MA27999A1 - Inhibiteurs de caspases contenant un cycle isoxazolinique - Google Patents

Inhibiteurs de caspases contenant un cycle isoxazolinique

Info

Publication number
MA27999A1
MA27999A1 MA28820A MA28820A MA27999A1 MA 27999 A1 MA27999 A1 MA 27999A1 MA 28820 A MA28820 A MA 28820A MA 28820 A MA28820 A MA 28820A MA 27999 A1 MA27999 A1 MA 27999A1
Authority
MA
Morocco
Prior art keywords
isoxazolinic
caspases
inhibitors
cycle
derivative
Prior art date
Application number
MA28820A
Other languages
English (en)
Inventor
Hye-Kyung Chang
Yeong-Soo Oh
Cheol-Won Park
Yong-Jin Jang
Tae-Kyo Park
Sung-Sub Kim
Min-Jung Kim
Mi-Jeong Park
Jung-Gyu Park
Hee-Dong Park
Kyeong-Sik Min
Tae-Soo Lee
Sang-Kyun Lee
Soo-Hyeon Kim
Hee-Kyung Jeong
Sun-Hwa Lee
Hwa-Dong Kim
Ae-Ri Kim
Ki-Sook Park
Hyun-Ik Shin
Hyeong-Wook Choi
Kyu-Woong Lee
Jae-Hoon Lee
Tae-Ho Heo
Ho-Jun Kim
Tae-Sik Kwon
Original Assignee
Hyeong-Wook Choi
Kyu-Woong Lee
Jae-Hoon Lee
Tae-Ho Heo
Ho-Jun Kim
Tae-Sik Kwon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hyeong-Wook Choi, Kyu-Woong Lee, Jae-Hoon Lee, Tae-Ho Heo, Ho-Jun Kim, Tae-Sik Kwon filed Critical Hyeong-Wook Choi
Publication of MA27999A1 publication Critical patent/MA27999A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La présente invention concerne un dérivé isoxazolinique constituant un inhibiteur de diverses caspases, un procédé de préparation de ce dérivé et une composition thérapeutique destinée à prévenir l'inflammation et l'apoptose, cette composition comprenant ledit dérivé.
MA28820A 2003-08-27 2006-02-17 Inhibiteurs de caspases contenant un cycle isoxazolinique MA27999A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20030059451 2003-08-27

Publications (1)

Publication Number Publication Date
MA27999A1 true MA27999A1 (fr) 2006-07-03

Family

ID=36102769

Family Applications (1)

Application Number Title Priority Date Filing Date
MA28820A MA27999A1 (fr) 2003-08-27 2006-02-17 Inhibiteurs de caspases contenant un cycle isoxazolinique

Country Status (26)

Country Link
US (1) US7557133B2 (fr)
EP (1) EP1660464B1 (fr)
JP (1) JP4503017B2 (fr)
KR (1) KR100594544B1 (fr)
CN (1) CN1842521B (fr)
AP (1) AP2104A (fr)
AR (1) AR045503A1 (fr)
BR (1) BRPI0413848B8 (fr)
CA (1) CA2535711C (fr)
EA (1) EA012080B1 (fr)
EC (1) ECSP066378A (fr)
EG (1) EG25751A (fr)
IL (1) IL173638A (fr)
MA (1) MA27999A1 (fr)
MX (1) MXPA06002267A (fr)
MY (1) MY162110A (fr)
NO (1) NO335620B1 (fr)
NZ (1) NZ545216A (fr)
OA (1) OA13244A (fr)
PE (1) PE20050371A1 (fr)
TR (1) TR200600899T2 (fr)
TW (1) TWI346110B (fr)
UA (1) UA83240C2 (fr)
UY (1) UY28494A1 (fr)
WO (1) WO2005021516A1 (fr)
ZA (1) ZA200601586B (fr)

Families Citing this family (32)

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KR100774999B1 (ko) 2005-02-26 2007-11-09 주식회사 엘지생명과학 이소옥사졸린 유도체 및 그의 제조 방법
US7754909B1 (en) * 2005-04-06 2010-07-13 The Florida State University Research Foundation, Inc. Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
KR101299720B1 (ko) * 2006-08-16 2013-08-28 주식회사 엘지생명과학 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
KR20080042290A (ko) * 2006-11-09 2008-05-15 주식회사 엘지생명과학 피리돈 구조를 포함하는 캐스파제 저해제
EP2186804B1 (fr) * 2007-08-10 2015-06-17 Nippon Soda Co., Ltd. Composé hétérocyclique contenant de l'azote et agent de lutte contre les animaux nuisibles
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
DK2288615T3 (en) 2008-05-21 2017-09-04 Genesis Tech Ltd SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US9078442B2 (en) 2011-03-31 2015-07-14 Bayer Intellectual Property Gmbh Herbicidally and fungicidally active 3-phenylisoxazoline-5-carboxamides and 3-phenylisoxazoline-5-thioamides
EP2697246B1 (fr) 2011-04-15 2018-03-07 Genesis Technologies Limited Inhibiteurs sélectifs de cystéine protéase et leurs utilisations
JP6397820B2 (ja) * 2012-09-25 2018-09-26 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 除草活性と殺菌活性を示す３−ヘテロアリール−イソオキサゾリン−５−カルボキサミド類及び３−ヘテロアリール−イソオキサゾリン−５−チオアミド類
US9585392B2 (en) * 2012-09-25 2017-03-07 Bayer Cropscience Ag 3-phenylisoxazolin derivatives with herbicidal action
WO2014048882A1 (fr) 2012-09-25 2014-04-03 Bayer Cropscience Ag 3-phénylisoxazolin-5-carboxamides à substitution 5-oxy et 3-phénylisoxazolin-5-thioamides à substitution 5-oxy présentant une action herbicide et fongicide
JP2017095353A (ja) * 2014-03-27 2017-06-01 日本曹達株式会社 イソオキサゾリン−５−カルボキサミド化合物および有害生物防除剤
ES2751652T3 (es) 2014-05-12 2020-04-01 Conatus Pharmaceuticals Inc Tratamiento con inhibidor de caspasa emricasan de las complicaciones por las enfermedades hepáticas crónicas
CN105753853B (zh) 2014-12-16 2020-08-04 沈阳中化农药化工研发有限公司 一种含异恶唑啉的脲嘧啶类化合物及其用途
WO2017079566A1 (fr) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Inhibiteurs de caspase destinés à être utilisés dans le traitement du cancer
JP2019500397A (ja) 2015-12-31 2019-01-10 クオナトウス ファーマシューティカルズ，インコーポレイテッド カスパーゼ阻害剤を肝疾患の治療に使用する方法
RU2019113150A (ru) 2016-10-05 2020-11-06 Новартис Аг Комбинация композиций, содержащих агонисты fxr, предназначенная для лечения или предупреждения фиброзирующего, цирротического заболевания или нарушения
WO2018133870A1 (fr) * 2017-01-23 2018-07-26 正大天晴药业集团股份有限公司 Composé cyclique lié en tant qu'inhibiteur de caspase
WO2018228985A1 (fr) 2017-06-13 2018-12-20 Bayer Aktiengesellschaft 3-phénylisoxazoline-5-carboxamides d'acides carboxyliques et d'esters de tétrahydro- et dihydrofurane à effet herbicide
CN110799511B (zh) 2017-06-13 2023-09-01 拜耳公司 除草活性的四氢和二氢呋喃甲酰胺的3-苯基异噁唑啉-5-甲酰胺
CN111164077B (zh) 2017-08-17 2023-12-19 拜耳公司 除草活性的环戊基羧酸和其酯的3-苯基-5-三氟甲基异噁唑啉-5-甲酰胺
EA202091774A1 (ru) 2018-01-25 2020-12-07 Байер Акциенгезельшафт Гербицидно-активные 3-фенилизоксазолин-5-карбоксамиды производных циклопентенилкарбоновой кислоты
CA3133025A1 (fr) 2019-03-12 2020-09-17 Bayer Aktiengesellschaft 3-phenyl-isoxazoline-5-carboxamides d'esters d'acide cyclopentenyl-carboxylique soufres a action herbicide
JP2022529973A (ja) * 2019-04-19 2022-06-27 エルジー・ケム・リミテッド カスパーゼ阻害剤のプロドラッグ
WO2020222541A1 (fr) * 2019-04-30 2020-11-05 주식회사 엘지화학 Promédicament d'inhibiteur de caspase
EP3970698A4 (fr) * 2019-05-31 2022-08-31 LG Chem, Ltd. Composition injectable contenant un promédicament d'inhibiteurs de caspase, et son procédé de préparation
TWI906428B (zh) 2020-12-10 2025-12-01 南韓商Ｌｇ化學股份有限公司 酸（Ｂｏｒｏｎｉｃ Ａｃｉｄ）化合物
WO2022123062A1 (fr) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocage de la caspase et/ou de la fasl pour prévenir une issue fatale chez des patients atteints de la covid-19
CN114908028B (zh) * 2022-04-19 2024-05-31 杭州师范大学 一种双相体系下化学酶法级联催化腈类化合物的一锅法合成工艺
WO2026064271A1 (fr) 2024-09-23 2026-03-26 Fmc Corporation Dérivés amides bicycliques substitués utilisés en tant qu'herbicides

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IL118325A0 (en) * 1995-05-25 1996-10-31 Pont Merck And Pharmaceutical Integrin receptor antagonists and pharmaceutical compositions containing them
US5710159A (en) * 1996-05-09 1998-01-20 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
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DE60013147T2 (de) * 1999-09-17 2005-08-11 Lg Chem Investment, Ltd. Caspase-hemmer
WO2001021599A1 (fr) * 1999-09-17 2001-03-29 Lg Chemical Ltd. Inhibiteur de caspase

Also Published As

Publication number Publication date
IL173638A (en) 2011-12-29
MY162110A (en) 2017-05-31
EP1660464A1 (fr) 2006-05-31
NO20061362L (no) 2006-03-24
ECSP066378A (es) 2006-08-30
JP4503017B2 (ja) 2010-07-14
US7557133B2 (en) 2009-07-07
EG25751A (en) 2012-06-25
EA012080B1 (ru) 2009-08-28
PE20050371A1 (es) 2005-08-17
AP2006003509A0 (en) 2006-02-28
HK1092788A1 (en) 2007-02-16
AP2104A (en) 2010-02-06
KR20050022364A (ko) 2005-03-07
NO335620B1 (no) 2015-01-12
BRPI0413848B1 (pt) 2019-04-30
EP1660464B1 (fr) 2015-02-25
JP2007503429A (ja) 2007-02-22
OA13244A (en) 2007-01-31
MXPA06002267A (es) 2006-05-17
EP1660464A4 (fr) 2008-11-26
KR100594544B1 (ko) 2006-06-30
CN1842521A (zh) 2006-10-04
AR045503A1 (es) 2005-11-02
UA83240C2 (ru) 2008-06-25
TW200512199A (en) 2005-04-01
CA2535711C (fr) 2011-07-05
IL173638A0 (en) 2006-07-05
BRPI0413848B8 (pt) 2021-05-25
WO2005021516A1 (fr) 2005-03-10
TWI346110B (en) 2011-08-01
AU2004268895A1 (en) 2005-03-10
US20060223848A1 (en) 2006-10-05
TR200600899T2 (tr) 2006-09-21
NZ545216A (en) 2009-06-26
BRPI0413848A (pt) 2006-10-24
EA200600465A1 (ru) 2006-08-25
CA2535711A1 (fr) 2005-03-10
ZA200601586B (en) 2007-05-30
CN1842521B (zh) 2012-09-05
UY28494A1 (es) 2005-02-28

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