EE04274B1 - (R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod - Google Patents

(R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod

Info

Publication number: EE04274B1
Authority: EE; Estonia
Prior art keywords: osetane; phenylpiperidin; methylacetamide; dichlorophenyl; piperidin
Prior art date: 1998-08-05

Application number

EEP200100070A

Other languages

English (en)

Estonian (et)

Inventor

Alcade Alain

Anne-Archard Gilles

Grosclaude Patrick

Monnier Olivier

Roche J�rome

Original Assignee

Sanofi-Synthlabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-05

Filing date

1999-08-03

Publication date

2004-04-15

1999-08-03 Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo

2002-06-17 Publication of EE200100070A publication Critical patent/EE200100070A/xx

2004-04-15 Publication of EE04274B1 publication Critical patent/EE04274B1/xx

Links

125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 title 1
OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical compound CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 title 1
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EEP200100070A 1998-08-05 1999-08-03 (R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod EE04274B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9810107A FR2782082B3 (fr)	1998-08-05	1998-08-05	Formes cristallines de (r)-(+)-n-[[3-[1-benzoyl-3-(3,4- dichlorophenyl)piperidin-3-yl]prop-1-yl]-4-phenylpiperidin-4 -yl]-n-methylacetamide (osanetant) et procede pour la preparation dudit compose
PCT/FR1999/001914 WO2000007987A1 (fr)	1998-08-05	1999-08-03	Formes cristallines du osanetant

Publications (2)

Publication Number	Publication Date
EE200100070A EE200100070A (et)	2002-06-17
EE04274B1 true EE04274B1 (et)	2004-04-15

Family

ID=9529458

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100070A EE04274B1 (et)	1998-08-05	1999-08-03	(R)-(+)-N-[[3-[1-bensoüül-3-(3,4-diklorofenüül)piperidiin-3-üül] prop-1-üül]-4-fenüülpiperidiin-4-üül]-N-metüülatseetamiidi (osanetandi) kristallivormid ja nende valmistamise meetod

Country Status (31)

Country	Link
US (1)	US7041679B2 (de)
EP (1)	EP1102747B1 (de)
JP (1)	JP3807938B2 (de)
KR (1)	KR100571944B1 (de)
CN (1)	CN1114592C (de)
AR (1)	AR019953A1 (de)
AT (1)	ATE243197T1 (de)
AU (1)	AU748177B2 (de)
BR (1)	BR9913357A (de)
CA (1)	CA2339007A1 (de)
CO (1)	CO5070576A1 (de)
DE (1)	DE69908951T2 (de)
DK (1)	DK1102747T3 (de)
DZ (1)	DZ3074A1 (de)
EA (1)	EA003205B1 (de)
EE (1)	EE04274B1 (de)
ES (1)	ES2200535T3 (de)
FR (1)	FR2782082B3 (de)
HU (1)	HUP0103134A3 (de)
IS (1)	IS5821A (de)
MY (1)	MY121447A (de)
NO (1)	NO320645B1 (de)
NZ (1)	NZ509561A (de)
PL (1)	PL345999A1 (de)
PT (1)	PT1102747E (de)
SK (1)	SK1742001A3 (de)
TR (1)	TR200100261T2 (de)
TW (1)	TW527354B (de)
UA (1)	UA72890C2 (de)
WO (1)	WO2000007987A1 (de)
YU (1)	YU8601A (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0100902D0 (sv)	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
SE0202539D0 (sv)	2002-08-27	2002-08-27	Astrazeneca Ab	Compounds
US7648992B2 (en) *	2004-07-05	2010-01-19	Astrazeneca Ab	Hydantoin derivatives for the treatment of obstructive airway diseases
SE0401762D0 (sv) *	2004-07-05	2004-07-05	Astrazeneca Ab	Novel compounds
SE0403085D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Novel componds
SE0403086D0 (sv) *	2004-12-17	2004-12-17	Astrazeneca Ab	Compounds
TW200800954A (en) *	2006-03-16	2008-01-01	Astrazeneca Ab	Novel crystal modifications
TW200831488A (en) *	2006-11-29	2008-08-01	Astrazeneca Ab	Novel compounds
US20240336565A1 (en) *	2021-07-02	2024-10-10	Acer Therapeutics, Inc.	Solid forms of osanetant

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2719311B1 (fr)	1994-03-18	1998-06-26	Sanofi Sa	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
JPH1053576A (ja) *	1996-06-07	1998-02-24	Eisai Co Ltd	塩酸ドネペジルの多形結晶およびその製造法
EP0915849A2 (de) *	1996-08-05	1999-05-19	Smithkline Beecham S.p.A.	Verfahren zur herstellung von 3,3-disubstituierten piperidinen
US6040316A (en) *	1996-09-16	2000-03-21	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines
FR2757543B1 (fr) *	1996-12-23	1999-04-02	Sanofi Sa	Procede pour la cristallisation d'un derive de tetrahydropyridine et formes cristallines ainsi obtenues

1998
- 1998-08-05 FR FR9810107A patent/FR2782082B3/fr not_active Expired - Lifetime
1999
- 1999-07-25 DZ DZ990156A patent/DZ3074A1/xx active
- 1999-07-28 AR ARP990103741A patent/AR019953A1/es unknown
- 1999-08-03 SK SK174-2001A patent/SK1742001A3/sk unknown
- 1999-08-03 NZ NZ509561A patent/NZ509561A/xx unknown
- 1999-08-03 WO PCT/FR1999/001914 patent/WO2000007987A1/fr not_active Ceased
- 1999-08-03 EP EP99936672A patent/EP1102747B1/de not_active Expired - Lifetime
- 1999-08-03 AT AT99936672T patent/ATE243197T1/de not_active IP Right Cessation
- 1999-08-03 DK DK99936672T patent/DK1102747T3/da active
- 1999-08-03 BR BR9913357-1A patent/BR9913357A/pt not_active IP Right Cessation
- 1999-08-03 HU HU0103134A patent/HUP0103134A3/hu unknown
- 1999-08-03 DE DE69908951T patent/DE69908951T2/de not_active Expired - Fee Related
- 1999-08-03 PL PL99345999A patent/PL345999A1/xx not_active Application Discontinuation
- 1999-08-03 YU YU8601A patent/YU8601A/sh unknown
- 1999-08-03 MY MYPI99003297A patent/MY121447A/en unknown
- 1999-08-03 CA CA002339007A patent/CA2339007A1/en not_active Abandoned
- 1999-08-03 JP JP2000563621A patent/JP3807938B2/ja not_active Expired - Fee Related
- 1999-08-03 TR TR2001/00261T patent/TR200100261T2/xx unknown
- 1999-08-03 UA UA2001010591A patent/UA72890C2/xx unknown
- 1999-08-03 AU AU51685/99A patent/AU748177B2/en not_active Ceased
- 1999-08-03 KR KR1020017001460A patent/KR100571944B1/ko not_active Expired - Fee Related
- 1999-08-03 ES ES99936672T patent/ES2200535T3/es not_active Expired - Lifetime
- 1999-08-03 EE EEP200100070A patent/EE04274B1/xx not_active IP Right Cessation
- 1999-08-03 EA EA200100096A patent/EA003205B1/ru not_active IP Right Cessation
- 1999-08-03 PT PT99936672T patent/PT1102747E/pt unknown
- 1999-08-03 CN CN99810182A patent/CN1114592C/zh not_active Expired - Fee Related
- 1999-08-04 CO CO99049286A patent/CO5070576A1/es unknown
- 1999-08-04 TW TW088113235A patent/TW527354B/zh not_active IP Right Cessation
2001
- 2001-01-23 IS IS5821A patent/IS5821A/is unknown
- 2001-02-01 NO NO20010553A patent/NO320645B1/no unknown
2003
- 2003-08-28 US US10/651,313 patent/US7041679B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MY121447A (en)	2006-01-28
EE200100070A (et)	2002-06-17
KR100571944B1 (ko)	2006-04-18
CN1314888A (zh)	2001-09-26
JP3807938B2 (ja)	2006-08-09
EA200100096A1 (ru)	2001-08-27
HUP0103134A3 (en)	2003-03-28
SK1742001A3 (en)	2001-11-06
DK1102747T3 (da)	2003-09-29
ES2200535T3 (es)	2004-03-01
TW527354B (en)	2003-04-11
CA2339007A1 (en)	2000-02-17
NO20010553D0 (no)	2001-02-01
EA003205B1 (ru)	2003-02-27
NZ509561A (en)	2002-10-25
TR200100261T2 (tr)	2001-06-21
DE69908951D1 (de)	2003-07-24
BR9913357A (pt)	2001-05-15
IS5821A (is)	2001-01-23
PT1102747E (pt)	2003-09-30
FR2782082B3 (fr)	2000-09-22
DE69908951T2 (de)	2004-05-19
UA72890C2 (en)	2005-05-16
EP1102747A1 (de)	2001-05-30
DZ3074A1 (fr)	2004-07-20
HUP0103134A2 (en)	2002-06-29
EP1102747B1 (de)	2003-06-18
WO2000007987A1 (fr)	2000-02-17
JP2002522419A (ja)	2002-07-23
US7041679B2 (en)	2006-05-09
KR20010072220A (ko)	2001-07-31
AU748177B2 (en)	2002-05-30
PL345999A1 (en)	2002-01-14
CO5070576A1 (es)	2001-08-28
YU8601A (sh)	2003-07-07
US20040044215A1 (en)	2004-03-04
FR2782082A1 (fr)	2000-02-11
NO20010553L (no)	2001-04-05
AU5168599A (en)	2000-02-28
NO320645B1 (no)	2006-01-09
ATE243197T1 (de)	2003-07-15
AR019953A1 (es)	2002-03-27
CN1114592C (zh)	2003-07-16
HK1035535A1 (en)	2001-11-30

Legal Events

Date	Code	Title	Description
2005-02-15	HC1A	Change of owner name
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-04-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20070803

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