IS4529A - Aðferð til framleiðslu á 4,10-díasetoxý-2alfa-bensóýloxý-5beta, 20-epoxý-1,7beta-díhýdroxý-9-oxó-tax-11-en-13alfa-ýl(2R,3S)-3-bensóýlamínó-2-hýdroxý-3-fenýlprópíónat tríhýdrat - Google Patents

Aðferð til framleiðslu á 4,10-díasetoxý-2alfa-bensóýloxý-5beta, 20-epoxý-1,7beta-díhýdroxý-9-oxó-tax-11-en-13alfa-ýl(2R,3S)-3-bensóýlamínó-2-hýdroxý-3-fenýlprópíónat tríhýdrat

Info

Publication number: IS4529A
Authority: IS; Iceland
Prior art keywords: diazethoxy; 13alfa; 2alfa; 5beta; 7beta
Prior art date: 1995-01-25

Application number

IS4529A

Other languages

English (en)

Other versions

IS2033B (is

Inventor

Authelin Jean-René

Didier Eric

Leveiller Franck

Taillepied Isabelle

Original Assignee

Aventis Pharma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-25

Filing date

1997-07-22

Publication date

1997-07-22

1997-07-22 Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.

1997-07-22 Publication of IS4529A publication Critical patent/IS4529A/is

2005-08-15 Publication of IS2033B publication Critical patent/IS2033B/is

Links

RRGNLQYIUYOTQC-LQFAMLORSA-N (2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoic acid trihydrate Chemical compound O.O.O.C(C1=CC=CC=C1)(=O)N[C@H]([C@H](C(=O)O)O)C1=CC=CC=C1 RRGNLQYIUYOTQC-LQFAMLORSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Epidemiology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IS4529A 1995-01-25 1997-07-22 Aðferð til framleiðslu á 4,10-díasetoxý-2alfa-bensóýloxý-5beta, 20-epoxý-1,7beta-díhýdroxý-9-oxó-tax-11-en-13alfa-ýl(2R,3S)-3-bensóýlamínó-2-hýdroxý-3-fenýlprópíónat tríhýdrat IS2033B (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9500816A FR2729666A1 (fr)	1995-01-25	1995-01-25	Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
PCT/FR1996/000104 WO1996022984A1 (fr)	1995-01-25	1996-01-23	PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (2)

Publication Number	Publication Date
IS4529A true IS4529A (is)	1997-07-22
IS2033B IS2033B (is)	2005-08-15

Family

ID=9475464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS4529A IS2033B (is)	1995-01-25	1997-07-22	Aðferð til framleiðslu á 4,10-díasetoxý-2alfa-bensóýloxý-5beta, 20-epoxý-1,7beta-díhýdroxý-9-oxó-tax-11-en-13alfa-ýl(2R,3S)-3-bensóýlamínó-2-hýdroxý-3-fenýlprópíónat tríhýdrat

Country Status (43)

Country	Link
US (1)	US6002022A (is)
EP (1)	EP0805806B1 (is)
JP (1)	JP3782449B2 (is)
KR (1)	KR100384773B1 (is)
CN (1)	CN1067997C (is)
AP (1)	AP750A (is)
AT (1)	ATE187719T1 (is)
AU (1)	AU707603B2 (is)
BG (1)	BG62769B1 (is)
BR (1)	BR9606853A (is)
CO (1)	CO4700286A1 (is)
CZ (1)	CZ287079B6 (is)
DE (1)	DE69605651T2 (is)
DK (1)	DK0805806T3 (is)
DZ (1)	DZ1977A1 (is)
EE (1)	EE03396B1 (is)
ES (1)	ES2139332T3 (is)
FI (1)	FI119245B (is)
FR (1)	FR2729666A1 (is)
GE (1)	GEP19991833B (is)
GR (1)	GR3032110T3 (is)
HU (1)	HU223352B1 (is)
IL (1)	IL116903A (is)
IN (1)	IN184427B (is)
IS (1)	IS2033B (is)
MA (1)	MA23782A1 (is)
MY (1)	MY113230A (is)
NO (1)	NO316987B1 (is)
NZ (1)	NZ300958A (is)
OA (1)	OA10438A (is)
PE (1)	PE64896A1 (is)
PL (1)	PL183773B1 (is)
PT (1)	PT805806E (is)
RO (1)	RO115728B1 (is)
RU (1)	RU2154642C2 (is)
SK (1)	SK281958B6 (is)
TN (1)	TNSN96011A1 (is)
TR (1)	TR199700676T1 (is)
TW (1)	TW356469B (is)
UA (1)	UA47420C2 (is)
UY (1)	UY24149A1 (is)
WO (1)	WO1996022984A1 (is)
ZA (1)	ZA96523B (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL203300B1 (pl) *	2000-10-31	2009-09-30	Akad Medyczna	Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
US6891050B2 (en) *	2001-08-10	2005-05-10	Dabur India Limited	Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6894456B2 (en)	2001-11-07	2005-05-17	Quallion Llc	Implantable medical power module
US6881852B2 (en) *	2002-02-05	2005-04-19	Dabur India Limited	Process of purification of paclitaxel and docetaxel
US7247738B2 (en) *	2002-05-07	2007-07-24	Dabur India Limited	Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) *	2002-05-10	2005-05-31	Dabur India Limited	Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) *	2002-12-16	2005-01-04	Dabur India Limited	Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
EP1947094A3 (en)	2003-12-12	2009-02-18	Quiral Quimica Do Brasil	Process for the preparation of taxane derivatives
CN100420681C (zh) *	2005-04-29	2008-09-24	上海奥锐特国际贸易有限公司	多烯紫杉醇三水物的制备方法
WO2009137084A2 (en) *	2008-05-07	2009-11-12	Ivax Research, Llc	Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) *	2012-06-01	2014-01-21	The University Of Utah Research Foundation	Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) *	2014-03-04	2016-02-24	悦康药业集团有限公司	一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994021662A1 (en) *	1993-03-15	1994-09-29	Yale University	Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) *	1993-03-22	1995-04-21	Rhone Poulenc Rorer Sa	Procédé de purification des taxoïdes.
CA2163837C (en) *	1994-12-13	1999-07-20	Robert K. Perrone	Crystalline paclitaxel hydrates

1995
- 1995-01-25 FR FR9500816A patent/FR2729666A1/fr active Granted
1996
- 1996-01-15 PE PE1996000035A patent/PE64896A1/es not_active Application Discontinuation
- 1996-01-17 UY UY24149A patent/UY24149A1/es not_active IP Right Cessation
- 1996-01-22 DZ DZ960018A patent/DZ1977A1/fr active
- 1996-01-23 ES ES96901832T patent/ES2139332T3/es not_active Expired - Lifetime
- 1996-01-23 PT PT96901832T patent/PT805806E/pt unknown
- 1996-01-23 DE DE69605651T patent/DE69605651T2/de not_active Expired - Lifetime
- 1996-01-23 EP EP96901832A patent/EP0805806B1/fr not_active Expired - Lifetime
- 1996-01-23 MA MA24137A patent/MA23782A1/fr unknown
- 1996-01-23 HU HU9801437A patent/HU223352B1/hu not_active IP Right Cessation
- 1996-01-23 AP APAP/P/1997/001035A patent/AP750A/en active
- 1996-01-23 PL PL96321493A patent/PL183773B1/pl not_active IP Right Cessation
- 1996-01-23 AU AU46255/96A patent/AU707603B2/en not_active Ceased
- 1996-01-23 GE GEAP19963849A patent/GEP19991833B/en unknown
- 1996-01-23 RO RO97-01401A patent/RO115728B1/ro unknown
- 1996-01-23 AT AT96901832T patent/ATE187719T1/de active
- 1996-01-23 TR TR97/00676T patent/TR199700676T1/xx unknown
- 1996-01-23 TW TW085100768A patent/TW356469B/zh not_active IP Right Cessation
- 1996-01-23 CN CN96191612A patent/CN1067997C/zh not_active Expired - Fee Related
- 1996-01-23 DK DK96901832T patent/DK0805806T3/da active
- 1996-01-23 WO PCT/FR1996/000104 patent/WO1996022984A1/fr not_active Ceased
- 1996-01-23 BR BR9606853A patent/BR9606853A/pt not_active IP Right Cessation
- 1996-01-23 ZA ZA96523A patent/ZA96523B/xx unknown
- 1996-01-23 US US08/875,625 patent/US6002022A/en not_active Expired - Lifetime
- 1996-01-23 JP JP52266996A patent/JP3782449B2/ja not_active Expired - Lifetime
- 1996-01-23 EE EE9700157A patent/EE03396B1/xx not_active IP Right Cessation
- 1996-01-23 UA UA97063414A patent/UA47420C2/uk unknown
- 1996-01-23 NZ NZ300958A patent/NZ300958A/en not_active IP Right Cessation
- 1996-01-23 SK SK1008-97A patent/SK281958B6/sk not_active IP Right Cessation
- 1996-01-23 RU RU97114134/04A patent/RU2154642C2/ru not_active IP Right Cessation
- 1996-01-23 KR KR1019970705017A patent/KR100384773B1/ko not_active Expired - Fee Related
- 1996-01-23 CZ CZ19972362A patent/CZ287079B6/cs not_active IP Right Cessation
- 1996-01-24 IN IN152DE1996 patent/IN184427B/en unknown
- 1996-01-24 CO CO96002860A patent/CO4700286A1/es unknown
- 1996-01-24 TN TNTNSN96011A patent/TNSN96011A1/fr unknown
- 1996-01-25 IL IL11690396A patent/IL116903A/xx not_active IP Right Cessation
- 1996-01-25 MY MYPI96000282A patent/MY113230A/en unknown
1997
- 1997-07-11 NO NO19973247A patent/NO316987B1/no not_active IP Right Cessation
- 1997-07-22 IS IS4529A patent/IS2033B/is unknown
- 1997-07-24 OA OA70055A patent/OA10438A/fr unknown
- 1997-07-24 FI FI973105A patent/FI119245B/fi not_active IP Right Cessation
- 1997-07-25 BG BG101794A patent/BG62769B1/bg unknown
1999
- 1999-12-16 GR GR990402251T patent/GR3032110T3/el unknown

Also Published As

Publication number	Publication date
RO115728B1 (ro)	2000-05-30
HU223352B1 (hu)	2004-06-28
PL321493A1 (en)	1997-12-08
CN1067997C (zh)	2001-07-04
AU707603B2 (en)	1999-07-15
DE69605651D1 (de)	2000-01-20
EE9700157A (et)	1997-12-15
HUP9801437A3 (en)	2001-02-28
BG101794A (en)	1998-10-30
US6002022A (en)	1999-12-14
PL183773B1 (pl)	2002-07-31
ATE187719T1 (de)	2000-01-15
JPH10512871A (ja)	1998-12-08
CZ236297A3 (en)	1997-11-12
IN184427B (is)	2000-08-26
BG62769B1 (bg)	2000-07-31
WO1996022984A1 (fr)	1996-08-01
AP9701035A0 (en)	1997-07-31
DZ1977A1 (fr)	2002-07-20
GEP19991833B (en)	1999-11-05
SK281958B6 (sk)	2001-09-11
CO4700286A1 (es)	1998-12-29
EP0805806A1 (fr)	1997-11-12
GR3032110T3 (en)	2000-03-31
BR9606853A (pt)	1997-11-25
RU2154642C2 (ru)	2000-08-20
NZ300958A (en)	1999-09-29
SK100897A3 (en)	1998-01-14
FI119245B (fi)	2008-09-15
KR100384773B1 (ko)	2003-08-21
MY113230A (en)	2001-12-31
MA23782A1 (fr)	1996-10-01
EE03396B1 (et)	2001-04-16
OA10438A (fr)	2002-03-22
FR2729666A1 (fr)	1996-07-26
NO316987B1 (no)	2004-07-19
EP0805806B1 (fr)	1999-12-15
UY24149A1 (es)	1996-05-20
IS2033B (is)	2005-08-15
AU4625596A (en)	1996-08-14
JP3782449B2 (ja)	2006-06-07
NO973247D0 (no)	1997-07-11
DK0805806T3 (da)	2000-05-01
FI973105L (fi)	1997-07-24
DE69605651T2 (de)	2000-07-06
ES2139332T3 (es)	2000-02-01
KR19980701623A (ko)	1998-06-25
HUP9801437A1 (hu)	1999-09-28
PT805806E (pt)	2000-05-31
AP750A (en)	1999-07-06
IL116903A0 (en)	1996-05-14
CZ287079B6 (en)	2000-08-16
NO973247L (no)	1997-07-11
FR2729666B1 (is)	1997-02-28
PE64896A1 (es)	1997-02-23
CN1169724A (zh)	1998-01-07
UA47420C2 (uk)	2002-07-15
FI973105A0 (fi)	1997-07-24
MX9705460A (es)	1997-10-31
ZA96523B (en)	1996-10-15
IL116903A (en)	2003-01-12
TNSN96011A1 (fr)	2005-03-15
TR199700676T1 (xx)	1998-01-21
TW356469B (en)	1999-04-21

Publication	Publication Date	Title
FI970069L (fi)	1997-01-07	Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatin valmistamiseksi
NO981800L (no)	1998-06-11	FremgangsmÕte for fremstilling av 1,1,1,3,3-pentafluorpentan
HUP9600549A3 (en)	1998-04-28	N-(3-benzofuranyl)urea-derivatives, medicaments containing the same and process for producing them
DE69016821D1 (de)	1995-03-23	Behandlungsmittel gegen Osteoarthritis.
FI101472B1 (fi)	1998-06-30	Menetelmä 1,3-diolien monoesterien valmistamiseksi
IS2033B (is)	2005-08-15	Aðferð til framleiðslu á 4,10-díasetoxý-2alfa-bensóýloxý-5beta, 20-epoxý-1,7beta-díhýdroxý-9-oxó-tax-11-en-13alfa-ýl(2R,3S)-3-bensóýlamínó-2-hýdroxý-3-fenýlprópíónat tríhýdrat
ZA961884B (en)	1997-09-09	Novel naphthyl pharmaceutical compounds.
FI934748A0 (fi)	1993-10-27	Foerfarande foer framstaellning av l-5-(2-acetoxipropionylamino)-2,4,6-trijod-isoftalsyradiklorid
FI974435A7 (fi)	1997-12-05	Menetelmä 2,4-diklooripyridiinien muuttamiseksi 2-aryylioksi-4-kloorip yridiineiksi
NO985535D0 (no)	1998-11-27	FremgangsmÕte for fremstilling av 1,3-alkandioler
TR199601018A1 (tr)	1997-07-21	Farmasötik bilesikler.
TR199700863A3 (tr)	1999-10-21	Paklitaksel hazirlama prosesi.
NO903712D0 (no)	1990-08-23	Fremgangsmaate for bryting av emulsjoner.
AU713086C (en)	2002-09-19	4,10beta-diacetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1- hydroxy-9-oxo-19-norcyclopropa(g)tax-11-en-13alpha-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3- phenylpropionate dihydrate and its process of preparation
NO894623L (no)	1990-05-25	Biologisk fremgangsmaate for bleking av pulp.
SI0805806T1 (en)	2000-02-29	Method for preparing 4,10-diacetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alfa-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
FR2736635B1 (fr)	1997-08-14	Procede de preparation d'alpha,omega-bromochloroalcanes
NO982085L (no)	1998-06-26	Fremgangsmate for rensing av erytropoietiner.
DK0842135T3 (da)	2000-04-17	Fremgangsmåde til fremstilling alpha, omega-bromchloralkaner
SE9503711D0 (sv)	1995-10-23	New pharmaceutical carrier
FI2067U1 (fi)	1995-08-29	Verktyg foer boejning av en flaens
FI953158A0 (fi)	1995-06-26	Foerfarande foer biologisk rening av vatten, saerskilt foer minskning av kvaevehalten