EE04801B1 - Leptiin kui tuumorirakkude proliferatsiooni inhibiitor - Google Patents

Leptiin kui tuumorirakkude proliferatsiooni inhibiitor

Info

Publication number: EE04801B1
Authority: EE; Estonia
Prior art keywords: leptin; inhibitor; cell proliferation; tumor cell; tumor
Prior art date: 1997-04-29

Application number

EEP199900510A

Other languages

English (en)

Estonian (et)

Inventor

Barkan Dalit

Cohen Batya

Rubinstein Menachem

Original Assignee

Yeda Research And Development Co. Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-29

Filing date

1998-04-26

Publication date

2007-04-16

1998-04-26 Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.

2000-06-15 Publication of EE9900510A publication Critical patent/EE9900510A/xx

2007-04-16 Publication of EE04801B1 publication Critical patent/EE04801B1/xx

Links

102000016267 Leptin Human genes 0.000 title 1
108010092277 Leptin Proteins 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
229940039781 leptin Drugs 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EEP199900510A 1997-04-29 1998-04-26 Leptiin kui tuumorirakkude proliferatsiooni inhibiitor EE04801B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL12073397A IL120733A0 (en)	1997-04-29	1997-04-29	Leptin as an inhibitor of cell proliferation
PCT/IL1998/000196 WO1998048831A1 (en)	1997-04-29	1998-04-26	Leptin as an inhibitor of tumor cell proliferation

Publications (2)

Publication Number	Publication Date
EE9900510A EE9900510A (et)	2000-06-15
EE04801B1 true EE04801B1 (et)	2007-04-16

Family

ID=11070075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900510A EE04801B1 (et)	1997-04-29	1998-04-26	Leptiin kui tuumorirakkude proliferatsiooni inhibiitor

Country Status (25)

Country	Link
US (1)	US7109159B1 (de)
EP (1)	EP0981365B1 (de)
JP (1)	JP4330662B2 (de)
KR (1)	KR100507731B1 (de)
CN (1)	CN1168497C (de)
AR (1)	AR012626A1 (de)
AT (1)	ATE283702T1 (de)
AU (1)	AU742927B2 (de)
BG (1)	BG63490B1 (de)
CA (1)	CA2288238A1 (de)
CZ (1)	CZ299872B6 (de)
DE (1)	DE69827942T2 (de)
EA (1)	EA002353B1 (de)
EE (1)	EE04801B1 (de)
ES (1)	ES2232944T3 (de)
HU (1)	HUP0002427A3 (de)
IL (2)	IL120733A0 (de)
NO (1)	NO322304B1 (de)
NZ (1)	NZ500589A (de)
PL (1)	PL195275B1 (de)
PT (1)	PT981365E (de)
SK (1)	SK284848B6 (de)
UA (1)	UA66793C2 (de)
WO (1)	WO1998048831A1 (de)
ZA (1)	ZA983608B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7208572B2 (en)	1998-08-21	2007-04-24	Albany Medical College	Leptin-related peptides
US6777388B1 (en)	1998-08-21	2004-08-17	Clf Medical Technology Acceleration Program, Inc.	Leptin-related peptides
US20050272652A1 (en)	1999-03-29	2005-12-08	Gault Victor A	Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) *	1999-09-05	2001-03-19	Yeda Res & Dev	Use of leptin in inhibition of endothelial cell proliferation
KR20140011431A (ko)	2004-02-11	2014-01-28	아밀린 파마슈티칼스, 엘엘씨.	선택가능한 특성을 갖는 하이브리드 폴리펩티드
US8076288B2 (en)	2004-02-11	2011-12-13	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides having glucose lowering activity
US8969291B2 (en)	2004-10-08	2015-03-03	Enzo Therapeutics, Inc.	Methods for decreasing leptin levels or activity for treating inflammation
US7863240B2 (en) *	2004-10-08	2011-01-04	Enzo Therapeutics, Inc.	Methods and uses of leptin in hepatocellular carcinoma
CA2597649A1 (en)	2005-02-11	2006-08-17	Amylin Pharmaceuticals, Inc.	Gip analog and hybrid polypeptides with selectable properties
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
EP2330125A3 (de)	2005-08-11	2012-12-12	Amylin Pharmaceuticals, Inc.	Hybridpolypeptide mit auswählbaren Eigenschaften
EP1922336B1 (de)	2005-08-11	2012-11-21	Amylin Pharmaceuticals, LLC	Hybridpolypeptide mit auswählbaren eigenschaften
US8227408B2 (en) *	2005-09-07	2012-07-24	Neurotez, Inc.	Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en)	2006-08-17	2013-07-30	Amylin Pharmaceuticals, Llc	DPP-IV resistant GIP hybrid polypeptides with selectable properties
SG188143A1 (en) *	2008-02-08	2013-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
KR20110028457A (ko) *	2008-05-21	2011-03-18	뉴로테즈 인코포레이티드	신경섬유 매듭과 연관된 신경변성 장애를 치료하는 방법
CA2742600A1 (en) *	2008-11-04	2010-05-14	Nikolaos Tezapsidis	Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
WO2010146059A2 (en)	2009-06-16	2010-12-23	F. Hoffmann-La Roche Ag	Biomarkers for igf-1r inhibitor therapy
TWI824372B (zh)	2015-10-12	2023-12-01	美商再生元醫藥公司	活化瘦素受體的抗原結合蛋白
MA45801B1 (fr)	2016-11-08	2021-11-30	Regeneron Pharma	Protéines de liaison à l'antigène qui sont des antagonistes du récepteur de leptine
SG11202005146VA (en)	2017-12-18	2020-06-29	Regeneron Pharma	Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof
SMT202500283T1 (it)	2018-04-06	2025-09-12	Regeneron Pharma	Un anticorpo agonista del recettore della leptina da utilizzare per aumentare la massa ossea in un soggetto affetto da disfunzione metabolica o ipoleptinemia
CN120629571B (zh) *	2025-06-13	2026-03-27	蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）	Lepr基因或蛋白作为靶标在制备胆管细胞癌治疗产品中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU695934B2 (en) *	1995-06-30	1998-08-27	Eli Lilly And Company	Methods for treating diabetes
AU7072896A (en) *	1995-09-19	1997-04-09	Eli Lilly And Company	Dna encoding medicinal proteins
AU731685C (en) *	1996-01-23	2002-08-22	Indevus Pharmaceuticals, Inc.	Methods for using the obese gene and its gene product to stimulate hematopoietic development

1997
- 1997-04-29 IL IL12073397A patent/IL120733A0/xx unknown
1998
- 1998-04-26 UA UA99116415A patent/UA66793C2/uk unknown
- 1998-04-26 EE EEP199900510A patent/EE04801B1/xx not_active IP Right Cessation
- 1998-04-26 ES ES98917580T patent/ES2232944T3/es not_active Expired - Lifetime
- 1998-04-26 JP JP54678798A patent/JP4330662B2/ja not_active Expired - Fee Related
- 1998-04-26 CA CA002288238A patent/CA2288238A1/en not_active Abandoned
- 1998-04-26 AU AU70762/98A patent/AU742927B2/en not_active Ceased
- 1998-04-26 HU HU0002427A patent/HUP0002427A3/hu unknown
- 1998-04-26 AT AT98917580T patent/ATE283702T1/de active
- 1998-04-26 CN CNB988066920A patent/CN1168497C/zh not_active Expired - Fee Related
- 1998-04-26 DE DE69827942T patent/DE69827942T2/de not_active Expired - Lifetime
- 1998-04-26 EP EP98917580A patent/EP0981365B1/de not_active Expired - Lifetime
- 1998-04-26 NZ NZ500589A patent/NZ500589A/xx not_active IP Right Cessation
- 1998-04-26 PT PT98917580T patent/PT981365E/pt unknown
- 1998-04-26 EA EA199900981A patent/EA002353B1/ru not_active IP Right Cessation
- 1998-04-26 CZ CZ0384899A patent/CZ299872B6/cs not_active IP Right Cessation
- 1998-04-26 SK SK1471-99A patent/SK284848B6/sk not_active IP Right Cessation
- 1998-04-26 US US09/403,897 patent/US7109159B1/en not_active Expired - Fee Related
- 1998-04-26 PL PL98336582A patent/PL195275B1/pl not_active IP Right Cessation
- 1998-04-26 KR KR10-1999-7009705A patent/KR100507731B1/ko not_active Expired - Fee Related
- 1998-04-26 WO PCT/IL1998/000196 patent/WO1998048831A1/en not_active Ceased
- 1998-04-29 ZA ZA983608A patent/ZA983608B/xx unknown
- 1998-04-29 AR ARP980102003A patent/AR012626A1/es unknown
1999
- 1999-10-25 BG BG103832A patent/BG63490B1/bg unknown
- 1999-10-28 NO NO19995267A patent/NO322304B1/no not_active IP Right Cessation
- 1999-10-28 IL IL132633A patent/IL132633A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1168497C (zh)	2004-09-29
IL132633A (en)	2007-07-04
SK284848B6 (sk)	2006-01-05
PL336582A1 (en)	2000-07-03
EE9900510A (et)	2000-06-15
ES2232944T3 (es)	2005-06-01
WO1998048831A1 (en)	1998-11-05
CZ299872B6 (cs)	2008-12-17
BG103832A (en)	2000-10-31
AU742927B2 (en)	2002-01-17
PT981365E (pt)	2005-03-31
HUP0002427A3 (en)	2003-02-28
EA199900981A1 (ru)	2000-04-24
HK1028350A1 (en)	2001-02-16
CA2288238A1 (en)	1998-11-05
DE69827942T2 (de)	2005-12-08
HUP0002427A2 (hu)	2000-12-28
EP0981365B1 (de)	2004-12-01
JP2001524968A (ja)	2001-12-04
NO322304B1 (no)	2006-09-11
AR012626A1 (es)	2000-11-08
SK147199A3 (en)	2000-06-12
EA002353B1 (ru)	2002-04-25
KR100507731B1 (ko)	2005-08-10
CN1261802A (zh)	2000-08-02
NO995267D0 (no)	1999-10-28
CZ384899A3 (cs)	2000-06-14
ZA983608B (en)	1998-11-02
KR20010012080A (ko)	2001-02-15
DE69827942D1 (de)	2005-01-05
BG63490B1 (bg)	2002-03-29
EP0981365A1 (de)	2000-03-01
NO995267L (no)	1999-12-28
JP4330662B2 (ja)	2009-09-16
AU7076298A (en)	1998-11-24
ATE283702T1 (de)	2004-12-15
US7109159B1 (en)	2006-09-19
NZ500589A (en)	2001-03-30
UA66793C2 (uk)	2004-06-15
PL195275B1 (pl)	2007-08-31
IL120733A0 (en)	1997-08-14

Legal Events

Date	Code	Title	Description
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2013-12-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20130426

Publication	Publication Date	Title
EE9900510A (et)	2000-06-15	Leptiin kui tuumorirakkude proliferatsiooni inhibiitor
EE200000706A (et)	2002-06-17	Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid
EE9800351A (et)	1999-04-15	Asendatud benseensulfoonamiidi derivaadid kui COX-2 inhibiitorite eelravimid
FI980038L (fi)	1998-02-24	Tuumorinekroositekijän alfa inhibiittoreita
DE69928195D1 (de)	2005-12-15	Komplettierung von Untrerdruck-Bohrlöchern
DE69716615D1 (de)	2002-11-28	Heterozyklische metalloproteaseinhibitoren
DE19882069T1 (de)	2000-04-27	Voraussage logarithmischer Reduktionswerte
ID24612A (id)	2000-07-27	Hidrogenolisis gliserol
DK1027332T3 (da)	2004-10-04	Hidtil ukendte lactametalloproteaseinhibitorer
FI971935A7 (fi)	1997-05-06	Polyanioniset bentsyyliglykosidit sileän lihaskudoksen solujen lisääntymisen estäjinä
DK0958287T3 (da)	2003-01-20	Sulfamidmetalloprotease-inhibitorer
DK1181269T3 (da)	2004-07-05	Celleproliferationsinhibitorer
DE69941468D1 (de)	2009-11-12	Zeitabgleichung von Aufwärtsverbindungs CDMA-Signalen
PT927183E (pt)	2004-12-31	Inibidores espirociclicos de metaloproteases
NO994069L (no)	1999-10-22	Forbindelser for immunoterapi av prostatacancer og fremgangsmate for anvendelse derav
EP1108008A4 (de)	2004-12-08	Neuartige ubiquitin ligasen als therapeutische ziele
FI971934A7 (fi)	1997-05-06	Asyloituja bentsyyliglykosideja sileälihassolulisääntymisen inhibiittoreina
EE03871B1 (et)	2002-10-15	Tsüanoguanidiinid kui rakkude paljunemise inhibiitorid
FI971936L (fi)	1997-05-06	Sileän lihaskudoksen solujen lisääntymisen estäjät
IT240802Y1 (it)	2001-04-11	Struttura di dischetto levatrucco
ID16838A (id)	1997-11-13	Komposisi dekafluoropentana
PL337031A1 (en)	2000-07-31	Cyanoguanidines as inhibitors of cell proliferation
ID17419A (id)	1997-12-24	Komposisi dekafluoropentana
IL132633A0 (en)	2001-03-19	Leptin as an inhibitor of tumor cell proliferation
SI0981365T1 (en)	2005-04-30	Leptin as an inhibitor of tumor cell proliferation