EE9700202A - Diasendatud 1,4-piperidiini estrid ja amiidid, mis omavad 5-HT4 antagonistlikku aktiivsust - Google Patents
Diasendatud 1,4-piperidiini estrid ja amiidid, mis omavad 5-HT4 antagonistlikku aktiivsustInfo
- Publication number
- EE9700202A EE9700202A EE9700202A EE9700202A EE9700202A EE 9700202 A EE9700202 A EE 9700202A EE 9700202 A EE9700202 A EE 9700202A EE 9700202 A EE9700202 A EE 9700202A EE 9700202 A EE9700202 A EE 9700202A
- Authority
- EE
- Estonia
- Prior art keywords
- disubstituted
- amides
- antagonist activity
- piperidine esters
- piperidine
- Prior art date
Links
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical class FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 239000003523 serotonin 4 antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI000491A IT1275903B1 (it) | 1995-03-14 | 1995-03-14 | Esteri e ammidi della 1,4-piperidina disostituita |
| PCT/EP1996/000903 WO1996028424A1 (en) | 1995-03-14 | 1996-03-04 | Di-substituted 1,4-piperidine esters and amides having 5-ht4 antagonistic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9700202A true EE9700202A (et) | 1998-02-16 |
Family
ID=11370883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9700202A EE9700202A (et) | 1995-03-14 | 1996-03-04 | Diasendatud 1,4-piperidiini estrid ja amiidid, mis omavad 5-HT4 antagonistlikku aktiivsust |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6002009A (it) |
| EP (1) | EP0815080B1 (it) |
| JP (1) | JP4021477B2 (it) |
| KR (1) | KR19980702972A (it) |
| AR (1) | AR002967A1 (it) |
| AT (1) | ATE269304T1 (it) |
| AU (1) | AU5101096A (it) |
| BG (1) | BG101711A (it) |
| BR (1) | BR9607347A (it) |
| CA (1) | CA2209904C (it) |
| CO (1) | CO4700521A1 (it) |
| CZ (1) | CZ285997A3 (it) |
| DE (1) | DE69632724T2 (it) |
| EE (1) | EE9700202A (it) |
| ES (1) | ES2224159T3 (it) |
| HR (1) | HRP960116A2 (it) |
| IL (1) | IL117446A0 (it) |
| IT (1) | IT1275903B1 (it) |
| NO (1) | NO974236D0 (it) |
| NZ (1) | NZ303941A (it) |
| PE (1) | PE7698A1 (it) |
| PL (1) | PL322211A1 (it) |
| SK (1) | SK121397A3 (it) |
| TR (1) | TR199700948T1 (it) |
| WO (1) | WO1996028424A1 (it) |
| YU (1) | YU14196A (it) |
| ZA (1) | ZA962009B (it) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2164151T3 (es) * | 1995-06-06 | 2002-02-16 | Pfizer | N-(indol-2-carbonil)glicinamidas sustituidas y derivados como inhibidores de la glucogeno fosforilasa. |
| AU7001796A (en) * | 1995-09-22 | 1997-04-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and medicinal use thereof |
| TW445263B (en) | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
| US6339087B1 (en) | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
| IL125658A0 (en) | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
| TW570920B (en) | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| GB0211230D0 (en) * | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| CA2537127C (en) * | 2003-09-03 | 2011-04-05 | Pfizer Inc. | Benzimidazolone compounds having 5-ht4 receptor agonistic activity |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| AU2005254800B2 (en) * | 2004-06-15 | 2010-12-09 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| US7737163B2 (en) * | 2004-06-15 | 2010-06-15 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| AP2418A (en) * | 2004-06-15 | 2012-06-04 | Pfizer | Benzimidazolone carboxylic acid derivatives. |
| JP2008509088A (ja) * | 2004-09-02 | 2008-03-27 | ファイザー株式会社 | ベンズイミダゾロンカルボン酸誘導体 |
| JP5042028B2 (ja) * | 2004-11-05 | 2012-10-03 | セラヴァンス， インコーポレーテッド | キノリノン−カルボキサミド化合物 |
| DE602005016446D1 (de) * | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| KR20070091665A (ko) * | 2004-12-22 | 2007-09-11 | 세라밴스 인코포레이티드 | 인다졸－카르복사미드 화합물 |
| NZ556627A (en) * | 2005-02-22 | 2010-09-30 | Pfizer | Oxyindole derivatives as 5HT4 receptor agonists |
| WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
| ES2359673T3 (es) * | 2005-06-07 | 2011-05-25 | Theravance, Inc. | Compuestos de benzoimidazolona-carboxamida como agonista del receptor 5-ht4. |
| MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| US8232315B2 (en) * | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| KR101783632B1 (ko) | 2009-11-06 | 2017-10-10 | 에스케이바이오팜 주식회사 | 주의력 결핍/과잉행동 장애(ａｄｈｄ)의 치료 방법 |
| WO2011055944A2 (en) | 2009-11-06 | 2011-05-12 | Sk Holdings Co., Ltd. | Methods for treating fibromyalgia syndrome |
| WO2011163594A2 (en) * | 2010-06-24 | 2011-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9103862D0 (en) * | 1991-02-25 | 1991-04-10 | Glaxo Group Ltd | Chemical compounds |
| GB9204565D0 (en) * | 1992-03-03 | 1992-04-15 | Smithkline Beecham Plc | Pharmaceuticals |
| EP0664794A1 (en) * | 1992-10-16 | 1995-08-02 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists |
| EP0774460A1 (en) * | 1994-03-30 | 1997-05-21 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compound and use thereof as medicine |
-
1995
- 1995-03-14 IT IT95MI000491A patent/IT1275903B1/it active IP Right Grant
-
1996
- 1996-03-04 CZ CZ972859A patent/CZ285997A3/cs unknown
- 1996-03-04 WO PCT/EP1996/000903 patent/WO1996028424A1/en not_active Ceased
- 1996-03-04 ES ES96907342T patent/ES2224159T3/es not_active Expired - Lifetime
- 1996-03-04 KR KR1019970706380A patent/KR19980702972A/ko not_active Withdrawn
- 1996-03-04 BR BR9607347A patent/BR9607347A/pt not_active Application Discontinuation
- 1996-03-04 CA CA002209904A patent/CA2209904C/en not_active Expired - Lifetime
- 1996-03-04 JP JP52723396A patent/JP4021477B2/ja not_active Expired - Lifetime
- 1996-03-04 DE DE69632724T patent/DE69632724T2/de not_active Expired - Lifetime
- 1996-03-04 AU AU51010/96A patent/AU5101096A/en not_active Abandoned
- 1996-03-04 NZ NZ303941A patent/NZ303941A/en unknown
- 1996-03-04 SK SK1213-97A patent/SK121397A3/sk unknown
- 1996-03-04 US US08/913,425 patent/US6002009A/en not_active Expired - Lifetime
- 1996-03-04 AT AT96907342T patent/ATE269304T1/de active
- 1996-03-04 PL PL96322211A patent/PL322211A1/xx unknown
- 1996-03-04 EE EE9700202A patent/EE9700202A/xx unknown
- 1996-03-04 TR TR97/00948T patent/TR199700948T1/xx unknown
- 1996-03-04 EP EP96907342A patent/EP0815080B1/en not_active Expired - Lifetime
- 1996-03-05 PE PE1996000151A patent/PE7698A1/es not_active Application Discontinuation
- 1996-03-08 AR ARP960101670A patent/AR002967A1/es unknown
- 1996-03-11 YU YU14196A patent/YU14196A/sh unknown
- 1996-03-12 IL IL11744696A patent/IL117446A0/xx unknown
- 1996-03-13 CO CO96012408A patent/CO4700521A1/es unknown
- 1996-03-13 ZA ZA9602009A patent/ZA962009B/xx unknown
- 1996-03-13 HR HRMI95A000491A patent/HRP960116A2/hr not_active Application Discontinuation
-
1997
- 1997-07-01 BG BG101711A patent/BG101711A/xx unknown
- 1997-09-12 NO NO974236A patent/NO974236D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69632724T2 (de) | 2005-07-07 |
| AU5101096A (en) | 1996-10-02 |
| EP0815080A1 (en) | 1998-01-07 |
| IT1275903B1 (it) | 1997-10-24 |
| JP4021477B2 (ja) | 2007-12-12 |
| ITMI950491A1 (it) | 1996-09-14 |
| JPH11501640A (ja) | 1999-02-09 |
| PE7698A1 (es) | 1998-03-11 |
| ITMI950491A0 (it) | 1995-03-14 |
| KR19980702972A (ko) | 1998-09-05 |
| CZ285997A3 (cs) | 1998-02-18 |
| US6002009A (en) | 1999-12-14 |
| NO974236L (no) | 1997-09-12 |
| CA2209904A1 (en) | 1996-09-19 |
| CA2209904C (en) | 2007-11-13 |
| MX9706826A (es) | 1997-11-29 |
| YU14196A (sh) | 1999-03-04 |
| ZA962009B (en) | 1997-09-15 |
| PL322211A1 (en) | 1998-01-19 |
| ATE269304T1 (de) | 2004-07-15 |
| BR9607347A (pt) | 1997-12-30 |
| WO1996028424A1 (en) | 1996-09-19 |
| BG101711A (en) | 1998-02-27 |
| DE69632724D1 (de) | 2004-07-22 |
| SK121397A3 (en) | 1998-02-04 |
| EP0815080B1 (en) | 2004-06-16 |
| ES2224159T3 (es) | 2005-03-01 |
| NO974236D0 (no) | 1997-09-12 |
| HRP960116A2 (en) | 1997-10-31 |
| AR002967A1 (es) | 1998-05-27 |
| CO4700521A1 (es) | 1998-12-29 |
| NZ303941A (en) | 1998-11-25 |
| TR199700948T1 (xx) | 1998-03-21 |
| IL117446A0 (en) | 1996-07-23 |
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