EE200200169A - Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid - Google Patents

Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Info

Publication number
EE200200169A
EE200200169A EEP200200169A EEP200200169A EE200200169A EE 200200169 A EE200200169 A EE 200200169A EE P200200169 A EEP200200169 A EE P200200169A EE P200200169 A EEP200200169 A EE P200200169A EE 200200169 A EE200200169 A EE 200200169A
Authority
EE
Estonia
Prior art keywords
indolyl
acid derivatives
glyoxylic acid
therapeutically valuable
valuable properties
Prior art date
Application number
EEP200200169A
Other languages
English (en)
Estonian (et)
Inventor
Nickel Bernd
Klenner Thomas
Bacher Gerald
Beckers Thomas
Emig Peter
Engel J�rgen
Bruyneel Erik
Kamp G�nter
Peters Kirsten
Original Assignee
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19946301A external-priority patent/DE19946301A1/de
Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
Publication of EE200200169A publication Critical patent/EE200200169A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EEP200200169A 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid EE200200169A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19946301A DE19946301A1 (de) 1998-04-02 1999-09-28 Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
PCT/EP2000/009390 WO2001022954A2 (de) 1999-09-28 2000-09-26 Indolyl-3-glyoxylsäurederivate als antitumormittel

Publications (1)

Publication Number Publication Date
EE200200169A true EE200200169A (et) 2003-04-15

Family

ID=7923485

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200169A EE200200169A (et) 1999-09-28 2000-09-26 Terapeutiliselt väärtuslike omadustega indolüül-3-glüoksüülhappe derivaadid

Country Status (32)

Country Link
EP (1) EP1218006B1 (is)
JP (1) JP2003510274A (is)
KR (1) KR100759242B1 (is)
CN (1) CN1301712C (is)
AR (1) AR025885A1 (is)
AT (1) ATE459356T1 (is)
AU (1) AU783436B2 (is)
BG (1) BG106639A (is)
BR (1) BR0014378A (is)
CA (1) CA2386069C (is)
CZ (1) CZ303246B6 (is)
DE (1) DE50015879D1 (is)
DZ (1) DZ3196A1 (is)
EE (1) EE200200169A (is)
ES (1) ES2342042T3 (is)
GE (1) GEP20043250B (is)
HK (1) HK1048941B (is)
HR (1) HRP20020369A2 (is)
HU (1) HUP0202788A3 (is)
IL (2) IL148670A0 (is)
IS (1) IS6319A (is)
MX (1) MXPA02002824A (is)
NO (1) NO322614B1 (is)
NZ (1) NZ517988A (is)
PL (1) PL199576B1 (is)
RS (1) RS51302B (is)
RU (1) RU2282444C2 (is)
SK (1) SK287533B6 (is)
TW (1) TWI269654B (is)
UA (1) UA75872C2 (is)
WO (1) WO2001022954A2 (is)
ZA (1) ZA200202556B (is)

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DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
NZ522074A (en) 2000-05-31 2004-06-25 Astrazeneca Ab Indole derivatives with vascular damaging activity
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
EP1484329A1 (de) * 2003-06-06 2004-12-08 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
BRPI0410998A (pt) * 2003-06-05 2006-07-04 Zentaris Gmbh derivados de indol com efeito de indução de apoptose
EP1595878A1 (de) * 2004-05-15 2005-11-16 Zentaris GmbH Indolderivate mit Apoptose induzierender Wirkung
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
EP1751115A4 (en) * 2004-05-23 2010-10-20 Gerard M Housey THERAMUTEINMODULATOREN
AU2005304952B2 (en) * 2004-11-08 2013-04-04 Baxter Healthcare S.A. Nanoparticulate compositions of tubulin inhibitors
US20060100432A1 (en) 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
WO2006073973A2 (en) 2004-12-31 2006-07-13 Reddy Us Therapeutics, Inc. Novel benzylamine derivatives as cetp inhibitors
US7851476B2 (en) 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
EP2091532A1 (en) * 2006-11-28 2009-08-26 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
US9199967B2 (en) 2011-08-18 2015-12-01 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (CETP) inhibitors
MX352074B (es) 2011-09-27 2017-11-08 Dr Reddys Laboratories Ltd Derivados de 5-bencilaminometil-6-aminopirazolo [3,4-b] piridina como inhibidores de proteina de transferencia de ester de colesterilo (cetp) utiles para el tratamiento de aterosclerosis.
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
US10201623B2 (en) 2013-03-15 2019-02-12 Memorial Sloan Kettering Cancer Center HSP90-targeted cardiac imaging and therapy
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
CN109111501B (zh) * 2017-06-23 2022-04-22 首都医科大学 脂肪氨基酸修饰的吲哚乙醇衍生物, 其合成，活性和应用
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
WO2022182415A1 (en) 2021-02-24 2022-09-01 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4128089A (en) 1988-09-15 1990-03-22 Rorer International (Overseas) Inc. Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
RU2047603C1 (ru) * 1991-12-09 1995-11-10 Матвей Абрамович Рехтер 1-алкил-2-ацилиндолы и способы их получения
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
AU671865B2 (en) * 1992-10-20 1996-09-12 Toray Industries, Inc. Eosinophil infiltration inhibitor
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
CA2286038A1 (en) 1997-04-08 1998-10-15 Banyu Pharmaceutical Co., Ltd. Cancerous metastasis-associated gene
EE200000488A (et) * 1998-02-25 2002-02-15 Genetics Institute, Inc. Fosfolipaasensüümide inhibiitorid ja farmatseutilised kompositsioonid
WO1999046237A1 (en) * 1998-03-12 1999-09-16 Novo Nordisk A/S Modulators of protein tyrosine phosphatases
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
JP2000239252A (ja) * 1999-02-16 2000-09-05 Mitsubishi Chemicals Corp インドール誘導体
AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof

Also Published As

Publication number Publication date
PL199576B1 (pl) 2008-10-31
EP1218006B1 (de) 2010-03-03
DZ3196A1 (fr) 2001-04-05
KR100759242B1 (ko) 2007-09-18
JP2003510274A (ja) 2003-03-18
ZA200202556B (en) 2003-08-27
HK1048941A1 (en) 2003-04-25
CA2386069A1 (en) 2001-04-05
MXPA02002824A (es) 2003-07-21
NO20021367D0 (no) 2002-03-19
RU2282444C2 (ru) 2006-08-27
IL148670A (en) 2009-09-01
SK287533B6 (sk) 2011-01-04
HUP0202788A3 (en) 2003-02-28
UA75872C2 (en) 2006-06-15
CZ20021005A3 (cs) 2004-01-14
CZ303246B6 (cs) 2012-06-20
BG106639A (bg) 2002-12-29
IL148670A0 (en) 2002-09-12
CA2386069C (en) 2012-08-14
EP1218006A2 (de) 2002-07-03
GEP20043250B (en) 2004-06-25
CN1376064A (zh) 2002-10-23
AU7782900A (en) 2001-04-30
HRP20020369A2 (en) 2004-12-31
ES2342042T3 (es) 2010-07-01
DE50015879D1 (de) 2010-04-15
KR20030019295A (ko) 2003-03-06
HUP0202788A2 (hu) 2003-01-28
NO20021367L (no) 2002-05-22
WO2001022954A2 (de) 2001-04-05
AR025885A1 (es) 2002-12-18
HK1048941B (zh) 2007-09-21
ATE459356T1 (de) 2010-03-15
BR0014378A (pt) 2003-07-29
AU783436B2 (en) 2005-10-27
YU22702A (sh) 2004-12-31
TWI269654B (en) 2007-01-01
IS6319A (is) 2002-03-21
WO2001022954A3 (de) 2002-03-28
NO322614B1 (no) 2006-11-06
RS51302B (sr) 2010-12-31
PL364811A1 (en) 2004-12-13
SK4072002A3 (en) 2003-11-04
NZ517988A (en) 2004-10-29
CN1301712C (zh) 2007-02-28

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Legal Events

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