EG18529A - Process for preparing b-lactam hydrate - Google Patents

Process for preparing b-lactam hydrate

Info

Publication number: EG18529A
Authority: EG; Egypt
Prior art keywords: lactam; hydrate; preparing; lactam hydrate
Prior art date: 1987-10-06

Application number

EG506/88A

Other languages

English (en)

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-06

Filing date

1988-10-03

Publication date

1993-04-30

1988-10-03 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-04-30 Application granted granted Critical

1993-04-30 Publication of EG18529A publication Critical patent/EG18529A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EG506/88A 1987-10-06 1988-10-03 Process for preparing b-lactam hydrate EG18529A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US10576687A	1987-10-06	1987-10-06

Publications (1)

Publication Number	Publication Date
EG18529A true EG18529A (en)	1993-04-30

Family

ID=22307671

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG506/88A EG18529A (en)	1987-10-06	1988-10-03	Process for preparing b-lactam hydrate

Country Status (32)

Country	Link
EP (1)	EP0311366B1 (de)
JP (1)	JP2641745B2 (de)
KR (1)	KR970002637B1 (de)
CN (1)	CN1029966C (de)
AR (1)	AR248407A1 (de)
AT (1)	ATE103916T1 (de)
AU (1)	AU598155B2 (de)
BG (1)	BG47036A3 (de)
CA (1)	CA1334970C (de)
CS (1)	CS270594B2 (de)
DD (1)	DD273634A5 (de)
DE (1)	DE3888913T2 (de)
DK (1)	DK170070B1 (de)
EG (1)	EG18529A (de)
ES (1)	ES2063049T3 (de)
FI (1)	FI884554L (de)
HK (1)	HK15497A (de)
HU (1)	HU206348B (de)
IE (1)	IE62108B1 (de)
IL (1)	IL87905A (de)
MX (1)	MX13277A (de)
MY (1)	MY104063A (de)
NO (1)	NO884416L (de)
NZ (1)	NZ226450A (de)
OA (1)	OA08958A (de)
PH (1)	PH31002A (de)
PL (1)	PL152022B1 (de)
PT (1)	PT88662B (de)
SU (1)	SU1731058A3 (de)
UA (1)	UA19149A (de)
YU (1)	YU46699B (de)
ZA (1)	ZA887409B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU46700B (sh) *	1987-10-07	1994-04-05	Eli Lilly And Co.	Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika
CA2002597C (en) *	1988-11-14	1999-03-23	Thomas M. Eckrich	Solvates of b-lactam antibiotic
CA2002596A1 (en) *	1988-11-14	1990-05-14	Thomas M. Eckrich	Hydrates of b-lactam antibiotic
CA2034592C (en) *	1990-01-26	2001-06-05	Ralph R. Pfeiffer	Crystalline hydrochloride of new beta-lactam antibiotic and process therefor
US5399686A (en) *	1993-06-04	1995-03-21	Eli Lilly And Company	Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5352782A (en) *	1993-06-04	1994-10-04	Eli Lilly And Company	Process for preparing crystalline β-lactam monohydrate
US5374719A (en) *	1993-06-04	1994-12-20	Eli Lilly And Company	Process for converting loracarbef dihydrate to loracarbef monohydrate
US5550231A (en) *	1993-06-15	1996-08-27	Eli Lilly And Company	Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5412094A (en) *	1993-06-28	1995-05-02	Eli Lilly And Company	Bicyclic beta-lactam/paraben complexes
US5580977A (en) *	1995-03-01	1996-12-03	Eli Lilly And Company	Process for preparing loracarbef monohydrate
US6001996A (en) *	1995-05-11	1999-12-14	Eli Lilly And Company	Complexes of cephalosporins and carbacephalosporins with parabens
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
KR20070120617A (ko)	2001-01-26	2007-12-24	쉐링 코포레이션	치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156445A0 (en)	2001-01-26	2004-01-04	Schering Corp	Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EP1429756B1 (de)	2001-09-21	2006-11-22	Schering Corporation	Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
CA2504916A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
WO2004081002A1 (en)	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
DE602004018617D1 (de)	2003-03-07	2009-02-05	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081004A1 (en)	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3655656A (en) *	1970-06-04	1972-04-11	Lilly Co Eli	Crystalline cephalexin monohydrate
JPS5672698A (en) *	1979-11-14	1981-06-16	Kyowa Hakko Kogyo Co Ltd	Preparation of optically active cephalosporin analogue
YU46700B (sh) *	1987-10-07	1994-04-05	Eli Lilly And Co.	Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika

1988
- 1988-10-03 ZA ZA887409A patent/ZA887409B/xx unknown
- 1988-10-03 DD DD88320417A patent/DD273634A5/de unknown
- 1988-10-03 CA CA000579158A patent/CA1334970C/en not_active Expired - Fee Related
- 1988-10-03 MY MYPI88001103A patent/MY104063A/en unknown
- 1988-10-03 YU YU184588A patent/YU46699B/sh unknown
- 1988-10-03 EG EG506/88A patent/EG18529A/xx active
- 1988-10-04 BG BG085594A patent/BG47036A3/xx unknown
- 1988-10-04 DK DK553788A patent/DK170070B1/da active IP Right Grant
- 1988-10-04 AU AU23372/88A patent/AU598155B2/en not_active Expired
- 1988-10-04 AR AR88312109A patent/AR248407A1/es active
- 1988-10-04 PH PH37636A patent/PH31002A/en unknown
- 1988-10-04 FI FI884554A patent/FI884554L/fi not_active Application Discontinuation
- 1988-10-04 MX MX1327788A patent/MX13277A/es unknown
- 1988-10-04 PT PT88662A patent/PT88662B/pt not_active IP Right Cessation
- 1988-10-04 IL IL87905A patent/IL87905A/xx active Protection Beyond IP Right Term
- 1988-10-04 NZ NZ226450A patent/NZ226450A/xx unknown
- 1988-10-04 JP JP63251712A patent/JP2641745B2/ja not_active Expired - Fee Related
- 1988-10-05 HU HU885171A patent/HU206348B/hu unknown
- 1988-10-05 KR KR1019880012961A patent/KR970002637B1/ko not_active Expired - Lifetime
- 1988-10-05 OA OA59444A patent/OA08958A/xx unknown
- 1988-10-05 AT AT88309261T patent/ATE103916T1/de not_active IP Right Cessation
- 1988-10-05 IE IE301588A patent/IE62108B1/en not_active IP Right Cessation
- 1988-10-05 EP EP88309261A patent/EP0311366B1/de not_active Expired - Lifetime
- 1988-10-05 UA UA4356543A patent/UA19149A/uk unknown
- 1988-10-05 NO NO88884416A patent/NO884416L/no unknown
- 1988-10-05 SU SU884356543A patent/SU1731058A3/ru active
- 1988-10-05 PL PL1988275093A patent/PL152022B1/pl unknown
- 1988-10-05 DE DE3888913T patent/DE3888913T2/de not_active Expired - Lifetime
- 1988-10-05 CN CN88109140A patent/CN1029966C/zh not_active Expired - Lifetime
- 1988-10-05 ES ES88309261T patent/ES2063049T3/es not_active Expired - Lifetime
- 1988-10-06 CS CS886666A patent/CS270594B2/cs not_active IP Right Cessation
1997
- 1997-02-05 HK HK15497A patent/HK15497A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK170070B1 (da)	1995-05-15
KR970002637B1 (ko)	1997-03-07
MX13277A (es)	1993-11-01
SU1731058A3 (ru)	1992-04-30
CS666688A2 (en)	1989-11-14
NZ226450A (en)	1990-05-28
JP2641745B2 (ja)	1997-08-20
CN1029966C (zh)	1995-10-11
DK553788A (da)	1989-04-07
DD273634A5 (de)	1989-11-22
IL87905A0 (en)	1989-03-31
DE3888913T2 (de)	1994-08-11
EP0311366A1 (de)	1989-04-12
CA1334970C (en)	1995-03-28
ZA887409B (en)	1990-06-27
JPH01128983A (ja)	1989-05-22
PT88662B (pt)	1992-12-31
IE883015L (en)	1989-04-06
DK553788D0 (da)	1988-10-04
PH31002A (en)	1997-12-23
IE62108B1 (en)	1994-12-14
AU2337288A (en)	1989-04-06
ATE103916T1 (de)	1994-04-15
HK15497A (en)	1997-02-14
NO884416D0 (no)	1988-10-05
PT88662A (pt)	1988-11-01
CN1032793A (zh)	1989-05-10
ES2063049T3 (es)	1995-01-01
KR890006644A (ko)	1989-06-15
PL152022B1 (en)	1990-10-31
AU598155B2 (en)	1990-06-14
MY104063A (en)	1993-11-30
FI884554A0 (fi)	1988-10-04
YU184588A (en)	1990-02-28
CS270594B2 (en)	1990-07-12
YU46699B (sh)	1994-04-05
IL87905A (en)	1992-06-21
FI884554A7 (fi)	1989-04-07
UA19149A (uk)	1997-12-25
BG47036A3 (bg)	1990-04-16
HU206348B (en)	1992-10-28
EP0311366B1 (de)	1994-04-06
NO884416L (no)	1989-04-07
OA08958A (en)	1990-11-30
HUT48884A (en)	1989-07-28
AR248407A1 (es)	1995-08-18
DE3888913D1 (de)	1994-05-11
PL275093A1 (en)	1989-05-02
FI884554L (fi)	1989-04-07

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