EG25751A - Caspase inhibitors containing isoxazoline ring - Google Patents

Caspase inhibitors containing isoxazoline ring

Info

Publication number
EG25751A
EG25751A EG2004080370A EG2004080370A EG25751A EG 25751 A EG25751 A EG 25751A EG 2004080370 A EG2004080370 A EG 2004080370A EG 2004080370 A EG2004080370 A EG 2004080370A EG 25751 A EG25751 A EG 25751A
Authority
EG
Egypt
Prior art keywords
caspase inhibitors
inhibitors containing
isoxazoline ring
containing isoxazoline
ring
Prior art date
Application number
EG2004080370A
Other languages
English (en)
Inventor
Hye-Kyung Chang
Yeong-Soo Oh
Cheol-Won Park
Yong-Jin Jang
Tae-Kyo Park
Sung-Sub Kim
Min-Jung Kim
Mi-Jeong Park
Jung-Gyu Park
Hee-Dong Park
Kyeong-Sik Min
Tae-Soo Lee
Sang-Kyun Lee
Soo-Hyeon Kim
Hee-Kyung Jeong
Sun-Hwa Lee
Hwa-Dong Kim
Ae-Ri Kim
Ki-Sook Park
Hyun-Ik Shin
Hyeong-Wook Choi
Kyu-Woong Lee
Jae-Hoon Lee
Tae-Ho Heo
Ho-Jun Kim
Tae-Sik Kwon
Jeong Hui Seong
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Application granted granted Critical
Publication of EG25751A publication Critical patent/EG25751A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EG2004080370A 2003-08-27 2004-08-26 Caspase inhibitors containing isoxazoline ring EG25751A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20030059451 2003-08-27

Publications (1)

Publication Number Publication Date
EG25751A true EG25751A (en) 2012-06-25

Family

ID=36102769

Family Applications (1)

Application Number Title Priority Date Filing Date
EG2004080370A EG25751A (en) 2003-08-27 2004-08-26 Caspase inhibitors containing isoxazoline ring

Country Status (26)

Country Link
US (1) US7557133B2 (pt)
EP (1) EP1660464B1 (pt)
JP (1) JP4503017B2 (pt)
KR (1) KR100594544B1 (pt)
CN (1) CN1842521B (pt)
AP (1) AP2104A (pt)
AR (1) AR045503A1 (pt)
BR (1) BRPI0413848B8 (pt)
CA (1) CA2535711C (pt)
EA (1) EA012080B1 (pt)
EC (1) ECSP066378A (pt)
EG (1) EG25751A (pt)
IL (1) IL173638A (pt)
MA (1) MA27999A1 (pt)
MX (1) MXPA06002267A (pt)
MY (1) MY162110A (pt)
NO (1) NO335620B1 (pt)
NZ (1) NZ545216A (pt)
OA (1) OA13244A (pt)
PE (1) PE20050371A1 (pt)
TR (1) TR200600899T2 (pt)
TW (1) TWI346110B (pt)
UA (1) UA83240C2 (pt)
UY (1) UY28494A1 (pt)
WO (1) WO2005021516A1 (pt)
ZA (1) ZA200601586B (pt)

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US7754909B1 (en) * 2005-04-06 2010-07-13 The Florida State University Research Foundation, Inc. Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
KR101299720B1 (ko) * 2006-08-16 2013-08-28 주식회사 엘지생명과학 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
KR20080042290A (ko) * 2006-11-09 2008-05-15 주식회사 엘지생명과학 피리돈 구조를 포함하는 캐스파제 저해제
WO2009022746A1 (ja) 2007-08-10 2009-02-19 Nippon Soda Co., Ltd. 含窒素複素環化合物および有害生物防除剤
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
AU2012234393B2 (en) 2011-03-31 2017-02-02 Bayer Cropscience Aktiengesellschaft Herbicidally and fungicidally active 3-phenylisoxazoline-5-carboxamides and 3-phenylisoxazoline-5-thioamides
EP2697246B1 (en) 2011-04-15 2018-03-07 Genesis Technologies Limited Selective cysteine protease inhibitors and uses thereof
US10104892B2 (en) 2012-09-25 2018-10-23 Bayer Cropscience Ag Herbicidally and fungicidally active 3-heteroaryl-isoxazoline-5-carboxamides and 3-heteroaryl-isoxazoline-5-thioamides
EP2900645B1 (de) * 2012-09-25 2019-08-21 Bayer CropScience AG Herbizid wirksame 3-phenylisoxazolinderivate
KR102040740B1 (ko) * 2012-09-25 2019-11-05 바이엘 크롭사이언스 악티엔게젤샤프트 제초 및 살진균성 5-옥시-치환된 3-페닐이속사졸린-5-카복사미드 및 5-옥시-치환된 3-페닐이속사졸린-5-티오아미드
JP2017095353A (ja) * 2014-03-27 2017-06-01 日本曹達株式会社 イソオキサゾリン−5−カルボキサミド化合物および有害生物防除剤
EP3142649B1 (en) 2014-05-12 2019-07-24 Conatus Pharmaceuticals, Inc. Treatment of the complications of chronic liver disease with caspase inhibitor emricasan
CN105753853B (zh) 2014-12-16 2020-08-04 沈阳中化农药化工研发有限公司 一种含异恶唑啉的脲嘧啶类化合物及其用途
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
EP3397251A1 (en) 2015-12-31 2018-11-07 Conatus Pharmaceuticals, Inc. Methods of using caspase inhibitors in treatment of liver disease
EP3522883A1 (en) 2016-10-05 2019-08-14 Novartis AG Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder
JP7113831B2 (ja) * 2017-01-23 2022-08-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド カスパーゼ阻害薬としての二環式化合物
HUE056695T2 (hu) 2017-06-13 2022-03-28 Bayer Ag Tetrahidro- és dihidrofurán-karbonsav-amidok gyomirtó 3-fenilizoxazolin-5-karboxamidjai
EP3638665B1 (de) 2017-06-13 2021-07-21 Bayer Aktiengesellschaft Herbizid wirksame 3-phenylisoxazolin-5-carboxamide von tetrahydro- und dihydrofurancarbonsäuren und -estern
US20200369630A1 (en) 2017-08-17 2020-11-26 Bayer Aktiengesellschaft Herbicidally active 3-phenyl-5-trifluoromethylisoxazoline-5-carboxamides of cyclopentylcarboxylic acids and esters
JP7217751B2 (ja) 2018-01-25 2023-02-03 バイエル・アクチエンゲゼルシヤフト 除草活性を示すシクロペンテニルカルボン酸誘導体の3-フェニルイソオキサゾリン-5-カルボキサミド類
CA3133025A1 (en) 2019-03-12 2020-09-17 Bayer Aktiengesellschaft Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenyl carboxylic acid esters
ES2980695T3 (es) * 2019-04-19 2024-10-02 Lg Chemical Ltd Profármaco de inhibidor de caspasas
JP7442914B2 (ja) * 2019-04-30 2024-03-05 エルジー・ケム・リミテッド カスパーゼ阻害剤のプロドラッグ
KR102366226B1 (ko) * 2019-05-31 2022-02-22 주식회사 엘지화학 캐스파제 저해제 프로드럭을 함유하는 주사용 조성물 및 이의 제조 방법
TWI906428B (zh) 2020-12-10 2025-12-01 南韓商Lg化學股份有限公司 酸(Boronic Acid)化合物
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients
CN114908028B (zh) * 2022-04-19 2024-05-31 杭州师范大学 一种双相体系下化学酶法级联催化腈类化合物的一锅法合成工艺
WO2026064271A1 (en) 2024-09-23 2026-03-26 Fmc Corporation Substituted bicyclic amide derivatives as herbicides

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EP0730587B1 (en) * 1993-11-26 1999-12-08 Pfizer Inc. 3-phenyl-2-isoxazolines as antiinflammatory agents
ATE154932T1 (de) * 1993-11-26 1997-07-15 Pfizer Isoxazolinverbindungen als entzündungshemmende mittel
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CN1137888C (zh) * 1999-09-17 2004-02-11 株式会社Lgci 半胱氨酰天冬氨酸蛋白酶抑制剂

Also Published As

Publication number Publication date
JP2007503429A (ja) 2007-02-22
EP1660464B1 (en) 2015-02-25
ZA200601586B (en) 2007-05-30
AU2004268895A1 (en) 2005-03-10
AR045503A1 (es) 2005-11-02
OA13244A (en) 2007-01-31
WO2005021516A1 (en) 2005-03-10
KR20050022364A (ko) 2005-03-07
CA2535711C (en) 2011-07-05
NZ545216A (en) 2009-06-26
EA200600465A1 (ru) 2006-08-25
TW200512199A (en) 2005-04-01
BRPI0413848B8 (pt) 2021-05-25
CA2535711A1 (en) 2005-03-10
UY28494A1 (es) 2005-02-28
MY162110A (en) 2017-05-31
UA83240C2 (ru) 2008-06-25
TR200600899T2 (tr) 2006-09-21
MXPA06002267A (es) 2006-05-17
US7557133B2 (en) 2009-07-07
EP1660464A1 (en) 2006-05-31
CN1842521B (zh) 2012-09-05
HK1092788A1 (en) 2007-02-16
EA012080B1 (ru) 2009-08-28
AP2104A (en) 2010-02-06
KR100594544B1 (ko) 2006-06-30
MA27999A1 (fr) 2006-07-03
AP2006003509A0 (en) 2006-02-28
ECSP066378A (es) 2006-08-30
IL173638A (en) 2011-12-29
US20060223848A1 (en) 2006-10-05
IL173638A0 (en) 2006-07-05
NO335620B1 (no) 2015-01-12
BRPI0413848B1 (pt) 2019-04-30
NO20061362L (no) 2006-03-24
BRPI0413848A (pt) 2006-10-24
JP4503017B2 (ja) 2010-07-14
PE20050371A1 (es) 2005-08-17
CN1842521A (zh) 2006-10-04
TWI346110B (en) 2011-08-01
EP1660464A4 (en) 2008-11-26

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