ECSP982497A - Inhibidores de proteasas v - Google Patents
Inhibidores de proteasas vInfo
- Publication number
- ECSP982497A ECSP982497A ECSP982497A ECSP982497A EC SP982497 A ECSP982497 A EC SP982497A EC SP982497 A ECSP982497 A EC SP982497A EC SP982497 A ECSP982497 A EC SP982497A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- het
- alkenyl
- alkynyl
- co2nr
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000006529 (C3-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 206010065687 Bone loss Diseases 0.000 abstract 1
- 102000004171 Cathepsin K Human genes 0.000 abstract 1
- 108090000625 Cathepsin K Proteins 0.000 abstract 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta invención se refiere a los compuestos según la fórmula (I) (gráfico), en la que: Y es Ar o NR1R2; R1 es R¿¿RC(O), R¿¿C(S), R¿¿SO2, R¿¿ OC(O), R¿¿R¿NC(O),ÓR¿¿R¿Nc(S); R2 e H, alquilo (C1-C6), alquinilo (C2--C6),Ar, alquilo (C0-C6)ó Het-alquilo C0-C6); R3 es H, alquenilo (C2-C6), alquinilo C2-C6), Het, Ar, o alquilo (C1-C6)opcionalmente sustituido con OR¿, SR¿, NR¿¿2, N(R¿)C(O)oR¿¿, CO2r¿, CO2NR¿2, N(C=NH)NH2, Het o Ar; R4 es H, alquilo (C1-C6), alquenilo (C2-C6), Ar-alquilo (C0-C6), o Het-alquilo (C0-C6), (gráfico), Ar-alquilo (C0-C6), Het-alquilo (C0-C6), adamntil-C(0)-, Ar-C(O)-, ó Het-C(0)-; R6 es R¿¿, R¿¿, R¿¿C(0), R¿¿c(S), R¿¿SO2, R¿¿OC(0), R¿¿OC(0), R¿¿OC(O), R¿¿R¿NC(0), R¿¿R¿¿NC(S), ó R¿¿OC(0)NR¿CH(R*)C(0); R7 es cicloalquil (C3-C6)-alquilo (C0-C6), Ar-alquilo (C0-C6), Het-alquilo (C0-C6), Ar-alcoxi (C0-C6), Het-alcoxi(C0-C6) o alquilo (C1-C6) opcionalmente sustituido con OR{, SR{, NR¿2, N(R¿), C(=)OR¿¿, CO2R¿, CO2NR¿2, N(N0NH)NH2, Het o Ar; R*e H, alquilo (C1-C6), alquenilo (C2-C6), cicloalquil (C3-C6)-alquilo (C0-C6), Ar-alquilo (C0-C6), Het-alquilo (C0-C6), cada R¿independientemente es H, alquilo (C1-C6), alquenilo (C2-C6), Ar-alquilo (C0-C6) o Het-alquilo (C0-C6), cicloalquil (C3-C6)-alquilo (C0-C6), Ar alquinilo (C0-C6), o Het-alquilo (C0-C6); R¿¿es H alquilo (C1-C6); Z es C(0) ó CH2; y n es 1,2 ó 3; o una sal aceptable farmacéuticamente de los mismos, que son inhibidores de proteasas de cisteína, en particular de la catepsina K, y los útiles en el tratamiento de enfermedades en las que la inhibición de la perdida ósea es un factor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982497 ECSP982497A (es) | 1998-05-06 | 1998-05-06 | Inhibidores de proteasas v |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP982497 ECSP982497A (es) | 1998-05-06 | 1998-05-06 | Inhibidores de proteasas v |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP982497A true ECSP982497A (es) | 1999-04-13 |
Family
ID=42043418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP982497 ECSP982497A (es) | 1998-05-06 | 1998-05-06 | Inhibidores de proteasas v |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP982497A (es) |
-
1998
- 1998-05-06 EC ECSP982497 patent/ECSP982497A/es unknown
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