EE03124B1 - Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine - Google Patents

Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine

Info

Publication number
EE03124B1
EE03124B1 EE9400336A EE9400336A EE03124B1 EE 03124 B1 EE03124 B1 EE 03124B1 EE 9400336 A EE9400336 A EE 9400336A EE 9400336 A EE9400336 A EE 9400336A EE 03124 B1 EE03124 B1 EE 03124B1
Authority
EE
Estonia
Prior art keywords
deacetylbaccatin iii
obtaining
yew
deacetylbaccatin
iii
Prior art date
Application number
EE9400336A
Other languages
English (en)
Estonian (et)
Inventor
Margraff Rodolphe
Original Assignee
Rh�Ne-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rh�Ne-Poulenc Rorer S.A. filed Critical Rh�Ne-Poulenc Rorer S.A.
Publication of EE03124B1 publication Critical patent/EE03124B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EE9400336A 1992-10-05 1994-11-18 Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine EE03124B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211745A FR2696462B1 (fr) 1992-10-05 1992-10-05 Procédé d'obtention de la désacétyl-10 baccatine III.

Publications (1)

Publication Number Publication Date
EE03124B1 true EE03124B1 (et) 1998-10-15

Family

ID=9434123

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400336A EE03124B1 (et) 1992-10-05 1994-11-18 Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine

Country Status (30)

Country Link
US (2) US5393896A (de)
EP (1) EP0663909B1 (de)
JP (1) JP3299753B2 (de)
KR (1) KR100301238B1 (de)
CN (1) CN1041310C (de)
AT (1) ATE147381T1 (de)
AU (1) AU680440B2 (de)
CA (2) CA2470124C (de)
CZ (2) CZ286452B6 (de)
DE (1) DE69307333T2 (de)
DK (1) DK0663909T3 (de)
EE (1) EE03124B1 (de)
ES (1) ES2095672T3 (de)
FI (1) FI109797B (de)
FR (1) FR2696462B1 (de)
GE (1) GEP19981433B (de)
GR (1) GR3022229T3 (de)
HU (1) HU225969B1 (de)
LT (1) LT3465B (de)
LV (1) LV10620B (de)
MX (1) MX9305770A (de)
NO (1) NO310414B1 (de)
NZ (1) NZ256449A (de)
PL (1) PL173993B1 (de)
RU (1) RU2108330C1 (de)
SK (1) SK280335B6 (de)
TW (1) TW404944B (de)
UA (1) UA40601C2 (de)
WO (1) WO1994007881A1 (de)
ZA (1) ZA937312B (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69403966T3 (de) 1993-07-19 2008-04-17 Angiotech Pharmaceuticals, Inc., Vancouver Anti-angiogene mittel und verfahren zu deren verwendung
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) * 1994-05-24 1995-11-29 郭明 红豆杉属植物提取物及其应用
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
US5965752A (en) * 1996-08-23 1999-10-12 Institut National De La Recherche Scientifique Preparative scale isolation and purification of taxanes
EP1019347B1 (de) * 1997-08-21 2003-03-19 Florida State University Verfahren zur synthese von taxanen
US6066748A (en) * 1997-12-17 2000-05-23 Han; Man Woo Process of extracting TAXOL® from taxus cuspidata
DK1068192T3 (da) 1998-01-14 2002-10-14 Bristol Myers Squibb Co Hidtil ukendte krystallinske komplekser af baccatin III med imidazol, 2-methylimidazol eller isopropanol
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US5969165A (en) * 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
US6495705B2 (en) 2000-03-16 2002-12-17 Napro Biotherapeutics, Inc. Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes
US6281368B1 (en) 2000-03-16 2001-08-28 Napro Biotherapeutics, Inc. Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III
CA2307393A1 (en) 2000-05-01 2001-11-01 The University Of British Columbia Ginsenoside chemotherapy
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
EP1418945A2 (de) * 2001-03-13 2004-05-19 Angiotech Pharmaceuticals, Inc. Mizellare arzneimittelabgabe vehikel und ihre anwendungen
US20030157170A1 (en) * 2001-03-13 2003-08-21 Richard Liggins Micellar drug delivery vehicles and precursors thereto and uses thereof
JP2004532847A (ja) * 2001-04-20 2004-10-28 ザ ユニヴァーシティ オヴ ブリティッシュ コロンビア 疎水性薬物のためのミセル薬物送達システム
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
EP1594668A4 (de) * 2002-12-31 2006-06-07 Natural Pharmaceuticals Inc Pelletisierung von eibenbiomasse zur extraktion von taxanen und anderen naturprodukten
CA2525647A1 (en) 2003-05-16 2005-02-24 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
US8770459B2 (en) * 2003-10-17 2014-07-08 Covidien Lp Surgical stapling device with independent tip rotation
WO2005040758A2 (en) 2003-10-24 2005-05-06 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US20060127510A1 (en) * 2003-12-30 2006-06-15 Natural Pharmaceuticals, Inc. Harvesting and pelletizing yew biomass for extraction of taxanes and other natural products
US8003122B2 (en) 2004-03-31 2011-08-23 Cordis Corporation Device for local and/or regional delivery employing liquid formulations of therapeutic agents
US7846940B2 (en) 2004-03-31 2010-12-07 Cordis Corporation Solution formulations of sirolimus and its analogs for CAD treatment
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
US20050240036A1 (en) * 2004-04-23 2005-10-27 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates from a mixture of taxanes
US20050250954A1 (en) * 2004-05-04 2005-11-10 Phytogen Life Sciences Inc. Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes
US20050272807A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
DE602005012587D1 (de) * 2004-07-02 2009-03-19 Ivax Pharmaceuticals Sro Verfahren zur trennung von paclitaxel und cephalomannin
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US20060188508A1 (en) 2005-02-17 2006-08-24 Cohen Stanley N Methods and compositions for modulating angiogenesis
WO2007045093A1 (en) * 2005-10-21 2007-04-26 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service Preparation of taxanes
CA2646156C (en) 2006-03-22 2016-05-24 Medigene Ag Treatment of triple receptor negative breast cancer
EP2043704B2 (de) 2006-06-30 2017-04-19 Cook Medical Technologies LLC Verfahren zur herstellung und modifizierung von taxan-beschichtungen für implantierbare medizinische vorrichtungen
CN100404520C (zh) * 2006-08-15 2008-07-23 北京诺瑞医药技术有限公司 从欧洲红豆杉枝叶中提取分离10－去乙酰基巴卡汀ⅲ的方法
CN101230053B (zh) * 2007-12-04 2010-06-02 北京诺瑞医药技术有限公司 从红豆杉枝叶中超声提取分离10-去乙酰基巴卡汀ⅲ的方法
US8409601B2 (en) 2008-03-31 2013-04-02 Cordis Corporation Rapamycin coated expandable devices
US8420110B2 (en) 2008-03-31 2013-04-16 Cordis Corporation Drug coated expandable devices
US8273404B2 (en) 2008-05-19 2012-09-25 Cordis Corporation Extraction of solvents from drug containing polymer reservoirs
EP2859916B1 (de) 2008-05-22 2017-11-29 Galera Labs, LLC Antimitotika mit Superoxid Dismutase Mimetika für die Kombinationstherapie gegen Krebs
EP2310507A4 (de) 2008-07-08 2013-03-20 David Gladstone Inst Verfahren und zusammensetzungen zur angiogenesemodulierung
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US20120302954A1 (en) 2011-05-25 2012-11-29 Zhao Jonathon Z Expandable devices coated with a paclitaxel composition
US20120303115A1 (en) 2011-05-25 2012-11-29 Dadino Ronald C Expandable devices coated with a rapamycin composition
WO2013069027A1 (en) 2011-09-26 2013-05-16 Fresenius Kabi Oncology Ltd. Processes for the preparation of cabazitaxel involving c(7) -oh and c(13) -oh silylation or just c(7) -oh silylation
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
CN104582717B (zh) 2012-07-19 2018-03-13 雷德伍德生物科技股份有限公司 对cd22有特异性的抗体及其使用方法
CN104884056A (zh) 2012-11-12 2015-09-02 雷德伍德生物科技股份有限公司 用于制备缀合物的化合物和方法
IL305629A (en) 2013-02-15 2023-11-01 Univ California Chimeric antigen receptor and methods of using it
KR20150135332A (ko) 2013-03-14 2015-12-02 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법
CN103508984B (zh) * 2013-10-22 2017-03-08 北京诺瑞医药技术有限公司 连续浸漉吸附富集法从红豆杉中提取10-dab的方法
CN115504924A (zh) 2013-11-27 2022-12-23 雷德伍德生物科技股份有限公司 肼基-吡咯并化合物及用于生成缀合物的方法
DK3107899T3 (da) 2014-02-19 2020-11-16 Aviv Therapeutics Inc Mitokondriel aldehyddehydrogenase 2 (aldh2)-bindende polycykliske amider og anvendelse deraf til cancerbehandling
US10517961B2 (en) 2015-09-25 2019-12-31 ZY Therapeutics, Inc. Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
US10654875B2 (en) 2015-11-12 2020-05-19 The Board Of Trustees Of The Leland Stanford Junior University Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery
HUP1500603A2 (en) * 2015-12-11 2017-06-28 Rotachrom Tech Kft Process for the separation of 10-deacetyl baccatin iii
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
DK3463308T4 (da) 2016-06-01 2026-02-09 Servier Ip Uk Ltd Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf
CN106397371A (zh) * 2016-08-31 2017-02-15 重庆市碚圣医药科技股份有限公司 一种用曼地亚红豆杉高产10‑dabⅲ的方法
TWI852903B (zh) 2017-01-05 2024-08-21 杏國新藥股份有限公司 胰臟癌治療
SG10202107808SA (en) 2017-01-18 2021-08-30 F1 Oncology Inc Chimeric antigen receptors against axl or ror2 and methods of use thereof
EP3388082A1 (de) 2017-04-13 2018-10-17 Galera Labs, LLC Kombinationskrebsimmuntherapie mit makrocyclischem pentaaza-ringkomplex
EP3630189A4 (de) 2017-05-24 2021-06-23 The Board of Regents of The University of Texas System Linker für antikörper-arzneimittelkonjugate
AU2019215032A1 (en) 2018-01-31 2020-09-10 Board Of Regents Of The University Of Texas System Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent
EP3773633A4 (de) 2018-04-06 2022-01-26 The Regents of The University of California Verfahren zur behandlung von glioblastomen
CA3096202A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas
KR20210009315A (ko) 2018-04-11 2021-01-26 오하이오 스테이트 이노베이션 파운데이션 안약 전달용 서방형 마이크로 입자를 이용한 방법 및 조성물
MX2021000644A (es) 2018-07-18 2021-08-19 Manzanita Pharmaceuticals Inc Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos.
US11529402B2 (en) 2019-01-14 2022-12-20 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
US11685904B2 (en) 2019-02-14 2023-06-27 Ignite Immunotherapy, Inc. Recombinant vaccinia virus and methods of use thereof
WO2020206033A1 (en) 2019-04-02 2020-10-08 Kenjockety Biotechnology, Inc. Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
BR112022011158A2 (pt) 2019-12-12 2022-08-30 Ignite Immunotherapy Inc Vírus vaccinia oncolítico variante e métodos de uso do mesmo
US12692311B2 (en) 2020-01-29 2026-07-28 William Robert Arathoon Living Trust Dated August 29, 2016 Anti-MDR1 antibodies and uses thereof
CN116323662A (zh) 2020-06-04 2023-06-23 肯乔克蒂生物技术股份有限公司 抗abcg2抗体及其用途
CN116529267A (zh) 2020-06-04 2023-08-01 肯乔克蒂生物技术股份有限公司 Abcg2外排泵-癌症抗原多特异性抗体及其相关组合物、试剂、试剂盒和方法
MX2023000734A (es) 2020-07-14 2023-02-13 Pfizer Virus vaccinia recombinante.
JP7747741B2 (ja) 2020-09-02 2025-10-01 ウィリアム ロバート アラスーン リビング トラスト デイテッド オーガスト 29, 2016 抗ａｂｃｃ１抗体及びその使用
US20240010747A1 (en) 2020-11-13 2024-01-11 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
MX2023005979A (es) 2020-11-20 2023-08-11 Scherer Technologies Llc R P Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco.
CN112694458A (zh) * 2020-12-29 2021-04-23 重庆臻源红豆杉发展有限公司 一种10-去乙酰基巴卡亭ⅲ提取纯化方法
KR20240116829A (ko) 2021-12-13 2024-07-30 윌리엄 로버트 아라툰 리빙 트러스트 데이티드 어거스트 29, 2016 항-abcb1 항체
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies
CA3251059A1 (en) 2022-05-02 2023-11-09 The Board Of Trustees Of The Leland Stanford Junior University Compositions, systems and methods for modulating a target gene
WO2026099776A1 (en) 2024-11-11 2026-05-15 Fresenius Kabi Oncology Ltd. A process for the preparation of paclitaxel

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5279953A (en) * 1992-06-24 1994-01-18 Esca Genetics Corporation In vivo production of taxanes
FR2696463B1 (fr) * 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé d'obtention de la désacétyl-10 baccatine III.
FR2703049B1 (fr) * 1993-03-22 1995-04-21 Rhone Poulenc Rorer Sa Procédé de purification des taxoïdes.

Also Published As

Publication number Publication date
UA40601C2 (uk) 2001-08-15
ES2095672T3 (es) 1997-02-16
CA2146248A1 (fr) 1994-04-14
CA2470124C (fr) 2007-08-07
AU680440B2 (en) 1997-07-31
CN1085552A (zh) 1994-04-20
NZ256449A (en) 1996-09-25
LV10620B (en) 1995-10-20
DE69307333T2 (de) 1997-04-30
CZ286593B6 (cs) 2000-05-17
SK43195A3 (en) 1995-08-09
DE69307333D1 (de) 1997-02-20
MX9305770A (es) 1994-05-31
US5393896A (en) 1995-02-28
PL308243A1 (en) 1995-07-24
KR950703549A (ko) 1995-09-20
AU5115493A (en) 1994-04-26
DK0663909T3 (de) 1997-01-27
ATE147381T1 (de) 1997-01-15
JPH08501791A (ja) 1996-02-27
PL173993B1 (pl) 1998-05-29
EP0663909A1 (de) 1995-07-26
CA2470124A1 (fr) 1994-04-14
GR3022229T3 (en) 1997-04-30
FI109797B (fi) 2002-10-15
GEP19981433B (en) 1998-10-30
NO951281L (no) 1995-04-03
NO951281D0 (no) 1995-04-03
US5736366A (en) 1998-04-07
LT3465B (en) 1995-10-25
CZ286452B6 (en) 2000-04-12
SK280335B6 (sk) 1999-12-10
LTIP1398A (en) 1994-11-25
FR2696462B1 (fr) 1994-11-25
CN1041310C (zh) 1998-12-23
EP0663909B1 (de) 1997-01-08
HUT72678A (en) 1996-05-28
FI951590A0 (fi) 1995-04-04
NO310414B1 (no) 2001-07-02
HU225969B1 (en) 2008-01-28
CZ84495A3 (en) 1995-09-13
RU2108330C1 (ru) 1998-04-10
KR100301238B1 (ko) 2001-11-22
LV10620A (lv) 1995-04-20
TW404944B (en) 2000-09-11
ZA937312B (en) 1994-04-25
FI951590L (fi) 1995-04-04
WO1994007881A1 (fr) 1994-04-14
CA2146248C (fr) 2006-12-12
RU95110662A (ru) 1996-12-27
FR2696462A1 (fr) 1994-04-08
JP3299753B2 (ja) 2002-07-08
HU9500969D0 (en) 1995-06-28

Similar Documents

Publication Publication Date Title
DE69307333D1 (de) Verfahren zur gewinnung von 10-deacetylbaccatin-iii
EE03126B1 (et) Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine
ATE273945T1 (de) Verfahren zur kristallisierung von sterisch gehinderten verbindungen
ATE181325T1 (de) Verfahren zur herstellung von ascorbinsäure
ATE223394T1 (de) Verahren zur selektiven acylierung von 10- deacetylbaccatin-iii in der c-10 position
ATE366236T1 (de) Reinigungsverfahren von 1,4-butanediol mononitrat
ES2131765T3 (es) Procedimiento para producir derivados del acido ascorbico.
JPS524650A (en) Purifying method for polluted water
DE69615562D1 (de) Verfahren zu extrahieren und isolierung von 10-desacetylbachatin iii
JPS51135172A (en) Method of anaerobically digesting organic waste liquor

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231