IS3570A7 - Aðferð við framleiðslu á efnasamsetningu sem gerð er úr uppbótarefnum (3-substistuted) og kristalsamböndum (2-oxindole) - Google Patents

Aðferð við framleiðslu á efnasamsetningu sem gerð er úr uppbótarefnum (3-substistuted) og kristalsamböndum (2-oxindole)

Info

Publication number
IS3570A7
IS3570A7 IS3570A IS3570A IS3570A7 IS 3570 A7 IS3570 A7 IS 3570A7 IS 3570 A IS3570 A IS 3570A IS 3570 A IS3570 A IS 3570A IS 3570 A7 IS3570 A7 IS 3570A7
Authority
IS
Iceland
Prior art keywords
oxindole
additives
substituted
preparation
chemical composition
Prior art date
Application number
IS3570A
Other languages
English (en)
Other versions
IS1636B (is
Inventor
Jacob Ehrgott Frederick
Joseph Goddard Carl
Richard Schulte Gary
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of IS3570A7 publication Critical patent/IS3570A7/is
Publication of IS1636B publication Critical patent/IS1636B/is

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
IS3570A 1989-04-18 1990-04-09 Aðferð við framleiðslu á efnasamsetningu sem gerðer úr uppbótarefnum (3-substistuted) og kristalsamböndum (2-oxindole) IS1636B (is)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34011389A 1989-04-18 1989-04-18

Publications (2)

Publication Number Publication Date
IS3570A7 true IS3570A7 (is) 1990-10-19
IS1636B IS1636B (is) 1996-09-20

Family

ID=23331948

Family Applications (1)

Application Number Title Priority Date Filing Date
IS3570A IS1636B (is) 1989-04-18 1990-04-09 Aðferð við framleiðslu á efnasamsetningu sem gerðer úr uppbótarefnum (3-substistuted) og kristalsamböndum (2-oxindole)

Country Status (33)

Country Link
US (4) US5047554A (is)
EP (1) EP0393936B1 (is)
JP (2) JP2506478B2 (is)
KR (1) KR920006394B1 (is)
CN (1) CN1022832C (is)
AP (1) AP142A (is)
AT (1) ATE118767T1 (is)
AU (1) AU633767B2 (is)
BG (1) BG60646B1 (is)
CA (1) CA2014467C (is)
CZ (1) CZ284340B6 (is)
DD (1) DD293822A5 (is)
DE (1) DE69017066T2 (is)
DK (1) DK0393936T3 (is)
EG (1) EG19122A (is)
ES (1) ES2068334T3 (is)
FI (1) FI106378B (is)
GR (1) GR3015811T3 (is)
HU (2) HUT58314A (is)
IE (1) IE65091B1 (is)
IL (3) IL94047A (is)
IS (1) IS1636B (is)
MA (1) MA21808A1 (is)
MX (1) MX20359A (is)
NO (1) NO176759C (is)
NZ (1) NZ233320A (is)
OA (1) OA09205A (is)
PL (2) PL163951B1 (is)
PT (1) PT93785B (is)
RO (1) RO106402B1 (is)
RU (2) RU2039042C1 (is)
YU (1) YU47588B (is)
ZA (1) ZA902871B (is)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208421B (en) * 1988-10-18 1993-10-28 Pfizer Process for producing starting materials for producing 3-acyl-2-oxindol-carboxamides ofantiphlogistic activity
EP0365194B1 (en) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
IL95880A (en) * 1989-10-13 1995-12-31 Pfizer Use of 3-Transformed History of 2-Oxindole for the Preparation of Pharmaceuticals for Inhibition of Interlaukio-1 Biosynthesis
US5064851A (en) * 1990-07-24 1991-11-12 Pfizer Inc. 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
ATE146181T1 (de) * 1992-11-23 1996-12-15 Pfizer Regioselektive synthese von 4-chlor-2- thiophencarbonsäure
US5298522A (en) * 1993-01-22 1994-03-29 Pfizer Inc. 6-chloro-5-fluoro-3-(2-thenoyl)-2-oxindole-1-carboxamide as an analgesic and anti-inflammatory agent while maintaining a normal urine protein/creatinine ratio
WO1994018194A1 (en) * 1993-02-09 1994-08-18 Pfizer Inc. Oxindole 1-[n-(alkoxycarbonyl)]carboxamides and 1-(n-carboxamido)carboxamides as intiinflammatory agents
ES2076106B1 (es) * 1993-08-26 1996-06-16 Pfizer Composiciones farmaceuticas a base de 2-oxindol-1-carboxamidas 3-sustituidas
US5783664A (en) * 1993-09-17 1998-07-21 Smithkline Beecham Corporation Cytokine suppressive anit-inflammatory drug binding proteins
EP0679396A1 (en) * 1994-03-02 1995-11-02 Pfizer Inc. Use of 3-substituted-2-oxidole-1-carboxamides for the manufacture of a medicament in the treatment and prevention of ischemia induced myocardial injury and cytokine mediated myocardial injury
CN1051452C (zh) * 1994-07-26 2000-04-19 中国医学科学院血液学研究所 3-取代芳基氧化吲哚类化合物的应用
US5545656A (en) * 1995-04-05 1996-08-13 Pfizer Inc. 2-Oxidole-1-carboxamide pharmaceutical agents for the treatment of alzheimer's disease
WO1997022605A1 (en) * 1995-12-19 1997-06-26 Pfizer Inc. Stable, long acting salts of indole derivatives for the treatment of joint diseases
EP0826685A1 (en) * 1996-08-21 1998-03-04 Pfizer Inc. Stable, long acting salts of carboxamides for the treatment of joint disease
AU6226598A (en) * 1997-04-04 1998-10-30 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
GB9818641D0 (en) * 1998-08-26 1998-10-21 Rh Ne Poulenc Rorer Limited Chemical compounds
US6649645B1 (en) * 1998-12-23 2003-11-18 Pharmacia Corporation Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
US6355648B1 (en) 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
DE122008000002I1 (de) * 2000-02-15 2008-04-17 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
MXPA02008801A (es) * 2000-03-09 2003-07-07 Ono Pharmaceutical Co Derivados de indol, proceso para la preparacion de los mismos y su uso.
WO2002060373A2 (en) * 2001-01-29 2002-08-08 Insight Strategy And Marketing Ltd Indole derivatives and their uses as heparanase inhibitors
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
JP2004529110A (ja) * 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
EP1434774A1 (en) 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituted heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors
BR0309412A (pt) * 2002-04-22 2005-02-01 Pfizer Prod Inc Indol-2-onas como inibidores seletivos da ciclooxigenase-2
RS53599B1 (sr) 2005-05-10 2015-02-27 Intermune, Inc. Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza
AR060403A1 (es) * 2006-04-12 2008-06-11 Sanofi Aventis Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2
CA2696609C (en) 2007-08-27 2017-09-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン， インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
US8933248B2 (en) 2012-06-21 2015-01-13 Council Of Scientific & Industrial Research 3-substituted-3-hydroxy oxindole derivatives and process for preparation thereof
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
CN106459042B (zh) 2014-04-02 2019-06-28 英特穆恩公司 抗纤维化吡啶酮类
BR122021017881B1 (pt) 2014-06-06 2021-11-23 Basf Se Uso dos compostos, composição agroquímica e método para o combate dos fungos fitopatogênicos
WO2016150937A1 (en) 2015-03-25 2016-09-29 Lonza Ltd Method for preparation of thiophenecarbonyl chlorides
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
WO2017081309A1 (en) 2015-11-13 2017-05-18 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN108289449A (zh) 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
US10986839B2 (en) 2016-04-11 2021-04-27 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN108299354A (zh) * 2017-01-12 2018-07-20 中国科学院宁波材料技术与工程研究所 一种2,5-呋喃二甲酸或其酯化物的制备方法
CN115403566B (zh) * 2022-09-21 2024-01-30 山东大学 3-取代吲哚-2-酮化合物及其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1255658A (en) * 1917-11-12 1918-02-05 Adamson Stephens Mfg Co Carrier for belt conveyers.
BE756447A (fr) * 1969-10-15 1971-03-22 Pfizer Oxindolecarboxamides
US3900563A (en) * 1973-06-18 1975-08-19 American Cyanamid Co Method of using 3-(2-(4-phenyl-1-piperazinyl)ethyl)-indolines
US4721712A (en) * 1984-06-12 1988-01-26 Pfizer Inc. 1,3-disubstituted 2-oxindoles as analgesic and anti-inflammatory agents
IN162090B (is) * 1984-03-19 1988-03-26 Pfizer
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
IN161509B (is) * 1984-05-04 1987-12-19 Pfizer
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
HU203350B (en) * 1984-08-24 1991-07-29 Pfizer Process for producing antiinflammatory tricyclic oxindole derivatives
US4808601A (en) * 1984-09-19 1989-02-28 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
FI80270C (fi) * 1984-09-19 1990-05-10 Pfizer Foerfarande foer framstaellning av analgetiska och anti-inflammatoriska 1,3-diacyl-2-oxoindol-foereningar och mellanprodukter.
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
US4752609A (en) * 1985-06-20 1988-06-21 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
WO1988003658A1 (en) * 1986-11-14 1988-05-19 Kalervo Alfred August Hermas Lens for receiving and/or transmitting infrared radiation
US4962117A (en) * 1987-11-25 1990-10-09 Merck Frosst Canada, Inc. Heterazole dialkanoic acids
US4861794A (en) * 1988-04-13 1989-08-29 Pfizer Inc. 3-substituted-2-oxindole-1-carboxamides as inhibitors of interleukin-1 biosynthesis
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives

Also Published As

Publication number Publication date
NO176759B (no) 1995-02-13
JP2581525B2 (ja) 1997-02-12
FI106378B (fi) 2001-01-31
IL110173A0 (en) 1994-10-07
JPH02292258A (ja) 1990-12-03
IE65091B1 (en) 1995-10-04
AU5362690A (en) 1990-11-22
DE69017066D1 (de) 1995-03-30
IL94047A (en) 1995-10-31
PL163951B1 (pl) 1994-05-31
AU621477B2 (en) 1992-03-12
BG91773A (bg) 1993-12-24
IS1636B (is) 1996-09-20
AP9000175A0 (en) 1990-04-30
MX20359A (es) 1994-02-28
ATE118767T1 (de) 1995-03-15
CN1046525A (zh) 1990-10-31
AP142A (en) 1991-09-26
EP0393936A1 (en) 1990-10-24
PL163941B1 (pl) 1994-05-31
CN1022832C (zh) 1993-11-24
PL284817A1 (en) 1991-03-25
CA2014467A1 (en) 1990-10-18
HUT58314A (en) 1992-02-28
RU2039042C1 (ru) 1995-07-09
DE69017066T2 (de) 1995-06-14
RO106402B1 (ro) 1993-04-30
ZA902871B (en) 1991-11-27
NO901684D0 (no) 1990-04-17
US5047554A (en) 1991-09-10
US6174883B1 (en) 2001-01-16
OA09205A (en) 1992-06-30
CA2014467C (en) 2000-02-08
FI901915A0 (fi) 1990-04-17
PT93785B (pt) 1996-09-30
JP2506478B2 (ja) 1996-06-12
NZ233320A (en) 1991-09-25
HU211150A9 (en) 1995-10-30
EG19122A (en) 1994-07-30
CZ184890A3 (cs) 1998-07-15
DK0393936T3 (da) 1995-06-26
JPH07118261A (ja) 1995-05-09
KR920006394B1 (ko) 1992-08-06
GR3015811T3 (en) 1995-07-31
IE901360L (en) 1990-10-18
PL287812A1 (en) 1991-07-15
CZ284340B6 (cs) 1998-10-14
NO176759C (no) 1995-05-24
BG60646B1 (bg) 1995-11-30
DD293822A5 (de) 1991-09-12
US5919809A (en) 1999-07-06
EP0393936B1 (en) 1995-02-22
US5290802A (en) 1994-03-01
HU902462D0 (en) 1990-08-28
KR900016189A (ko) 1990-11-12
RU2073671C1 (ru) 1997-02-20
AU1051092A (en) 1992-04-09
MA21808A1 (fr) 1990-12-31
IL110173A (en) 1997-06-10
YU47588B (sh) 1995-10-24
ES2068334T3 (es) 1995-04-16
PT93785A (pt) 1990-11-20
NO901684L (no) 1990-10-19
YU75590A (sh) 1992-07-20
AU633767B2 (en) 1993-02-04
IL94047A0 (en) 1991-01-31

Similar Documents

Publication Publication Date Title
IS3570A7 (is) Aðferð við framleiðslu á efnasamsetningu sem gerð er úr uppbótarefnum (3-substistuted) og kristalsamböndum (2-oxindole)
NO842340L (no) Fremgangsmaate og sammensetninger for frakturering av underjordiske formasjoner
DK664887A (da) 3-substituerede 3-aroyloxy-propanaminer og fremgangsmaade til fremstilling deraf
NO893559D0 (no) Flamme- og roekhemmende blanding for isolasjon av traad og kontakter.
GR80171B (en) N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use
NO172950C (no) Framgangsmaate og apparat for broennboring
NO875259D0 (no) Fremgangsmaate og anordning for fremstilling av syntesegass
DK566484D0 (da) Dihydropyridinderivat og fremgangsmaade til fremstilling deraf
DK456884A (da) Sammensaetning og fremgangsmaade til fremstilling af vandige borevaeskeadditiver
NO168124C (no) Innretning og fremgangsmaate for innfoering og blanding paa stedet av hydroksyaluminium i kvikkleire
NO842095L (no) Fremgangsmaate for fremstilling av etylen og propylen
NO884416D0 (no) Krystallinsk beta-laktamhydrat og fremgangsmaate for fremstilling derav.
NO160916C (no) Fremgangsmaate og anordning for dannelse av glassfibere.
NO845005L (no) Fremgangsmaate for fremstilling av antibiotikum l 17392 (deglukoteicoplanin) og salter derav
NO159436C (no) Stabilisert beleggingsblanding og fremgangsmaate til belegging av glassbeholdere med tinnoksid.
NO171045C (no) Anordning og fremgangsmaate for fremstilling av syntesegass
GB2202876B (en) Cementing aggregate apparatus and method
NO884447D0 (no) Fremgangsmaate for maling under vann og anordning for paafoering av malingen.
FI870565L (fi) Halogenoitujen imidien valmistusmenetelmä, niitä sisältävät koostumukset ja niiden käyttö tulenkestäviksi tekevinä aineina
NO901272L (no) Sammensetning og fremgangsmaate for fjerning av sulfider.
NO166726C (no) Fremgangsmaate for fremstilling av arylglycidyletere og 3-substituerte 1-alkylamino-2-propanoler.
NO162992C (no) Prosess for fremstilling av roere og blandingsanordning for fremstillingen av roeren.
NO159764C (no) Fremgangsmaate og anordning ved fremstilling av pariserpoteter.
NO921168L (no) Fremgangsmaate og anordning for fremstilling av elementaertjod i ren form
NO840116L (no) Fremgangsmaate og anordning for frembringelse av automatisk blokkering av belasningsfrakopling naermest feilsted