EE04660B1 - Ravim artriitiliste haiguste raviks - Google Patents

Ravim artriitiliste haiguste raviks

Info

Publication number: EE04660B1
Authority: EE; Estonia
Prior art keywords: treatment; arthritic diseases; drug; zinc; hyaluronic acid
Prior art date: 1999-03-10

Application number

EEP200100478A

Other languages

English (en)

Estonian (et)

Inventor

Serizawa Isao

Maekawa Keisei

Illes Janos

Neszmeli Erzsebet

Original Assignee

Takata Seiyaku Co., Ltd.

Richter Gedeon Vegy�Szeti Gy�R Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-10

Filing date

2000-03-10

Publication date

2006-08-15

2000-03-10 Application filed by Takata Seiyaku Co., Ltd., Richter Gedeon Vegy�Szeti Gy�R Rt. filed Critical Takata Seiyaku Co., Ltd.

2003-02-17 Publication of EE200100478A publication Critical patent/EE200100478A/xx

2006-08-15 Publication of EE04660B1 publication Critical patent/EE04660B1/xx

Links

230000002917 arthritic effect Effects 0.000 title abstract 2
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
229920002674 hyaluronan Polymers 0.000 abstract 2
229960003160 hyaluronic acid Drugs 0.000 abstract 2
210000002437 synoviocyte Anatomy 0.000 abstract 2
239000011701 zinc Substances 0.000 abstract 2
229910052725 zinc Inorganic materials 0.000 abstract 2
108010015302 Matrix metalloproteinase-9 Proteins 0.000 abstract 1
102100030412 Matrix metalloproteinase-9 Human genes 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
230000035755 proliferation Effects 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

EEP200100478A 1999-03-10 2000-03-10 Ravim artriitiliste haiguste raviks EE04660B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP06371899A JP2003089647A (ja)	1999-03-10	1999-03-10	関節性疾患治療剤
PCT/JP2000/001487 WO2000053194A1 (fr)	1999-03-10	2000-03-10	Medicaments contre les affections articulaires

Publications (2)

Publication Number	Publication Date
EE200100478A EE200100478A (et)	2003-02-17
EE04660B1 true EE04660B1 (et)	2006-08-15

Family

ID=13237463

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100478A EE04660B1 (et)	1999-03-10	2000-03-10	Ravim artriitiliste haiguste raviks

Country Status (21)

Country	Link
US (1)	US6608043B1 (fr)
EP (1)	EP1166788B8 (fr)
JP (1)	JP2003089647A (fr)
KR (1)	KR100728096B1 (fr)
CN (1)	CN1165315C (fr)
AT (1)	ATE466584T1 (fr)
AU (1)	AU2942500A (fr)
BG (1)	BG65681B1 (fr)
CA (1)	CA2364451C (fr)
CY (1)	CY1109773T1 (fr)
CZ (1)	CZ301736B6 (fr)
DE (1)	DE60044341D1 (fr)
DK (1)	DK1166788T3 (fr)
EA (1)	EA005010B1 (fr)
EE (1)	EE04660B1 (fr)
ES (1)	ES2344677T3 (fr)
PL (1)	PL200848B1 (fr)
PT (1)	PT1166788E (fr)
SK (1)	SK287223B6 (fr)
UA (1)	UA72913C2 (fr)
WO (1)	WO2000053194A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0303779A2 (en) *	2003-11-20	2006-02-28	Richter Gedeon Vegyeszet	Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
ITRM20030590A1 (it) *	2003-12-22	2005-06-23	Univ Siena	Formulazione a base di polimetafosfati per la cura di artropatie microcristalline.
WO2005089800A1 (fr) *	2004-03-17	2005-09-29	Locomogene, Inc.	COMPOSITION PHARMACEUTIQUE CONTENANT DE LA hsHRD3
US20070099867A1 (en) *	2005-05-24	2007-05-03	Glycoscience Laboratories, Inc.	Pharmaceutical agent containing hyaluronan as an active ingredient
CA2560844C (fr) *	2005-09-26	2011-05-17	Glycoscience Laboratories, Inc.	Agent pharmaceutique contenant de l'hyaluronane en tant qu'ingredient actif
JP2009091248A (ja) *	2006-01-17	2009-04-30	Toshitsu Kagaku Kenkyusho:Kk	外傷性神経障害および／または運動機能障害の治療薬
CN101389342B (zh)	2006-12-05	2012-08-08	株式会社糖质科学研究所	用于变性关节炎的治疗剂
FR2927255B1 (fr) *	2008-02-07	2011-08-12	Keysan Consulting	Produits injectables biocompatibles a liberation de zinc et/ou de sel de saccharide sous forme de zinc et leurs utilisations.
US8462765B2 (en) *	2008-08-20	2013-06-11	Qualcomm Incorporated	Method and apparatus to perform ranging operations for wireless stations
JP5587637B2 (ja) *	2009-04-10	2014-09-10	生化学工業株式会社	マトリックスメタロプロテアーゼ阻害剤及びその用途
HUP0900717A3 (en)	2009-11-18	2012-02-28	Richter Gedeon Nyrt	Pharmaceutical composition for urological use containing zinc hyaluronate
US8455436B2 (en)	2010-12-28	2013-06-04	Depuy Mitek, Llc	Compositions and methods for treating joints
US8524662B2 (en)	2010-12-28	2013-09-03	Depuy Mitek, Llc	Compositions and methods for treating joints
US8398611B2 (en)	2010-12-28	2013-03-19	Depuy Mitek, Inc.	Compositions and methods for treating joints
US8623839B2 (en)	2011-06-30	2014-01-07	Depuy Mitek, Llc	Compositions and methods for stabilized polysaccharide formulations
EP2545925B1 (fr) *	2011-07-12	2018-02-14	Holy Stone Healthcare Co.,Ltd.	Compositions comprenant de l'acide hyaluronique pour le traitement et la prévention de maladies liées aux muqueuses
US9682099B2 (en)	2015-01-20	2017-06-20	DePuy Synthes Products, Inc.	Compositions and methods for treating joints

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0259485A4 (fr) *	1986-03-14	1988-07-29	Bio Technology General Corp	Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens.
US4746504A (en) *	1986-03-14	1988-05-24	Bio-Technology General Corp.	Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
EP0356435B1 (fr)	1987-03-19	1995-10-18	Arthropharm Pty. Limited	Composes et compositions anti-inflammatoires
AU616502B2 (en) *	1988-04-22	1991-10-31	Medvet Science Pty. Ltd.	Treatment of inflammatory disorders in humans
HU203372B (en) *	1989-02-24	1991-07-29	Richter Gedeon Vegyeszet	Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
CZ202591A3 (cs) *	1991-07-02	1993-01-13	Hypro Vyzkum	Prostředek pro prevenci dekubitft a topickou terapii kožních lézt
US5744442A (en) *	1992-08-26	1998-04-28	Bristol Meyers Squibb Company	Regulation of cellular invasiveness
IT1281877B1 (it) *	1995-05-10	1998-03-03	Fidia Advanced Biopolymers Srl	Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici
IT1288290B1 (it) *	1996-06-21	1998-09-11	Fidia Spa In Amministrazione S	Acido ialuronico autoreticolato e relative composizioni farmaceutiche per il trattamento delle artropatie
EP0834319A1 (fr) *	1996-10-07	1998-04-08	Kartar Dr. Lalvani	Composition à base de minéraux et de vitamin, pour le traitement des douleurs arthritiques

1999
- 1999-03-10 JP JP06371899A patent/JP2003089647A/ja active Pending
2000
- 2000-03-10 EA EA200100963A patent/EA005010B1/ru not_active IP Right Cessation
- 2000-03-10 CN CNB008047391A patent/CN1165315C/zh not_active Expired - Lifetime
- 2000-03-10 SK SK1250-2001A patent/SK287223B6/sk not_active IP Right Cessation
- 2000-03-10 AT AT00908017T patent/ATE466584T1/de active
- 2000-03-10 CZ CZ20013110A patent/CZ301736B6/cs not_active IP Right Cessation
- 2000-03-10 KR KR1020017011505A patent/KR100728096B1/ko not_active Expired - Fee Related
- 2000-03-10 AU AU29425/00A patent/AU2942500A/en not_active Abandoned
- 2000-03-10 EP EP00908017A patent/EP1166788B8/fr not_active Expired - Lifetime
- 2000-03-10 DK DK00908017.7T patent/DK1166788T3/da active
- 2000-03-10 PT PT00908017T patent/PT1166788E/pt unknown
- 2000-03-10 EE EEP200100478A patent/EE04660B1/xx unknown
- 2000-03-10 US US09/936,245 patent/US6608043B1/en not_active Expired - Lifetime
- 2000-03-10 DE DE60044341T patent/DE60044341D1/de not_active Expired - Lifetime
- 2000-03-10 WO PCT/JP2000/001487 patent/WO2000053194A1/fr not_active Ceased
- 2000-03-10 PL PL350289A patent/PL200848B1/pl unknown
- 2000-03-10 CA CA2364451A patent/CA2364451C/fr not_active Expired - Lifetime
- 2000-03-10 ES ES00908017T patent/ES2344677T3/es not_active Expired - Lifetime
- 2000-10-03 UA UA2001096233A patent/UA72913C2/uk unknown
2001
- 2001-09-10 BG BG105885A patent/BG65681B1/bg unknown
2010
- 2010-06-08 CY CY20101100507T patent/CY1109773T1/el unknown

Also Published As

Publication number	Publication date
KR100728096B1 (ko)	2007-06-14
AU2942500A (en)	2000-09-28
SK12502001A3 (sk)	2002-02-05
CA2364451A1 (fr)	2000-09-14
CY1109773T1 (el)	2014-09-10
EA005010B1 (ru)	2004-10-28
UA72913C2 (en)	2005-05-16
EA200100963A1 (ru)	2002-02-28
CZ20013110A3 (cs)	2002-01-16
DE60044341D1 (de)	2010-06-17
EP1166788A1 (fr)	2002-01-02
BG65681B1 (bg)	2009-06-30
BG105885A (en)	2002-06-28
SK287223B6 (sk)	2010-03-08
PL200848B1 (pl)	2009-02-27
EE200100478A (et)	2003-02-17
DK1166788T3 (da)	2010-08-23
WO2000053194A1 (fr)	2000-09-14
CA2364451C (fr)	2011-08-02
ATE466584T1 (de)	2010-05-15
PL350289A1 (en)	2002-12-02
EP1166788B8 (fr)	2010-06-16
CZ301736B6 (cs)	2010-06-09
US6608043B1 (en)	2003-08-19
CN1343122A (zh)	2002-04-03
CN1165315C (zh)	2004-09-08
KR20010108343A (ko)	2001-12-07
JP2003089647A (ja)	2003-03-28
PT1166788E (pt)	2010-06-25
EP1166788B1 (fr)	2010-05-05
EP1166788A4 (fr)	2007-10-10
ES2344677T3 (es)	2010-09-03

Legal Events

Date	Code	Title	Description
2003-04-15	HB1A	Correction of owner name or address
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231

Publication	Publication Date	Title
CY1109773T1 (el)	2014-09-10	Φαρμακα για ασθενειες των αρθρωσεων
BR0012450A (pt)	2002-04-02	Benzimidazóis substituìdos
ATE293995T1 (de)	2005-05-15	Pharmazeutische zusammensetzungen, die wirkstoffabsorptionsfördernde verbindungen enthalten
BR0313371A (pt)	2005-07-05	Composto, uso de um composto e método de tratamento de doença
ATE339406T1 (de)	2006-10-15	Chinazoline verbindungen als heilmittel
ATE277929T1 (de)	2004-10-15	Immunsuppressive wirkungen von pteridinderivaten
PT750618E (pt)	2003-06-30	Derivados de oxazolidinona e composicoes farmaceuticas que os contem
BR0308613A (pt)	2005-03-01	Combinação de compostos orgânicos
CY1108932T1 (el)	2014-07-02	Ενωσεις 4-(ετεροκυκλυλ)-βενζολοσουλφοξιμινης για την θεραπευτικη αγωγη φλεγμονωδων ασθενειων
NO20035025L (no)	2003-11-12	Anvendelse av osteopontin for behandling og/eller for a hindre nevrologiske sykdommer, samt farmasoytisk sammensetning omfattende osteopontin eller en antagonist med osteopontinaktivitet.
GB0222514D0 (en)	2002-11-06	Organic compounds
YU30002A (sh)	2004-12-31	Upotreba dipiridamola ili mopidamola u pripremanju leka za lečenje i prevenciju mikrocirkulacionih poremećaja koji zavise od fibrina
MXPA04002510A (es)	2004-05-31	Combinacion de opioides selectos con antagonistas de muscarina para tratamiento de incontinencia urinaria.
EA200200742A1 (ru)	2002-12-26	1,2-диарилбензимидазолы для лечения заболеваний, связанных с активацией микроглии
BRPI0411176A (pt)	2006-07-18	combinação farmacêutica consistindo de modafinil e outra droga
TW200505408A (en)	2005-02-16	Agent for preventing and/or treating tissue disruption-accompanied diseases
EA199800717A1 (ru)	1999-02-25	Способ лечения заболеваний млекопитающих и цвиттерионная композиция
MX9403032A (es)	1995-01-31	Quinolil-dihidropiridinas condensadas, procedimiento para su fabricacion ysu uso en medicamentos.
GB0623258D0 (en)	2007-01-03	Thiadiazole derivatives for the treatment of neuro-degenerative diseases
NO20031650D0 (no)	2003-04-10	Nye legemidler for leversykdommer
EP1563836A4 (fr)	2006-04-12	Medicament permettant d'inhiber la production de metalloprotease-9 de matrice
ES2190581T3 (es)	2003-08-01	2-aminotetralina opticamente activa, procedimiento para su preparacion y composiciones farmaceuticas que la contienen, activa en la prevencion y tratamiento de shock septico.
WO2002085368A3 (fr)	2003-02-20	Utilisation de composes antiradicalaires dans le traitement et la prevention de troubles de la microcirculation no-dependants
PE20030732A1 (es)	2003-09-27	Empleo de alquilfosfocolinas en el tratamiento preventivo de enfermedades causadas por protozoarios
EA200400382A1 (ru)	2004-10-28	Применение специфической дозы фондапаринукса натрия для лечения окс