EE9800144A - Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon - Google Patents

Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon

Info

Publication number: EE9800144A
Authority: EE; Estonia
Prior art keywords: dione; oxime derivatives; het; indole; ring
Prior art date: 1996-10-01

Application number

EE9800144A

Other languages

English (en)

Estonian (et)

Inventor

W�tjen Frank

Drejer J�rgen

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-10-01

Publication date

1998-10-15

1997-10-01 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

1998-10-15 Publication of EE9800144A publication Critical patent/EE9800144A/xx

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
125000005092 alkenyloxycarbonyl group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000005225 alkynyloxycarbonyl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
125000005605 benzo group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
229930195712 glutamate Natural products 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
-1 hydroxy, carboxy Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EE9800144A 1996-10-01 1997-10-01 Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon EE9800144A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK106996		1996-10-01
DK127796		1996-11-13
PCT/DK1997/000418 WO1998014447A1 (en)	1996-10-01	1997-10-01	Novel indole-2,3-dione-3-oxime derivatives

Publications (1)

Publication Number	Publication Date
EE9800144A true EE9800144A (et)	1998-10-15

Family

ID=26065167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9800144A EE9800144A (et)	1996-10-01	1997-10-01	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon

Country Status (28)

Country	Link
US (3)	US6124285A (pt)
EP (1)	EP0869958B1 (pt)
JP (1)	JP3319762B2 (pt)
KR (1)	KR100492052B1 (pt)
CN (1)	CN1093859C (pt)
AT (1)	ATE286052T1 (pt)
AU (1)	AU716435B2 (pt)
BG (1)	BG63874B1 (pt)
BR (1)	BR9706765A (pt)
CA (1)	CA2238410C (pt)
CZ (1)	CZ297938B6 (pt)
DE (1)	DE69732090T2 (pt)
DK (1)	DK0869958T3 (pt)
EE (1)	EE9800144A (pt)
ES (1)	ES2235253T3 (pt)
HU (1)	HU225145B1 (pt)
IL (1)	IL124563A (pt)
IS (1)	IS2123B (pt)
NO (1)	NO310722B1 (pt)
NZ (1)	NZ330456A (pt)
PL (1)	PL193041B1 (pt)
PT (1)	PT869958E (pt)
RU (1)	RU2190612C2 (pt)
SI (1)	SI0869958T1 (pt)
SK (1)	SK282729B6 (pt)
TR (1)	TR199800956T1 (pt)
UA (1)	UA54403C2 (pt)
WO (1)	WO1998014447A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
AU751414B2 (en) *	1998-03-31	2002-08-15	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives for therapeutic use
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation
IT1318636B1 (it) *	2000-07-21	2003-08-27	Roberto Pellicciari	Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato.
JP2004523543A (ja) *	2001-02-15	2004-08-05	ニューロサーチ、アクティーゼルスカブ	神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法
DE60206762T2 (de)	2001-07-13	2006-07-13	Pharmacia & Upjohn Co. Llc, Kalamazoo	Hexahydroazepino(4,5-g)indole und -indoline als 5-ht rezeptor-liganden
ATE318815T1 (de) *	2002-08-22	2006-03-15	Neurosearch As	Verfahren zur herstellung von enantiomeren von indol-2,3-dion-3-oximderivaten
GB0507298D0 (en)	2005-04-11	2005-05-18	Novartis Ag	Organic compounds
WO2007059608A1 (en) *	2005-11-23	2007-05-31	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2007115409A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2007115403A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
US20100041691A1 (en) *	2006-09-12	2010-02-18	Neurosearch A/S	Pharmaceutical compositions comprising combinations of an ampa/kainate antagonistic compound and an inhibitor of a multidrug resistance protein
US20080108622A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
US20080108603A1 (en) *	2006-10-19	2008-05-08	Eisenach James C	Combination therapy for the treatment of pain
WO2010104324A2 (ko) *	2009-03-10	2010-09-16	한국과학기술연구원	베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를 가지는 할로겐화 이소인돌론 화합물, 및 이의 제조 방법 및 용도
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
RS61688B1 (sr)	2015-04-29	2021-05-31	Janssen Pharmaceutica Nv	Azabenzimidazoli i njihiova upotreba kao modulatori ampa receptora
US10604484B2 (en)	2015-04-29	2020-03-31	Janssen Pharmaceutica Nv	Indolone compounds and their use as AMPA receptor modulators
WO2016176457A1 (en)	2015-04-29	2016-11-03	Janssen Pharmaceutica Nv	Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
AU2016255424B2 (en)	2015-04-29	2020-10-08	Janssen Pharmaceutica Nv	Benzimidazolone and benzothiazolone compounds and their use as AMPA receptor modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE69677B1 (en) *	1989-12-11	1996-10-02	Neurosearch As	Isatine derivatives their preparation and use
CA2076948C (en) *	1991-08-28	2002-04-16	Frank Watjen	Isatineoxime derivatives, their preparation and use
MY128102A (en) *	1993-02-17	2007-01-31	Chugai Pharmaceutical Co Ltd	Indolin-2-one-derivatives
US5721230A (en)	1993-05-10	1998-02-24	Hoffmann-La Roche Inc.	Substituted pyrroles
CA2161783C (en) *	1993-05-13	2006-08-15	Frank Watjen	Ampa antagonists and a method of treatment therewith
DK81593D0 (da) *	1993-07-07	1993-07-07	Neurosearch As	Nye isatinoximderivater, deres fremstilling og anvendelse
US5801174A (en) *	1994-09-14	1998-09-01	Neurosearch A/S	Fused indole and quinoxaline derivatives, their preparation and use
AU687255B2 (en) *	1994-09-14	1998-02-19	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1997
- 1997-01-10 UA UA98052752A patent/UA54403C2/uk unknown
- 1997-10-01 US US09/077,554 patent/US6124285A/en not_active Expired - Lifetime
- 1997-10-01 HU HU9901630A patent/HU225145B1/hu not_active IP Right Cessation
- 1997-10-01 DK DK97941880T patent/DK0869958T3/da active
- 1997-10-01 TR TR1998/00956T patent/TR199800956T1/xx unknown
- 1997-10-01 SI SI9730698T patent/SI0869958T1/xx unknown
- 1997-10-01 JP JP51615898A patent/JP3319762B2/ja not_active Expired - Fee Related
- 1997-10-01 CA CA002238410A patent/CA2238410C/en not_active Expired - Fee Related
- 1997-10-01 PL PL327073A patent/PL193041B1/pl not_active IP Right Cessation
- 1997-10-01 DE DE69732090T patent/DE69732090T2/de not_active Expired - Lifetime
- 1997-10-01 WO PCT/DK1997/000418 patent/WO1998014447A1/en not_active Ceased
- 1997-10-01 KR KR10-1998-0704103A patent/KR100492052B1/ko not_active Expired - Fee Related
- 1997-10-01 EP EP97941880A patent/EP0869958B1/en not_active Expired - Lifetime
- 1997-10-01 CZ CZ0160698A patent/CZ297938B6/cs not_active IP Right Cessation
- 1997-10-01 IL IL12456397A patent/IL124563A/xx not_active IP Right Cessation
- 1997-10-01 NZ NZ330456A patent/NZ330456A/en unknown
- 1997-10-01 AT AT97941880T patent/ATE286052T1/de not_active IP Right Cessation
- 1997-10-01 PT PT97941880T patent/PT869958E/pt unknown
- 1997-10-01 AU AU43768/97A patent/AU716435B2/en not_active Ceased
- 1997-10-01 ES ES97941880T patent/ES2235253T3/es not_active Expired - Lifetime
- 1997-10-01 EE EE9800144A patent/EE9800144A/xx unknown
- 1997-10-01 BR BR9706765-2A patent/BR9706765A/pt not_active Application Discontinuation
- 1997-10-01 CN CN97191602A patent/CN1093859C/zh not_active Expired - Fee Related
- 1997-10-01 US US09/956,892 patent/USRE38200E1/en not_active Expired - Fee Related
- 1997-10-01 SK SK676-98A patent/SK282729B6/sk not_active IP Right Cessation
- 1997-10-01 RU RU98112237/04A patent/RU2190612C2/ru not_active IP Right Cessation
1998
- 1998-05-18 IS IS4748A patent/IS2123B/xx unknown
- 1998-05-26 BG BG102489A patent/BG63874B1/bg unknown
- 1998-05-29 NO NO19982466A patent/NO310722B1/no not_active IP Right Cessation
2000
- 2000-05-31 US US09/584,117 patent/US6693111B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HK1017682A1 (en)	1999-11-26
NO982466D0 (no)	1998-05-29
BR9706765A (pt)	1999-09-14
USRE38200E1 (en)	2003-07-22
NO982466L (no)	1998-07-31
DK0869958T3 (da)	2005-04-18
EP0869958B1 (en)	2004-12-29
EP0869958A1 (en)	1998-10-14
AU716435B2 (en)	2000-02-24
HUP9901630A3 (en)	2001-11-28
CZ297938B6 (cs)	2007-05-02
NO310722B1 (no)	2001-08-20
KR100492052B1 (ko)	2005-09-30
BG102489A (en)	1999-04-30
PL327073A1 (en)	1998-11-23
KR19990071823A (ko)	1999-09-27
DE69732090D1 (de)	2005-02-03
HU225145B1 (en)	2006-07-28
IL124563A (en)	2005-05-17
PL193041B1 (pl)	2007-01-31
JP2000501432A (ja)	2000-02-08
RU2190612C2 (ru)	2002-10-10
US6693111B1 (en)	2004-02-17
UA54403C2 (uk)	2003-03-17
ATE286052T1 (de)	2005-01-15
WO1998014447A1 (en)	1998-04-09
HUP9901630A2 (hu)	1999-08-30
CA2238410C (en)	2007-06-12
SI0869958T1 (en)	2005-06-30
TR199800956T1 (xx)	1998-12-21
IS4748A (is)	1998-05-18
CZ160698A3 (cs)	1998-10-14
CN1093859C (zh)	2002-11-06
JP3319762B2 (ja)	2002-09-03
IS2123B (is)	2006-07-14
PT869958E (pt)	2005-05-31
BG63874B1 (bg)	2003-04-30
CA2238410A1 (en)	1998-04-09
DE69732090T2 (de)	2005-12-29
ES2235253T3 (es)	2005-07-01
SK282729B6 (sk)	2002-11-06
AU4376897A (en)	1998-04-24
NZ330456A (en)	1998-11-25
CN1207100A (zh)	1999-02-03
US6124285A (en)	2000-09-26
MX9804365A (es)	1998-10-31
SK67698A3 (en)	1998-11-04
IL124563A0 (en)	1998-12-06

Publication	Publication Date	Title
EE9800144A (et)	1998-10-15	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon
TW349098B (en)	1999-01-01	Naphthalene derivatives, process for the preparation thereof, and intermediates therefor
FI954609A0 (fi)	1995-09-28	1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
ES2162466T3 (es)	2001-12-16	Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
EA200301094A1 (ru)	2004-06-24	Аминопроизводные как ингибиторы протеазы
PT807633E (pt)	2003-02-28	Novas pirimidin-4-onas substituidas em 2,3, e fundidas com heteroarilo em (5,6)
AR005597A1 (es)	1999-06-23	Derivados de benzoxazina , composiciones farmaceuticas para el tratamiento de infecciones bacterianas, y metodo para la preparacion de dichos derivados.
BG94282A (bg)	1993-12-24	2,9-дизаместени-4н-пиридо/1,2,-а/пиримидин-4-они
DE69924292D1 (de)	2005-04-21	Pyrazol verbindungen und ihre verwendung
NO305287B1 (no)	1999-05-03	AMPA antagonister
IT1317048B1 (it)	2003-05-26	Uso dell'acido pamoico o di un suo derivato, o di un suo analogo, perla preparazione di un medicamento per il trattamento di patologie
IL91648A (en)	1997-03-18	Amino acid quinoline and naphthyridine derivatives, their preparation and pharmaceutical compositions containing them
EA199700205A1 (ru)	1998-02-26	Прокинетические оксадиазолы
FR2671349B1 (fr)	1993-04-23	Nouveaux derives de 1,4-dihydropyridine, leur procede de preparation et composition therapeutique les contenant.
DE60310928D1 (de)	2007-02-15	Par-2-aktivierendes peptidderivat und pharmazeutische zusammensetzung, in der dieses verwendet wird
HUP9903893A2 (hu)	2001-04-28	Eljárás szívelégtelenségnek ciklopentánnal kondenzált heterogyűrűs endotelin-antagonistákkal történő kezelésére
TW367328B (en)	1999-08-21	Benzofuro[3,2-b]pyridine derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EE03355B1 (et)	2001-02-15	Indool-2,3-dioon-3-oksiimi derivaadid, nende valmistamine ja kasutamine
AR019390A1 (es)	2002-02-20	Derivados de acidos sulfonilaminofosfinicos y sulfonilaminofosfonicos, procedimiento para su preparacion, compuestos intermediarios, medicamentos, procedimiento para su preparacion y empleo de dichos derivados para la preparacion de un medicamento.
AP9901559A0 (en)	1999-06-30	Tricyclic 3-keto derivatives of 6-0-methylerythromycin.
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