EE04872B1 - a-tsklodekstriini v?i selle derivaadi kasutamineLH-RH peptiidanaloogi sisaldavate farmatseutiliste kompositsioonide valmistamiseks ja a-tsklodekstriinil p?hinev farmatseutiline kompositsioon LH-RHpeptiidanaloogide peroraalseks manustamiseks - Google Patents

a-tsklodekstriini v?i selle derivaadi kasutamineLH-RH peptiidanaloogi sisaldavate farmatseutiliste kompositsioonide valmistamiseks ja a-tsklodekstriinil p?hinev farmatseutiline kompositsioon LH-RHpeptiidanaloogide peroraalseks manustamiseks

Info

Publication number
EE04872B1
EE04872B1 EEP200100196A EEP200100196A EE04872B1 EE 04872 B1 EE04872 B1 EE 04872B1 EE P200100196 A EEP200100196 A EE P200100196A EE P200100196 A EEP200100196 A EE P200100196A EE 04872 B1 EE04872 B1 EE 04872B1
Authority
EE
Estonia
Prior art keywords
clodextrin
peptide
derivative
preparation
oral administration
Prior art date
Application number
EEP200100196A
Other languages
English (en)
Inventor
Delansorne R�mi
Bonnet Paule
Paris Jacques
Original Assignee
Laboratoire Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire Theramex filed Critical Laboratoire Theramex
Publication of EE200100196A publication Critical patent/EE200100196A/et
Publication of EE04872B1 publication Critical patent/EE04872B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
EEP200100196A 1998-09-30 1999-09-23 a-tsklodekstriini v?i selle derivaadi kasutamineLH-RH peptiidanaloogi sisaldavate farmatseutiliste kompositsioonide valmistamiseks ja a-tsklodekstriinil p?hinev farmatseutiline kompositsioon LH-RHpeptiidanaloogide peroraalseks manustamiseks EE04872B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98402403A EP0998940A1 (en) 1998-09-30 1998-09-30 Pharmaceutical compositions based on alpha-cyclodextrin for the oral administration of LH-RH analogues
PCT/EP1999/007389 WO2000018423A1 (en) 1998-09-30 1999-09-23 Pharmaceutical compositions based on alpha-cyclodextrin for the oral administration of lh-rh analogues

Publications (2)

Publication Number Publication Date
EE200100196A EE200100196A (et) 2002-06-17
EE04872B1 true EE04872B1 (et) 2007-08-15

Family

ID=8235503

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100196A EE04872B1 (et) 1998-09-30 1999-09-23 a-tsklodekstriini v?i selle derivaadi kasutamineLH-RH peptiidanaloogi sisaldavate farmatseutiliste kompositsioonide valmistamiseks ja a-tsklodekstriinil p?hinev farmatseutiline kompositsioon LH-RHpeptiidanaloogide peroraalseks manustamiseks

Country Status (28)

Country Link
EP (2) EP0998940A1 (et)
JP (1) JP4485060B2 (et)
KR (1) KR100652457B1 (et)
CN (1) CN1200727C (et)
AR (1) AR023056A1 (et)
AT (1) ATE218358T1 (et)
AU (1) AU756233B2 (et)
BR (1) BR9914125A (et)
CA (1) CA2344470C (et)
CZ (1) CZ302343B6 (et)
DE (1) DE69901721T2 (et)
DK (1) DK1117420T3 (et)
EE (1) EE04872B1 (et)
ES (1) ES2178478T3 (et)
HK (1) HK1042047B (et)
HU (1) HUP0103649A3 (et)
ID (1) ID28650A (et)
IL (2) IL142112A0 (et)
MX (1) MXPA01003340A (et)
NO (1) NO330234B1 (et)
NZ (1) NZ510446A (et)
PL (1) PL200693B1 (et)
PT (1) PT1117420E (et)
RU (1) RU2214270C2 (et)
SI (1) SI1117420T1 (et)
TR (1) TR200100887T2 (et)
WO (1) WO2000018423A1 (et)
ZA (1) ZA200102452B (et)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10024451A1 (de) * 2000-05-18 2001-11-29 Asta Medica Ag Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung
SE0104462D0 (sv) 2001-12-29 2001-12-29 Carlbiotech Ltd As Peptide purifcation (Peptidrening)
CN100486641C (zh) * 2006-08-11 2009-05-13 南京师范大学 口服复方骨肽药物组合物及其制备方法
WO2024210903A1 (en) * 2023-04-07 2024-10-10 Najib Lamharzi Modified peptide ligands for stable delivery of highly potent payloads to tumors: method of making and using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659696A (en) * 1982-04-30 1987-04-21 Takeda Chemical Industries, Ltd. Pharmaceutical composition and its nasal or vaginal use
US4659969A (en) * 1984-08-09 1987-04-21 Synektron Corporation Variable reluctance actuator having position sensing and control
PT88490B (pt) * 1987-09-14 1992-11-30 Novo Nordisk As Processo para a preparacao de composicoes farmaceuticas para libertacao nao-enterica trans-mucosa contendo monossacaridos ou oligossacaridos
SI9300470A (en) * 1993-09-10 1995-04-30 Lek Tovarna Farmacevtskih Inclusion complexes of optically active and racemic ibuproxan with cyclodextrin derivates,process for their preparation,pharmaceutical preparations comprising the same and their use
JPH11292787A (ja) * 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
AU1808897A (en) * 1995-12-13 1997-07-03 Dullatur Limited A calcitonin preparation
ES2221019T3 (es) * 1996-10-31 2004-12-16 Takeda Chemical Industries, Ltd. Preparacion de liberacion mantenida.
EP0842946A1 (en) * 1996-11-14 1998-05-20 Laboratoire Theramex S.A. Conformationally constrained LH-RH analogues, their uses and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE69901721T2 (de) 2003-01-09
EP0998940A1 (en) 2000-05-10
EP1117420B1 (en) 2002-06-05
JP4485060B2 (ja) 2010-06-16
ZA200102452B (en) 2002-03-26
PT1117420E (pt) 2002-10-31
MXPA01003340A (es) 2004-04-21
NO20011576L (no) 2001-03-28
RU2214270C2 (ru) 2003-10-20
KR100652457B1 (ko) 2006-11-30
DE69901721D1 (de) 2002-07-11
EE200100196A (et) 2002-06-17
AR023056A1 (es) 2002-09-04
JP2002525336A (ja) 2002-08-13
DK1117420T3 (da) 2002-09-16
CZ20011173A3 (cs) 2001-09-12
NO20011576D0 (no) 2001-03-28
CA2344470C (en) 2009-01-06
AU756233B2 (en) 2003-01-09
TR200100887T2 (tr) 2001-10-22
SI1117420T1 (en) 2002-12-31
KR20010075255A (ko) 2001-08-09
BR9914125A (pt) 2001-06-19
CN1200727C (zh) 2005-05-11
ID28650A (id) 2001-06-21
HUP0103649A3 (en) 2002-05-28
ES2178478T3 (es) 2002-12-16
AU6199999A (en) 2000-04-17
EP1117420A1 (en) 2001-07-25
ATE218358T1 (de) 2002-06-15
HUP0103649A2 (hu) 2002-02-28
CA2344470A1 (en) 2000-04-06
HK1042047B (zh) 2005-12-16
PL200693B1 (pl) 2009-01-30
CN1324241A (zh) 2001-11-28
CZ302343B6 (cs) 2011-03-23
NO330234B1 (no) 2011-03-07
IL142112A0 (en) 2002-03-10
WO2000018423A1 (en) 2000-04-06
NZ510446A (en) 2003-01-31
PL346939A1 (en) 2002-03-11
IL142112A (en) 2006-10-31

Similar Documents

Publication Publication Date Title
DE69613463D1 (de) Filmbildende pharmazeutische zusammensetzungen zur transdermalen verabreichung
FI941987L (fi) Uudet aminohappojohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset
DE69212879D1 (de) Magensaftstabile pharmazeutische Formulierungen zur Oral Verbreichung von Gallensäuren
DK0936913T3 (da) Oralt farmaceutisk præparat indeholdende ibandronat
FI962952L (fi) Delta 12,13-iso-taksolianalogit, niiden antineoplastinen käyttö ja niitä sisältävät farmaseuttiset koostumukset
FI955310L (fi) Farmaseuttinen koostumus flavonoidien antamiseksi oraalisesti
EE04954B1 (et) Peroraalselt v?i paikselt manustatav farmatseutiline preparaat ja selle ravimvorm
EE04015B1 (et) Asendatud 2,4-tiasolidiindiooni derivaadid, nendevalmistamismeetodid ja neid sisaldavad farmatseutilised kompositsioonid
IT9019112A1 (it) Composizioni farmaceutiche e forme di dosaggio per la somministrazione orale di calcitonina
EE200100051A (et) Vastavast (-)-stereoisomeerist põhiliselt vaba (+)-nortsisapriidi või selle farmatseutiliselt vastuvõetava soola kasutamine ja farmatseutiline kompositsioon
ITMI932014A0 (it) Composizioni farmaceutiche orali effervescenti contenenti estrone
FI941517A7 (fi) Bentsonaftyridiinin-1,8 johdannaiset, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset
EE04095B1 (et) Ketoliidide ja nende farmatseutiliselt vastuvõetavate soolade kasutamine farmatseutiliste kompositsioonide valmistamiseks
DE69812962D1 (de) Oral anzuwendende Arzneizubereitung enthaltend S-(3-Hydroxypropyl)-L-Cystein
EE200100196A (et) a-tsüklodekstriinil põhinevad farmatseutilised kompositsioonid LH-RH analoogide peroraalseks manustamiseks
IT9021021A0 (it) Composizioni farmaceutiche per la somministrazione orale di irudina
ITMI913510A1 (it) Composizioni farmaceutiche contenenti progesterone ad elevata biodisponibilita'
NZ241309A (en) Heterocyclic amido prostaglandin analogues, preparation and pharmaceutical compositions thereof
KR970701559A (ko) 펩타이드의 경구 투여를 위한 안정화된 조성물(stabilized composition for oral administration of peptides)
ITMI920214A1 (it) Composizioni farmaceutiche stabili per la somministrazione orale di calcitonina
IL81926A0 (en) Pharmaceutical compositions for the oral administration of active proteins
ITPD920141A0 (it) Formulazione farmaceutiche per la somministraziane orale di calcitoni-na
IL93270A0 (en) Pharmaceutical compositions for oral administration
IE900393L (en) Pharmaceutical compositions for oral administration
IT8821879A0 (it) 2 tiolpropionil arginine, loro sali, procedimento per la loro prepara zione e relative composizioni farmaceutiche

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20110923