EE9700157A - Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks - Google Patents

Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks

Info

Publication number: EE9700157A
Authority: EE; Estonia
Prior art keywords: oxotax; diacetoxy; benzoylamino; benzoyloxy; dihydroxy
Prior art date: 1995-01-25

Application number

EE9700157A

Other languages

English (en)

Other versions

EE03396B1 (et

Inventor

Authelin Jean-Ren�

Didier Eric

Leveiller Franck

Taillepied Isabelle

Original Assignee

Rh�Ne-Poulenc Rorer S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-25

Filing date

1996-01-23

Publication date

1997-12-15

1996-01-23 Application filed by Rh�Ne-Poulenc Rorer S.A. filed Critical Rh�Ne-Poulenc Rorer S.A.

1997-12-15 Publication of EE9700157A publication Critical patent/EE9700157A/et

2001-04-16 Publication of EE03396B1 publication Critical patent/EE03396B1/et

Links

LQEDVQKEJNVDAW-UHFFFAOYSA-N 3-phenylpropanoic acid;trihydrate Chemical compound O.O.O.OC(=O)CCC1=CC=CC=C1 LQEDVQKEJNVDAW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EE9700157A 1995-01-25 1996-01-23 Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks EE03396B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9500816A FR2729666A1 (fr)	1995-01-25	1995-01-25	Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
PCT/FR1996/000104 WO1996022984A1 (fr)	1995-01-25	1996-01-23	PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (2)

Publication Number	Publication Date
EE9700157A true EE9700157A (et)	1997-12-15
EE03396B1 EE03396B1 (et)	2001-04-16

Family

ID=9475464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700157A EE03396B1 (et)	1995-01-25	1996-01-23	Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks

Country Status (43)

Country	Link
US (1)	US6002022A (et)
EP (1)	EP0805806B1 (et)
JP (1)	JP3782449B2 (et)
KR (1)	KR100384773B1 (et)
CN (1)	CN1067997C (et)
AP (1)	AP750A (et)
AT (1)	ATE187719T1 (et)
AU (1)	AU707603B2 (et)
BG (1)	BG62769B1 (et)
BR (1)	BR9606853A (et)
CO (1)	CO4700286A1 (et)
CZ (1)	CZ287079B6 (et)
DE (1)	DE69605651T2 (et)
DK (1)	DK0805806T3 (et)
DZ (1)	DZ1977A1 (et)
EE (1)	EE03396B1 (et)
ES (1)	ES2139332T3 (et)
FI (1)	FI119245B (et)
FR (1)	FR2729666A1 (et)
GE (1)	GEP19991833B (et)
GR (1)	GR3032110T3 (et)
HU (1)	HU223352B1 (et)
IL (1)	IL116903A (et)
IN (1)	IN184427B (et)
IS (1)	IS2033B (et)
MA (1)	MA23782A1 (et)
MY (1)	MY113230A (et)
NO (1)	NO316987B1 (et)
NZ (1)	NZ300958A (et)
OA (1)	OA10438A (et)
PE (1)	PE64896A1 (et)
PL (1)	PL183773B1 (et)
PT (1)	PT805806E (et)
RO (1)	RO115728B1 (et)
RU (1)	RU2154642C2 (et)
SK (1)	SK281958B6 (et)
TN (1)	TNSN96011A1 (et)
TR (1)	TR199700676T1 (et)
TW (1)	TW356469B (et)
UA (1)	UA47420C2 (et)
UY (1)	UY24149A1 (et)
WO (1)	WO1996022984A1 (et)
ZA (1)	ZA96523B (et)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL203300B1 (pl) *	2000-10-31	2009-09-30	Akad Medyczna	Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
US6891050B2 (en) *	2001-08-10	2005-05-10	Dabur India Limited	Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6894456B2 (en)	2001-11-07	2005-05-17	Quallion Llc	Implantable medical power module
US6881852B2 (en) *	2002-02-05	2005-04-19	Dabur India Limited	Process of purification of paclitaxel and docetaxel
US7247738B2 (en) *	2002-05-07	2007-07-24	Dabur India Limited	Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) *	2002-05-10	2005-05-31	Dabur India Limited	Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) *	2002-12-16	2005-01-04	Dabur India Limited	Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
EP1947094A3 (en)	2003-12-12	2009-02-18	Quiral Quimica Do Brasil	Process for the preparation of taxane derivatives
CN100420681C (zh) *	2005-04-29	2008-09-24	上海奥锐特国际贸易有限公司	多烯紫杉醇三水物的制备方法
WO2009137084A2 (en) *	2008-05-07	2009-11-12	Ivax Research, Llc	Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) *	2012-06-01	2014-01-21	The University Of Utah Research Foundation	Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) *	2014-03-04	2016-02-24	悦康药业集团有限公司	一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994021662A1 (en) *	1993-03-15	1994-09-29	Yale University	Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) *	1993-03-22	1995-04-21	Rhone Poulenc Rorer Sa	Procédé de purification des taxoïdes.
CA2163837C (en) *	1994-12-13	1999-07-20	Robert K. Perrone	Crystalline paclitaxel hydrates

1995
- 1995-01-25 FR FR9500816A patent/FR2729666A1/fr active Granted
1996
- 1996-01-15 PE PE1996000035A patent/PE64896A1/es not_active Application Discontinuation
- 1996-01-17 UY UY24149A patent/UY24149A1/es not_active IP Right Cessation
- 1996-01-22 DZ DZ960018A patent/DZ1977A1/fr active
- 1996-01-23 ES ES96901832T patent/ES2139332T3/es not_active Expired - Lifetime
- 1996-01-23 PT PT96901832T patent/PT805806E/pt unknown
- 1996-01-23 DE DE69605651T patent/DE69605651T2/de not_active Expired - Lifetime
- 1996-01-23 EP EP96901832A patent/EP0805806B1/fr not_active Expired - Lifetime
- 1996-01-23 MA MA24137A patent/MA23782A1/fr unknown
- 1996-01-23 HU HU9801437A patent/HU223352B1/hu not_active IP Right Cessation
- 1996-01-23 AP APAP/P/1997/001035A patent/AP750A/en active
- 1996-01-23 PL PL96321493A patent/PL183773B1/pl not_active IP Right Cessation
- 1996-01-23 AU AU46255/96A patent/AU707603B2/en not_active Ceased
- 1996-01-23 GE GEAP19963849A patent/GEP19991833B/en unknown
- 1996-01-23 RO RO97-01401A patent/RO115728B1/ro unknown
- 1996-01-23 AT AT96901832T patent/ATE187719T1/de active
- 1996-01-23 TR TR97/00676T patent/TR199700676T1/xx unknown
- 1996-01-23 TW TW085100768A patent/TW356469B/zh not_active IP Right Cessation
- 1996-01-23 CN CN96191612A patent/CN1067997C/zh not_active Expired - Fee Related
- 1996-01-23 DK DK96901832T patent/DK0805806T3/da active
- 1996-01-23 WO PCT/FR1996/000104 patent/WO1996022984A1/fr not_active Ceased
- 1996-01-23 BR BR9606853A patent/BR9606853A/pt not_active IP Right Cessation
- 1996-01-23 ZA ZA96523A patent/ZA96523B/xx unknown
- 1996-01-23 US US08/875,625 patent/US6002022A/en not_active Expired - Lifetime
- 1996-01-23 JP JP52266996A patent/JP3782449B2/ja not_active Expired - Lifetime
- 1996-01-23 EE EE9700157A patent/EE03396B1/et not_active IP Right Cessation
- 1996-01-23 UA UA97063414A patent/UA47420C2/uk unknown
- 1996-01-23 NZ NZ300958A patent/NZ300958A/en not_active IP Right Cessation
- 1996-01-23 SK SK1008-97A patent/SK281958B6/sk not_active IP Right Cessation
- 1996-01-23 RU RU97114134/04A patent/RU2154642C2/ru not_active IP Right Cessation
- 1996-01-23 KR KR1019970705017A patent/KR100384773B1/ko not_active Expired - Fee Related
- 1996-01-23 CZ CZ19972362A patent/CZ287079B6/cs not_active IP Right Cessation
- 1996-01-24 IN IN152DE1996 patent/IN184427B/en unknown
- 1996-01-24 CO CO96002860A patent/CO4700286A1/es unknown
- 1996-01-24 TN TNTNSN96011A patent/TNSN96011A1/fr unknown
- 1996-01-25 IL IL11690396A patent/IL116903A/xx not_active IP Right Cessation
- 1996-01-25 MY MYPI96000282A patent/MY113230A/en unknown
1997
- 1997-07-11 NO NO19973247A patent/NO316987B1/no not_active IP Right Cessation
- 1997-07-22 IS IS4529A patent/IS2033B/is unknown
- 1997-07-24 OA OA70055A patent/OA10438A/fr unknown
- 1997-07-24 FI FI973105A patent/FI119245B/fi not_active IP Right Cessation
- 1997-07-25 BG BG101794A patent/BG62769B1/bg unknown
1999
- 1999-12-16 GR GR990402251T patent/GR3032110T3/el unknown

Also Published As

Publication number	Publication date
RO115728B1 (ro)	2000-05-30
HU223352B1 (hu)	2004-06-28
PL321493A1 (en)	1997-12-08
CN1067997C (zh)	2001-07-04
AU707603B2 (en)	1999-07-15
DE69605651D1 (de)	2000-01-20
HUP9801437A3 (en)	2001-02-28
BG101794A (en)	1998-10-30
US6002022A (en)	1999-12-14
PL183773B1 (pl)	2002-07-31
ATE187719T1 (de)	2000-01-15
JPH10512871A (ja)	1998-12-08
IS4529A (is)	1997-07-22
CZ236297A3 (en)	1997-11-12
IN184427B (et)	2000-08-26
BG62769B1 (bg)	2000-07-31
WO1996022984A1 (fr)	1996-08-01
AP9701035A0 (en)	1997-07-31
DZ1977A1 (fr)	2002-07-20
GEP19991833B (en)	1999-11-05
SK281958B6 (sk)	2001-09-11
CO4700286A1 (es)	1998-12-29
EP0805806A1 (fr)	1997-11-12
GR3032110T3 (en)	2000-03-31
BR9606853A (pt)	1997-11-25
RU2154642C2 (ru)	2000-08-20
NZ300958A (en)	1999-09-29
SK100897A3 (en)	1998-01-14
FI119245B (fi)	2008-09-15
KR100384773B1 (ko)	2003-08-21
MY113230A (en)	2001-12-31
MA23782A1 (fr)	1996-10-01
EE03396B1 (et)	2001-04-16
OA10438A (fr)	2002-03-22
FR2729666A1 (fr)	1996-07-26
NO316987B1 (no)	2004-07-19
EP0805806B1 (fr)	1999-12-15
UY24149A1 (es)	1996-05-20
IS2033B (is)	2005-08-15
AU4625596A (en)	1996-08-14
JP3782449B2 (ja)	2006-06-07
NO973247D0 (no)	1997-07-11
DK0805806T3 (da)	2000-05-01
FI973105L (fi)	1997-07-24
DE69605651T2 (de)	2000-07-06
ES2139332T3 (es)	2000-02-01
KR19980701623A (ko)	1998-06-25
HUP9801437A1 (hu)	1999-09-28
PT805806E (pt)	2000-05-31
AP750A (en)	1999-07-06
IL116903A0 (en)	1996-05-14
CZ287079B6 (en)	2000-08-16
NO973247L (no)	1997-07-11
FR2729666B1 (et)	1997-02-28
PE64896A1 (es)	1997-02-23
CN1169724A (zh)	1998-01-07
UA47420C2 (uk)	2002-07-15
FI973105A0 (fi)	1997-07-24
MX9705460A (es)	1997-10-31
ZA96523B (en)	1996-10-15
IL116903A (en)	2003-01-12
TNSN96011A1 (fr)	2005-03-15
TR199700676T1 (xx)	1998-01-21
TW356469B (en)	1999-04-21

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2004-12-15	HC1A	Change of owner name
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2010-02-15	KB4A	Valid patent at the end of a year	Effective date: 20091231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2014-10-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20140123

Publication	Publication Date	Title
FI970069L (fi)	1997-01-07	Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatin valmistamiseksi
EE04277B1 (et)	2004-04-15	Taksoidide klassi kuuluvate derivaatide valmistamismeetod
PT754407E (pt)	2002-06-28	Formulacoes liquidas de 1,2-benzisotiazolin-3-ona
EE03048B1 (et)	1997-10-15	Meetod lovastatiini valmistamiseks
FR2675976B1 (fr)	1995-02-17	Agencement d'appareil de radiocommunication.
EE03396B1 (et)	2001-04-16	Meetod 4,10-diatsetoksü-2a-bensoüüloksü-5ß,20 -epoksü-1,7ß-dihüdroksü-9-okso-taks-11-een-13a-üüli (2R,3S)-3-bensoüülamino-2-hüdroksü-3-fenüülpropionaadi trihüdraadi valmistamiseks
FI934748A0 (fi)	1993-10-27	Foerfarande foer framstaellning av l-5-(2-acetoxipropionylamino)-2,4,6-trijod-isoftalsyradiklorid
DE69632237D1 (de)	2004-05-27	Kosmetische Zusammensetzungen enthaltend Tricholinecitrat
FI973229L (fi)	1997-08-05	Uusi farmaseuttinen koostumus
DK0769251T3 (da)	2001-07-30	Pasteuriseringsanordning
DE69621673D1 (de)	2002-07-18	(3S)-(6E)-2,3-Dihydrofarnesol enthaltendes Parfüm
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
PL322979A1 (en)	1998-03-02	Method of obtaining from 1 of ranitidine chlorhydride
TR199700863A3 (tr)	1999-10-21	Paklitaksel hazirlama prosesi.
DE69632032D1 (de)	2004-05-06	Gefässverschliessende substituierte 2,3- dihydro -1,4- dioxinopyridine
DE69611546D1 (de)	2001-02-15	Herstellung von 2,6-dimethylnaphthalin
NO903712D0 (no)	1990-08-23	Fremgangsmaate for bryting av emulsjoner.
FI924881A7 (fi)	1993-05-16	Menetelmä (2R, 3E)-4-halo-3-buten-2-olien valmistamiseksi
SI0805806T1 (en)	2000-02-29	Method for preparing 4,10-diacetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alfa-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
ITMI921907A1 (it)	1994-02-03	Procedimento per la preparazione di ditiocarbonati da tritiocarbonati.
KR100194393B1 (ko)	1999-06-15	탁산형 디테르펜의 제조방법
ES1032283Y (es)	1996-10-16	Boligrafo de la suerte.
FI2067U1 (fi)	1995-08-29	Verktyg foer boejning av en flaens
ES1028166Y (es)	1995-05-16	Paletizador de cajas llenas.
FI892339A0 (fi)	1989-05-16	Foerfarande foer framstaellning av 3/4-brom-2-fluorfenyl) metyl/-3,4-dihydro-4-oxo-1-ftalazinaettiksyra.