ECSP19077884A - Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia - Google Patents

Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia

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Publication number
ECSP19077884A
ECSP19077884A ECSENADI201977884A ECDI201977884A ECSP19077884A EC SP19077884 A ECSP19077884 A EC SP19077884A EC SENADI201977884 A ECSENADI201977884 A EC SENADI201977884A EC DI201977884 A ECDI201977884 A EC DI201977884A EC SP19077884 A ECSP19077884 A EC SP19077884A
Authority
EC
Ecuador
Prior art keywords
tils
immunotherapy
tumors
processes
production
Prior art date
Application number
ECSENADI201977884A
Other languages
English (en)
Inventor
Bender James
T Lotze Michael
WARDELL Seth
Original Assignee
Iovance Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Iovance Biotherapeutics Inc filed Critical Iovance Biotherapeutics Inc
Publication of ECSP19077884A publication Critical patent/ECSP19077884A/es

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    • A61K35/14—Blood; Artificial blood
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A01N1/10—Preservation of living parts
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    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K2039/55511—Organic adjuvants
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    • A—HUMAN NECESSITIES
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/30—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cancer cells, e.g. reversion of tumour cells

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  • Health & Medical Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
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Abstract

La presente invención proporciona mejores métodos y/o métodos acortados para expandir TILs y producir poblaciones terapéuticas de TILs, incluyendo nuevos métodos para expandir las poblaciones de TILs en un sistema cerrado que llevan a una mayor eficacia, mayor fenotipo y mayor salud metabólica de los TILs en un período de tiempo más corto, mientras permite una contaminación microbiana reducida así como menores costos. Estos TILs se usan en regímenes de tratamiento terapéuticos.
ECSENADI201977884A 2017-03-29 2019-10-29 Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia ECSP19077884A (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762478506P 2017-03-29 2017-03-29
US201762539410P 2017-07-31 2017-07-31
US201762548306P 2017-08-21 2017-08-21
US201762554538P 2017-09-05 2017-09-05
US201762559374P 2017-09-15 2017-09-15
US201762567121P 2017-10-02 2017-10-02
US201762577655P 2017-10-26 2017-10-26
US201762582874P 2017-11-07 2017-11-07
US201762596374P 2017-12-08 2017-12-08

Publications (1)

Publication Number Publication Date
ECSP19077884A true ECSP19077884A (es) 2020-01-31

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ID=61569356

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ECSENADI201977884A ECSP19077884A (es) 2017-03-29 2019-10-29 Procesos para la producción de linfocitos infiltrantes de tumores y usos de ellos en inmunoterapia

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Country Link
US (60) US10894063B2 (es)
EP (6) EP4279574A3 (es)
JP (6) JP7169291B2 (es)
KR (2) KR20240114787A (es)
CN (1) CN110785486A (es)
AU (2) AU2018243355B2 (es)
BR (1) BR112019020326A2 (es)
CA (1) CA3057975A1 (es)
CL (2) CL2019002769A1 (es)
CO (1) CO2019011995A2 (es)
CR (1) CR20190487A (es)
CY (1) CY1124136T1 (es)
DK (3) DK3601533T3 (es)
EC (1) ECSP19077884A (es)
ES (3) ES2874335T3 (es)
FI (2) FI3730608T3 (es)
HR (3) HRP20241688T1 (es)
HU (3) HUE054829T2 (es)
IL (2) IL305198A (es)
JO (1) JOP20190224A1 (es)
LT (3) LT3730608T (es)
MA (2) MA68598B1 (es)
MD (3) MD3601533T2 (es)
MX (2) MX2019011768A (es)
NZ (2) NZ796152A (es)
PE (1) PE20191841A1 (es)
PH (1) PH12019502247A1 (es)
PL (3) PL3722415T3 (es)
PT (3) PT3722415T (es)
RS (3) RS66400B1 (es)
SG (1) SG11201908994RA (es)
SI (3) SI3601533T1 (es)
SM (3) SMT202500027T1 (es)
TN (1) TN2019000273A1 (es)
TW (1) TWI799402B (es)
UA (1) UA130566C2 (es)
WO (1) WO2018182817A1 (es)

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