EE04340B1 - Sulfonüülalkanoüülamino-hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid - Google Patents

Sulfonüülalkanoüülamino-hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid

Info

Publication number: EE04340B1
Authority: EE; Estonia
Prior art keywords: protease inhibitors; retroviral; sulfonylalkanoylamino; hydroxyethylamino; protease
Prior art date: 1995-03-10

Application number

EE9700199A

Other languages

English (en)

Other versions

EE9700199A (et

Inventor

A. Decrescenzo Gary

N. Freskos John

L. Vazquez Michael

A. Sikorski James

J. Mcdonald Joseph

P. Getman Daniel

Devadas Balekudru

R. Nagarajan Srinivasan

Original Assignee

G.D. Searle & Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-10

Filing date

1996-03-07

Publication date

2004-08-16

1996-03-07 Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.

1998-02-16 Publication of EE9700199A publication Critical patent/EE9700199A/et

2004-08-16 Publication of EE04340B1 publication Critical patent/EE04340B1/et

Links

230000001177 retroviral effect Effects 0.000 title abstract 4
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title abstract 3
239000000137 peptide hydrolase inhibitor Substances 0.000 title abstract 3
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
108091005804 Peptidases Proteins 0.000 abstract 2
239000004365 Protease Substances 0.000 abstract 2
206010038997 Retroviral infections Diseases 0.000 abstract 2
108010010369 HIV Protease Proteins 0.000 abstract 1
102000035195 Peptidases Human genes 0.000 abstract 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 hydroxyethylamine sulfonamide compounds Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
241001430294 unidentified retrovirus Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/41—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
- C07D249/20—Benzotriazoles with aryl radicals directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Furan Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Quinoline Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Peptides Or Proteins (AREA)

EE9700199A 1995-03-10 1996-03-07 Sulfonüülalkanoüülamino-hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid EE04340B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US40183895A	1995-03-10	1995-03-10
US08/478,625 US5705500A (en)	1995-03-10	1995-06-07	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
PCT/US1996/002682 WO1996028418A1 (en)	1995-03-10	1996-03-07	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

Publications (2)

Publication Number	Publication Date
EE9700199A EE9700199A (et)	1998-02-16
EE04340B1 true EE04340B1 (et)	2004-08-16

Family

ID=27017619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700199A EE04340B1 (et)	1995-03-10	1996-03-07	Sulfonüülalkanoüülamino-hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid

Country Status (26)

Country	Link
US (1)	US5705500A (et)
EP (2)	EP0813519B1 (et)
JP (2)	JPH11503414A (et)
KR (1)	KR100460892B1 (et)
CN (1)	CN1244575C (et)
AT (2)	ATE201014T1 (et)
AU (1)	AU711098B2 (et)
BR (1)	BR9607450A (et)
CA (1)	CA2215066C (et)
CZ (1)	CZ297933B6 (et)
DE (2)	DE69612739T2 (et)
DK (2)	DK0813519T3 (et)
EA (1)	EA000533B1 (et)
EE (1)	EE04340B1 (et)
ES (2)	ES2157437T3 (et)
GR (1)	GR3036254T3 (et)
HU (1)	HU225410B1 (et)
MX (1)	MX9706947A (et)
NO (1)	NO310353B1 (et)
NZ (1)	NZ306026A (et)
PL (1)	PL186059B1 (et)
PT (2)	PT1052250E (et)
SI (1)	SI0813519T1 (et)
SK (1)	SK282893B6 (et)
UA (1)	UA56129C2 (et)
WO (1)	WO1996028418A1 (et)

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US6667307B2 (en)	1997-12-19	2003-12-23	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
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PT2336134T (pt)	1998-06-23	2016-10-19	The Board Of Trustees Of The Univ Of Illionis	Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
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NZ538714A (en)	2002-08-14	2007-03-30	Tibotec Pharm Ltd	Broadspectrum substituted oxindole sulfonamide HIV protease inhibitors
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JP4818124B2 (ja)	2003-12-23	2011-11-16	テイボテク・フアーマシユーチカルズ・リミテツド	（３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
KR101192859B1 (ko)	2003-12-23	2012-10-19	얀센 알 앤드 디 아일랜드	（3ｒ,3ａｓ,6ａｒ）-헥사하이드로푸로〔2,3-ｂ〕푸란-3-일（1ｓ,2ｒ）-3-〔〔（4-아미노페닐）설포닐〕（이소부틸）아미노〕-1-벤질-2-하이드록시프로필카바메이트의 제조방법
WO2005087728A1 (en)	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
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1995
- 1995-06-07 US US08/478,625 patent/US5705500A/en not_active Expired - Fee Related
1996
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- 1996-03-07 JP JP8527646A patent/JPH11503414A/ja active Pending
- 1996-03-07 PT PT00114155T patent/PT1052250E/pt unknown
- 1996-03-07 HU HU9800294A patent/HU225410B1/hu not_active IP Right Cessation
- 1996-03-07 DE DE69612739T patent/DE69612739T2/de not_active Expired - Fee Related
- 1996-03-07 WO PCT/US1996/002682 patent/WO1996028418A1/en not_active Ceased
- 1996-03-07 ES ES96911229T patent/ES2157437T3/es not_active Expired - Lifetime
- 1996-03-07 ES ES00114155T patent/ES2226665T3/es not_active Expired - Lifetime
- 1996-03-07 AT AT96911229T patent/ATE201014T1/de not_active IP Right Cessation
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- 1996-03-07 DE DE69632926T patent/DE69632926T2/de not_active Expired - Fee Related
- 1996-03-07 SK SK1223-97A patent/SK282893B6/sk unknown
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- 1996-03-07 CN CNB961936096A patent/CN1244575C/zh not_active Expired - Fee Related
- 1996-03-07 DK DK00114155T patent/DK1052250T3/da active
- 1996-03-07 KR KR1019970706314A patent/KR100460892B1/ko not_active Expired - Fee Related
- 1996-03-07 CZ CZ0282297A patent/CZ297933B6/cs not_active IP Right Cessation
- 1996-07-03 UA UA97104993A patent/UA56129C2/uk unknown
1997
- 1997-09-09 NO NO19974146A patent/NO310353B1/no unknown
2001
- 2001-07-24 GR GR20010401103T patent/GR3036254T3/el not_active IP Right Cessation
2007
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Also Published As

Publication number	Publication date
AU6695196A (en)	1996-10-02
PT1052250E (pt)	2004-11-30
HU225410B1 (en)	2006-11-28
EA000533B1 (ru)	1999-10-28
CA2215066A1 (en)	1996-09-19
DK1052250T3 (da)	2004-11-01
KR100460892B1 (ko)	2005-06-28
AU711098B2 (en)	1999-10-07
NO974146L (no)	1997-11-07
SK122397A3 (en)	1998-02-04
DE69632926D1 (de)	2004-08-19
UA56129C2 (uk)	2003-05-15
US5705500A (en)	1998-01-06
DE69612739D1 (de)	2001-06-13
PL186059B1 (pl)	2003-09-30
SI0813519T1 (en)	2001-08-31
SK282893B6 (sk)	2003-01-09
JP2007326863A (ja)	2007-12-20
KR19980702906A (ko)	1998-09-05
DE69632926T2 (de)	2005-07-21
ATE201014T1 (de)	2001-05-15
EP1052250A1 (en)	2000-11-15
EE9700199A (et)	1998-02-16
CA2215066C (en)	2006-06-06
ES2157437T3 (es)	2001-08-16
CZ297933B6 (cs)	2007-05-02
PL322169A1 (en)	1998-01-19
DK0813519T3 (da)	2001-05-28
GR3036254T3 (en)	2001-10-31
EP0813519A1 (en)	1997-12-29
HUP9800294A3 (en)	2000-07-28
DE69612739T2 (de)	2001-11-29
HUP9800294A2 (hu)	1998-07-28
CN1244575C (zh)	2006-03-08
NO310353B1 (no)	2001-06-25
EA199700222A1 (ru)	1998-04-30
ATE271034T1 (de)	2004-07-15
NZ306026A (en)	1999-01-28
EP0813519B1 (en)	2001-05-09
NO974146D0 (no)	1997-09-09
JPH11503414A (ja)	1999-03-26
MX9706947A (es)	1997-11-29
EP1052250B1 (en)	2004-07-14
PT813519E (pt)	2001-10-31
CN1183767A (zh)	1998-06-03
WO1996028418A1 (en)	1996-09-19
BR9607450A (pt)	1998-06-30
CZ282297A3 (cs)	1998-02-18
ES2226665T3 (es)	2005-04-01

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Publication	Publication Date	Title
EE9700199A (et)	1998-02-16	Sulfonüülalkanoüülamino-hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid
EE9700200A (et)	1998-02-16	Bis-aminohappe hüdroksüetüülamino-sulfoonamiidsed retroviirusliku proteaasi inhibiitorid
BR9607638A (pt)	1998-05-26	Inibidores de protease retrovirais de hidroxietilamino sulfonamida de aminoácido
NO974147L (no)	1997-11-04	Heterocykelkarbonylaminosyre hydroksyetylaminosulfonamid retroviral protease
MX9706912A (es)	1998-01-31	Inhibidores de protesa retroviral de sulfonamida de hidroxietilamino de amino acido y uso de los mismos.