EE200200363A - Sulfoonamiidid ja nende derivaadid, mis moduleerivad endoteliini aktiivsust - Google Patents

Sulfoonamiidid ja nende derivaadid, mis moduleerivad endoteliini aktiivsust

Info

Publication number: EE200200363A
Authority: EE; Estonia
Prior art keywords: endothelin; isoxazolyl; derivatives; methods; activity
Prior art date: 1999-12-31

Application number

EEP200200363A

Other languages

English (en)

Inventor

Wu Chengde

W. Holland George

Blok Natalie

Original Assignee

Texas Biotechnology Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-31

Filing date

2000-12-29

Publication date

2003-08-15

2000-12-29 Application filed by Texas Biotechnology Corporation filed Critical Texas Biotechnology Corporation

2003-08-15 Publication of EE200200363A publication Critical patent/EE200200363A/et

Links

108050009340 Endothelin Proteins 0.000 title abstract 5
102000002045 Endothelin Human genes 0.000 title abstract 4
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 4
150000003456 sulfonamides Chemical class 0.000 title abstract 4
230000000694 effects Effects 0.000 title abstract 3
238000000034 method Methods 0.000 abstract 3
229940124530 sulfonamide Drugs 0.000 abstract 3
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
102000010180 Endothelin receptor Human genes 0.000 abstract 1
108050001739 Endothelin receptor Proteins 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
HLBCDKJOMBEQMZ-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)-1h-pyrrole-2-sulfonamide Chemical class C=1C=CNC=1S(=O)(=O)NC=1C=CON=1 HLBCDKJOMBEQMZ-UHFFFAOYSA-N 0.000 abstract 1
NRNITHABNQZDAT-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NC=1C=CON=1 NRNITHABNQZDAT-UHFFFAOYSA-N 0.000 abstract 1
WDPJORZQTNVWPF-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)furan-2-sulfonamide Chemical class C=1C=COC=1S(=O)(=O)NC=1C=CON=1 WDPJORZQTNVWPF-UHFFFAOYSA-N 0.000 abstract 1
REPFEAIBUZAYOL-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)thiophene-2-sulfonamide Chemical class C=1C=CSC=1S(=O)(=O)NC=1C=CON=1 REPFEAIBUZAYOL-UHFFFAOYSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

EEP200200363A 1999-12-31 2000-12-29 Sulfoonamiidid ja nende derivaadid, mis moduleerivad endoteliini aktiivsust EE200200363A (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17410499P	1999-12-31	1999-12-31
PCT/US2000/035599 WO2001049685A2 (en)	1999-12-31	2000-12-29	Sulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number	Publication Date
EE200200363A true EE200200363A (et)	2003-08-15

Family

ID=22634839

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200200363A EE200200363A (et)	1999-12-31	2000-12-29	Sulfoonamiidid ja nende derivaadid, mis moduleerivad endoteliini aktiivsust

Country Status (24)

Country	Link
US (1)	US6686382B2 (et)
EP (1)	EP1244657B1 (et)
JP (1)	JP4202649B2 (et)
KR (1)	KR20020072285A (et)
CN (1)	CN1414965A (et)
AT (2)	ATE286051T1 (et)
AU (1)	AU2464301A (et)
BR (1)	BR0016821A (et)
CA (1)	CA2395684C (et)
CZ (1)	CZ20022293A3 (et)
DE (2)	DE60034605T2 (et)
DK (1)	DK1533311T3 (et)
EA (1)	EA004735B1 (et)
EE (1)	EE200200363A (et)
ES (2)	ES2236028T3 (et)
HU (1)	HUP0203935A3 (et)
IL (1)	IL150311A0 (et)
MX (1)	MXPA02006461A (et)
NO (1)	NO20023168L (et)
NZ (1)	NZ519717A (et)
PL (1)	PL197782B1 (et)
PT (1)	PT1533311E (et)
SK (1)	SK9532002A3 (et)
WO (1)	WO2001049685A2 (et)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en) *	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JP3455233B2 (ja)	1997-04-28	2003-10-14	テキサス・バイオテクノロジー・コーポレイシヨン	エンドテリン介在障害治療用のスルホンアミド類
MXPA02006461A (es)	1999-12-31	2003-09-05	Texas Biotechnology Corp	Sulfonamidas y derivados de las mismas que modulan la actividad de endotelina.
DK1471054T3 (da)	2002-01-11	2009-11-09	Daiichi Sankyo Co Ltd	Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse
US7205307B2 (en) *	2002-02-14	2007-04-17	Icagen, Inc.	Pyrimidines as novel openers of potassium ion channels
AU2003291255A1 (en) *	2002-11-06	2004-06-03	Smithkline Beecham Corporation	Sulfonamides
NZ549162A (en)	2004-02-24	2009-12-24	Sankyo Co	Amino-pyrrol alcohol compounds
DK1817301T3 (da) *	2004-11-22	2012-02-27	Lilly Co Eli	Forstærkere af glutamat-receptorer
WO2007031933A2 (en)	2005-09-12	2007-03-22	Actelion Pharmaceuticals Ltd	Stable pharmaceutical composition comprising a pyrimidine-sulfamide
JP2009530284A (ja) *	2006-03-13	2009-08-27	エンサイシブ・ファーマシューティカルズ・インコーポレイテッド	拡張期心不全を治療するための方法と組成物
CA2644784A1 (en) *	2006-03-13	2007-09-20	Jinling Chen	Formulations of sitaxsentan sodium
US20080026061A1 (en) *	2006-06-22	2008-01-31	Reichwein John F	Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
KR20090036126A (ko) *	2006-08-04	2009-04-13	엔싸이시브 파마슈티칼즈 인코퍼레이티드	Ｎ-(2-아세틸-4,6-디메틸페닐)-3-｛[(3,4 디메틸-5-이속사졸릴)아미노]술포닐｝-2-티오펜카르복스아미드의 제조 방법
BRPI0715174A2 (pt) *	2006-08-04	2015-03-24	Encysive Pharmaceuticals Inc	Polimorfos de n-(2-acetil-4,6-dimetilfenil)-2-{[(3,4-dimetil-5-isoxazolil) -amino]sulfonil}-2-tiofenocarboxamida
EP1995241B1 (en)	2007-03-23	2010-03-17	ICAgen, Inc.	Inhibitors of ion channels
CN101730694A (zh)	2007-04-10	2010-06-09	奥斯拜客斯制药有限公司	用于治疗高血压的取代的氘富集的噻吩
KR100860539B1 (ko) *	2007-05-11	2008-09-26	한국화학연구원	아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물
BRPI0812966A2 (pt) *	2007-06-25	2017-05-16	Encysive Pharmaceuticals Inc	formulações de n-(2-acetil-4,6-dimetilfenil)-3-{[(3,4 dimetil-5-isoxazolil)amino]sulfonil}-2-tiofenocarboxamida
MX2010001837A (es)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	Derivados de 4-pirimidinasulfamida.
US8592470B2 (en) *	2012-01-31	2013-11-26	Eisai R&D Management Co., Ltd.	Sitaxentan derivative
KR101197618B1 (ko) *	2012-03-13	2012-11-07	한국화학연구원	결핵의 예방 또는 치료용 약제학적 조성물
WO2019036024A1 (en)	2017-08-17	2019-02-21	Bristol-Myers Squibb Company	2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
CA3217189A1 (en) *	2021-06-22	2022-12-29	Alchemedicine, Inc.	Compound, endothelin a receptor antagonist and pharmaceutical composition
PT4426434T (pt)	2021-11-02	2025-11-24	Flare Therapeutics Inc	Agonistas inversos de pparg e suas utilizações
WO2023205463A1 (en)	2022-04-22	2023-10-26	Vertex Pharmaceuticals Incorporated	Heteroaryl compounds for the treatment of pain

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3710795A (en)	1970-09-29	1973-01-16	Alza Corp	Drug-delivery device with stretched, rate-controlling membrane
GB1429184A (en)	1972-04-20	1976-03-24	Allen & Hanburys Ltd	Physically anti-inflammatory steroids for use in aerosols
US4044126A (en)	1972-04-20	1977-08-23	Allen & Hanburys Limited	Steroidal aerosol compositions and process for the preparation thereof
ES462774A1 (es)	1977-09-29	1978-05-16	Andreu Sa Dr	Procedimiento para la obtencion de nuevos ftalil derivados de sulfamidas.
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4914112A (en)	1986-06-03	1990-04-03	Sumitomo Pharmaceuticals Company, Limited	Aminoazole derivatives and their production and use
US5591761A (en)	1993-05-20	1997-01-07	Texas Biotechnology Corporation	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en)	1993-05-20	1996-11-05	Texas Biotechnology Corporation	Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en)	1993-05-20	1996-05-07	Immunopharmaceutics, Inc.	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en)	1993-05-20	1997-01-14	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5033252A (en)	1987-12-23	1991-07-23	Entravision, Inc.	Method of packaging and sterilizing a pharmaceutical product
US5052558A (en)	1987-12-23	1991-10-01	Entravision, Inc.	Packaged pharmaceutical product
US5306822A (en)	1988-05-25	1994-04-26	Warner-Lambert Company	Arylmethylenyl derivatives of oxazolidinone
US5082838A (en)	1989-06-21	1992-01-21	Takeda Chemical Industries, Ltd.	Sulfur-containing fused pyrimidine derivatives, their production and use
JPH0347163A (ja)	1989-06-30	1991-02-28	Fujisawa Pharmaceut Co Ltd	アントラキノン誘導体およびその製造
US5230999A (en)	1989-07-24	1993-07-27	Takeda Chemical Industries, Ltd.	Monoclonal antibody to endothelin-3 or precursor thereof and use thereof
CA2032559C (en)	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
JPH05505822A (ja)	1990-03-30	1993-08-26	メルク・エンド・カムパニー・インコーポレーテツド	ピラゾール類、イソキサゾール類及びイソチアゾール置換体
CA2059380A1 (en)	1991-01-24	1992-07-25	Yiu-Kuen T. Lam	Endothelin receptor antagonists isolated from microbispora
ATE164588T1 (de)	1991-01-29	1998-04-15	Shionogi & Co	Triterpenderivat
DE69212011T2 (de)	1991-02-15	1997-01-09	Takeda Chemical Industries Ltd	Endothelin Antagoniste
TW270116B (et)	1991-04-25	1996-02-11	Hoffmann La Roche
US5382569A (en)	1991-05-16	1995-01-17	Warner-Lambert Company	Endotherlin antagonists
RU2086544C1 (ru)	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
FR2679906B1 (fr)	1991-07-31	1995-01-20	Adir	Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB2259450A (en)	1991-09-11	1993-03-17	Fujisawa Pharmaceutical Co	Compositions with endothelin antagonist activity
HUT67665A (en)	1991-11-05	1995-04-28	Smithkline Beckman Corp	Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
US5198548A (en)	1992-01-30	1993-03-30	Warner-Lambert Company	Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof
TW224462B (et)	1992-02-24	1994-06-01	Squibb & Sons Inc
US5378715A (en)	1992-02-24	1995-01-03	Bristol-Myers Squibb Co.	Sulfonamide endothelin antagonists
US5240910A (en)	1992-04-17	1993-08-31	Merck & Co., Inc.	Antihypertensive compounds produced by fermentation
US5514696A (en)	1992-05-06	1996-05-07	Bristol-Myers Squibb Co.	Phenyl sulfonamide endothelin antagonists
NZ247440A (en) *	1992-05-06	1995-04-27	Squibb & Sons Inc	Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
US5323907A (en)	1992-06-23	1994-06-28	Multi-Comp, Inc.	Child resistant package assembly for dispensing pharmaceutical medications
US5352800A (en)	1993-03-11	1994-10-04	Merck & Co., Inc.	Process for the production of a novel endothelin antagonist
US5334598A (en)	1993-03-19	1994-08-02	Merck & Co., Inc.	Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US6030991A (en)	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
SK20396A3 (en)	1993-08-19	1997-03-05	Warner Lambert Co	Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
US6063911A (en)	1993-12-01	2000-05-16	Marine Polymer Technologies, Inc.	Methods and compositions for treatment of cell proliferative disorders
US5612359A (en)	1994-08-26	1997-03-18	Bristol-Myers Squibb Company	Substituted biphenyl isoxazole sulfonamides
ES2180664T3 (es)	1994-12-20	2003-02-16	Hoffmann La Roche	Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina.
ATE243203T1 (de) *	1995-04-04	2003-07-15	Texas Biotechnology Corp	Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität
UA58494C2 (uk)	1995-06-07	2003-08-15	Зенека Лімітед	Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
US5922759A (en)	1996-06-21	1999-07-13	Warner-Lambert Company	Butenolide endothelin antagonists
US5846990A (en)	1995-07-24	1998-12-08	Bristol-Myers Squibb Co.	Substituted biphenyl isoxazole sulfonamides
JP3087968B2 (ja)	1995-12-20	2000-09-18	山之内製薬株式会社	アリールエテンスルホンアミド誘導体及びその医薬組成物
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US6133263A (en)	1996-04-10	2000-10-17	Warner-Lambert Company	Endothelin antagonists with ether-linked groups
WO1997037987A1 (en)	1996-04-10	1997-10-16	Warner-Lambert Company	Ketoacid endothelin antagonists
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TW536540B (en)	1997-01-30	2003-06-11	Bristol Myers Squibb Co	Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
JP3455233B2 (ja) *	1997-04-28	2003-10-14	テキサス・バイオテクノロジー・コーポレイシヨン	エンドテリン介在障害治療用のスルホンアミド類
US5783705A (en) *	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
MXPA02006461A (es)	1999-12-31	2003-09-05	Texas Biotechnology Corp	Sulfonamidas y derivados de las mismas que modulan la actividad de endotelina.

2000
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
- 2000-12-29 EP EP00988434A patent/EP1244657B1/en not_active Expired - Lifetime
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Ceased
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 EE EEP200200363A patent/EE200200363A/et unknown
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en not_active Ceased
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
2002
- 2002-06-28 NO NO20023168A patent/NO20023168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ519717A (en)	2003-06-30
WO2001049685A2 (en)	2001-07-12
EP1244657B1 (en)	2004-12-29
AU2464301A (en)	2001-07-16
US6686382B2 (en)	2004-02-03
KR20020072285A (ko)	2002-09-14
ATE360628T1 (de)	2007-05-15
HUP0203935A3 (en)	2006-02-28
PL355951A1 (en)	2004-05-31
ATE286051T1 (de)	2005-01-15
SK9532002A3 (en)	2003-06-03
DE60017195D1 (de)	2005-02-03
EA004735B1 (ru)	2004-08-26
NO20023168D0 (no)	2002-06-28
JP2003519230A (ja)	2003-06-17
DE60034605D1 (de)	2007-06-06
WO2001049685A3 (en)	2002-02-14
CN1414965A (zh)	2003-04-30
DE60034605T2 (de)	2007-09-06
DK1533311T3 (da)	2007-09-17
PL197782B1 (pl)	2008-04-30
EA200200713A1 (ru)	2002-12-26
JP4202649B2 (ja)	2008-12-24
ES2285334T3 (es)	2007-11-16
PT1533311E (pt)	2007-06-14
NO20023168L (no)	2002-08-30
EP1244657A2 (en)	2002-10-02
US20010056183A1 (en)	2001-12-27
CA2395684A1 (en)	2001-07-12
ES2236028T3 (es)	2005-07-16
HUP0203935A2 (hu)	2003-04-28
MXPA02006461A (es)	2003-09-05
CZ20022293A3 (cs)	2003-04-16
BR0016821A (pt)	2002-12-10
DE60017195T2 (de)	2005-12-22
IL150311A0 (en)	2002-12-01
CA2395684C (en)	2012-01-03

Publication	Publication Date	Title
EE200200363A (et)	2003-08-15	Sulfoonamiidid ja nende derivaadid, mis moduleerivad endoteliini aktiivsust
AP9901471A0 (en)	1999-03-31	Sulfonamides and derivatives thereof that modulate the activity of endothelin.
CA2217169A1 (en)	1996-10-10	Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
EP4506001A3 (en)	2025-04-30	SUBSTITUTED TETRAHYDROFURANS AS SODIUM CHANNEL MODULATORS
EA200400289A1 (ru)	2004-06-24	Производные аминоизоксазола, активные в качестве ингибиторов киназы
EA200000702A1 (ru)	2000-12-25	Пролекарства ингибиторов аспартилпротеаз
DE602006017261D1 (de)	2010-11-11	Behandlung von neovaskulären augenerkrankungen, wie z.b. maculadegeneration, angioiden streifen, uveitis und makulaödemen
DK0951474T3 (da)	2002-09-16	Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf
TR200202738T2 (tr)	2003-03-21	Endotelin ile ilgili hastalıkların tedavisinde kullanılan sülfanoamidler
TR200400526T4 (tr)	2004-04-21	Göz kurumasının tedavisi için lipoksin A4 ve analogları
DE69531944D1 (de)	2003-11-20	Neue hiv-protease-inhibitoren
ATE288747T1 (de)	2005-02-15	Methoden und zusammensetzungen zur modulierung der aktivität von alpha-adrenergen rezeptoren
BR0113590A (pt)	2003-07-22	7-oxo-piridopirimidinas
JOP20220093A1 (ar)	2023-01-30	تركيبة صيدلانية تشتمل على سيليكسيباغ
WO2002012326A3 (en)	2003-08-28	Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein
DE50006420D1 (de)	2004-06-17	Zyklische peptidomimetische urokinaserezeptorantagonisten
BR9804995A (pt)	2001-05-22	Compostos de anel de 5 membros fundido substituìdos com sulfonamida, seu uso como medicamento e preparações farmacêuticas compreendendo os mesmos
DK1074264T3 (da)	2008-11-24	Inhibitorer for neovaskularisering
DE69910787D1 (de)	2003-10-02	Neuartige, pharmazeutisch aktive verbindung
WO1999052936A3 (en)	2000-01-13	Arginine peptide analogs useful as fibroblast growth factor antagonists
CY1106694T1 (el)	2012-05-23	Σουλφοναμιδια και παραγωγα αυτων που ρυθμιζουν τη δραστικοτητα ενδοθηλινης
WO2003032974A3 (en)	2003-06-05	Use of sulfonamide derivatives as pharmaceuticals compounds
ATE382342T1 (de)	2008-01-15	Pomolsäure zur behandlung von mehrfachresistenten tumoren
DK1668027T3 (da)	2010-08-23	Cykliske peptider, der virker som urotensin-II antagonister
CA2288439A1 (en)	1996-10-10	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin