NO933367L - Sterkt vannloeselige, stablie, krystallinske salter av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin og2',3'dideoksy-2'-fluorisin, og fremgangsmaate til fremstilling derav - Google Patents

Sterkt vannloeselige, stablie, krystallinske salter av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin og2',3'dideoksy-2'-fluorisin, og fremgangsmaate til fremstilling derav

Info

Publication number: NO933367L
Authority: NO; Norway
Prior art keywords: dideoxy; salts; dideoxyinosine; fluorisine; didehydrotymidine
Prior art date: 1989-05-15

Application number

NO93933367A

Other languages

English (en)

Other versions

NO933367D0 (no

NO176609C (no

NO176609B (no

Inventor

Murray Arthur Kaplan

Robert Kevin Perrone

Joseph Ballard Bogardus

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-15

Filing date

1993-09-22

Publication date

1990-11-16

1990-11-16 Publication of NO933367L publication Critical patent/NO933367L/no

1993-09-22 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1993-09-22 Priority to NO933367A priority Critical patent/NO176609C/no

1993-09-22 Publication of NO933367D0 publication Critical patent/NO933367D0/no

1995-01-23 Publication of NO176609B publication Critical patent/NO176609B/no

1995-05-03 Publication of NO176609C publication Critical patent/NO176609C/no

Links

150000003839 salts Chemical class 0.000 title abstract 3
BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical class O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 title 1
239000003443 antiviral agent Substances 0.000 abstract 1
150000001767 cationic compounds Chemical group 0.000 abstract 1
229960002656 didanosine Drugs 0.000 abstract 1
229910001411 inorganic cation Chemical group 0.000 abstract 1
150000002892 organic cations Chemical group 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

NO933367A 1989-05-15 1993-09-22 Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin NO176609C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US35206589A	1989-05-15	1989-05-15
US51426190A	1990-05-01	1990-05-01
NO902148A NO174102C (no)	1989-05-15	1990-05-15	Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Publications (4)

Publication Number	Publication Date
NO933367L true NO933367L (no)	1990-11-16
NO933367D0 NO933367D0 (no)	1993-09-22
NO176609B NO176609B (no)	1995-01-23
NO176609C NO176609C (no)	1995-05-03

Family

ID=26997373

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO902148A NO174102C (no)	1989-05-15	1990-05-15	Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO902148A NO174102C (no)	1989-05-15	1990-05-15	Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat

Country Status (16)

Country	Link
EP (1)	EP0398230B1 (no)
KR (1)	KR970001160B1 (no)
CN (2)	CN1027896C (no)
AT (1)	ATE162528T1 (no)
AU (1)	AU617614B2 (no)
BG (1)	BG60517B1 (no)
DE (1)	DE69031962T2 (no)
DK (1)	DK0398230T3 (no)
EG (1)	EG19154A (no)
ES (1)	ES2113851T3 (no)
FI (1)	FI95269C (no)
GR (1)	GR3025984T3 (no)
HU (1)	HU206628B (no)
IE (1)	IE81107B1 (no)
NO (2)	NO174102C (no)
PT (1)	PT94040B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO920714L (no) *	1991-03-01	1992-09-02	Bristol Myers Squibb Co	Tetrahydrofuran-mellomprodukt
US5221611A (en) *	1991-06-19	1993-06-22	Sigma Chemical Company	Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
WO1995018815A1 (en) *	1994-01-07	1995-07-13	Merrell Pharmaceuticals Inc.	Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
EP1765379A4 (en) *	2004-06-17	2009-05-27	Transform Pharmaceuticals Inc	PHARMACEUTICAL CO-CRYSTAL COMPOSITIONS AND RELEVANT USE METHOD
JP5485140B2 (ja)	2008-04-10	2014-05-07	浜理薬品工業株式会社	５−メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987001284A1 (en) *	1985-08-26	1987-03-12	United States Of America, Represented By The Unite	Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) *	1986-09-24	1996-01-26	예일 유니버시티	레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) *	1986-12-17	1990-12-18	Yale University	Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) *	1987-04-17	1999-07-13	Victor E. Marquez	Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
CA1312599C (en) *	1988-02-16	1993-01-12	Larry Wayne Hertel	2',3'dideoxy-2',2'difluoronucleosides
GB8823319D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds

1990
- 1990-05-11 FI FI902360A patent/FI95269C/fi active IP Right Grant
- 1990-05-14 EP EP90109065A patent/EP0398230B1/en not_active Expired - Lifetime
- 1990-05-14 KR KR1019900006857A patent/KR970001160B1/ko not_active Expired - Fee Related
- 1990-05-14 BG BG92000A patent/BG60517B1/bg unknown
- 1990-05-14 ES ES90109065T patent/ES2113851T3/es not_active Expired - Lifetime
- 1990-05-14 IE IE173490A patent/IE81107B1/en not_active IP Right Cessation
- 1990-05-14 DK DK90109065T patent/DK0398230T3/da active
- 1990-05-14 AU AU55011/90A patent/AU617614B2/en not_active Ceased
- 1990-05-14 DE DE69031962T patent/DE69031962T2/de not_active Expired - Fee Related
- 1990-05-14 EG EG28490A patent/EG19154A/xx active
- 1990-05-14 AT AT90109065T patent/ATE162528T1/de not_active IP Right Cessation
- 1990-05-14 CN CN90103580A patent/CN1027896C/zh not_active Expired - Fee Related
- 1990-05-15 PT PT94040A patent/PT94040B/pt not_active IP Right Cessation
- 1990-05-15 HU HU903038A patent/HU206628B/hu not_active IP Right Cessation
- 1990-05-15 NO NO902148A patent/NO174102C/no unknown
1993
- 1993-09-22 NO NO933367A patent/NO176609C/no unknown
1994
- 1994-08-23 CN CN94116469A patent/CN1057443C/zh not_active Expired - Fee Related
1998
- 1998-01-22 GR GR970403458T patent/GR3025984T3/el unknown

Also Published As

Publication number	Publication date
AU5501190A (en)	1990-11-15
DK0398230T3 (da)	1998-09-21
NO933367D0 (no)	1993-09-22
PT94040A (pt)	1991-01-08
KR970001160B1 (ko)	1997-01-29
HU206628B (en)	1992-12-28
PT94040B (pt)	1996-12-31
NO176609C (no)	1995-05-03
EP0398230B1 (en)	1998-01-21
NO174102B (no)	1993-12-06
EG19154A (en)	1994-09-29
IE901734L (en)	1990-11-15
CN1109755A (zh)	1995-10-11
CN1027896C (zh)	1995-03-15
GR3025984T3 (en)	1998-04-30
CN1057443C (zh)	2000-10-18
AU617614B2 (en)	1991-11-28
HU903038D0 (en)	1990-09-28
DE69031962D1 (de)	1998-02-26
ES2113851T3 (es)	1998-05-16
KR900017591A (ko)	1990-12-19
ATE162528T1 (de)	1998-02-15
BG60517B1 (bg)	1995-07-28
NO174102C (no)	1994-03-16
FI95269B (fi)	1995-09-29
DE69031962T2 (de)	1998-09-17
NO176609B (no)	1995-01-23
FI902360A0 (fi)	1990-05-11
HUT53528A (en)	1990-11-28
CN1047676A (zh)	1990-12-12
EP0398230A3 (en)	1991-06-26
NO902148D0 (no)	1990-05-15
NO902148L (no)	1990-11-16
EP0398230A2 (en)	1990-11-22
BG92000A (bg)	1993-12-24
IE81107B1 (en)	2000-03-08
FI95269C (fi)	1996-01-10

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