EG19122A - Process for preparing of -2- substituted oxindole derivatives - Google Patents

Process for preparing of -2- substituted oxindole derivatives

Info

Publication number: EG19122A
Authority: EG; Egypt
Prior art keywords: preparing; oxindole derivatives; substituted oxindole; substituted; derivatives
Prior art date: 1989-04-18

Application number

EG23590A

Other languages

English (en)

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-18

Filing date

1990-04-18

Publication date

1994-07-30

1990-04-18 Application filed by Pfizer filed Critical Pfizer

1994-07-30 Application granted granted Critical

1994-07-30 Publication of EG19122A publication Critical patent/EG19122A/xx

Links

238000004519 manufacturing process Methods 0.000 title 1
125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Hematology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

EG23590A 1989-04-18 1990-04-18 Process for preparing of -2- substituted oxindole derivatives EG19122A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34011389A	1989-04-18	1989-04-18

Publications (1)

Publication Number	Publication Date
EG19122A true EG19122A (en)	1994-07-30

Family

ID=23331948

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG23590A EG19122A (en)	1989-04-18	1990-04-18	Process for preparing of -2- substituted oxindole derivatives

Country Status (33)

Country	Link
US (4)	US5047554A (pl)
EP (1)	EP0393936B1 (pl)
JP (2)	JP2506478B2 (pl)
KR (1)	KR920006394B1 (pl)
CN (1)	CN1022832C (pl)
AP (1)	AP142A (pl)
AT (1)	ATE118767T1 (pl)
AU (1)	AU633767B2 (pl)
BG (1)	BG60646B1 (pl)
CA (1)	CA2014467C (pl)
CZ (1)	CZ284340B6 (pl)
DD (1)	DD293822A5 (pl)
DE (1)	DE69017066T2 (pl)
DK (1)	DK0393936T3 (pl)
EG (1)	EG19122A (pl)
ES (1)	ES2068334T3 (pl)
FI (1)	FI106378B (pl)
GR (1)	GR3015811T3 (pl)
HU (2)	HUT58314A (pl)
IE (1)	IE65091B1 (pl)
IL (3)	IL110173A (pl)
IS (1)	IS1636B (pl)
MA (1)	MA21808A1 (pl)
MX (1)	MX20359A (pl)
NO (1)	NO176759C (pl)
NZ (1)	NZ233320A (pl)
OA (1)	OA09205A (pl)
PL (2)	PL163951B1 (pl)
PT (1)	PT93785B (pl)
RO (1)	RO106402B1 (pl)
RU (2)	RU2039042C1 (pl)
YU (1)	YU47588B (pl)
ZA (1)	ZA902871B (pl)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5118703A (en) *	1988-10-18	1992-06-02	Pfizer Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
EP0365194B1 (en) *	1988-10-18	1995-08-02	Pfizer Inc.	Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives
IL95880A (en) *	1989-10-13	1995-12-31	Pfizer	Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
TW438798B (en) *	1992-10-07	2001-06-07	Pfizer	3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
DE69306595T2 (de) *	1992-11-23	1997-04-03	Pfizer	Regioselektive synthese von 4-chlor-2-thiophencarbonsäure
US5298522A (en) *	1993-01-22	1994-03-29	Pfizer Inc.	6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
US5607959A (en) *	1993-02-09	1997-03-04	Pfizer Inc.	Oxindole 1-[N-(alkoxycarbonyl) ] carboxamides and 1-(N-carboxamido) carboxamides as antiinflammatory agents
ES2076106B1 (es) *	1993-08-26	1996-06-16	Pfizer	Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5783664A (en) *	1993-09-17	1998-07-21	Smithkline Beecham Corporation	Cytokine suppressive anit-inflammatory drug binding proteins
EP0679396A1 (en) *	1994-03-02	1995-11-02	Pfizer Inc.	Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
CN1051452C (zh) *	1994-07-26	2000-04-19	中国医学科学院血液学研究所	3-取代芳基氧化吲哚类化合物的应用
US5545656A (en) *	1995-04-05	1996-08-13	Pfizer Inc.	2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
AU7503496A (en) *	1995-12-19	1997-07-14	Pfizer Inc.	Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (en) *	1996-08-21	1998-03-04	Pfizer Inc.	Stable, long acting salts of carboxamides for the treatment of joint disease
AU6226598A (en) *	1997-04-04	1998-10-30	Pfizer Inc.	Processes and intermediates for preparing 2-fluorothiophene derivatives
US6291514B1 (en)	1998-02-09	2001-09-18	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
GB9818641D0 (en) *	1998-08-26	1998-10-21	Rh Ne Poulenc Rorer Limited	Chemical compounds
US6649645B1 (en) *	1998-12-23	2003-11-18	Pharmacia Corporation	Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US6355648B1 (en)	1999-05-04	2002-03-12	American Home Products Corporation	Thio-oxindole derivatives
US6509334B1 (en)	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
HRP20020751B1 (hr)	2000-02-15	2011-01-31	Sugen	Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
KR20030010589A (ko) *	2000-03-09	2003-02-05	오노 야꾸힝 고교 가부시키가이샤	인돌 유도체, 그 제조 방법 및 용도
AU2002230056A1 (en) *	2001-01-29	2002-08-12	Insight Strategy And Marketing Ltd	Indole derivatives and their uses as heparanase inhibitors
AR042586A1 (es) *	2001-02-15	2005-06-29	Sugen Inc	3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
WO2002070478A1 (en) *	2001-03-06	2002-09-12	Astrazeneca Ab	Indolone derivatives having vascular-damaging activity
JP2005508953A (ja)	2001-10-10	2005-04-07	スージェン・インコーポレーテッド	キナーゼ阻害剤としての３−［４−（置換ヘテロサイクリル）−ピロール−２−イルメチリデン］−２−インドリノン誘導体
GT200300083A (es) *	2002-04-22	2004-03-29	Pfizer	Inhibidores selectivos de la ciclooxigenasa-2
AP2007004244A0 (en)	2005-05-10	2007-12-31	Intermune Inc	Method of modulating stress-activated protein kinase system
DOP2007000068A (es) *	2006-04-12	2007-10-31	Sanofi Aventis Us Llc	Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
US8222243B2 (en) *	2007-08-27	2012-07-17	Dart Neuroscience (Cayman) Ltd	Therapeutic isoxazole compounds
EP2296653B1 (en)	2008-06-03	2016-01-27	Intermune, Inc.	Compounds and methods for treating inflammatory and fibrotic disorders
CN107233337A (zh)	2009-04-29	2017-10-10	阿马里纳药物爱尔兰有限公司	含有epa和心血管剂的药物组合物以及使用其的方法
US8933248B2 (en)	2012-06-21	2015-01-13	Council Of Scientific & Industrial Research	3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
RU2692485C2 (ru)	2014-04-02	2019-06-25	Интермьюн, Инк.	Противофиброзные пиридиноны
BR122021017872B1 (pt)	2014-06-06	2021-11-23	Basf Se	Uso dos compostos, composição agroquímica e método para o combate dos fungos fitopatogênicos
WO2016150937A1 (en)	2015-03-25	2016-09-29	Lonza Ltd	Method for preparation of thiophenecarbonyl chlorides
EP3373735A1 (en)	2015-11-13	2018-09-19	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
AR106679A1 (es)	2015-11-13	2018-02-07	Basf Se	Oxadiazoles sustituidos para combatir hongos fitopatógenos
KR20180083419A (ko)	2015-11-19	2018-07-20	바스프 에스이	식물병원성 진균을 퇴치하기 위한 치환 옥사디아졸
US10986839B2 (en)	2016-04-11	2021-04-27	Basf Se	Substituted oxadiazoles for combating phytopathogenic fungi
CN108299354A (zh) *	2017-01-12	2018-07-20	中国科学院宁波材料技术与工程研究所	一种2,5-呋喃二甲酸或其酯化物的制备方法
CN115403566B (zh) *	2022-09-21	2024-01-30	山东大学	3-取代吲哚-2-酮化合物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1255658A (en) *	1917-11-12	1918-02-05	Adamson Stephens Mfg Co	Carrier for belt conveyers.
BE756447A (fr) *	1969-10-15	1971-03-22	Pfizer	Oxindolecarboxamides
US3900563A (en) *	1973-06-18	1975-08-19	American Cyanamid Co	Method of using 3-(2-(4-phenyl-1-piperazinyl)ethyl)-indolines
US4721712A (en) *	1984-06-12	1988-01-26	Pfizer Inc.	1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
US4556672A (en) *	1984-03-19	1985-12-03	Pfizer Inc.	3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN162090B (pl) *	1984-03-19	1988-03-26	Pfizer
IN161509B (pl) *	1984-05-04	1987-12-19	Pfizer
US4569942A (en) *	1984-05-04	1986-02-11	Pfizer Inc.	N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
HU203238B (en) *	1984-08-24	1991-06-28	Pfizer	Process for producing antiinflammatory tricyclic oxindole derivatives
FI80270C (fi) *	1984-09-19	1990-05-10	Pfizer	Foerfarande foer framstaellning av analgetiska och anti-inflammatoriska 1,3-diacyl-2-oxoindol-foereningar och mellanprodukter.
US4808601A (en) *	1984-09-19	1989-02-28	Pfizer Inc.	Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4690943A (en) *	1984-09-19	1987-09-01	Pfizer Inc.	Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) *	1985-06-20	1988-06-21	Pfizer Inc.	Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
WO1988003658A1 (en) *	1986-11-14	1988-05-19	Kalervo Alfred August Hermas	Lens for receiving and/or transmitting infrared radiation
US4962117A (en) *	1987-11-25	1990-10-09	Merck Frosst Canada, Inc.	Heterazole dialkanoic acids
US4861794A (en) *	1988-04-13	1989-08-29	Pfizer Inc.	3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) *	1989-04-18	1991-09-10	Pfizer Inc.	3-substituted-2-oxindole derivatives

1990
- 1990-01-31 US US07/473,266 patent/US5047554A/en not_active Expired - Lifetime
- 1990-04-08 IL IL110173A patent/IL110173A/xx not_active IP Right Cessation
- 1990-04-08 IL IL9404790A patent/IL94047A/en not_active IP Right Cessation
- 1990-04-09 IS IS3570A patent/IS1636B/is unknown
- 1990-04-09 AP APAP/P/1990/000175A patent/AP142A/en active
- 1990-04-12 NZ NZ233320A patent/NZ233320A/xx unknown
- 1990-04-12 EP EP90303992A patent/EP0393936B1/en not_active Expired - Lifetime
- 1990-04-12 DK DK90303992.3T patent/DK0393936T3/da active
- 1990-04-12 DE DE69017066T patent/DE69017066T2/de not_active Expired - Fee Related
- 1990-04-12 CZ CS901848A patent/CZ284340B6/cs not_active IP Right Cessation
- 1990-04-12 AT AT90303992T patent/ATE118767T1/de not_active IP Right Cessation
- 1990-04-12 ES ES90303992T patent/ES2068334T3/es not_active Expired - Lifetime
- 1990-04-12 OA OA59776A patent/OA09205A/xx unknown
- 1990-04-12 CA CA002014467A patent/CA2014467C/en not_active Expired - Fee Related
- 1990-04-16 BG BG91773A patent/BG60646B1/bg unknown
- 1990-04-17 PT PT93785A patent/PT93785B/pt not_active IP Right Cessation
- 1990-04-17 CN CN90102176A patent/CN1022832C/zh not_active Expired - Fee Related
- 1990-04-17 FI FI901915A patent/FI106378B/fi not_active IP Right Cessation
- 1990-04-17 PL PL90287812A patent/PL163951B1/pl unknown
- 1990-04-17 ZA ZA902871A patent/ZA902871B/xx unknown
- 1990-04-17 MA MA22068A patent/MA21808A1/fr unknown
- 1990-04-17 NO NO901684A patent/NO176759C/no not_active IP Right Cessation
- 1990-04-17 PL PL90284817A patent/PL163941B1/pl unknown
- 1990-04-17 RO RO144837A patent/RO106402B1/ro unknown
- 1990-04-17 YU YU75590A patent/YU47588B/sh unknown
- 1990-04-17 HU HU902462A patent/HUT58314A/hu unknown
- 1990-04-17 KR KR1019900005296A patent/KR920006394B1/ko not_active Expired
- 1990-04-18 IE IE136090A patent/IE65091B1/en not_active IP Right Cessation
- 1990-04-18 MX MX2035990A patent/MX20359A/es unknown
- 1990-04-18 JP JP2102775A patent/JP2506478B2/ja not_active Expired - Fee Related
- 1990-04-18 EG EG23590A patent/EG19122A/xx active
- 1990-04-18 DD DD90339845A patent/DD293822A5/de not_active IP Right Cessation
1991
- 1991-06-05 US US07/712,169 patent/US5290802A/en not_active Expired - Fee Related
- 1991-10-01 RU SU5001607/04A patent/RU2039042C1/ru not_active IP Right Cessation
1992
- 1992-01-28 AU AU10510/92A patent/AU633767B2/en not_active Ceased
- 1992-01-31 RU SU925010870A patent/RU2073671C1/ru active
1993
- 1993-11-04 US US08/148,764 patent/US5919809A/en not_active Expired - Fee Related
1994
- 1994-06-30 IL IL11017394A patent/IL110173A0/xx unknown
- 1994-08-08 JP JP6186078A patent/JP2581525B2/ja not_active Expired - Fee Related
1995
- 1995-04-17 GR GR950400941T patent/GR3015811T3/el unknown
- 1995-06-07 US US08/477,729 patent/US6174883B1/en not_active Expired - Fee Related
- 1995-06-23 HU HU95P/P00430P patent/HU211150A9/hu unknown

Also Published As

Publication number	Publication date
DK0393936T3 (da)	1995-06-26
YU47588B (sh)	1995-10-24
KR900016189A (ko)	1990-11-12
US5047554A (en)	1991-09-10
PL163951B1 (pl)	1994-05-31
ES2068334T3 (es)	1995-04-16
GR3015811T3 (en)	1995-07-31
JP2506478B2 (ja)	1996-06-12
IE901360L (en)	1990-10-18
RU2073671C1 (ru)	1997-02-20
HU902462D0 (en)	1990-08-28
BG60646B1 (bg)	1995-11-30
NO901684L (no)	1990-10-19
BG91773A (bg)	1993-12-24
PL284817A1 (en)	1991-03-25
ATE118767T1 (de)	1995-03-15
CN1046525A (zh)	1990-10-31
HU211150A9 (en)	1995-10-30
OA09205A (en)	1992-06-30
PT93785B (pt)	1996-09-30
CA2014467A1 (en)	1990-10-18
JPH02292258A (ja)	1990-12-03
NO176759C (no)	1995-05-24
IE65091B1 (en)	1995-10-04
IS1636B (is)	1996-09-20
CZ184890A3 (cs)	1998-07-15
CN1022832C (zh)	1993-11-24
FI106378B (fi)	2001-01-31
CZ284340B6 (cs)	1998-10-14
RO106402B1 (ro)	1993-04-30
ZA902871B (en)	1991-11-27
JPH07118261A (ja)	1995-05-09
EP0393936B1 (en)	1995-02-22
RU2039042C1 (ru)	1995-07-09
IL110173A0 (en)	1994-10-07
AU5362690A (en)	1990-11-22
MX20359A (es)	1994-02-28
JP2581525B2 (ja)	1997-02-12
DD293822A5 (de)	1991-09-12
NO176759B (no)	1995-02-13
DE69017066T2 (de)	1995-06-14
CA2014467C (en)	2000-02-08
AP142A (en)	1991-09-26
US5290802A (en)	1994-03-01
US6174883B1 (en)	2001-01-16
PT93785A (pt)	1990-11-20
AP9000175A0 (en)	1990-04-30
IL110173A (en)	1997-06-10
NZ233320A (en)	1991-09-25
MA21808A1 (fr)	1990-12-31
AU633767B2 (en)	1993-02-04
AU621477B2 (en)	1992-03-12
IL94047A0 (en)	1991-01-31
YU75590A (sh)	1992-07-20
NO901684D0 (no)	1990-04-17
PL287812A1 (en)	1991-07-15
US5919809A (en)	1999-07-06
DE69017066D1 (de)	1995-03-30
IS3570A7 (is)	1990-10-19
EP0393936A1 (en)	1990-10-24
IL94047A (en)	1995-10-31
KR920006394B1 (ko)	1992-08-06
HUT58314A (en)	1992-02-28
AU1051092A (en)	1992-04-09
PL163941B1 (pl)	1994-05-31
FI901915A0 (fi)	1990-04-17

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