ECSP19020141A - Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino - Google Patents

Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino

Info

Publication number
ECSP19020141A
ECSP19020141A ECSENADI201920141A ECDI201920141A ECSP19020141A EC SP19020141 A ECSP19020141 A EC SP19020141A EC SENADI201920141 A ECSENADI201920141 A EC SENADI201920141A EC DI201920141 A ECDI201920141 A EC DI201920141A EC SP19020141 A ECSP19020141 A EC SP19020141A
Authority
EC
Ecuador
Prior art keywords
steroid
disustituted
pirazolyl
crystaline
formula
Prior art date
Application number
ECSENADI201920141A
Other languages
English (en)
Inventor
James Doherty
Paul Watson
Stephen Kanes
Bret Berner
John Reid
Jian Wang
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of ECSP19020141A publication Critical patent/ECSP19020141A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

Esta invención se refiere a un esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) y formas sólidas cristalinas y composiciones del mismo. También se describen en la presente métodos de preparación de formas sólidas cristalinas del esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) y métodos de uso del esteroide 19-nor-C21-pirazolilo C3,3-disustituido de la fórmula (I) o formas sólidas cristalinas, sales farmacéuticamente aceptables, y composiciones farmacéuticamente aceptables del mismo.
ECSENADI201920141A 2016-08-23 2019-03-22 Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino ECSP19020141A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662378582P 2016-08-23 2016-08-23

Publications (1)

Publication Number Publication Date
ECSP19020141A true ECSP19020141A (es) 2019-04-30

Family

ID=59772778

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201920141A ECSP19020141A (es) 2016-08-23 2019-03-22 Un esteroide 19-nor-c21-n-pirazolilo c3,3-disustituido cristalino

Country Status (24)

Country Link
US (4) US11236121B2 (es)
EP (2) EP3504189A1 (es)
JP (3) JP2019524853A (es)
KR (2) KR20190040043A (es)
CN (4) CN110088091A (es)
AR (3) AR109393A1 (es)
AU (2) AU2017315682B2 (es)
BR (1) BR112019003637A2 (es)
CA (1) CA3034262A1 (es)
CL (2) CL2019000477A1 (es)
CO (1) CO2019002596A2 (es)
EA (1) EA201990565A1 (es)
EC (1) ECSP19020141A (es)
IL (2) IL302480A (es)
JO (3) JOP20190022B1 (es)
MA (1) MA46042A (es)
MX (2) MX393240B (es)
MY (1) MY200479A (es)
PE (2) PE20190915A1 (es)
PH (1) PH12019500375A1 (es)
SG (1) SG11201901445TA (es)
TW (3) TWI808945B (es)
WO (1) WO2018039378A1 (es)
ZA (1) ZA201901051B (es)

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