ATE222587T1 - TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN - Google Patents

TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN

Info

Publication number
ATE222587T1
ATE222587T1 AT95915869T AT95915869T ATE222587T1 AT E222587 T1 ATE222587 T1 AT E222587T1 AT 95915869 T AT95915869 T AT 95915869T AT 95915869 T AT95915869 T AT 95915869T AT E222587 T1 ATE222587 T1 AT E222587T1
Authority
AT
Austria
Prior art keywords
pct
inhibitors
ßreuptakeß
tropan
neurotransmitters
Prior art date
Application number
AT95915869T
Other languages
English (en)
Inventor
Peter Moldt
Frank Waetjen
Jorgen Scheel-Krueger
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE222587T1 publication Critical patent/ATE222587T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT95915869T 1994-04-19 1995-04-12 TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN ATE222587T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK44794 1994-04-19
DK133894 1994-11-24
PCT/EP1995/001358 WO1995028401A1 (en) 1994-04-19 1995-04-12 Tropane-2-aldoxine derivatives as neurotransmitter reuptake inhibitors

Publications (1)

Publication Number Publication Date
ATE222587T1 true ATE222587T1 (de) 2002-09-15

Family

ID=26064021

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95915869T ATE222587T1 (de) 1994-04-19 1995-04-12 TROPAN-2-ALDOXIMDERIVATE ALS NEUROTRANSMITTER ßREUPTAKEß INHIBITOREN

Country Status (25)

Country Link
US (1) US5736556A (de)
EP (1) EP0756596B1 (de)
JP (1) JP2899418B2 (de)
KR (1) KR100210417B1 (de)
CN (1) CN1043763C (de)
AT (1) ATE222587T1 (de)
AU (1) AU690257B2 (de)
BG (1) BG63259B1 (de)
BR (1) BR9507489A (de)
CA (1) CA2187309C (de)
CZ (1) CZ284379B6 (de)
DE (1) DE69527839T2 (de)
DK (1) DK0756596T3 (de)
EE (1) EE03877B1 (de)
FI (1) FI965074A0 (de)
GE (1) GEP19991749B (de)
HU (1) HU215830B (de)
LV (1) LV11738B (de)
NO (1) NO964180L (de)
NZ (1) NZ284075A (de)
PL (1) PL183025B1 (de)
RU (1) RU2134264C1 (de)
SK (1) SK280875B6 (de)
UA (1) UA49801C2 (de)
WO (1) WO1995028401A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69637097T2 (de) * 1995-10-13 2007-09-20 Neurosearch A/S 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
US6241963B1 (en) * 1995-10-19 2001-06-05 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
NZ321970A (en) * 1995-11-02 2000-02-28 Neurosearch As Fused tropane-derivatives as neurotransmitter reuptake inhibitors
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
JP3238414B2 (ja) * 1996-02-22 2001-12-17 ニューロサーチ・アクティーゼルスカブ トロパン―誘導体、その製造方法及びその使用方法
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
US20040229908A1 (en) * 1999-07-13 2004-11-18 Jodi Nelson Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias
EP1261340B1 (de) 1999-07-13 2009-05-13 Alpha Research Group, LLC Zusammensetzungen und verfahren zur behandlung der parkinson-krankheit
CN100355753C (zh) * 2000-05-26 2007-12-19 辉瑞大药厂 用于制备具有治疗作用的莨菪烷衍生物的中间体
US6667314B2 (en) 2000-05-26 2003-12-23 Pfizer, Inc. Tropane derivatives useful in therapy
JP2005508872A (ja) * 2001-05-23 2005-04-07 ニューロサーチ、アクティーゼルスカブ トロパン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害剤として使用する方法
US6610849B2 (en) * 2001-06-28 2003-08-26 Boehringer Ingelheim Pharma Kg Process for the manufacture of tropenol
US7381733B2 (en) 2001-11-30 2008-06-03 Neurosearch A/S Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
CA2480742A1 (en) * 2002-03-28 2003-12-04 President And Fellows Of Harvard College Tropane compounds
KR100777885B1 (ko) 2003-10-03 2007-11-28 화이자 인코포레이티드 Ｈｉｖ 및 염증 치료를 위한 ｃｃｒ5 수용체 길항제 활성을갖는 이미다조피리딘 치환된 트로판 유도체
EP1675591B1 (de) 2003-10-16 2011-08-10 NeuroSearch A/S Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem acetylcholinesterase-hemmer
EP1708707A1 (de) * 2004-01-22 2006-10-11 Neurosearch A/S Pharmazeutische zusammensetzung mit einem monoamin-neurotransmitter-wiederaufnahmehemmer und einem n-methyl-d-aspartat (nmda)-rezeptorantagonisten
CA2553649A1 (en) * 2004-01-22 2005-08-04 Neurosearch A/S Compounds for the sustained reduction of body weight
RU2352332C1 (ru) * 2005-01-14 2009-04-20 Частное Предприятие "Славянская Клиника" Применение местного анестетика для коррекции пищевого поведения человека и способ применения
EP1779851A1 (de) 2005-10-31 2007-05-02 Boehringer Ingelheim Pharma GmbH & Co.KG Behandlung von Diabetes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
SU941369A1 (ru) * 1978-12-29 1982-07-07 Научно-исследовательский институт фармакологии АМН СССР Хлоргидраты W-аминоацильных эфиров тропан-3-ола как стимул торы центральной нервной системы
AT397962B (de) * 1985-12-27 1994-08-25 Madaus & Co Dr Verfahren zur herstellung von azoniaspironortropanolestern
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds

Also Published As

Publication number Publication date
CA2187309C (en) 2000-11-21
FI965074A7 (fi) 1996-12-17
EE9600132A (et) 1997-04-15
UA49801C2 (uk) 2002-10-15
EE03877B1 (et) 2002-10-15
JP2899418B2 (ja) 1999-06-02
CN1148854A (zh) 1997-04-30
PL183025B1 (pl) 2002-05-31
CZ298296A3 (en) 1997-06-11
GEP19991749B (en) 1999-09-10
US5736556A (en) 1998-04-07
BR9507489A (pt) 1997-08-12
SK280875B6 (sk) 2000-08-14
NO964180L (no) 1996-12-16
DK0756596T3 (da) 2002-12-23
NZ284075A (en) 1998-01-26
CN1043763C (zh) 1999-06-23
AU690257B2 (en) 1998-04-23
CZ284379B6 (cs) 1998-11-11
DE69527839D1 (en) 2002-09-26
HUT75865A (en) 1997-05-28
JPH09505607A (ja) 1997-06-03
DE69527839T2 (de) 2003-01-02
RU2134264C1 (ru) 1999-08-10
MX9604966A (es) 1998-05-31
AU2257595A (en) 1995-11-10
HU215830B (hu) 2001-05-28
SK128896A3 (en) 1997-04-09
FI965074A0 (fi) 1996-12-17
EP0756596B1 (de) 2002-08-21
PL316876A1 (en) 1997-02-17
LV11738B (en) 1997-12-20
HU9602707D0 (en) 1996-11-28
BG63259B1 (bg) 2001-07-31
KR100210417B1 (ko) 1999-07-15
NO964180D0 (no) 1996-10-02
LV11738A (lv) 1997-04-20
CA2187309A1 (en) 1995-10-26
WO1995028401A1 (en) 1995-10-26
BG100883A (en) 1998-03-31
EP0756596A1 (de) 1997-02-05

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee