EE200000620A - 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon - Google Patents

3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon

Info

Publication number: EE200000620A
Authority: EE; Estonia
Prior art keywords: aminoalkyl; amino; preparation; pharmaceutical composition; pyridinone derivatives
Prior art date: 1998-04-27

Application number

EEP200000620A

Other languages

English (en)

Estonian (et)

Inventor

Bisagni �mile

Dolle Val�rie

Hung Nguyen Chi

Monneret Claude

Grierson David

Aubertin Anne-Marie

Original Assignee

Centre National De La Recherche Scientifique

Institut Curie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-27

Filing date

1999-04-27

Publication date

2002-04-15

1999-04-27 Application filed by Centre National De La Recherche Scientifique, Institut Curie filed Critical Centre National De La Recherche Scientifique

2002-04-15 Publication of EE200000620A publication Critical patent/EE200000620A/xx

Links

125000004103 aminoalkyl group Chemical group 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
150000005299 pyridinones Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200000620A 1998-04-27 1999-04-27 3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon EE200000620A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8308298P	1998-04-27	1998-04-27
PCT/EP1999/003023 WO1999055676A1 (en)	1998-04-27	1999-04-27	3-(amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of hiv related diseases

Publications (1)

Publication Number	Publication Date
EE200000620A true EE200000620A (et)	2002-04-15

Family

ID=22176061

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000620A EE200000620A (et)	1998-04-27	1999-04-27	3-(amino- või aminoalküül)püridinooni derivaadid,nende valmistamismeetod ja kasutamine ning farmatseutiline kompositsioon

Country Status (27)

Country	Link
US (2)	US6451822B1 (cs)
EP (1)	EP1073637B1 (cs)
JP (1)	JP2002513004A (cs)
KR (1)	KR20010087128A (cs)
CN (1)	CN1303378A (cs)
AP (1)	AP2000001991A0 (cs)
AT (1)	ATE334966T1 (cs)
AU (1)	AU4137899A (cs)
BG (1)	BG104984A (cs)
BR (1)	BR9909976A (cs)
CA (1)	CA2330304A1 (cs)
CZ (1)	CZ20003978A3 (cs)
DE (1)	DE69932611T2 (cs)
EE (1)	EE200000620A (cs)
HR (1)	HRP20000716A2 (cs)
HU (1)	HUP0101595A3 (cs)
ID (1)	ID27502A (cs)
IL (1)	IL139239A0 (cs)
MX (1)	MXPA00010490A (cs)
NO (1)	NO20005387L (cs)
NZ (1)	NZ508297A (cs)
PL (1)	PL343685A1 (cs)
RU (1)	RU2000129671A (cs)
SK (1)	SK16072000A3 (cs)
TR (1)	TR200003113T2 (cs)
WO (1)	WO1999055676A1 (cs)
ZA (1)	ZA200006037B (cs)

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US6436972B1 (en) *	2000-04-10	2002-08-20	Dalhousie University	Pyridones and their use as modulators of serine hydrolase enzymes
US6803370B2 (en) *	2000-07-21	2004-10-12	Elan Pharmaceuticals, Inc.	Alpha amino acid derivatives—inhibitors of leukocyte adhesion mediated by VLA-4
ATE319706T1 (de) *	2000-09-19	2006-03-15	Centre Nat Rech Scient	Pyridinon und pyridinethion-derivate mit hiv- hemmenden eigenschaften
US7482366B2 (en)	2001-12-21	2009-01-27	X-Ceptor Therapeutics, Inc.	Modulators of LXR
US7998986B2 (en)	2001-12-21	2011-08-16	Exelixis Patent Company Llc	Modulators of LXR
US7642277B2 (en) *	2002-12-04	2010-01-05	Boehringer Ingelheim International Gmbh	Non-nucleoside reverse transcriptase inhibitors
WO2004085406A1 (en) *	2003-03-24	2004-10-07	F. Hoffmann-La Roche Ag	Benzyl-pyridazinons as reverse transcriptase inhibitors
EP1516873A1 (en) *	2003-09-22	2005-03-23	Facultés Universitaires Notre-Dame de la Paix	2-pyridinone derivatives, having HIV inhibiting properties
MXPA06013315A (es) *	2004-05-17	2007-02-02	Tibotec Pharm Ltd	1,5-dihidro-pirido[3,2-b]indol-2-onas 4-sustituidas.
MY148809A (en) *	2004-07-06	2013-05-31	Eisai R&D Man Co Ltd	Crystals of 1,2-dihydropyridine compound and their production process
GB0420722D0 (en) *	2004-09-17	2004-10-20	Addex Pharmaceuticals Sa	Novel allosteric modulators
MX2007007919A (es) *	2004-12-31	2008-01-22	Reddy Us Therapeutics Inc	Nuevos derivados de bencilaminas como inhibidores de la proteina de transferencia de colesteril-ester(cetp).
AP2007004244A0 (en)	2005-05-10	2007-12-31	Intermune Inc	Method of modulating stress-activated protein kinase system
AU2006285038A1 (en)	2005-08-29	2007-03-08	Vertex Pharmaceuticals Incorporated	3,5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
WO2007027729A1 (en)	2005-08-29	2007-03-08	Vertex Pharmaceuticals Incorporated	3, 5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
JP5112317B2 (ja)	2005-08-29	2013-01-09	バーテックスファーマシューティカルズインコーポレイテッド	非受容体型チロシンキナーゼのｔｅｃファミリーの阻害剤として有用な３，５−二置換ピリド−２−オン
CA2632565A1 (en) *	2005-12-19	2007-07-05	Syngenta Limited	Substituted aromatic heterocyclic compounds as fungicides
CN101952274A (zh) *	2007-11-20	2011-01-19	默沙东公司	非核苷逆转录酶抑制剂
EP2296653B1 (en)	2008-06-03	2016-01-27	Intermune, Inc.	Compounds and methods for treating inflammatory and fibrotic disorders
US20110184029A1 (en) *	2008-07-14	2011-07-28	Korea Research Institute Of Chemical Technology	Pyridone derivatives as non-nucleoside reverse transcriptase inhibitors
US8318737B2 (en)	2009-09-02	2012-11-27	Canthera Therapeutics Inc.	Compounds and compositions for treating cancer
US8349832B2 (en) *	2009-09-02	2013-01-08	Canthera Therapeutics	Compounds and compositions for treating cancer
CN102001994B (zh) *	2010-10-22	2014-07-09	北京大学	吡啶酮类hiv-1逆转录酶抑制剂的制备及其应用
CN103288719A (zh) *	2012-03-05	2013-09-11	苏州欧凯医药技术有限公司	非核甘艾滋病毒抑制物-吡啶酮类先导体的合成
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
JO3470B1 (ar)	2012-10-08	2020-07-05	Merck Sharp & Dohme	مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
RU2692485C2 (ru)	2014-04-02	2019-06-25	Интермьюн, Инк.	Противофиброзные пиридиноны
BR112017003745A2 (pt)	2014-08-29	2017-12-05	Tes Pharma S R L	inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
MX2021007382A (es) *	2018-12-18	2021-07-15	Merck Sharp & Dohme Llc	Derivados de pirimidona como agentes citotoxicos selectivos contra celulas infectadas por vih.
AU2020279954B2 (en) *	2019-05-22	2025-11-13	Merck Sharp & Dohme Llc	Pyridinone derivatives as selective cytotoxic agents against HIV infected cells

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NZ238576A (en) *	1990-06-18	1994-12-22	Merck & Co Inc	Pyridinone derivatives, preparation and pharmaceutical compositions thereof
US5308854A (en) *	1990-06-18	1994-05-03	Merck & Co., Inc.	Inhibitors of HIV reverse transcriptase
FR2737496B1 (fr) *	1995-07-31	1997-12-19	Centre Nat Rech Scient	4-aryl-thio-pyridin-2(1h)-ones, medicaments les contenant et leurs utilisations dans le traitement de maladies liees aux vih 1 et 2

1999
- 1999-04-27 CZ CZ20003978A patent/CZ20003978A3/cs unknown
- 1999-04-27 JP JP2000545836A patent/JP2002513004A/ja not_active Withdrawn
- 1999-04-27 EP EP99924870A patent/EP1073637B1/en not_active Expired - Lifetime
- 1999-04-27 WO PCT/EP1999/003023 patent/WO1999055676A1/en not_active Ceased
- 1999-04-27 ID IDW20002191A patent/ID27502A/id unknown
- 1999-04-27 PL PL99343685A patent/PL343685A1/xx unknown
- 1999-04-27 RU RU2000129671/04A patent/RU2000129671A/ru unknown
- 1999-04-27 CA CA002330304A patent/CA2330304A1/en not_active Abandoned
- 1999-04-27 EE EEP200000620A patent/EE200000620A/xx unknown
- 1999-04-27 AP APAP/P/2000/001991A patent/AP2000001991A0/en unknown
- 1999-04-27 KR KR1020007011918A patent/KR20010087128A/ko not_active Withdrawn
- 1999-04-27 CN CN99806829A patent/CN1303378A/zh active Pending
- 1999-04-27 AU AU41378/99A patent/AU4137899A/en not_active Abandoned
- 1999-04-27 BR BR9909976-4A patent/BR9909976A/pt not_active IP Right Cessation
- 1999-04-27 TR TR2000/03113T patent/TR200003113T2/xx unknown
- 1999-04-27 IL IL13923999A patent/IL139239A0/xx unknown
- 1999-04-27 SK SK1607-2000A patent/SK16072000A3/sk unknown
- 1999-04-27 US US09/673,635 patent/US6451822B1/en not_active Expired - Fee Related
- 1999-04-27 HR HR20000716A patent/HRP20000716A2/hr not_active Application Discontinuation
- 1999-04-27 NZ NZ508297A patent/NZ508297A/xx unknown
- 1999-04-27 DE DE69932611T patent/DE69932611T2/de not_active Expired - Lifetime
- 1999-04-27 MX MXPA00010490A patent/MXPA00010490A/es unknown
- 1999-04-27 AT AT99924870T patent/ATE334966T1/de not_active IP Right Cessation
- 1999-04-27 HU HU0101595A patent/HUP0101595A3/hu unknown
2000
- 2000-10-25 ZA ZA200006037A patent/ZA200006037B/en unknown
- 2000-10-26 NO NO20005387A patent/NO20005387L/no not_active Application Discontinuation
- 2000-11-24 BG BG104984A patent/BG104984A/xx unknown
2002
- 2002-07-15 US US10/194,240 patent/US6683079B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ20003978A3 (cs)	2001-09-12
IL139239A0 (en)	2001-11-25
NO20005387D0 (no)	2000-10-26
KR20010087128A (ko)	2001-09-15
SK16072000A3 (sk)	2002-04-04
US6451822B1 (en)	2002-09-17
TR200003113T2 (tr)	2001-05-21
RU2000129671A (ru)	2004-02-20
NO20005387L (no)	2000-12-04
AU4137899A (en)	1999-11-16
CA2330304A1 (en)	1999-11-04
AP2000001991A0 (en)	2000-12-31
ATE334966T1 (de)	2006-08-15
EP1073637B1 (en)	2006-08-02
HUP0101595A3 (en)	2002-12-28
US20030125340A1 (en)	2003-07-03
EP1073637A1 (en)	2001-02-07
ZA200006037B (en)	2002-01-25
NZ508297A (en)	2002-12-20
HRP20000716A2 (en)	2001-06-30
PL343685A1 (en)	2001-08-27
MXPA00010490A (es)	2002-10-17
BG104984A (en)	2001-07-31
CN1303378A (zh)	2001-07-11
JP2002513004A (ja)	2002-05-08
ID27502A (id)	2001-04-12
DE69932611T2 (de)	2007-10-11
WO1999055676A1 (en)	1999-11-04
DE69932611D1 (de)	2006-09-14
BR9909976A (pt)	2000-12-26
US6683079B2 (en)	2004-01-27
HUP0101595A2 (hu)	2001-11-28

Publication	Publication Date	Title
EE200100252A (et)	2002-10-15	Pürimidiinderivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja sellevalmistamismeetod, kombinatsioon ning saadus
EE04275B1 (et)	2004-04-15	Kinoliini derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutilised kompositsioonid
EE200000596A (et)	2002-06-17	Tienüülasolüülalkoksüetaanamiinderivaadid, nende ja nende soolade valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja kasutamine ning vaheühend ja selle valmistamismeetod
EE200100684A (et)	2003-04-15	Indalüülasendatud benseenkarboksamiidid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
EE04915B1 (et)	2007-10-15	Kinuklidiinderivaadid, nende valmistamismeetod, vahehendid, farmatseutiline kompositsioon ja nende kasutamine
EE200100431A (et)	2002-12-16	16-halogenoepotilooni derivaadid, nende valmistamismeetod ja farmatseutiline kasutamine
EE05214B1 (et)	2009-10-15	Polool-IFN- β konjugaat, selle valmistamismeetod ja farmatseutiline kompositsioon
EE200200487A (et)	2004-02-16	Asetidiini derivaadid, nende valmistamismeetodid ja farmatseutiline kompositsioon
EE200000707A (et)	2002-04-15	Oksasolidinooni derivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
EE9800302A (et)	1999-02-15	Arüülglütsiinamiidi derivaadid, nende valmistamismeetod ja kasutamine ning farmatseutiline preparaat
NO20001409D0 (no)	2000-03-17	Karboksamidotiazolderivater, fremgangsmåte for fremstilling derav og farmasøytiske blandinger
EE05455B1 (et)	2011-08-15	3-heterotskll-asendatud bensolderivaadid ja neid sisaldavad vahendid, nende saamise meetodid ning nende kasutamine herbitsiididena
EE200000319A (et)	2001-08-15	hGRF-PEG konjugaatide saitspetsiifiline valmistamismeetod, hGRF-PEG konjugaadid, nende vaheühendid, kasutamine ja farmatseutiline kompositsioon
EE04721B1 (et)	2006-10-16	Fenüülksantiini derivaadid, nende valmistamismeetodid ja kasutamine
NO20005387D0 (no)	2000-10-26	3-(amino- eller aminoalkyl-)pyridinonderivater og deres anvendelse for behandling av HIV-relaterte sykdommer
EE03825B1 (et)	2002-08-15	2-tsüanoiminoimidasooli derivaadid, nende valmistamismeetod, kasutamine ja farmatseutilised kompositsioonid
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