MA51046A - Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc - Google Patents
Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du sncInfo
- Publication number
- MA51046A MA51046A MA051046A MA51046A MA51046A MA 51046 A MA51046 A MA 51046A MA 051046 A MA051046 A MA 051046A MA 51046 A MA51046 A MA 51046A MA 51046 A MA51046 A MA 51046A
- Authority
- MA
- Morocco
- Prior art keywords
- pregan
- deuterates
- pyrazol
- cyano
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762596725P | 2017-12-08 | 2017-12-08 | |
| US201862731539P | 2018-09-14 | 2018-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA51046A true MA51046A (fr) | 2021-03-17 |
Family
ID=65003476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA051046A MA51046A (fr) | 2017-12-08 | 2018-12-07 | Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US20200291059A1 (fr) |
| EP (2) | EP3720867A1 (fr) |
| JP (4) | JP2021505608A (fr) |
| KR (1) | KR20200096596A (fr) |
| MA (1) | MA51046A (fr) |
| WO (1) | WO2019113494A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013112605A2 (fr) | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Formulation de stéroïde neuroactif et procédés de traitement des troubles de snc |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| HRP20190232T1 (hr) | 2013-04-17 | 2019-03-22 | Sage Therapeutics, Inc. | 19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu |
| WO2015195962A1 (fr) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs, leurs compositions et utilisations |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| ES2793237T3 (es) | 2014-11-27 | 2020-11-13 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| CN115974954A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
| EP3720867A1 (fr) | 2017-12-08 | 2020-10-14 | Sage Therapeutics, Inc. | Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc |
| AU2019406803B2 (en) | 2018-12-17 | 2025-04-24 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2021023213A1 (fr) * | 2019-08-07 | 2021-02-11 | 上海翰森生物医药科技有限公司 | Sel et forme cristalline d'un régulateur de dérivé de stéroïde |
| US10857163B1 (en) | 2019-09-30 | 2020-12-08 | Athenen Therapeutics, Inc. | Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof |
| US20230346801A1 (en) | 2020-03-25 | 2023-11-02 | Sage Therapeutics, Inc. | Use of agents for treatment of respiratory conditions |
| WO2022040545A1 (fr) * | 2020-08-20 | 2022-02-24 | Intra-Cellular Therapies, Inc. | Composés organiques |
| KR20240148425A (ko) | 2022-02-16 | 2024-10-11 | 세이지 테라퓨틱스, 인크. | Cns-관련 장애의 치료를 위한 신경활성 스테로이드 |
| WO2023163879A1 (fr) | 2022-02-28 | 2023-08-31 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs pour le traitement de maladies ou d'états gastro-intestinaux |
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|---|---|---|---|---|
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| ES2293638T3 (es) * | 1994-03-25 | 2008-03-16 | Isotechnika, Inc. | Mejora de la eficacia de farmacos por deuteracion. |
| WO2010054158A2 (fr) * | 2008-11-07 | 2010-05-14 | Auspex Pharmaceuticals, Inc. | Modulateurs stéroïdiens du récepteur des glucocorticoïdes |
| ES2738526T3 (es) | 2011-10-14 | 2020-01-23 | Sage Therapeutics Inc | Compuestos 19-norpregnano 3,3-disustituidos, composiciones y usos de los mismos |
| WO2013112605A2 (fr) | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Formulation de stéroïde neuroactif et procédés de traitement des troubles de snc |
| US20150175651A1 (en) | 2012-06-15 | 2015-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| SG10201607230SA (en) * | 2012-06-19 | 2016-10-28 | Intercept Pharmaceuticals Inc | Preparation, Uses And Solid Forms Of Obeticholic Acid |
| US20140050789A1 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
| IL275725B (en) | 2012-08-21 | 2022-08-01 | Sage Therapeutics Inc | Treatment methods for epilepsy and status epilepticus |
| EP4335505A3 (fr) | 2012-11-30 | 2024-06-05 | The Regents of The University of California | Activité anticonvulsivante de stéroïdes |
| BR112015014397B1 (pt) | 2012-12-18 | 2021-02-02 | Washington University | composto, composição farmacêutica e uso de um composto |
| GB201302368D0 (en) * | 2013-02-11 | 2013-03-27 | Univ Bath | Compound |
| US20160068563A1 (en) | 2013-04-17 | 2016-03-10 | Boyd L. Harrison | 19-nor neuroactive steroids and methods of use thereof |
| HRP20190232T1 (hr) * | 2013-04-17 | 2019-03-22 | Sage Therapeutics, Inc. | 19-nor c3,3-disupstituirani c21-n-pirazolil steroidi i postupci za njihovu upotrebu |
| HRP20200995T1 (hr) | 2013-04-17 | 2020-11-27 | Sage Therapeutics, Inc. | 19-nor neuroaktivni steroidi za metode liječenja |
| WO2014169831A1 (fr) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor-hétéroaryl-stéroïdes c21-c-liés c3,3-disubstitués et procédés d'utilisation de ceux-ci |
| SMT202100229T1 (it) | 2013-07-19 | 2021-05-07 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e loro usi |
| SMT202100048T1 (it) | 2013-08-23 | 2021-03-15 | Sage Therapeutics Inc | Steroidi neuroattivi, composizioni e loro usi |
| HUE050028T2 (hu) | 2014-05-29 | 2021-12-28 | Sage Therapeutics Inc | Neuroaktív szteroidok, készítmények és alkalmazásuk |
| WO2015195962A1 (fr) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs, leurs compositions et utilisations |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| AU2015331749A1 (en) | 2014-10-16 | 2017-05-04 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| JP6742308B2 (ja) * | 2014-10-16 | 2020-08-19 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害を処置するための組成物および方法 |
| ES2793237T3 (es) | 2014-11-27 | 2020-11-13 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| SI3250210T1 (sl) | 2015-01-26 | 2021-07-30 | Sage Therapeutics, Inc. | Sestavki in metode za zdravljenje CNS motenj |
| CN105985396A (zh) * | 2015-02-16 | 2016-10-05 | 苏州泽璟生物制药有限公司 | 氘代鹅去氧胆酸衍生物以及包含该化合物的药物组合物 |
| US10329320B2 (en) | 2015-02-20 | 2019-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2016164763A1 (fr) * | 2015-04-10 | 2016-10-13 | Sage Therapeutics, Inc. | Compositions et méthodes permettant de traiter des troubles du snc |
| AR105044A1 (es) | 2015-06-18 | 2017-08-30 | Sage Therapeutics Inc | Soluciones de esteroides neuroactivos y sus métodos de uso, recipiente |
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| CN115974954A (zh) | 2016-08-23 | 2023-04-18 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇的晶体 |
| AU2018327357B2 (en) | 2017-09-07 | 2024-08-22 | Sage Therapeutics, LLC | Neuroactive steroids and their methods of use |
| US20200276209A1 (en) | 2017-09-11 | 2020-09-03 | Sage Therapeutics, Inc. | Methods of treating epilepsy or status epilepticus |
| EP4696301A2 (fr) | 2017-09-14 | 2026-02-18 | Sage Therapeutics, Inc. | Stéroïde c21-n-pyrazolyl 19-nor c3,3-disubstitué et ses procédés d'utilisation |
| EP3720867A1 (fr) | 2017-12-08 | 2020-10-14 | Sage Therapeutics, Inc. | Dérivés de 21-[4-cyano-pyrazol-1-yl]-19-nor-pregan-3. alpha-ol-20-one deutérés pour le traitement de troubles du snc |
| MA51315A (fr) | 2017-12-22 | 2020-10-28 | Sage Therapeutics Inc | Compositions et méthodes permettant de traiter des troubles du snc |
| AR114044A1 (es) | 2017-12-22 | 2020-07-15 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos en el sistema nervioso central |
| JP7538040B2 (ja) | 2018-01-12 | 2024-08-21 | セージ セラピューティクス， インコーポレイテッド | ＣＮＳ障害の処置における使用のためのアザ、オキサ、およびチア－プレグナン－２０－オン－３α－オール化合物 |
| AU2019287491B2 (en) | 2018-06-12 | 2025-05-15 | Sage Therapeutics, LLC | A 19-nor C3,3-disubstituted C21 -N-pyrazolyl steroid and methods of use thereof |
| EP3864022B1 (fr) | 2018-10-12 | 2023-09-20 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs substitués en position 10 avec un groupe cyclique pour une utilisation dans le traitement de troubles du système nerveux central |
| AU2019359899B2 (en) | 2018-10-19 | 2024-07-04 | Sage Therapeutics, Inc. | 9(11)-unsaturated neuroactive steroids and their methods of use |
| BR112021010996A2 (pt) | 2018-12-05 | 2021-08-31 | Sage Therapeutics, Inc. | Esteroides neuroativos e seus métodos de uso |
| WO2020132504A1 (fr) | 2018-12-21 | 2020-06-25 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs de 3.alpha.-hydroxy-17.bêta.-amide et compositions associées |
| TW202523658A (zh) | 2019-05-24 | 2025-06-16 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
| CN114206900A (zh) | 2019-05-31 | 2022-03-18 | 萨奇治疗股份有限公司 | 神经活性类固醇及其组合物 |
| CN114787174A (zh) | 2019-06-27 | 2022-07-22 | 萨奇治疗股份有限公司 | 用于治疗cns病症的组合物和方法 |
| AU2020302748A1 (en) | 2019-06-27 | 2022-01-06 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| CN114729000A (zh) | 2019-06-27 | 2022-07-08 | 萨奇治疗股份有限公司 | 用于治疗cns病症的化合物 |
| CN114761019A (zh) | 2019-12-05 | 2022-07-15 | 萨奇治疗股份有限公司 | 19-去甲c3,3-二取代的c21-n-吡唑基类固醇及其使用方法 |
| WO2021168106A1 (fr) | 2020-02-18 | 2021-08-26 | Praxis Precision Medicines, Inc. | Neurostéroïde deutéré |
| TW202143976A (zh) | 2020-03-18 | 2021-12-01 | 美商賽吉醫療公司 | 神經活性類固醇及其使用方法 |
| US20230346801A1 (en) | 2020-03-25 | 2023-11-02 | Sage Therapeutics, Inc. | Use of agents for treatment of respiratory conditions |
| EP4172171A1 (fr) | 2020-06-24 | 2023-05-03 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs 3.alpha.-hydroxy, 17.beta.-c(o)-n-aryl-substitués et compositions associées |
| PE20231301A1 (es) | 2020-07-20 | 2023-08-24 | Sage Therapeutics Inc | Formulaciones del esteroide c21-n-pirazolilo 19-nor c3,3-disustituido y metodos de uso de este |
| WO2022040545A1 (fr) | 2020-08-20 | 2022-02-24 | Intra-Cellular Therapies, Inc. | Composés organiques |
| MX2023006063A (es) | 2020-11-25 | 2023-08-09 | Sage Therapeutics Inc | Composiciones y metodos para el tratamiento de trastornos del sistema nervioso central. |
| JP2024507638A (ja) | 2021-01-28 | 2024-02-21 | セージ セラピューティクス， インコーポレイテッド | 性機能障害処置のための神経刺激性ステロイドの使用 |
| US20240148756A1 (en) | 2021-02-18 | 2024-05-09 | Sage Therapeutics, Inc. | Use of neuroactive steroid for treatment of sexual dysfunction |
| WO2022197901A1 (fr) | 2021-03-17 | 2022-09-22 | Sage Therapeutics, Inc. | Stéroïde 19-nor c3,3-disubstitué c21-n-pyrazolyl pour le traitement d'un trouble dépressif majeur |
| JP2024513581A (ja) | 2021-04-12 | 2024-03-26 | セージ セラピューティクス， インコーポレイテッド | 本態性振戦の治療 |
| AU2022267304A1 (en) | 2021-04-29 | 2023-11-02 | Sage Therapeutics, LLC | Neuroactive steroid for use in treating major depressive disorder and postpartum depression in a lactating female |
| KR20240006026A (ko) | 2021-04-29 | 2024-01-12 | 세이지 테라퓨틱스, 인크. | 주요 우울 장애 및 산후 우울증을 치료하는 데 사용하기 위한 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 |
| KR20240148425A (ko) | 2022-02-16 | 2024-10-11 | 세이지 테라퓨틱스, 인크. | Cns-관련 장애의 치료를 위한 신경활성 스테로이드 |
| WO2023163879A1 (fr) | 2022-02-28 | 2023-08-31 | Sage Therapeutics, Inc. | Stéroïdes neuroactifs pour le traitement de maladies ou d'états gastro-intestinaux |
-
2018
- 2018-12-07 EP EP18830574.2A patent/EP3720867A1/fr not_active Ceased
- 2018-12-07 MA MA051046A patent/MA51046A/fr unknown
- 2018-12-07 KR KR1020207019345A patent/KR20200096596A/ko not_active Ceased
- 2018-12-07 US US16/770,398 patent/US20200291059A1/en not_active Abandoned
- 2018-12-07 WO PCT/US2018/064546 patent/WO2019113494A1/fr not_active Ceased
- 2018-12-07 JP JP2020531058A patent/JP2021505608A/ja not_active Withdrawn
- 2018-12-07 EP EP24200003.2A patent/EP4484440A3/fr active Pending
-
2021
- 2021-12-08 US US17/545,290 patent/US11667668B2/en active Active
-
2023
- 2023-04-24 US US18/305,529 patent/US12060386B2/en active Active
- 2023-06-06 JP JP2023093131A patent/JP7569412B2/ja active Active
-
2024
- 2024-02-05 JP JP2024015700A patent/JP2024033000A/ja active Pending
- 2024-06-27 US US18/756,278 patent/US12534495B2/en active Active
-
2025
- 2025-12-25 JP JP2025282062A patent/JP2026040695A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019113494A1 (fr) | 2019-06-13 |
| KR20200096596A (ko) | 2020-08-12 |
| EP3720867A1 (fr) | 2020-10-14 |
| JP2023105082A (ja) | 2023-07-28 |
| US20240092824A1 (en) | 2024-03-21 |
| JP2024033000A (ja) | 2024-03-12 |
| JP7569412B2 (ja) | 2024-10-17 |
| US20200291059A1 (en) | 2020-09-17 |
| US12534495B2 (en) | 2026-01-27 |
| EP4484440A2 (fr) | 2025-01-01 |
| US12060386B2 (en) | 2024-08-13 |
| US20250171491A1 (en) | 2025-05-29 |
| US20220098231A1 (en) | 2022-03-31 |
| JP2026040695A (ja) | 2026-03-09 |
| US11667668B2 (en) | 2023-06-06 |
| EP4484440A3 (fr) | 2025-03-26 |
| JP2021505608A (ja) | 2021-02-18 |
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