ECSP982486A - PROTEASE INHIBITORS II - Google Patents
PROTEASE INHIBITORS IIInfo
- Publication number
- ECSP982486A ECSP982486A ECSP982486A ECSP982486A EC SP982486 A ECSP982486 A EC SP982486A EC SP982486 A ECSP982486 A EC SP982486A EC SP982486 A ECSP982486 A EC SP982486A
- Authority
- EC
- Ecuador
- Prior art keywords
- disease
- cartilage
- present
- matrix
- excessive
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 208000024693 gingival disease Diseases 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona compuestos que inhiben proteasas, incluyendo catepsina K, composiciones farmacéuticas de tales compuestos, y métodos para tratar enfermedades de excesiva pérdida ósea o degradación de cartílago o matriz, incluyendo osteoporosis; enfermedad gingival, incluyendo gingivitis y artritis reumatoide; enfermedad de Paget: hipercalcemia de enfermedades malignas; y enfermedad ósea o degradación excesiva de cartílago o matriz administrando un compuesto de la presente invención a un paciente con necesidad de ello.The present invention provides compounds that inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods of treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease, including gingivitis and rheumatoid arthritis; Paget's disease: hypercalcemia of malignant diseases; and bone disease or excessive degradation of cartilage or matrix by administering a compound of the present invention to a patient in need thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982486 ECSP982486A (en) | 1998-04-27 | 1998-04-27 | PROTEASE INHIBITORS II |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982486 ECSP982486A (en) | 1998-04-27 | 1998-04-27 | PROTEASE INHIBITORS II |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982486A true ECSP982486A (en) | 1999-01-12 |
Family
ID=42043408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982486 ECSP982486A (en) | 1998-04-27 | 1998-04-27 | PROTEASE INHIBITORS II |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982486A (en) |
-
1998
- 1998-04-27 EC ECSP982486 patent/ECSP982486A/en unknown
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