ECSP982404A - ARILSULFONIL HYDROXAMIC ACID DERIVATIVES - Google Patents
ARILSULFONIL HYDROXAMIC ACID DERIVATIVESInfo
- Publication number
- ECSP982404A ECSP982404A ECSP982404A ECSP982404A EC SP982404 A ECSP982404 A EC SP982404A EC SP982404 A ECSP982404 A EC SP982404A EC SP982404 A ECSP982404 A EC SP982404A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- cancer
- arilsulfonil
- acid derivatives
- hydroxamic acid
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- -1 Aunomycin Chemical compound 0.000 abstract 1
- 206010053177 Epidermolysis Diseases 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 206010028289 Muscle atrophy Diseases 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 206010039705 Scleritis Diseases 0.000 abstract 1
- 206010040047 Sepsis Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- 238000011284 combination treatment Methods 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 229960005420 etoposide Drugs 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 229940124641 pain reliever Drugs 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 208000037803 restenosis Diseases 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
- 229960004528 vincristine Drugs 0.000 abstract 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
El invento se refiere a un compuesto de fórmula en la que R1, R2, R3, R4, R5, R6, R7, R8, R9 y Q son como se han definido anteriormente, útil en el tratamiento de un trastorno seleccionado entre el grupo formado por artritis, cáncer, ulceración del tejido, degeneración muscular, restenosis, enfermedad periodontal, epidermólisis vesicular, escleritis y otras enfermedades caracterizadas por la actividad de metaloproteinasas de la matriz, SIDA, septicemia, choque séptico y otras enfermedades que implican la producción de TNF. Además, los compuestos de la presente invención se pueden usar en tratamiento de combinación con fármacos antiinflamatorios no esteroideos (AINE) y analgésicos convencionales, y en combinación con fármacos citotóxicos como adriamicina, aunomicina, cisplatino, etopósido, taxol, taxótero y otros alcaloides, como vincristina en el tratamiento de cáncer.The invention relates to a compound of the formula in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and Q are as defined above, useful in the treatment of a disorder selected from the group formed for arthritis, cancer, tissue ulceration, muscle degeneration, restenosis, periodontal disease, vesicular epidermolysis, scleritis and other diseases characterized by the activity of matrix metalloproteinases, AIDS, sepsis, septic shock and other diseases that involve the production of TNF. Furthermore, the compounds of the present invention can be used in combination treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and conventional pain relievers, and in combination with cytotoxic drugs such as adriamycin, Aunomycin, cisplatin, etoposide, taxol, taxater and other alkaloids, such as Vincristine in the treatment of cancer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982404 ECSP982404A (en) | 1998-02-10 | 1998-02-10 | ARILSULFONIL HYDROXAMIC ACID DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982404 ECSP982404A (en) | 1998-02-10 | 1998-02-10 | ARILSULFONIL HYDROXAMIC ACID DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982404A true ECSP982404A (en) | 1998-12-29 |
Family
ID=42043327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982404 ECSP982404A (en) | 1998-02-10 | 1998-02-10 | ARILSULFONIL HYDROXAMIC ACID DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982404A (en) |
-
1998
- 1998-02-10 EC ECSP982404 patent/ECSP982404A/en unknown
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