EE04499B1 - A1-adenosiiniretseptori agonistid, nende valmistamismeetod ja kasutamine - Google Patents

A1-adenosiiniretseptori agonistid, nende valmistamismeetod ja kasutamine

Info

Publication number
EE04499B1
EE04499B1 EEP200000283A EEP200000283A EE04499B1 EE 04499 B1 EE04499 B1 EE 04499B1 EE P200000283 A EEP200000283 A EE P200000283A EE P200000283 A EEP200000283 A EE P200000283A EE 04499 B1 EE04499 B1 EE 04499B1
Authority
EE
Estonia
Prior art keywords
preparation
receptor agonists
adenosine receptor
adenosine
agonists
Prior art date
Application number
EEP200000283A
Other languages
English (en)
Estonian (et)
Inventor
David Eldred Colin
Michael Kenneth Pennell Andrew
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of EE200000283A publication Critical patent/EE200000283A/xx
Publication of EE04499B1 publication Critical patent/EE04499B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
EEP200000283A 1997-11-08 1998-11-06 A1-adenosiiniretseptori agonistid, nende valmistamismeetod ja kasutamine EE04499B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723590.7A GB9723590D0 (en) 1997-11-08 1997-11-08 Chemical compounds
PCT/EP1998/007023 WO1999024451A2 (en) 1997-11-08 1998-11-06 Adenosine a1 receptor agonists

Publications (2)

Publication Number Publication Date
EE200000283A EE200000283A (et) 2001-08-15
EE04499B1 true EE04499B1 (et) 2005-06-15

Family

ID=10821761

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000283A EE04499B1 (et) 1997-11-08 1998-11-06 A1-adenosiiniretseptori agonistid, nende valmistamismeetod ja kasutamine

Country Status (27)

Country Link
US (2) US6544960B1 (is)
EP (1) EP1030856B1 (is)
JP (1) JP2001522859A (is)
KR (1) KR20010031878A (is)
CN (1) CN1217952C (is)
AP (1) AP2000001804A0 (is)
AT (1) ATE273989T1 (is)
AU (1) AU763414B2 (is)
BR (1) BR9813989A (is)
CA (1) CA2309202C (is)
DE (1) DE69825779T2 (is)
EA (1) EA003087B1 (is)
EE (1) EE04499B1 (is)
ES (1) ES2222619T3 (is)
GB (1) GB9723590D0 (is)
HR (1) HRP20000277A2 (is)
HU (1) HUP0004102A3 (is)
ID (1) ID24758A (is)
IL (2) IL135966A0 (is)
IS (1) IS5479A (is)
NO (1) NO20002359L (is)
NZ (1) NZ504336A (is)
PL (1) PL340873A1 (is)
SK (1) SK6702000A3 (is)
TR (1) TR200001937T2 (is)
WO (1) WO1999024451A2 (is)
YU (1) YU26800A (is)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds
US6576619B2 (en) * 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
WO2001040799A2 (en) * 1999-12-03 2001-06-07 Cv Therapeutics, Inc. Method of identifying partial adenosine a1 receptor agonists and their use in the treatment of arrhythmias
US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
GB9930085D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
GB0015727D0 (en) * 2000-06-27 2000-08-16 Pfizer Ltd Purine derivatives
US6921753B2 (en) 2000-06-27 2005-07-26 Pfizer Inc Purine derivatives
GB0022695D0 (en) 2000-09-15 2000-11-01 Pfizer Ltd Purine Derivatives
GB0106867D0 (en) * 2001-03-20 2001-05-09 Glaxo Group Ltd Process
EP1258247A1 (en) * 2001-05-14 2002-11-20 Aventis Pharma Deutschland GmbH Adenosine analogues for the treatment of insulin resistance syndrome and diabetes
US7157440B2 (en) 2001-07-13 2007-01-02 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
US7713946B2 (en) 2002-07-11 2010-05-11 Cv Therapeutics, Inc. Partial and full agonists A1 adenosine receptors
US6946449B2 (en) 2001-07-13 2005-09-20 Cv Therapeutics, Inc. Partial and full agonists of A1 adenosine receptors
GB0221694D0 (en) * 2002-09-18 2002-10-30 Glaxo Group Ltd Compounds
GB0228723D0 (en) * 2002-12-09 2003-01-15 Cambridge Biotechnology Ltd Treatment of pain
NZ541651A (en) 2003-02-03 2009-01-31 Cv Therapeutics Inc Partial and full agonists of A1 adenosine receptors
GB0305153D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Identification of therapeutic compounds
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
DK1641444T3 (en) * 2003-06-02 2016-06-27 Isis Innovation Treatment of muscle fatigue
AU2004245567B2 (en) 2003-06-03 2011-06-23 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives
FR2862873A1 (fr) * 2003-12-01 2005-06-03 Pf Medicament Utilisation des acides gras polyinsatures omega 3 dans l'apnee du sommeil
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
MY144906A (en) 2005-10-21 2011-11-30 Novartis Ag Human antibodies against il13 and therapeutic uses
JP5203214B2 (ja) * 2005-11-30 2013-06-05 イノテック ファーマシューティカルズ コーポレイション プリン化合物およびその使用方法
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
MX2009001875A (es) 2006-08-21 2009-03-02 Genentech Inc Compuestos de aza-benzotiofenilo y metodos de uso de los mismos.
RU2009115954A (ru) 2006-09-29 2010-11-10 Новартис АГ (CH) Пиразолопиримидины в качестве ингибиторов липидной киназы р13к
JP2010508315A (ja) 2006-10-30 2010-03-18 ノバルティス アーゲー 抗炎症剤としてのヘテロ環式化合物
ES2730879T3 (es) 2008-01-04 2019-11-13 Univ Oxford Innovation Ltd Cuerpos de cetona y ésteres de cuerpos de cetona como agentes reductores de lípidos de la sangre
KR20100113557A (ko) 2008-01-11 2010-10-21 노파르티스 아게 키나제 억제제로서의 피리미딘
CN101602786B (zh) * 2008-06-10 2014-04-30 中国医学科学院药物研究所 N6-取代腺苷衍生物、其制法以及药物组合物与用途
US8642654B2 (en) 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
HRP20121006T1 (hr) 2009-01-29 2013-01-31 Novartis Ag Supstituirani benzimidazoli za lijeäśenje astrocitoma
CN101857622B (zh) * 2009-04-07 2014-12-03 中国医学科学院药物研究所 一种腺苷衍生物及其制备方法和应用
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
CA2770873A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
GEP201706639B (en) 2009-08-17 2017-03-27 Intellikine Llc Heterocyclic compounds and uses thereof
CA2771432A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
CN104382924B (zh) * 2009-12-10 2017-12-22 中国医学科学院药物研究所 N6‑取代腺苷衍生物和n6‑取代腺嘌呤衍生物及其用途
WO2011069294A1 (zh) * 2009-12-10 2011-06-16 中国医学科学院药物研究所 N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途
MX2012007661A (es) 2010-01-11 2012-08-01 Inotek Pharmaceuticals Corp Combinacion, kit y metodo para reducir la presion intraocular.
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
US8476247B2 (en) 2010-03-26 2013-07-02 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
KR20140014184A (ko) 2011-02-25 2014-02-05 아이알엠 엘엘씨 Trk 억제제로서의 화합물 및 조성물
AU2012310168B2 (en) 2011-09-15 2015-07-16 Novartis Ag 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
WO2013078440A2 (en) 2011-11-23 2013-05-30 Intellikine, Llc Enhanced treatment regimens using mtor inhibitors
CA2861009A1 (en) 2012-01-26 2013-08-01 Inotek Pharmaceuticals Corporation Anhydrous polymorphs of [(2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof
EP3964513A1 (en) 2012-04-03 2022-03-09 Novartis AG Combination products with tyrosine kinase inhibitors and their use
AU2013337308B2 (en) 2012-11-05 2018-06-21 Tdeltas Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
CN105246870A (zh) 2013-03-14 2016-01-13 伊希斯创新有限公司 (r)-3-羟基丁酸(r)-3-羟基丁酯的制备方法
WO2014151147A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
AU2014239222A1 (en) 2013-03-15 2015-10-01 Inotek Pharmaceuticals Corporation Ophthalmic formulations
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
BR112017001695A2 (pt) 2014-07-31 2017-11-21 Novartis Ag terapia de combinação
US12324807B2 (en) 2018-06-01 2025-06-10 Cornell University Combination therapy for PI3K-associated disease or disorder
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4738954A (en) * 1985-11-06 1988-04-19 Warner-Lambert Company Novel N6 -substituted-5'-oxidized adenosine analogs
US4868160A (en) * 1985-11-06 1989-09-19 Warner-Lambert Company Method of treating psychosis using N6 -substituted -5'-oxidized adenosine analogs
JPH0723394B2 (ja) * 1986-11-27 1995-03-15 日本臓器製薬株式会社 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
SG80526A1 (en) * 1990-09-25 2001-05-22 Rhone Poulenc Rorer Int Compounds having antihypertensive and anti- ischemic properies
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
US5652366A (en) * 1990-09-25 1997-07-29 Rhone-Poulenc Rorer Pharmaceuticals Inc. DI (1R)-(-)camphosulfonic acid) salt, preparation thereof and use thereof
DK62592D0 (is) * 1992-05-14 1992-05-14 Novo Nordisk As
US5705491A (en) * 1992-10-27 1998-01-06 Nippon Zoki Pharmaceutical Co., Ltd. Adenosine deaminase inhibitor
US5589467A (en) 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
JPH07118156A (ja) * 1993-10-26 1995-05-09 Nippon Zoki Pharmaceut Co Ltd アデノシンデアミナーゼ阻害剤
JPH08269083A (ja) * 1995-04-03 1996-10-15 Banyu Pharmaceut Co Ltd Ｎ６−置換アデノシン誘導体
AU2022497A (en) * 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
AU2022597A (en) 1996-03-13 1997-10-01 Novo Nordisk A/S A method of treating disorders related to cytokines in mammals
GB9610031D0 (en) * 1996-05-14 1996-07-17 Glaxo Group Ltd Chemical compounds
UA51716C2 (uk) 1996-07-08 2002-12-16 Авентіс Фармасьютікалз Продактс Інк. Сполуки, що мають гіпотензивну, кардіопротекторну, анти-ішемічну та антиліполітичну властивості, фармацевтична композиція та способи лікування
GB9723590D0 (en) * 1997-11-08 1998-01-07 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
US20030158146A1 (en) 2003-08-21
ID24758A (id) 2000-08-03
PL340873A1 (en) 2001-03-12
AU763414B2 (en) 2003-07-24
WO1999024451A2 (en) 1999-05-20
YU26800A (sh) 2002-12-10
TR200001937T2 (tr) 2000-11-21
CA2309202C (en) 2008-06-17
ES2222619T3 (es) 2005-02-01
ATE273989T1 (de) 2004-09-15
HUP0004102A2 (hu) 2001-04-28
AP2000001804A0 (en) 2000-06-30
AU1666599A (en) 1999-05-31
EP1030856A2 (en) 2000-08-30
BR9813989A (pt) 2000-09-26
WO1999024451A3 (en) 1999-08-19
EE200000283A (et) 2001-08-15
EA200000398A1 (ru) 2000-12-25
DE69825779T2 (de) 2005-08-25
KR20010031878A (ko) 2001-04-16
HRP20000277A2 (en) 2000-10-31
CA2309202A1 (en) 1999-05-20
IS5479A (is) 2000-05-03
CN1285844A (zh) 2001-02-28
DE69825779D1 (de) 2004-09-23
NZ504336A (en) 2002-11-26
NO20002359D0 (no) 2000-05-05
IL135966A0 (en) 2001-05-20
EA003087B1 (ru) 2002-12-26
EP1030856B1 (en) 2004-08-18
HUP0004102A3 (en) 2002-09-30
US6544960B1 (en) 2003-04-08
US6740644B2 (en) 2004-05-25
CN1217952C (zh) 2005-09-07
IL135966A (en) 2006-06-11
GB9723590D0 (en) 1998-01-07
SK6702000A3 (en) 2001-01-18
JP2001522859A (ja) 2001-11-20
NO20002359L (no) 2000-07-05

Similar Documents

Publication Publication Date Title
EE04499B1 (et) A1-adenosiiniretseptori agonistid, nende valmistamismeetod ja kasutamine
ATE242259T1 (de) Adenosin a1-rezeptor agonisten
DE69825780D1 (de) Adenosin a1-rezeptor agonisten
EE03482B1 (et) Kinasoliiniderivaadid, nende valmistamismeetod ja kasutamine
EE04721B1 (et) Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
EE200000319A (et) hGRF-PEG konjugaatide saitspetsiifiline valmistamismeetod, hGRF-PEG konjugaadid, nende vaheühendid, kasutamine ja farmatseutiline kompositsioon
PT1189916E (pt) N-pirazole agonistas do receptor a2a
ATA904399A (de) Adenosin a3-rezeptor-modulatoren
FI973522A7 (fi) Vesipitoisia, lesitiinipohjaisia irrotteita ja menetelmät niiden käytt ämiseksi
FI955235L (fi) Oksatsolidiinionijohdannaiset, niiden valmistus ja käyttö
EE04617B1 (et) 2,3-diarüülpürasolo[1,5-b]püridasiini derivaadid,nende valmistamine ja kasutamine tsüklooksügenaas2 (COX-2) inhibiitoritena
EE03568B1 (et) Bensimidasooli derivaadid, nende valmistamismeetod ja kasutamine
FI962494A7 (fi) 5-(2-imidatsolinyyliamino)bentsimidatsolijohdannaisia, niiden valmistu s ja niiden käyttö alpha-2-adrenoseptoriagonisteina
EE9900359A (et) Diasendatud bitsüklilised heterotsüklid, nende valmistamine ja kasutamine ravimitena
CY2013003I1 (el) Φωσφονοκεφεμικα παραγωγα, διαδικασια για την παρασκευη τους, και χρηση αυτων
NO975977L (no) Substituerte purinderivater, fremgangsmÕter for fremstilling og anvendelse derav
FI20051072L (fi) Polyamidi-oligonukleotidijohdoksia, niiden valmistus ja niiden käyttö
BR9711724A (pt) Derivado de 3,4,5,6,7,8-hexaidro-pirido (4',3':4,5)tieno-(2,3-d) pirimidina 3-substitu¡da e uso do mesmo
DK1025100T3 (da) 3-substituerede tetrahydropyridopyrimidinonderivater, fremstilling og anvendelsen heraf
EE04087B1 (et) Antimükootiline kompositsioon, selle kasutamine ja valmistamismeetod ning antimükootiline toode
EE03387B1 (et) Kombineeritud ravimpreparaat, selle kasutamine ja meetod selle valmistamiseks
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
DK0880524T3 (da) Adenosinantagonister, fremgangsmåde til fremstilling deraf og deres anvendelse som medikamenter
EE04260B1 (et) Farmatseutiline kompositsioon, selle valmistamisemeetod ja kasutamine
FI970750L (fi) Indoli-2,3-dioni-3-oksimijohdannaisia, niiden valmistus ja käyttö

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20111106