ECSP982484A - PIRAZOLOPIRIMIDONAS FOR SEXUAL DYSFUNCTION - Google Patents
PIRAZOLOPIRIMIDONAS FOR SEXUAL DYSFUNCTIONInfo
- Publication number
- ECSP982484A ECSP982484A ECSP982484A ECSP982484A EC SP982484 A ECSP982484 A EC SP982484A EC SP982484 A ECSP982484 A EC SP982484A EC SP982484 A ECSP982484 A EC SP982484A
- Authority
- EC
- Ecuador
- Prior art keywords
- optionally substituted
- alkyl
- alkoxy
- heterocyclic group
- attached
- Prior art date
Links
- 201000001880 Sexual dysfunction Diseases 0.000 title 1
- 231100000872 sexual dysfunction Toxicity 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 CORNR5R6 Chemical group 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 206010057671 Female sexual dysfunction Diseases 0.000 abstract 1
- 101150085511 PEDS1 gene Proteins 0.000 abstract 1
- 102100037592 Plasmanylethanolamine desaturase Human genes 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920003199 poly(diethylsiloxane) Polymers 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El invento se refiere a un compuesto de fórmula (IA) e (IB): (gráfico), o sales farmacéutica o veterinariamente aceptables de los mismos o solvatos farmacéutica o veterinariamente aceptables de cualquier entidad, en las que R1 es alquilo C1 a C3 sustituido con cicloalquilo C3 a C6, CORNR5R6 o un grupo heterocíclico unido a través de un átomo de N; (CH2) nHet o (CH2) nAr; R2 es alquilo C1 a C6; R3 es alquilo C1 a C6 opcionalmente sustituído con alcoxi C1 a C4; R4 es SO2NR7R8; cada R5 y R6 se seleccionan independientemente entre H y alquilo C1 a C4 opcionalmente sustituído con alcoxi C1 a C4 o, junto con el átomo de nitrógeno al que están unidos, forman un grupo heterocíclico de 5 ó 6 miembros; R7 y R8 junto con el átomo de nitrógeno al que estan unidos, forman un grupo 4-R10-piperazinilo; R10 es H o alquilo C1 a C4 opcionalmente sustituido con OH, alcoxi C1 a C2 o CONH2; Het es un grupo es heterocíclico de 5 ó 6 miembros unido a través de un átomo de C, opcionalmente sustituido; Ares fenilo opcionalmente sustituido; y n es 0 ó 1; son inhibidores potentes y selectivos de GMP PDES útiles en el tratamiento de, entre otros trastornos, la disfunción eréctil masculina y la disfunción sexual femenina.The invention relates to a compound of formula (IA) and (IB): (graph), or pharmaceutically or veterinarily acceptable salts thereof or pharmaceutically or veterinarily acceptable solvates of any entity, wherein R1 is C1 to C3 substituted alkyl with C3 to C6 cycloalkyl, CORNR5R6, or a heterocyclic group attached through an N atom; (CH2) nHet or (CH2) nAr; R2 is C1 to C6 alkyl; R3 is C1 to C6 alkyl optionally substituted with C1 to C4 alkoxy; R4 is SO2NR7R8; each R5 and R6 are independently selected from H and C1 to C4 alkyl optionally substituted with C1 to C4 alkoxy or, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic group; R7 and R8 together with the nitrogen atom to which they are attached, form a 4-R10-piperazinyl group; R10 is H or C1 to C4 alkyl optionally substituted with OH, C1 to C2 alkoxy or CONH2; Het is a 5- or 6-membered heterocyclic group linked via an optionally substituted C atom; Optionally substituted phenyl ares; and n is 0 or 1; they are potent and selective GMP PDES inhibitors useful in the treatment of, among other disorders, male erectile dysfunction and female sexual dysfunction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982484 ECSP982484A (en) | 1998-04-24 | 1998-04-24 | PIRAZOLOPIRIMIDONAS FOR SEXUAL DYSFUNCTION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982484 ECSP982484A (en) | 1998-04-24 | 1998-04-24 | PIRAZOLOPIRIMIDONAS FOR SEXUAL DYSFUNCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982484A true ECSP982484A (en) | 1999-01-12 |
Family
ID=42043406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982484 ECSP982484A (en) | 1998-04-24 | 1998-04-24 | PIRAZOLOPIRIMIDONAS FOR SEXUAL DYSFUNCTION |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982484A (en) |
-
1998
- 1998-04-24 EC ECSP982484 patent/ECSP982484A/en unknown
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