ECSP19013196A - Derivado de triazolopirazinona útil como un inhibidor de pde1 humana - Google Patents

Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Info

Publication number
ECSP19013196A
ECSP19013196A ECSENADI201913196A ECDI201913196A ECSP19013196A EC SP19013196 A ECSP19013196 A EC SP19013196A EC SENADI201913196 A ECSENADI201913196 A EC SENADI201913196A EC DI201913196 A ECDI201913196 A EC DI201913196A EC SP19013196 A ECSP19013196 A EC SP19013196A
Authority
EC
Ecuador
Prior art keywords
inhibitor
derivative useful
human pde1
triazolopyrazinone
pde1
Prior art date
Application number
ECSENADI201913196A
Other languages
English (en)
Inventor
Qing Shi
Mark David Rekhter
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP19013196A publication Critical patent/ECSP19013196A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto de Fórmula I: o una sal del mismo farmacéuticamente aceptable, para uso como un inhibidor de PDE1 humana.
ECSENADI201913196A 2016-08-25 2019-02-22 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana ECSP19013196A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662379372P 2016-08-25 2016-08-25

Publications (1)

Publication Number Publication Date
ECSP19013196A true ECSP19013196A (es) 2019-03-29

Family

ID=59762063

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201913196A ECSP19013196A (es) 2016-08-25 2019-02-22 Derivado de triazolopirazinona útil como un inhibidor de pde1 humana

Country Status (37)

Country Link
US (1) US10138244B2 (es)
EP (1) EP3504208B1 (es)
JP (1) JP6633246B2 (es)
KR (1) KR20190028544A (es)
CN (1) CN109641902B (es)
AR (1) AR109328A1 (es)
AU (1) AU2017317111A1 (es)
BR (1) BR112019000988A2 (es)
CA (1) CA3034828A1 (es)
CL (1) CL2019000487A1 (es)
CO (1) CO2019001644A2 (es)
CR (1) CR20190078A (es)
CY (1) CY1123406T1 (es)
DK (1) DK3504208T3 (es)
DO (1) DOP2019000021A (es)
EA (1) EA201990313A1 (es)
EC (1) ECSP19013196A (es)
ES (1) ES2800433T3 (es)
HR (1) HRP20201187T1 (es)
HU (1) HUE050419T2 (es)
JO (1) JOP20170164A1 (es)
LT (1) LT3504208T (es)
MA (1) MA46039B1 (es)
MD (1) MD3504208T2 (es)
ME (1) ME03791B (es)
MX (1) MX2019002065A (es)
PE (1) PE20190452A1 (es)
PH (1) PH12019500370A1 (es)
PL (1) PL3504208T3 (es)
PT (1) PT3504208T (es)
RS (1) RS60442B1 (es)
SG (1) SG11201901311WA (es)
SI (1) SI3504208T1 (es)
SV (1) SV2019005838A (es)
TN (1) TN2019000038A1 (es)
TW (1) TWI651323B (es)
WO (1) WO2018039051A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR112457A1 (es) * 2017-08-02 2019-10-30 Lilly Co Eli Derivados de [1,2,4]triazolo[4,3-a]pirazin-6(5h)-ona
TW201920188A (zh) 2017-08-10 2019-06-01 美商美國禮來大藥廠 [1,2,4]三唑衍生物
US11453673B2 (en) 2018-02-06 2022-09-27 Eli Lilly And Company Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors
WO2021035157A1 (en) * 2019-08-22 2021-02-25 Intra-Cellular Therapies, Inc. Organic compounds
WO2025059641A1 (en) 2023-09-14 2025-03-20 Eli Lilly And Company Pde1 inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354027A (en) 1980-05-19 1982-10-12 Usv Pharmaceutical Corporation Triazoloquinoxalin-4-ones
CA2671980C (en) 2006-12-13 2015-05-05 Aska Pharmaceutical Co., Ltd. Quinoxaline derivatives
WO2008103357A1 (en) 2007-02-21 2008-08-28 E. I. Du Pont De Nemours And Company Fungicidal tricyclic 1,2,4-triazoles
JP5822080B2 (ja) 2010-09-07 2015-11-24 アステラス製薬株式会社 キノキサリン化合物
AU2013277294C1 (en) * 2012-06-18 2018-02-08 Dart Neuroscience (Cayman) Ltd Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
WO2016022825A1 (en) * 2014-08-07 2016-02-11 Intra-Cellular Therapies, Inc. Organic compounds
US20160083400A1 (en) * 2014-09-18 2016-03-24 Sunovion Pharmaceuticals Inc. Tricyclic guanidine derivative
TW201629064A (zh) * 2014-10-10 2016-08-16 Ｈ 朗德貝克公司 作爲ｐｄｅ１抑制劑之三唑並吡酮
TWI609870B (zh) 2016-02-12 2018-01-01 美國禮來大藥廠 Pde1抑制劑

Also Published As

Publication number Publication date
LT3504208T (lt) 2020-08-10
HRP20201187T1 (hr) 2020-11-13
JP6633246B2 (ja) 2020-01-22
CL2019000487A1 (es) 2019-07-12
PL3504208T3 (pl) 2020-11-16
RS60442B1 (sr) 2020-07-31
TW201819379A (zh) 2018-06-01
SI3504208T1 (sl) 2020-08-31
MX2019002065A (es) 2019-06-03
CN109641902A (zh) 2019-04-16
MD3504208T2 (ro) 2020-08-31
AU2017317111A1 (en) 2019-01-31
CR20190078A (es) 2019-04-05
US20180057494A1 (en) 2018-03-01
BR112019000988A2 (pt) 2019-05-14
SV2019005838A (es) 2019-04-04
KR20190028544A (ko) 2019-03-18
WO2018039051A1 (en) 2018-03-01
EP3504208A1 (en) 2019-07-03
TN2019000038A1 (en) 2020-07-15
JP2019526567A (ja) 2019-09-19
AR109328A1 (es) 2018-11-21
ES2800433T3 (es) 2020-12-30
MA46039B1 (fr) 2020-09-30
EA201990313A1 (ru) 2019-07-31
EP3504208B1 (en) 2020-06-10
PH12019500370A1 (en) 2019-10-21
SG11201901311WA (en) 2019-03-28
CN109641902B (zh) 2021-06-08
PE20190452A1 (es) 2019-03-29
CA3034828A1 (en) 2018-03-01
DOP2019000021A (es) 2019-02-28
DK3504208T3 (da) 2020-07-27
CO2019001644A2 (es) 2019-05-21
PT3504208T (pt) 2020-08-31
HUE050419T2 (hu) 2020-12-28
US10138244B2 (en) 2018-11-27
ME03791B (me) 2021-04-20
JOP20170164A1 (ar) 2019-01-30
CY1123406T1 (el) 2021-12-31
TWI651323B (zh) 2019-02-21

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