ECSP992959A - BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORS - Google Patents
BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORSInfo
- Publication number
- ECSP992959A ECSP992959A ECSP992959A ECSP992959A EC SP992959 A ECSP992959 A EC SP992959A EC SP992959 A ECSP992959 A EC SP992959A EC SP992959 A ECSP992959 A EC SP992959A
- Authority
- EC
- Ecuador
- Prior art keywords
- diseases
- protease inhibitors
- bis
- aminometil
- cartilage
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 title 1
- 206010065687 Bone loss Diseases 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 230000015556 catabolic process Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006731 degradation reaction Methods 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- RSBQFKJVGZVGFM-UHFFFAOYSA-N 1,3-diaminopropan-2-one Chemical group NCC(=O)CN RSBQFKJVGZVGFM-UHFFFAOYSA-N 0.000 abstract 1
- 208000037147 Hypercalcaemia Diseases 0.000 abstract 1
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 208000010191 Osteitis Deformans Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000027868 Paget disease Diseases 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- -1 captesin K Substances 0.000 abstract 1
- 208000024693 gingival disease Diseases 0.000 abstract 1
- 208000007565 gingivitis Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000000148 hypercalcaemia Effects 0.000 abstract 1
- 208000030915 hypercalcemia disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 208000027202 mammary Paget disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona inhibidores de proteasa de bis-aminometil-carbonilo y sales, hidratos o solvatos de los mismos aceptables farmacéuticamente, que inhiben proteasas, incluyendo la captesina K, composiciones farmacéuticas de tales compuestos, y métodos para tratar enfermedades de una excesiva pérdida ósea o degradación de cartilago o de matriz, incluyendo osteoporosis; enfermedades gingivales incluyendo gingivitis y periodontitis; artritis más especificamente osteoartritis y artritis reumatoide; enfermedad de paget; hipercalcemia de enfermedades malignas; y enfermedades óseas metabólicas, que comprende inhibir dicha pérdida de hueso o dicha excesiva degradación de cartilago o de matriz administrando a un paciente que lo necesite un compuesto según la presente invención.The present invention provides bis-aminomethyl carbonyl protease inhibitors and pharmaceutically acceptable salts, hydrates or solvates thereof, which inhibit proteases, including captesin K, pharmaceutical compositions of such compounds, and methods of treating diseases of excessive bone loss. or cartilage or matrix degradation, including osteoporosis; gingival diseases including gingivitis and periodontitis; arthritis more specifically osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignant diseases; and metabolic bone diseases, which comprises inhibiting said bone loss or said excessive cartilage or matrix degradation by administering to a patient in need a compound according to the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992959 ECSP992959A (en) | 1999-05-20 | 1999-05-20 | BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP992959 ECSP992959A (en) | 1999-05-20 | 1999-05-20 | BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP992959A true ECSP992959A (en) | 1999-10-06 |
Family
ID=42043948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP992959 ECSP992959A (en) | 1999-05-20 | 1999-05-20 | BIS-AMINOMETIL CARBONYL PROTEASE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP992959A (en) |
-
1999
- 1999-05-20 EC ECSP992959 patent/ECSP992959A/en unknown
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