EE200300083A - Bitsüklilised pürrooli amiidid kui glükogeeni fosforülaasi inhibiitorid - Google Patents

Bitsüklilised pürrooli amiidid kui glükogeeni fosforülaasi inhibiitorid

Info

Publication number
EE200300083A
EE200300083A EEP200300083A EEP200300083A EE200300083A EE 200300083 A EE200300083 A EE 200300083A EE P200300083 A EEP200300083 A EE P200300083A EE P200300083 A EEP200300083 A EE P200300083A EE 200300083 A EE200300083 A EE 200300083A
Authority
EE
Estonia
Prior art keywords
glycogen phosphorylase
phosphorylase inhibitors
pyrrole amides
bicyclic pyrrole
amide derivatives
Prior art date
Application number
EEP200300083A
Other languages
English (en)
Estonian (et)
Inventor
B. Bartlett Julie
Freeman Sue
Kenny Peter
Morley Andrew
Whittamore Paul
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200300083A publication Critical patent/EE200300083A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EEP200300083A 2000-09-06 2001-08-31 Bitsüklilised pürrooli amiidid kui glükogeeni fosforülaasi inhibiitorid EE200300083A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0021831.3A GB0021831D0 (en) 2000-09-06 2000-09-06 Chemical compounds
PCT/SE2001/001880 WO2002020530A1 (en) 2000-09-06 2001-08-31 Bicyclic pyrrolyl amides as glucogen phosphorylase inhibitors

Publications (1)

Publication Number Publication Date
EE200300083A true EE200300083A (et) 2004-12-15

Family

ID=9898927

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300083A EE200300083A (et) 2000-09-06 2001-08-31 Bitsüklilised pürrooli amiidid kui glükogeeni fosforülaasi inhibiitorid

Country Status (30)

Country Link
US (1) US20030232875A1 (de)
EP (1) EP1317459B1 (de)
JP (1) JP2004508376A (de)
KR (1) KR100802369B1 (de)
CN (2) CN1896078A (de)
AT (1) ATE263772T1 (de)
AU (2) AU8283301A (de)
BG (1) BG107624A (de)
BR (1) BR0113606A (de)
CA (1) CA2417594A1 (de)
CZ (1) CZ2003616A3 (de)
DE (1) DE60102710T2 (de)
DK (1) DK1317459T3 (de)
EE (1) EE200300083A (de)
ES (1) ES2217183T3 (de)
GB (1) GB0021831D0 (de)
HU (1) HUP0400784A3 (de)
IL (1) IL154291A0 (de)
IS (1) IS2110B (de)
MX (1) MXPA03001512A (de)
NO (1) NO20031024L (de)
NZ (1) NZ524011A (de)
PL (1) PL361024A1 (de)
PT (1) PT1317459E (de)
RU (1) RU2003104013A (de)
SK (1) SK2592003A3 (de)
TR (1) TR200401659T4 (de)
UA (1) UA73781C2 (de)
WO (1) WO2002020530A1 (de)
ZA (1) ZA200301013B (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5271699A1 (es) * 2000-01-24 2003-04-30 Pfizer Prod Inc Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa
TWI243164B (en) 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
PE20020856A1 (es) * 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-tetrahidronaftil aminas aciladas
GB0205162D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205170D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205166D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205165D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10215908B4 (de) * 2002-04-11 2005-08-18 Aventis Pharma Deutschland Gmbh Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
DE10225635C1 (de) * 2002-06-07 2003-12-24 Aventis Pharma Gmbh N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung
ATE444284T1 (de) * 2002-06-17 2009-10-15 Saltigo Gmbh Verfahren zur herstellung von mono-n- sulfonylierten diaminen
MXPA05000055A (es) * 2002-07-11 2005-04-08 Aventis Pharma Gmbh Acilureas sustituidas con urea y uretano, metodos para su produccion y su uso.
EP1388535A1 (de) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylierte Arylcycloalkylamine und ihre Anwendung als Arzneimittelwirkstoff
US7186735B2 (en) 2002-08-07 2007-03-06 Sanofi-Aventis Deutschland Gmbh Acylated arylcycloalkylamines and their use as pharmaceuticals
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
JP2006507294A (ja) * 2002-11-07 2006-03-02 ファイザー・プロダクツ・インク 抗糖尿病剤
EP1620427A1 (de) 2003-04-17 2006-02-01 Pfizer Products Inc. Carbonsäureamid-derivate als antidiabetika
JP2006528702A (ja) * 2003-05-21 2006-12-21 プロシディオン・リミテッド グリコーゲンホスホリラーゼのピロロピリジン−２−カルボン酸アミドインヒビター
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
WO2004113345A1 (ja) * 2003-06-20 2004-12-29 Japan Tobacco Inc. 縮合ピロール化合物及びその医薬用途
GB0318463D0 (en) * 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0318464D0 (en) * 2003-08-07 2003-09-10 Astrazeneca Ab Chemical compounds
GB0319759D0 (en) * 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
GB0319690D0 (en) * 2003-08-22 2003-09-24 Astrazeneca Ab Chemical compounds
WO2005020986A1 (en) * 2003-08-29 2005-03-10 Astrazeneca Ab Heterocyclic amide derivatives which posses glycogen phosphorylase inhibitory activity
WO2005020985A1 (en) * 2003-08-29 2005-03-10 Astrazeneca Ab Indolamide derivatives which possess glycogen phosphorylase inhibitory activity
GB0320422D0 (en) * 2003-08-30 2003-10-01 Astrazeneca Ab Chemical compounds
CN1922149A (zh) 2003-12-29 2007-02-28 塞普拉科公司 吡咯和吡唑daao抑制剂
US7453002B2 (en) * 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2006053274A2 (en) * 2004-11-15 2006-05-18 Bristol-Myers Squibb Company 2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006055462A1 (en) * 2004-11-15 2006-05-26 Bristol-Myers Squibb Company 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006055463A2 (en) * 2004-11-15 2006-05-26 Bristol-Myers Squibb Company 2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
PL1819704T3 (pl) 2004-12-02 2008-12-31 Prosidion Ltd Amidowe pochodne kwasu pirolopirydyno-2-karboksylowego użyteczne jako inhibitory fosforylazy glikogenowej
WO2006059163A1 (en) * 2004-12-02 2006-06-08 Prosidion Limited Treatment of diabetes with glycogen phosphorylase inhibitors
AU2006206654A1 (en) 2005-01-19 2006-07-27 Merck & Co., Inc. Tertiary carbinamines having substituted heterocycles, which are active as inhibitors of beta-secretase, for the treatment of Alzheimer's disease
EP1848693A1 (de) * 2005-02-05 2007-10-31 AstraZeneca AB Indanamidderivate mit glykogenphosphorylase hemmender wirkung
US20100137397A1 (en) * 2005-02-05 2010-06-03 Astrazeneca Ab Chemical Compounds
KR101381768B1 (ko) 2006-01-06 2014-04-07 선오비온 파마슈티컬스 인코포레이티드 테트랄론-기재 모노아민 재흡수 저해제
EP1976513B1 (de) 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamine als monoamin-wiederaufnahmehemmer
PT2816024T (pt) 2006-03-31 2017-10-20 Sunovion Pharmaceuticals Inc Aminas quirais
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US8492405B2 (en) 2006-10-18 2013-07-23 Takeda Pharmaceutical Company Limited Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100152200A1 (en) * 2008-11-17 2010-06-17 The Regents Of The University Of Michigan Alphavirus inhibitors and uses thereof
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
BR112016030690B1 (pt) 2014-06-27 2023-11-14 Nogra Pharma Limited Compostos moduladores do receptor de arila, composição farmacêutica compreendendo os mesmos e usos terapêuticos dos ditos compostos
EP3186242B1 (de) 2014-08-29 2021-10-06 Tes Pharma S.r.l. Inhibitoren von alpha-amino-beta-carboxymuconsäure semialdehyd-decarboxylase
TWI788830B (zh) * 2015-07-02 2023-01-01 瑞士商赫孚孟拉羅股份公司 雙環內醯胺及其使用方法
SG10201913587WA (en) * 2016-02-05 2020-02-27 Denali Therapeutics Inc Inhibitors of receptor-interacting protein kinase 1
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
EP3526219B1 (de) 2016-10-17 2021-12-15 F. Hoffmann-La Roche AG Bicyclische pyridonlactame und verfahren zur verwendung davon
US11072607B2 (en) 2016-12-16 2021-07-27 Genentech, Inc. Inhibitors of RIP1 kinase and methods of use thereof
JP7398391B2 (ja) 2018-04-20 2023-12-14 エフ． ホフマン－ラ ロシュ アーゲー Ｎ－［４－オキソ－２，３－ジヒドロ－１，５－ベンズオキサゼピン－３－イル］－５，６－ジヒドロ－４Ｈ－ピロロ［１，２－ｂ］ピラゾール－２－カルボキサミド誘導体及び例えば過敏性腸症候群（ＩＢＳ）を処置するためのＲＩＰ１キナーゼ阻害剤としての関連化合物
AR117122A1 (es) 2018-11-20 2021-07-14 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
TW202115086A (zh) * 2019-06-28 2021-04-16 美商輝瑞大藥廠 Bckdk抑制劑
JP7805583B2 (ja) * 2019-11-27 2026-01-26 国立研究開発法人理化学研究所 Ｇ９ａ阻害剤

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706810A (en) * 1970-09-15 1972-12-19 American Cyanamid Co N-morpholinoalkyl-thieno(3,2-b)pyrrole-5-carboxamides
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4720503A (en) * 1985-08-02 1988-01-19 Merck & Co., Inc. N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US4668769A (en) * 1985-08-02 1987-05-26 Hoover Dennis J Oxa- and azahomocyclostatine polypeptides
FR2601368B1 (fr) * 1986-07-08 1989-04-07 Synthelabo Derives de nitrofuranne, leur preparation et leur application en therapeutique.
DE3629545A1 (de) * 1986-08-30 1988-03-10 Bayer Ag Dihydropyridinverbindungen, verfahren zu ihrer herstellung und ihre verwendung
US4751231A (en) * 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
ES2081747B1 (es) * 1993-09-07 1997-01-16 Esteve Labor Dr Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos.
US5863903A (en) * 1994-03-09 1999-01-26 Novo Nordisk A/S Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes
FR2723739B1 (fr) * 1994-08-19 1997-02-14 Sanofi Sa Derives de glycinamide, procedes pour leur preparation et medicaments les contenant.
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
US5952322A (en) * 1996-12-05 1999-09-14 Pfizer Inc. Method of reducing tissue damage associated with non-cardiac ischemia using glycogen phosphorylase inhibitors
US5998463A (en) * 1998-02-27 1999-12-07 Pfizer Inc Glycogen phosphorylase inhibitors
JP2002506073A (ja) * 1998-03-12 2002-02-26 ノボ ノルディスク アクティーゼルスカブ プロテイン・チロシン・ホスファターゼ（ＰＴＰａｓｅｓ）のモジュレーター
DE60007592T2 (de) * 1999-09-30 2004-09-16 Pfizer Products Inc., Groton Bicyclische Pyrrolylamide als Glycogenphosphorylase-Inhibitoren
CO5271699A1 (es) * 2000-01-24 2003-04-30 Pfizer Prod Inc Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa
US6555569B2 (en) * 2000-03-07 2003-04-29 Pfizer Inc. Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use

Also Published As

Publication number Publication date
AU8283301A (en) 2002-03-22
HK1055299A1 (en) 2004-01-02
CZ2003616A3 (cs) 2003-05-14
IS6727A (is) 2003-02-24
BG107624A (bg) 2004-01-30
SK2592003A3 (en) 2003-08-05
HUP0400784A2 (hu) 2004-07-28
GB0021831D0 (en) 2000-10-18
PL361024A1 (en) 2004-09-20
CN1896078A (zh) 2007-01-17
NO20031024D0 (no) 2003-03-05
EP1317459A1 (de) 2003-06-11
NO20031024L (no) 2003-03-05
UA73781C2 (en) 2005-09-15
IL154291A0 (en) 2003-09-17
DK1317459T3 (da) 2004-07-12
WO2002020530A1 (en) 2002-03-14
HUP0400784A3 (en) 2007-09-28
TR200401659T4 (tr) 2004-09-21
MXPA03001512A (es) 2003-06-09
NZ524011A (en) 2004-08-27
DE60102710T2 (de) 2005-04-14
AU2001282833B2 (en) 2006-07-06
US20030232875A1 (en) 2003-12-18
KR20030025305A (ko) 2003-03-28
CA2417594A1 (en) 2002-03-14
JP2004508376A (ja) 2004-03-18
EP1317459B1 (de) 2004-04-07
IS2110B (is) 2006-05-15
CN1264846C (zh) 2006-07-19
RU2003104013A (ru) 2004-08-20
CN1473163A (zh) 2004-02-04
BR0113606A (pt) 2003-06-24
DE60102710D1 (de) 2004-05-13
ZA200301013B (en) 2004-05-05
ATE263772T1 (de) 2004-04-15
ES2217183T3 (es) 2004-11-01
PT1317459E (pt) 2004-08-31
KR100802369B1 (ko) 2008-02-14

Similar Documents

Publication Publication Date Title
NO20031024L (no) Bicykliske pyrrolyl amider som glukogen fosforylase inhibitorer
NO986055L (no) Nye heterocykliske forbindelser, deres fremstilling, farmas°ytiske preparater inneholdende forbindelsene og deres anvendelse ved behandling av diabetes og beslektede sykdommer
TW200504067A (en) New substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions
EA200300205A1 (ru) Производные пиразола и их применение в качестве ингибиторов протеинкиназы
WO2002085909A8 (en) 9-deazaguanine derivatives as inhibitors of gsk-3
GEP20084357B (en) Pyrimidine derivatives for the treatment of abnormal cell growth
FI950309A0 (fi) Proliiniamidijohdannaisia
YU20999A (sh) Heterociklični derivati koji inhibiraju faktor xa
JO2282B1 (en) Oxazole derivatives
DE60045508D1 (de) Dalda-analoge und ihre verwendung
BR0214277A (pt) Solvatos de paclitaxel
WO2005065195A3 (en) Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
DE59509846D1 (de) [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE
BRPI0410445A (pt) inibidores de amida de ácido pirrolopiridina-2-carboxìlico de glicogênio fosforilase
DE59510370D1 (de) [a]-ANNELIERTE PYRROLDERIVATE UND DEREN ANWENDUNG IN DER PHARMAZIE
ATE291018T1 (de) Pyrazol verbindungen und ihre verwendung
MXPA05013210A (es) Benzo[b]tiofenos cicloalquilsulfanil-sustituidos como agentes terapeuticos.
WO2003074513A3 (en) Indole amide derivatives and their use as glycogen phosphorylase inhibitors
MXPA05012953A (es) Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos.
GB9502644D0 (en) Heterocyclic derivatives
CA2534634A1 (en) Azolidinecarbonitriles and their use as dpp-iv inhibitors
TW200510370A (en) Urea derivatives
ATE440835T1 (de) Heterozyklische harnstoff-derivate für die behandlung von schmerzen.
AP2000001760A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
DK1104419T3 (da) N-substituerede azabicyloheptan-derivater, deres fremstilling og anvendelse