NO902148L - Fremgangsmaate til fremstilling av sterkt vannopploeselige,stabile, krystallinske salter av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og2',3'-dideoksy-2'-fluorinosinhemihydrat. - Google Patents

Fremgangsmaate til fremstilling av sterkt vannopploeselige,stabile, krystallinske salter av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og2',3'-dideoksy-2'-fluorinosinhemihydrat.

Info

Publication number: NO902148L
Authority: NO; Norway
Prior art keywords: dideoxy; salts; stable; water soluble; mononydryde
Prior art date: 1989-05-15

Application number

NO90902148A

Other languages

English (en)

Other versions

NO902148D0 (no

NO174102B (no

NO174102C (no

Inventor

Murray Arthur Kaplan

Robert Kevin Perrone

Joseph Ballard Bogardus

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-15

Filing date

1990-05-15

Publication date

1990-11-16

1990-05-15 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1990-05-15 Publication of NO902148D0 publication Critical patent/NO902148D0/no

1990-11-16 Publication of NO902148L publication Critical patent/NO902148L/no

1993-09-22 Priority to NO933367A priority Critical patent/NO176609C/no

1993-12-06 Publication of NO174102B publication Critical patent/NO174102B/no

1994-03-16 Publication of NO174102C publication Critical patent/NO174102C/no

Links

XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
229910001868 water Inorganic materials 0.000 title abstract 2
TYOLIMOHEMBOPU-UOERWJHTSA-N 9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;hydrate Chemical class O.O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 TYOLIMOHEMBOPU-UOERWJHTSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
239000003443 antiviral agent Substances 0.000 abstract 1
150000001767 cationic compounds Chemical group 0.000 abstract 1
229960002656 didanosine Drugs 0.000 abstract 1
229910001411 inorganic cation Chemical group 0.000 abstract 1
150000002892 organic cations Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)

NO902148A 1989-05-15 1990-05-15 Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat NO174102C (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35206589A	1989-05-15	1989-05-15
US51426190A	1990-05-01	1990-05-01

Publications (4)

Publication Number	Publication Date
NO902148D0 NO902148D0 (no)	1990-05-15
NO902148L true NO902148L (no)	1990-11-16
NO174102B NO174102B (no)	1993-12-06
NO174102C NO174102C (no)	1994-03-16

Family

ID=26997373

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO902148A NO174102C (no)	1989-05-15	1990-05-15	Analogifremgangsmåte til fremst. av et terapeutisk aktivt, stabilt, krystallinsk vannopplöselig salt av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og 2',3'-dideoksy-2'-fluorinosinhemihydrat
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO933367A NO176609C (no)	1989-05-15	1993-09-22	Fremgangsmåte til fremstilling av et sterkt vannlöselig, stabilt, krystallinsk salt av 2',3'-dideoksyinosin, 2',3'-dideoksy-2',3'didehydrotymidin eller 2',3'dideoksy-2'-fluorinosin

Country Status (16)

Country	Link
EP (1)	EP0398230B1 (no)
KR (1)	KR970001160B1 (no)
CN (2)	CN1027896C (no)
AT (1)	ATE162528T1 (no)
AU (1)	AU617614B2 (no)
BG (1)	BG60517B1 (no)
DE (1)	DE69031962T2 (no)
DK (1)	DK0398230T3 (no)
EG (1)	EG19154A (no)
ES (1)	ES2113851T3 (no)
FI (1)	FI95269C (no)
GR (1)	GR3025984T3 (no)
HU (1)	HU206628B (no)
IE (1)	IE81107B1 (no)
NO (2)	NO174102C (no)
PT (1)	PT94040B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO920714L (no) *	1991-03-01	1992-09-02	Bristol Myers Squibb Co	Tetrahydrofuran-mellomprodukt
US5221611A (en) *	1991-06-19	1993-06-22	Sigma Chemical Company	Ddi immunoassays, derivatives, conjugates and antibodies
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
ATE186732T1 (de) *	1994-01-07	1999-12-15	Merrell Pharma Inc	(e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
JP5017103B2 (ja) *	2004-06-17	2012-09-05	トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド	薬剤共結晶組成物および関連した使用方法
US8445669B2 (en)	2008-04-10	2013-05-21	Hamari Chemicals, Ltd.	Production process of ethynylthymidine compounds from 5-methyluridine as a starting material

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987001284A1 (en) *	1985-08-26	1987-03-12	United States Of America, Represented By The Unite	Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
KR960001372B1 (ko) *	1986-09-24	1996-01-26	예일 유니버시티	레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4978655A (en) *	1986-12-17	1990-12-18	Yale University	Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
CA1340645C (en) *	1987-04-17	1999-07-13	Victor E. Marquez	Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus
ZA891076B (en) *	1988-02-16	1990-10-31	Lilly Co Eli	2',3'-dideoxy-2',2'-difluoronucleosides
GB8823319D0 (en) *	1988-10-05	1988-11-09	Nycomed As	Chemical compounds

1990
- 1990-05-11 FI FI902360A patent/FI95269C/fi active IP Right Grant
- 1990-05-14 BG BG92000A patent/BG60517B1/bg unknown
- 1990-05-14 DK DK90109065T patent/DK0398230T3/da active
- 1990-05-14 KR KR1019900006857A patent/KR970001160B1/ko not_active Expired - Fee Related
- 1990-05-14 AU AU55011/90A patent/AU617614B2/en not_active Ceased
- 1990-05-14 CN CN90103580A patent/CN1027896C/zh not_active Expired - Fee Related
- 1990-05-14 DE DE69031962T patent/DE69031962T2/de not_active Expired - Fee Related
- 1990-05-14 AT AT90109065T patent/ATE162528T1/de not_active IP Right Cessation
- 1990-05-14 EP EP90109065A patent/EP0398230B1/en not_active Expired - Lifetime
- 1990-05-14 ES ES90109065T patent/ES2113851T3/es not_active Expired - Lifetime
- 1990-05-14 IE IE173490A patent/IE81107B1/en not_active IP Right Cessation
- 1990-05-14 EG EG28490A patent/EG19154A/xx active
- 1990-05-15 PT PT94040A patent/PT94040B/pt not_active IP Right Cessation
- 1990-05-15 HU HU903038A patent/HU206628B/hu not_active IP Right Cessation
- 1990-05-15 NO NO902148A patent/NO174102C/no unknown
1993
- 1993-09-22 NO NO933367A patent/NO176609C/no unknown
1994
- 1994-08-23 CN CN94116469A patent/CN1057443C/zh not_active Expired - Fee Related
1998
- 1998-01-22 GR GR970403458T patent/GR3025984T3/el unknown

Also Published As

Publication number	Publication date
GR3025984T3 (en)	1998-04-30
NO902148D0 (no)	1990-05-15
HUT53528A (en)	1990-11-28
NO174102B (no)	1993-12-06
BG60517B1 (bg)	1995-07-28
IE81107B1 (en)	2000-03-08
CN1057443C (zh)	2000-10-18
FI95269C (fi)	1996-01-10
PT94040B (pt)	1996-12-31
FI902360A0 (fi)	1990-05-11
NO174102C (no)	1994-03-16
NO176609C (no)	1995-05-03
EP0398230A2 (en)	1990-11-22
NO933367L (no)	1990-11-16
HU903038D0 (en)	1990-09-28
EP0398230B1 (en)	1998-01-21
NO176609B (no)	1995-01-23
EG19154A (en)	1994-09-29
DE69031962D1 (de)	1998-02-26
PT94040A (pt)	1991-01-08
KR970001160B1 (ko)	1997-01-29
FI95269B (fi)	1995-09-29
NO933367D0 (no)	1993-09-22
EP0398230A3 (en)	1991-06-26
DK0398230T3 (da)	1998-09-21
DE69031962T2 (de)	1998-09-17
IE901734L (en)	1990-11-15
HU206628B (en)	1992-12-28
CN1027896C (zh)	1995-03-15
BG92000A (bg)	1993-12-24
KR900017591A (ko)	1990-12-19
ES2113851T3 (es)	1998-05-16
CN1109755A (zh)	1995-10-11
AU617614B2 (en)	1991-11-28
CN1047676A (zh)	1990-12-12
AU5501190A (en)	1990-11-15
ATE162528T1 (de)	1998-02-15

Publication	Publication Date	Title
ES518227A0 (es)	1984-01-01	Procedimiento para preparar nuevos compuestos de cefem.
AU591640B2 (en)	1989-12-14	Quinolonecarboxylic acid derivatives
NO882626L (no)	1988-12-19	Fremgangsmaate for fremstilling av farmakologisk aktive pyridin-derivater.
GB8607921D0 (en)	1986-05-08	3,4-disubstituted-2-azetidinone derivatives
EP0314098A3 (en)	1990-01-03	Imide derivatives, their production and use
ES2046229T3 (es)	1994-02-01	Composicion antiulcerosa.
NO902148D0 (no)	1990-05-15	Fremgangsmaate til fremstilling av sterkt vannopploeselige,stabile, krystallinske salter av 2',3'-dideoksyinosinmonohydrat, 2',3'-dideoksy-2',3'-didehydrotymidinmonohydrat og2',3'-dideoksy-2'-fluorinosinhemihydrat.
HU912786D0 (en)	1992-01-28	Process for producing 4-substituted-dihydro-pyrido(4,3-d) pyrimidine derivatives as well as pharmaceutical preparatives containing said compounds
MY116824A (en)	2004-04-30	Antivaral,highly water soluble,stable,crystalline salts of 2'',3''-dideoxyinosine monohydrate,2'',3''-dideoxy-2'' ,3''-didehydrothymidine monohydrate and 2'',3''-dideoxy-2''-fluoroinosine hemihydrate
MX9100345A (es)	1992-02-28	Procedimiento para la preparacion de derivados 6-(aminopropionil sustituidos)de forscolina
ES2041790T3 (es)	1993-12-01	Derivados de tetrahidroisoquinolina amino-substituidos y su procedimiento de obtencion.
NO914192D0 (no)	1991-10-25	8-azabicyklo(3.2.1)oktylalkylthiazolidinon, fremgangsmaatefor fremstilling og anvendelse som medikamenter
ATE79625T1 (de)	1992-09-15	Substituierte 1,3,4,9-tetrahydropyrano(3,4b>indol-1-essigs\|uren.
HU905000D0 (en)	1991-01-28	Process for producing compounds suitable for treatment of gastric ulcer
TH8713A (th)	1991-04-01	ผลึกเกลือ 2',3'-ไดดีออกซิไอโนซีน โมโนไฮเดรท 2',3'-ไดดีออกซิ-2',3'-ไดดีไฮโดรไธมิดีน?โมโนไฮเดรท และ 2',3'-ไดดีออกซิ-2'-ฟลูออโรไอโนซีน ?เฮมิไฮเดรทสำหรับต่อต้านไวรัสซึ่งละลายน้ำได้ดี?และเสถียร
TH7375B (th)	1997-11-21	ผลึกเกลือ 2',3'-ไดดีออกซิไอโนซีน โมโนไฮเดรท 2',3'-ไดดีออกซิ-2',3'-ไดดีไฮโดรไธมิดีน?โมโนไฮเดรท และ 2',3'-ไดดีออกซิ-2'-ฟลูออโรไอโนซีน ?เฮมิไฮเดรทสำหรับต่อต้านไวรัสซึ่งละลายน้ำได้ดี?และเสถียร