ATE286051T1 - Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren - Google Patents

Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren

Info

Publication number: ATE286051T1
Authority: AT; Austria
Prior art keywords: endothelin; sulfonamides; activity; isoxazolyl; methods
Prior art date: 1999-12-31

Application number

AT00988434T

Other languages

English (en)

Inventor

Chengde Wu

George W Holland

Natalie Blok

Original Assignee

Encysive Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-31

Filing date

2000-12-29

Publication date

2005-01-15

2000-12-29 Application filed by Encysive Pharmaceuticals Inc filed Critical Encysive Pharmaceuticals Inc

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286051T1 publication Critical patent/ATE286051T1/de

Links

108050009340 Endothelin Proteins 0.000 title abstract 5
102000002045 Endothelin Human genes 0.000 title abstract 4
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 4
229940124530 sulfonamide Drugs 0.000 title abstract 4
150000003456 sulfonamides Chemical class 0.000 title abstract 4
230000000694 effects Effects 0.000 title abstract 3
238000000034 method Methods 0.000 abstract 3
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
102000010180 Endothelin receptor Human genes 0.000 abstract 1
108050001739 Endothelin receptor Proteins 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
HLBCDKJOMBEQMZ-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)-1h-pyrrole-2-sulfonamide Chemical class C=1C=CNC=1S(=O)(=O)NC=1C=CON=1 HLBCDKJOMBEQMZ-UHFFFAOYSA-N 0.000 abstract 1
NRNITHABNQZDAT-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)benzenesulfonamide Chemical class C=1C=CC=CC=1S(=O)(=O)NC=1C=CON=1 NRNITHABNQZDAT-UHFFFAOYSA-N 0.000 abstract 1
WDPJORZQTNVWPF-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)furan-2-sulfonamide Chemical class C=1C=COC=1S(=O)(=O)NC=1C=CON=1 WDPJORZQTNVWPF-UHFFFAOYSA-N 0.000 abstract 1
REPFEAIBUZAYOL-UHFFFAOYSA-N n-(1,2-oxazol-3-yl)thiophene-2-sulfonamide Chemical class C=1C=CSC=1S(=O)(=O)NC=1C=CON=1 REPFEAIBUZAYOL-UHFFFAOYSA-N 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
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Bioinformatics & Cheminformatics (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Pregnancy & Childbirth (AREA)
Hematology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

AT00988434T 1999-12-31 2000-12-29 Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren ATE286051T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17410499P	1999-12-31	1999-12-31
PCT/US2000/035599 WO2001049685A2 (en)	1999-12-31	2000-12-29	Sulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number	Publication Date
ATE286051T1 true ATE286051T1 (de)	2005-01-15

Family

ID=22634839

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00988434T ATE286051T1 (de)	1999-12-31	2000-12-29	Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren
AT04025616T ATE360628T1 (de)	1999-12-31	2000-12-29	Sulfonamide und deren derivate als modulatoren der endothelin-aktivität

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT04025616T ATE360628T1 (de)	1999-12-31	2000-12-29	Sulfonamide und deren derivate als modulatoren der endothelin-aktivität

Country Status (24)

Country	Link
US (1)	US6686382B2 (de)
EP (1)	EP1244657B1 (de)
JP (1)	JP4202649B2 (de)
KR (1)	KR20020072285A (de)
CN (1)	CN1414965A (de)
AT (2)	ATE286051T1 (de)
AU (1)	AU2464301A (de)
BR (1)	BR0016821A (de)
CA (1)	CA2395684C (de)
CZ (1)	CZ20022293A3 (de)
DE (2)	DE60034605T2 (de)
DK (1)	DK1533311T3 (de)
EA (1)	EA004735B1 (de)
EE (1)	EE200200363A (de)
ES (2)	ES2236028T3 (de)
HU (1)	HUP0203935A3 (de)
IL (1)	IL150311A0 (de)
MX (1)	MXPA02006461A (de)
NO (1)	NO20023168L (de)
NZ (1)	NZ519717A (de)
PL (1)	PL197782B1 (de)
PT (1)	PT1533311E (de)
SK (1)	SK9532002A3 (de)
WO (1)	WO2001049685A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962490A (en) *	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
JP3455233B2 (ja)	1997-04-28	2003-10-14	テキサス・バイオテクノロジー・コーポレイシヨン	エンドテリン介在障害治療用のスルホンアミド類
MXPA02006461A (es)	1999-12-31	2003-09-05	Texas Biotechnology Corp	Sulfonamidas y derivados de las mismas que modulan la actividad de endotelina.
DK1471054T3 (da)	2002-01-11	2009-11-09	Daiichi Sankyo Co Ltd	Aminoalkohol-derivat eller phosphonsyre-derivat og medicinsk sammensætning, der indeholder disse
US7205307B2 (en) *	2002-02-14	2007-04-17	Icagen, Inc.	Pyrimidines as novel openers of potassium ion channels
AU2003291255A1 (en) *	2002-11-06	2004-06-03	Smithkline Beecham Corporation	Sulfonamides
NZ549162A (en)	2004-02-24	2009-12-24	Sankyo Co	Amino-pyrrol alcohol compounds
DK1817301T3 (da) *	2004-11-22	2012-02-27	Lilly Co Eli	Forstærkere af glutamat-receptorer
WO2007031933A2 (en)	2005-09-12	2007-03-22	Actelion Pharmaceuticals Ltd	Stable pharmaceutical composition comprising a pyrimidine-sulfamide
JP2009530284A (ja) *	2006-03-13	2009-08-27	エンサイシブ・ファーマシューティカルズ・インコーポレイテッド	拡張期心不全を治療するための方法と組成物
CA2644784A1 (en) *	2006-03-13	2007-09-20	Jinling Chen	Formulations of sitaxsentan sodium
US20080026061A1 (en) *	2006-06-22	2008-01-31	Reichwein John F	Crystalline N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-methyl-4.5-(methylenedioxy)phenylacetyl]-thiophene-3-sulfonamide
KR20090036126A (ko) *	2006-08-04	2009-04-13	엔싸이시브 파마슈티칼즈 인코퍼레이티드	Ｎ-(2-아세틸-4,6-디메틸페닐)-3-｛[(3,4 디메틸-5-이속사졸릴)아미노]술포닐｝-2-티오펜카르복스아미드의 제조 방법
BRPI0715174A2 (pt) *	2006-08-04	2015-03-24	Encysive Pharmaceuticals Inc	Polimorfos de n-(2-acetil-4,6-dimetilfenil)-2-{[(3,4-dimetil-5-isoxazolil) -amino]sulfonil}-2-tiofenocarboxamida
EP1995241B1 (de)	2007-03-23	2010-03-17	ICAgen, Inc.	Ionenkanal-Hemmer
CN101730694A (zh)	2007-04-10	2010-06-09	奥斯拜客斯制药有限公司	用于治疗高血压的取代的氘富集的噻吩
KR100860539B1 (ko) *	2007-05-11	2008-09-26	한국화학연구원	아미노싸이오펜 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물
BRPI0812966A2 (pt) *	2007-06-25	2017-05-16	Encysive Pharmaceuticals Inc	formulações de n-(2-acetil-4,6-dimetilfenil)-3-{[(3,4 dimetil-5-isoxazolil)amino]sulfonil}-2-tiofenocarboxamida
MX2010001837A (es)	2007-08-17	2010-03-10	Actelion Pharmaceuticals Ltd	Derivados de 4-pirimidinasulfamida.
US8592470B2 (en) *	2012-01-31	2013-11-26	Eisai R&D Management Co., Ltd.	Sitaxentan derivative
KR101197618B1 (ko) *	2012-03-13	2012-11-07	한국화학연구원	결핵의 예방 또는 치료용 약제학적 조성물
WO2019036024A1 (en)	2017-08-17	2019-02-21	Bristol-Myers Squibb Company	2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
CA3217189A1 (en) *	2021-06-22	2022-12-29	Alchemedicine, Inc.	Compound, endothelin a receptor antagonist and pharmaceutical composition
PT4426434T (pt)	2021-11-02	2025-11-24	Flare Therapeutics Inc	Agonistas inversos de pparg e suas utilizações
WO2023205463A1 (en)	2022-04-22	2023-10-26	Vertex Pharmaceuticals Incorporated	Heteroaryl compounds for the treatment of pain

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3710795A (en)	1970-09-29	1973-01-16	Alza Corp	Drug-delivery device with stretched, rate-controlling membrane
GB1429184A (en)	1972-04-20	1976-03-24	Allen & Hanburys Ltd	Physically anti-inflammatory steroids for use in aerosols
US4044126A (en)	1972-04-20	1977-08-23	Allen & Hanburys Limited	Steroidal aerosol compositions and process for the preparation thereof
ES462774A1 (es)	1977-09-29	1978-05-16	Andreu Sa Dr	Procedimiento para la obtencion de nuevos ftalil derivados de sulfamidas.
US4522811A (en)	1982-07-08	1985-06-11	Syntex (U.S.A.) Inc.	Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4914112A (en)	1986-06-03	1990-04-03	Sumitomo Pharmaceuticals Company, Limited	Aminoazole derivatives and their production and use
US5591761A (en)	1993-05-20	1997-01-07	Texas Biotechnology Corporation	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en)	1993-05-20	1996-11-05	Texas Biotechnology Corporation	Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en)	1993-05-20	1996-05-07	Immunopharmaceutics, Inc.	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en)	1993-05-20	1997-01-14	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5033252A (en)	1987-12-23	1991-07-23	Entravision, Inc.	Method of packaging and sterilizing a pharmaceutical product
US5052558A (en)	1987-12-23	1991-10-01	Entravision, Inc.	Packaged pharmaceutical product
US5306822A (en)	1988-05-25	1994-04-26	Warner-Lambert Company	Arylmethylenyl derivatives of oxazolidinone
US5082838A (en)	1989-06-21	1992-01-21	Takeda Chemical Industries, Ltd.	Sulfur-containing fused pyrimidine derivatives, their production and use
JPH0347163A (ja)	1989-06-30	1991-02-28	Fujisawa Pharmaceut Co Ltd	アントラキノン誘導体およびその製造
US5230999A (en)	1989-07-24	1993-07-27	Takeda Chemical Industries, Ltd.	Monoclonal antibody to endothelin-3 or precursor thereof and use thereof
CA2032559C (en)	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
JPH05505822A (ja)	1990-03-30	1993-08-26	メルク・エンド・カムパニー・インコーポレーテツド	ピラゾール類、イソキサゾール類及びイソチアゾール置換体
CA2059380A1 (en)	1991-01-24	1992-07-25	Yiu-Kuen T. Lam	Endothelin receptor antagonists isolated from microbispora
ATE164588T1 (de)	1991-01-29	1998-04-15	Shionogi & Co	Triterpenderivat
DE69212011T2 (de)	1991-02-15	1997-01-09	Takeda Chemical Industries Ltd	Endothelin Antagoniste
TW270116B (de)	1991-04-25	1996-02-11	Hoffmann La Roche
US5382569A (en)	1991-05-16	1995-01-17	Warner-Lambert Company	Endotherlin antagonists
RU2086544C1 (ru)	1991-06-13	1997-08-10	Хоффманн-Ля Рош АГ	Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина
FR2679906B1 (fr)	1991-07-31	1995-01-20	Adir	Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
GB2259450A (en)	1991-09-11	1993-03-17	Fujisawa Pharmaceutical Co	Compositions with endothelin antagonist activity
HUT67665A (en)	1991-11-05	1995-04-28	Smithkline Beckman Corp	Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
US5198548A (en)	1992-01-30	1993-03-30	Warner-Lambert Company	Process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines and derivatives thereof
TW224462B (de)	1992-02-24	1994-06-01	Squibb & Sons Inc
US5378715A (en)	1992-02-24	1995-01-03	Bristol-Myers Squibb Co.	Sulfonamide endothelin antagonists
US5240910A (en)	1992-04-17	1993-08-31	Merck & Co., Inc.	Antihypertensive compounds produced by fermentation
US5514696A (en)	1992-05-06	1996-05-07	Bristol-Myers Squibb Co.	Phenyl sulfonamide endothelin antagonists
NZ247440A (en) *	1992-05-06	1995-04-27	Squibb & Sons Inc	Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof
US5323907A (en)	1992-06-23	1994-06-28	Multi-Comp, Inc.	Child resistant package assembly for dispensing pharmaceutical medications
US5352800A (en)	1993-03-11	1994-10-04	Merck & Co., Inc.	Process for the production of a novel endothelin antagonist
US5334598A (en)	1993-03-19	1994-08-02	Merck & Co., Inc.	Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US6030991A (en)	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
SK20396A3 (en)	1993-08-19	1997-03-05	Warner Lambert Co	Substituted 2(5h)furanone, 2(5h)thiophenone or 2(5h)pyrrolone derivatives and pharmaceutical compositions on their base
US6063911A (en)	1993-12-01	2000-05-16	Marine Polymer Technologies, Inc.	Methods and compositions for treatment of cell proliferative disorders
US5612359A (en)	1994-08-26	1997-03-18	Bristol-Myers Squibb Company	Substituted biphenyl isoxazole sulfonamides
ES2180664T3 (es)	1994-12-20	2003-02-16	Hoffmann La Roche	Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina.
ATE243203T1 (de) *	1995-04-04	2003-07-15	Texas Biotechnology Corp	Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität
UA58494C2 (uk)	1995-06-07	2003-08-15	Зенека Лімітед	Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну
US5922759A (en)	1996-06-21	1999-07-13	Warner-Lambert Company	Butenolide endothelin antagonists
US5846990A (en)	1995-07-24	1998-12-08	Bristol-Myers Squibb Co.	Substituted biphenyl isoxazole sulfonamides
JP3087968B2 (ja)	1995-12-20	2000-09-18	山之内製薬株式会社	アリールエテンスルホンアミド誘導体及びその医薬組成物
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US6133263A (en)	1996-04-10	2000-10-17	Warner-Lambert Company	Endothelin antagonists with ether-linked groups
WO1997037987A1 (en)	1996-04-10	1997-10-16	Warner-Lambert Company	Ketoacid endothelin antagonists
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TW536540B (en)	1997-01-30	2003-06-11	Bristol Myers Squibb Co	Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
JP3455233B2 (ja) *	1997-04-28	2003-10-14	テキサス・バイオテクノロジー・コーポレイシヨン	エンドテリン介在障害治療用のスルホンアミド類
US5783705A (en) *	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
MXPA02006461A (es)	1999-12-31	2003-09-05	Texas Biotechnology Corp	Sulfonamidas y derivados de las mismas que modulan la actividad de endotelina.

2000
- 2000-12-29 MX MXPA02006461A patent/MXPA02006461A/es active IP Right Grant
- 2000-12-29 AU AU24643/01A patent/AU2464301A/en not_active Abandoned
- 2000-12-29 JP JP2001550225A patent/JP4202649B2/ja not_active Expired - Lifetime
- 2000-12-29 EA EA200200713A patent/EA004735B1/ru not_active IP Right Cessation
- 2000-12-29 BR BR0016821-1A patent/BR0016821A/pt active Search and Examination
- 2000-12-29 ES ES00988434T patent/ES2236028T3/es not_active Expired - Lifetime
- 2000-12-29 PL PL355951A patent/PL197782B1/pl not_active IP Right Cessation
- 2000-12-29 US US09/751,825 patent/US6686382B2/en not_active Expired - Fee Related
- 2000-12-29 HU HU0203935A patent/HUP0203935A3/hu unknown
- 2000-12-29 DE DE60034605T patent/DE60034605T2/de not_active Expired - Lifetime
- 2000-12-29 EP EP00988434A patent/EP1244657B1/de not_active Expired - Lifetime
- 2000-12-29 IL IL15031100A patent/IL150311A0/xx unknown
- 2000-12-29 PT PT04025616T patent/PT1533311E/pt unknown
- 2000-12-29 CN CN00818061A patent/CN1414965A/zh active Pending
- 2000-12-29 AT AT00988434T patent/ATE286051T1/de not_active IP Right Cessation
- 2000-12-29 KR KR1020027008513A patent/KR20020072285A/ko not_active Ceased
- 2000-12-29 NZ NZ519717A patent/NZ519717A/xx unknown
- 2000-12-29 DE DE60017195T patent/DE60017195T2/de not_active Expired - Lifetime
- 2000-12-29 EE EEP200200363A patent/EE200200363A/xx unknown
- 2000-12-29 ES ES04025616T patent/ES2285334T3/es not_active Expired - Lifetime
- 2000-12-29 CZ CZ20022293A patent/CZ20022293A3/cs unknown
- 2000-12-29 WO PCT/US2000/035599 patent/WO2001049685A2/en not_active Ceased
- 2000-12-29 CA CA2395684A patent/CA2395684C/en not_active Expired - Lifetime
- 2000-12-29 SK SK953-2002A patent/SK9532002A3/sk unknown
- 2000-12-29 DK DK04025616T patent/DK1533311T3/da active
- 2000-12-29 AT AT04025616T patent/ATE360628T1/de active
2002
- 2002-06-28 NO NO20023168A patent/NO20023168L/no not_active Application Discontinuation

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Publication number	Publication date
NZ519717A (en)	2003-06-30
WO2001049685A2 (en)	2001-07-12
EP1244657B1 (de)	2004-12-29
AU2464301A (en)	2001-07-16
US6686382B2 (en)	2004-02-03
KR20020072285A (ko)	2002-09-14
ATE360628T1 (de)	2007-05-15
HUP0203935A3 (en)	2006-02-28
PL355951A1 (en)	2004-05-31
SK9532002A3 (en)	2003-06-03
DE60017195D1 (de)	2005-02-03
EA004735B1 (ru)	2004-08-26
NO20023168D0 (no)	2002-06-28
JP2003519230A (ja)	2003-06-17
DE60034605D1 (de)	2007-06-06
WO2001049685A3 (en)	2002-02-14
CN1414965A (zh)	2003-04-30
DE60034605T2 (de)	2007-09-06
DK1533311T3 (da)	2007-09-17
PL197782B1 (pl)	2008-04-30
EE200200363A (et)	2003-08-15
EA200200713A1 (ru)	2002-12-26
JP4202649B2 (ja)	2008-12-24
ES2285334T3 (es)	2007-11-16
PT1533311E (pt)	2007-06-14
NO20023168L (no)	2002-08-30
EP1244657A2 (de)	2002-10-02
US20010056183A1 (en)	2001-12-27
CA2395684A1 (en)	2001-07-12
ES2236028T3 (es)	2005-07-16
HUP0203935A2 (hu)	2003-04-28
MXPA02006461A (es)	2003-09-05
CZ20022293A3 (cs)	2003-04-16
BR0016821A (pt)	2002-12-10
DE60017195T2 (de)	2005-12-22
IL150311A0 (en)	2002-12-01
CA2395684C (en)	2012-01-03

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2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE286051T1 (de)	2005-01-15	Sulfonamide und ihre derivate, die die aktivität des endothelins modulieren
TR199900705T2 (xx)	1999-07-21	Endotelin etkinli�ini d�zenleyen s�lfonamidler ve t�revleri.
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ATE288747T1 (de)	2005-02-15	Methoden und zusammensetzungen zur modulierung der aktivität von alpha-adrenergen rezeptoren
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EA200601687A1 (ru)	2007-04-27	Тетрагидроизохинолиновые и тетрагидробензазепиновые производные (варианты), фармацевтическая композиция и фармацевтический набор, лекарственное и эталонное средство для тест-систем на их основе, способ лечения и профилактики заболевания, при котором благоприятна понижающая регуляция или ингибирование экспрессии или функции рецептора igf-1
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SE0203817D0 (sv)	2002-12-20	New composition
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CA2288439A1 (en)	1996-10-10	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin