EG18927A - Non-peptidic renin inhibitors - Google Patents

Non-peptidic renin inhibitors

Info

Publication number
EG18927A
EG18927A EG62988A EG62988A EG18927A EG 18927 A EG18927 A EG 18927A EG 62988 A EG62988 A EG 62988A EG 62988 A EG62988 A EG 62988A EG 18927 A EG18927 A EG 18927A
Authority
EG
Egypt
Prior art keywords
alkyl
renin inhibitors
peptidic renin
peptidic
halovinyl
Prior art date
Application number
EG62988A
Other languages
English (en)
Inventor
Robert L Rosati
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of EG18927A publication Critical patent/EG18927A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Detergent Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EG62988A 1987-12-15 1988-12-14 Non-peptidic renin inhibitors EG18927A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13237387A 1987-12-15 1987-12-15

Publications (1)

Publication Number Publication Date
EG18927A true EG18927A (en) 1996-03-31

Family

ID=22453720

Family Applications (1)

Application Number Title Priority Date Filing Date
EG62988A EG18927A (en) 1987-12-15 1988-12-14 Non-peptidic renin inhibitors

Country Status (27)

Country Link
EP (1) EP0321192B1 (cs)
JP (1) JPH0692366B2 (cs)
KR (1) KR900009022B1 (cs)
CN (1) CN1025676C (cs)
AT (1) ATE96433T1 (cs)
AU (1) AU593181B2 (cs)
CA (1) CA1314545C (cs)
CS (1) CS274671B2 (cs)
DD (1) DD283381A5 (cs)
DE (1) DE3885252T2 (cs)
DK (1) DK694888A (cs)
EG (1) EG18927A (cs)
ES (1) ES2059540T3 (cs)
FI (1) FI88295C (cs)
HU (1) HU201564B (cs)
IE (1) IE61548B1 (cs)
IL (1) IL88619A0 (cs)
MX (1) MX14210A (cs)
MY (1) MY104354A (cs)
NO (1) NO172935C (cs)
NZ (1) NZ227322A (cs)
PH (1) PH26974A (cs)
PL (1) PL152507B1 (cs)
PT (1) PT89210B (cs)
SU (1) SU1651786A3 (cs)
YU (1) YU46686B (cs)
ZA (1) ZA889307B (cs)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2638747B1 (fr) * 1988-11-08 1993-12-24 Synthelabo Derives de phenyloxypropanolamines, leur preparation et leur application en therapeutique
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
DE4035846A1 (de) * 1990-11-10 1991-06-06 Kuntze Angelgeraete Dam Angelrolle mit spule zur aufnahme der angelschnur
SK112899A3 (en) 1997-02-26 2001-05-10 Pfizer Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
EP1498417A1 (en) * 2000-02-04 2005-01-19 Pfizer Products Inc. Heterocyclic amide derivatives
BR0108002A (pt) * 2000-02-04 2002-10-29 Pfizer Prod Inc Derivados de amidas heterocìclicas
US20040097554A1 (en) * 2002-10-30 2004-05-20 Pfizer Inc Heteroaryl-hexanoic acid amide derivatives as immonomodulatory agents
CN100480249C (zh) * 2003-05-21 2009-04-22 普罗西迪恩有限公司 作为糖原磷酸化酶抑制剂的吡咯并吡啶-2-甲酸酰胺
EP1636224B1 (en) * 2003-05-21 2010-07-14 Prosidion Limited Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phoshorylase
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
CA2600973C (en) * 2003-11-26 2012-08-07 Novartis Ag .delta.-amino-.gamma.-hydroxy-.omega.-aryl-alkanoic acid
GB0419361D0 (en) * 2004-08-31 2004-10-06 Novartis Ag Organic compounds
CN108164528B (zh) * 2018-03-31 2019-03-22 杭州巴洛特生物科技有限公司 一种酰胺类衍生物及其在高血压、高血脂和动脉粥样硬化中的应用
CN108218865B (zh) * 2018-03-31 2020-06-26 济南市儿童医院 一种酰胺类衍生物及其在心脑血管方面的应用
CN108456207B (zh) * 2018-03-31 2020-11-20 浙江药苑生物科技有限公司 一种酰胺类衍生物及其在心脑血管方面的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0181110A3 (en) * 1984-10-22 1988-05-11 Kissei Pharmaceutical Co. Ltd. Histidine derivatives as renin inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives

Also Published As

Publication number Publication date
CS274671B2 (en) 1991-09-15
AU2688188A (en) 1989-06-15
IL88619A0 (en) 1989-07-31
PT89210A (pt) 1989-12-29
NZ227322A (en) 1990-06-26
NO885549L (no) 1989-06-16
CN1025676C (zh) 1994-08-17
DK694888D0 (da) 1988-12-14
EP0321192B1 (en) 1993-10-27
DE3885252D1 (de) 1993-12-02
NO885549D0 (no) 1988-12-14
MX14210A (es) 1993-05-01
FI88295B (fi) 1993-01-15
PH26974A (en) 1992-12-28
IE883731L (en) 1989-06-15
JPH0692366B2 (ja) 1994-11-16
NO172935C (no) 1993-09-29
HUT48277A (en) 1989-05-29
CS820388A2 (en) 1990-10-12
YU46686B (sh) 1994-04-05
CN1034366A (zh) 1989-08-02
HU201564B (en) 1990-11-28
FI885783A0 (fi) 1988-12-14
ES2059540T3 (es) 1994-11-16
DK694888A (da) 1989-08-11
JPH01250345A (ja) 1989-10-05
PL276363A1 (en) 1989-08-07
YU225788A (en) 1990-04-30
FI88295C (fi) 1993-04-26
EP0321192A3 (en) 1991-01-30
ZA889307B (en) 1990-08-29
EP0321192A2 (en) 1989-06-21
ATE96433T1 (de) 1993-11-15
AU593181B2 (en) 1990-02-01
PL152507B1 (en) 1991-01-31
NO172935B (no) 1993-06-21
KR890009867A (ko) 1989-08-04
CA1314545C (en) 1993-03-16
IE61548B1 (en) 1994-11-16
DD283381A5 (de) 1990-10-10
SU1651786A3 (ru) 1991-05-23
KR900009022B1 (ko) 1990-12-17
PT89210B (pt) 1993-09-30
MY104354A (en) 1994-03-31
DE3885252T2 (de) 1994-02-17
FI885783A7 (fi) 1989-06-16

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