ECSP20078586A - Compuestos de azabencimidazol y productos farmacéuticos - Google Patents

Compuestos de azabencimidazol y productos farmacéuticos

Info

Publication number
ECSP20078586A
ECSP20078586A ECSENADI202078586A ECDI202078586A ECSP20078586A EC SP20078586 A ECSP20078586 A EC SP20078586A EC SENADI202078586 A ECSENADI202078586 A EC SENADI202078586A EC DI202078586 A ECDI202078586 A EC DI202078586A EC SP20078586 A ECSP20078586 A EC SP20078586A
Authority
EC
Ecuador
Prior art keywords
compounds
bladder
pharmaceutical products
pam
azabenzimidazole
Prior art date
Application number
ECSENADI202078586A
Other languages
English (en)
Inventor
Akiko FUJIBAYASHI
Kouya OIKAWA
Kazuhiko Wakita
Sho Hirai
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of ECSP20078586A publication Critical patent/ECSP20078586A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/396—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having three-membered rings, e.g. aziridine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

El propósito de la presente invención es proporcionar compuestos que tengan una acción M3 PAM. Ejemplos de la presente invención incluyen compuestos de azabencimidazol representados, por ejemplo, por la fórmula [I] y sus sales farmacológicamente aceptables. Estos compuestos tienen actividad M3 PAM. Además, debido a que estos compuestos tienen actividad M3 PAM, estos compuestos son útiles como agentes para la prevención o tratamiento de trastornos de micción y/o almacenamiento en vejiga hipoactiva, vejiga hipotónica, vejiga contráctil, subactividad del detrusor y vejiga neurogénica.
ECSENADI202078586A 2018-05-08 2020-12-07 Compuestos de azabencimidazol y productos farmacéuticos ECSP20078586A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018089867 2018-05-08

Publications (1)

Publication Number Publication Date
ECSP20078586A true ECSP20078586A (es) 2021-01-29

Family

ID=68467433

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202078586A ECSP20078586A (es) 2018-05-08 2020-12-07 Compuestos de azabencimidazol y productos farmacéuticos

Country Status (35)

Country Link
US (1) US12319683B2 (es)
EP (1) EP3792260B1 (es)
JP (1) JP7235047B2 (es)
KR (1) KR102819951B1 (es)
CN (1) CN112368282B (es)
AU (1) AU2019265134B2 (es)
BR (1) BR112020022662A2 (es)
CA (1) CA3099655A1 (es)
CL (1) CL2020002868A1 (es)
CO (1) CO2020013848A2 (es)
DK (1) DK3792260T3 (es)
EC (1) ECSP20078586A (es)
ES (1) ES2992256T3 (es)
FI (1) FI3792260T3 (es)
HR (1) HRP20241414T1 (es)
HU (1) HUE068695T2 (es)
IL (1) IL278517B2 (es)
LT (1) LT3792260T (es)
MA (1) MA52587B1 (es)
MD (1) MD3792260T2 (es)
MX (1) MX2020011855A (es)
MY (1) MY202833A (es)
PE (1) PE20211384A1 (es)
PH (1) PH12020551873A1 (es)
PL (1) PL3792260T3 (es)
PT (1) PT3792260T (es)
RS (1) RS65996B1 (es)
SA (1) SA520420487B1 (es)
SG (1) SG11202011003TA (es)
SI (1) SI3792260T1 (es)
SM (1) SMT202400407T1 (es)
TW (1) TWI868068B (es)
UA (1) UA126774C2 (es)
WO (1) WO2019216294A1 (es)
ZA (1) ZA202007164B (es)

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* Cited by examiner, † Cited by third party
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PT3792260T (pt) 2018-05-08 2024-10-02 Nippon Shinyaku Co Ltd Compostos de azabenzimidazol e produtos farmacêuticos
BR112022008457A2 (pt) * 2019-11-13 2022-07-26 Nippon Shinyaku Co Ltd Agente terapêutico e agente profilático para distúrbios gastrointestinais funcionais e xerostomia
CA3161582A1 (en) 2019-11-13 2021-05-20 Nippon Shinyaku Co., Ltd. Azabenzimidazole compound and medicine
CN118045050B (zh) * 2023-11-16 2025-06-10 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种头颈部放疗患者适用的缓解口腔干燥的组合物及其制备方法
WO2025153078A1 (zh) * 2024-01-17 2025-07-24 盛睿泽华医药科技（苏州）有限公司 可溶性环氧水解酶抑制剂及其应用

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BR112022008457A2 (pt) 2019-11-13 2022-07-26 Nippon Shinyaku Co Ltd Agente terapêutico e agente profilático para distúrbios gastrointestinais funcionais e xerostomia
CA3161582A1 (en) 2019-11-13 2021-05-20 Nippon Shinyaku Co., Ltd. Azabenzimidazole compound and medicine

Also Published As

Publication number Publication date
PE20211384A1 (es) 2021-07-27
EP3792260B1 (en) 2024-09-11
MA52587B1 (fr) 2024-10-31
PT3792260T (pt) 2024-10-02
HRP20241414T1 (hr) 2024-12-20
ES2992256T3 (es) 2024-12-11
IL278517A (en) 2020-12-31
KR20210006437A (ko) 2021-01-18
UA126774C2 (uk) 2023-02-01
SA520420487B1 (ar) 2024-03-17
LT3792260T (lt) 2024-10-25
JP7235047B2 (ja) 2023-03-08
WO2019216294A1 (ja) 2019-11-14
FI3792260T3 (fi) 2024-10-01
IL278517B1 (en) 2024-05-01
CA3099655A1 (en) 2019-11-14
JPWO2019216294A1 (ja) 2021-05-13
CN112368282A (zh) 2021-02-12
MA52587A (fr) 2021-03-17
US12319683B2 (en) 2025-06-03
CO2020013848A2 (es) 2021-01-29
CN112368282B (zh) 2023-10-13
DK3792260T3 (da) 2024-10-14
MX2020011855A (es) 2021-01-20
SMT202400407T1 (it) 2024-11-15
BR112020022662A2 (pt) 2021-02-09
MY202833A (en) 2024-05-24
TW202016108A (zh) 2020-05-01
AU2019265134A1 (en) 2020-12-17
IL278517B2 (en) 2024-09-01
CL2020002868A1 (es) 2021-04-16
HUE068695T2 (hu) 2025-01-28
PL3792260T3 (pl) 2024-12-02
AU2019265134B2 (en) 2024-02-29
SI3792260T1 (sl) 2024-11-29
EP3792260A4 (en) 2022-02-09
MD3792260T2 (ro) 2024-12-31
TWI868068B (zh) 2025-01-01
KR102819951B1 (ko) 2025-06-13
US20210371412A1 (en) 2021-12-02
ZA202007164B (en) 2024-06-26
SG11202011003TA (en) 2020-12-30
EP3792260A1 (en) 2021-03-17
PH12020551873A1 (en) 2021-05-31
RS65996B1 (sr) 2024-10-31

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