un ácido farmacéuticamente aceptable. Medicamentos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1670004A FR3046793B1 (fr) | 2016-01-14 | 2016-01-14 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/FR2017/050075 WO2017121969A1 (fr) | 2016-01-14 | 2017-01-13 | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP18051972A true ECSP18051972A (es) | 2018-07-31 |
Family
ID=55752640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI201851972A ECSP18051972A (es) | 2016-01-14 | 2018-07-11 | Nuevos derivados de fosfinanos y azafosfinanos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen |
Country Status (47)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002014285A1 (en) * | 2000-08-17 | 2002-02-21 | Pfizer Limited | Substituted imidazoles as tafia inhibitors |
| SE0103272D0 (sv) * | 2001-09-28 | 2001-09-28 | Astrazeneca Ab | Chemical compounds |
| AU2002249275A1 (en) * | 2002-03-08 | 2003-09-22 | Warner-Lambert Company Llc | Oxo azabicyclic compounds |
| US7420000B2 (en) * | 2003-09-10 | 2008-09-02 | University Of Southern California | Amino phosphonate and amino bis-phosphonate derivatives |
| US20050143349A1 (en) * | 2003-12-17 | 2005-06-30 | Quatrx Pharmaceuticals Co. | Phosphorus containing compounds useful for the regulation of LDL and Lp(a) levels |
| JP2008536923A (ja) * | 2005-04-18 | 2008-09-11 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | 心筋の再灌流の増強およびｐｃｉの容易化のためのｔａｆｉ阻害剤の使用 |
| US8367706B2 (en) * | 2007-06-20 | 2013-02-05 | Merck Sharp & Dohme Corp. | Inhibitors of janus kinases |
| FR2920773B1 (fr) * | 2007-09-11 | 2009-10-23 | Servier Lab | Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2947266B1 (fr) * | 2009-06-26 | 2011-06-17 | Servier Lab | Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP2507249B1 (en) * | 2009-09-09 | 2015-11-11 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| JP6186434B2 (ja) * | 2012-07-18 | 2017-08-23 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 窒素複素環誘導体及びその医薬品への応用 |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
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2016
- 2016-01-14 FR FR1670004A patent/FR3046793B1/fr not_active Expired - Fee Related
- 2016-12-27 JO JOP/2016/0275A patent/JO3660B1/ar active
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2017
- 2017-01-11 UY UY0001037072A patent/UY37072A/es unknown
- 2017-01-12 TW TW106100930A patent/TWI625334B/zh not_active IP Right Cessation
- 2017-01-12 AR ARP170100074A patent/AR107433A1/es unknown
- 2017-01-13 MX MX2018008639A patent/MX367319B/es active IP Right Grant
- 2017-01-13 MD MDE20180097T patent/MD3271368T2/ro not_active IP Right Cessation
- 2017-01-13 US US15/548,533 patent/US10138260B2/en not_active Expired - Fee Related
- 2017-01-13 KR KR1020187023228A patent/KR20180101522A/ko not_active Abandoned
- 2017-01-13 CU CUP2018000072A patent/CU20180072A7/es unknown
- 2017-01-13 ES ES17706525T patent/ES2709376T3/es active Active
- 2017-01-13 UA UAA201808634A patent/UA121275C2/uk unknown
- 2017-01-13 EA EA201891599A patent/EA035072B1/ru not_active IP Right Cessation
- 2017-01-13 PL PL17706525T patent/PL3271368T3/pl unknown
- 2017-01-13 JP JP2018536455A patent/JP2019504070A/ja active Pending
- 2017-01-13 PT PT17706525T patent/PT3271368T/pt unknown
- 2017-01-13 MA MA41798A patent/MA41798B1/fr unknown
- 2017-01-13 HK HK18103808.6A patent/HK1244283B/zh not_active IP Right Cessation
- 2017-01-13 PE PE2018001210A patent/PE20181503A1/es unknown
- 2017-01-13 SG SG11201805757WA patent/SG11201805757WA/en unknown
- 2017-01-13 GE GEAP201714853A patent/GEP20207092B/en unknown
- 2017-01-13 TN TNP/2018/000226A patent/TN2018000226A1/fr unknown
- 2017-01-13 GE GEAP201914853A patent/GEAP201914853A/en unknown
- 2017-01-13 RU RU2018129027A patent/RU2729641C2/ru not_active IP Right Cessation
- 2017-01-13 WO PCT/FR2017/050075 patent/WO2017121969A1/fr not_active Ceased
- 2017-01-13 TR TR2018/20430T patent/TR201820430T4/tr unknown
- 2017-01-13 RS RS20190105A patent/RS58338B1/sr unknown
- 2017-01-13 LT LTEP17706525.7T patent/LT3271368T/lt unknown
- 2017-01-13 BR BR112018014020-1A patent/BR112018014020A2/pt not_active IP Right Cessation
- 2017-01-13 HU HUE17706525A patent/HUE042924T2/hu unknown
- 2017-01-13 AU AU2017207003A patent/AU2017207003B2/en not_active Expired - Fee Related
- 2017-01-13 DK DK17706525.7T patent/DK3271368T3/da active
- 2017-01-13 EP EP17706525.7A patent/EP3271368B1/fr active Active
- 2017-01-13 CA CA3011184A patent/CA3011184C/fr not_active Expired - Fee Related
- 2017-01-13 HR HRP20190193TT patent/HRP20190193T1/hr unknown
- 2017-01-13 ME MEP-2019-23A patent/ME03305B/me unknown
- 2017-01-13 SI SI201730013T patent/SI3271368T1/sl unknown
- 2017-01-13 CN CN201780008078.XA patent/CN108495857A/zh active Pending
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2018
- 2018-06-26 PH PH12018501373A patent/PH12018501373B1/en unknown
- 2018-06-29 ZA ZA2018/04391A patent/ZA201804391B/en unknown
- 2018-07-04 IL IL260425A patent/IL260425B/en active IP Right Grant
- 2018-07-05 SV SV2018005721A patent/SV2018005721A/es unknown
- 2018-07-06 NI NI201800073A patent/NI201800073A/es unknown
- 2018-07-09 DO DO2018000165A patent/DOP2018000165A/es unknown
- 2018-07-09 CL CL2018001862A patent/CL2018001862A1/es unknown
- 2018-07-11 EC ECSENADI201851972A patent/ECSP18051972A/es unknown
- 2018-07-12 CO CONC2018/0007271A patent/CO2018007271A2/es unknown
- 2018-10-04 US US16/151,597 patent/US10654878B2/en not_active Expired - Fee Related
- 2018-12-10 CY CY20181101320T patent/CY1121154T1/el unknown
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