EG19154A - Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate - Google Patents

Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate

Info

Publication number: EG19154A
Authority: EG; Egypt
Prior art keywords: dideoxy; monohydrate; salts; fluoroinosine; dideoxyinosine
Prior art date: 1989-05-15

Application number

EG28490A

Other languages

English (en)

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-15

Filing date

1990-05-14

Publication date

1994-09-29

1990-05-14 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1994-09-29 Application granted granted Critical

1994-09-29 Publication of EG19154A publication Critical patent/EG19154A/xx

Links

150000003839 salts Chemical class 0.000 title abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
-1 2,3 dideoxyinosine monohydrate Chemical class 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000001767 cationic compounds Chemical group 0.000 abstract 1
229960002656 didanosine Drugs 0.000 abstract 1
229910001411 inorganic cation Chemical group 0.000 abstract 1
150000002892 organic cations Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

EG28490A 1989-05-15 1990-05-14 Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate EG19154A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35206589A	1989-05-15	1989-05-15
US51426190A	1990-05-01	1990-05-01

Publications (1)

Publication Number	Publication Date
EG19154A true EG19154A (en)	1994-09-29

Family

ID=26997373

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG28490A EG19154A (en)	1989-05-15	1990-05-14	Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate

Country Status (16)

Country	Link
EP (1)	EP0398230B1 (no)
KR (1)	KR970001160B1 (no)
CN (2)	CN1027896C (no)
AT (1)	ATE162528T1 (no)
AU (1)	AU617614B2 (no)
BG (1)	BG60517B1 (no)
DE (1)	DE69031962T2 (no)
DK (1)	DK0398230T3 (no)
EG (1)	EG19154A (no)
ES (1)	ES2113851T3 (no)
FI (1)	FI95269C (no)
GR (1)	GR3025984T3 (no)
HU (1)	HU206628B (no)
IE (1)	IE81107B1 (no)
NO (2)	NO174102C (no)
PT (1)	PT94040B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO920714L (no) *	1991-03-01	1992-09-02	Bristol Myers Squibb Co	Tetrahydrofuran-mellomprodukt
US5221611A (en) *	1991-06-19	1993-06-22	Sigma Chemical Company	Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
WO1995018815A1 (en) *	1994-01-07	1995-07-13	Merrell Pharmaceuticals Inc.	Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
EP1765379A4 (en) *	2004-06-17	2009-05-27	Transform Pharmaceuticals Inc	PHARMACEUTICAL CO-CRYSTAL COMPOSITIONS AND RELEVANT USE METHOD
JP5485140B2 (ja)	2008-04-10	2014-05-07	浜理薬品工業株式会社	５−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987001284A1 (en) *	1985-08-26	1987-03-12	United States Of America, Represented By The Unite	Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) *	1986-09-24	1996-01-26	예일 유니버시티	레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) *	1986-12-17	1990-12-18	Yale University	Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) *	1987-04-17	1999-07-13	Victor E. Marquez	Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
CA1312599C (en) *	1988-02-16	1993-01-12	Larry Wayne Hertel	2',3'dideoxy-2',2'difluoronucleosides
GB8823319D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds

1990
- 1990-05-11 FI FI902360A patent/FI95269C/fi active IP Right Grant
- 1990-05-14 EP EP90109065A patent/EP0398230B1/en not_active Expired - Lifetime
- 1990-05-14 KR KR1019900006857A patent/KR970001160B1/ko not_active Expired - Fee Related
- 1990-05-14 BG BG92000A patent/BG60517B1/bg unknown
- 1990-05-14 ES ES90109065T patent/ES2113851T3/es not_active Expired - Lifetime
- 1990-05-14 IE IE173490A patent/IE81107B1/en not_active IP Right Cessation
- 1990-05-14 DK DK90109065T patent/DK0398230T3/da active
- 1990-05-14 AU AU55011/90A patent/AU617614B2/en not_active Ceased
- 1990-05-14 DE DE69031962T patent/DE69031962T2/de not_active Expired - Fee Related
- 1990-05-14 EG EG28490A patent/EG19154A/xx active
- 1990-05-14 AT AT90109065T patent/ATE162528T1/de not_active IP Right Cessation
- 1990-05-14 CN CN90103580A patent/CN1027896C/zh not_active Expired - Fee Related
- 1990-05-15 PT PT94040A patent/PT94040B/pt not_active IP Right Cessation
- 1990-05-15 HU HU903038A patent/HU206628B/hu not_active IP Right Cessation
- 1990-05-15 NO NO902148A patent/NO174102C/no unknown
1993
- 1993-09-22 NO NO933367A patent/NO176609C/no unknown
1994
- 1994-08-23 CN CN94116469A patent/CN1057443C/zh not_active Expired - Fee Related
1998
- 1998-01-22 GR GR970403458T patent/GR3025984T3/el unknown

Also Published As

Publication number	Publication date
AU5501190A (en)	1990-11-15
DK0398230T3 (da)	1998-09-21
NO933367L (no)	1990-11-16
NO933367D0 (no)	1993-09-22
PT94040A (pt)	1991-01-08
KR970001160B1 (ko)	1997-01-29
HU206628B (en)	1992-12-28
PT94040B (pt)	1996-12-31
NO176609C (no)	1995-05-03
EP0398230B1 (en)	1998-01-21
NO174102B (no)	1993-12-06
IE901734L (en)	1990-11-15
CN1109755A (zh)	1995-10-11
CN1027896C (zh)	1995-03-15
GR3025984T3 (en)	1998-04-30
CN1057443C (zh)	2000-10-18
AU617614B2 (en)	1991-11-28
HU903038D0 (en)	1990-09-28
DE69031962D1 (de)	1998-02-26
ES2113851T3 (es)	1998-05-16
KR900017591A (ko)	1990-12-19
ATE162528T1 (de)	1998-02-15
BG60517B1 (bg)	1995-07-28
NO174102C (no)	1994-03-16
FI95269B (fi)	1995-09-29
DE69031962T2 (de)	1998-09-17
NO176609B (no)	1995-01-23
FI902360A0 (fi)	1990-05-11
HUT53528A (en)	1990-11-28
CN1047676A (zh)	1990-12-12
EP0398230A3 (en)	1991-06-26
NO902148D0 (no)	1990-05-15
NO902148L (no)	1990-11-16
EP0398230A2 (en)	1990-11-22
BG92000A (bg)	1993-12-24
IE81107B1 (en)	2000-03-08
FI95269C (fi)	1996-01-10

Publication	Publication Date	Title
PL292101A1 (en)	1992-08-10	Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
ZA944739B (en)	1995-10-10	Amide and urea derivatives having anti-hypercholesteremic activity their preparation and their therapeutic uses
IL90271A0 (en)	1989-12-15	Antiviral drug
AU591640B2 (en)	1989-12-14	Quinolonecarboxylic acid derivatives
GR3004139T3 (no)	1993-03-31
ATE172463T1 (de)	1998-11-15	Pyrrolocarbazol
GB8607921D0 (en)	1986-05-08	3,4-disubstituted-2-azetidinone derivatives
EP0314098A3 (en)	1990-01-03	Imide derivatives, their production and use
GR3007460T3 (no)	1993-07-30
AU617614B2 (en)	1991-11-28	Antiviral, highly water soluble, stable, crystalline salts of 2',3'-dideoxyinosine monohydrate, 2',3'-dideoxy-2',3'-didehydrothymidine monohydrate and 2',3'-dideoxy-2'-fluoroinosine hemihydrate
GB8706662D0 (en)	1987-04-23	Anti-arrhythmia agents
MY116824A (en)	2004-04-30	Antivaral,highly water soluble,stable,crystalline salts of 2'',3''-dideoxyinosine monohydrate,2'',3''-dideoxy-2'' ,3''-didehydrothymidine monohydrate and 2'',3''-dideoxy-2''-fluoroinosine hemihydrate
ZA896741B (en)	1991-05-29	3-piperidinyl-indazole derivatives
GR3006108T3 (no)	1993-06-21
GR3015002T3 (en)	1995-05-31	1,4-Dihydro-4-oxo-3-quinolone derivatives as selectively toxic mammalian antibacterial agents.
HUT38607A (en)	1986-06-30	Process for producing phenyl-ethyl-amino-propiophenone derivatives and pharmaceutical composition containing them as active agents
EP0272849A3 (en)	1990-05-16	Use of 2-oxo-imidazolidine derivatives in the treatment of kidney diseases