EP0073847B1 - Sac à sang ayant un système de connexion - Google Patents

Sac à sang ayant un système de connexion Download PDF

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Publication number
EP0073847B1
EP0073847B1 EP81106885A EP81106885A EP0073847B1 EP 0073847 B1 EP0073847 B1 EP 0073847B1 EP 81106885 A EP81106885 A EP 81106885A EP 81106885 A EP81106885 A EP 81106885A EP 0073847 B1 EP0073847 B1 EP 0073847B1
Authority
EP
European Patent Office
Prior art keywords
bag
blood
break
blood bag
coupling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP81106885A
Other languages
German (de)
English (en)
Other versions
EP0073847A1 (fr
Inventor
Wolfram H Dr. Dipl.-Chem. Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest AG
Original Assignee
Biotest Serum Institut GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Serum Institut GmbH filed Critical Biotest Serum Institut GmbH
Priority to AT81106885T priority Critical patent/ATE23271T1/de
Priority to EP81106885A priority patent/EP0073847B1/fr
Publication of EP0073847A1 publication Critical patent/EP0073847A1/fr
Application granted granted Critical
Publication of EP0073847B1 publication Critical patent/EP0073847B1/fr
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means

Definitions

  • the invention relates to blood bags with a connection system that contains a connection piece (5) consisting of connection part (7), break-off part (8), predetermined breaking point (9) and possibly collar (6), the connection piece (5) directly with the blood bag (1) is connected, such that it is located directly on the upper bag edge and substantially flush therewith, said break-off part (8) projects into the bag, so that the break-off part (8) is present after canceling in -r -Beutelinneren.
  • Blood bags are used for the collection, storage, preparation and transfusion of blood and blood components.
  • One of the advantages of blood bags over blood bottles made of glass is that with multiple blood bag systems, blood preparations in a closed, i.e. sterile system are possible.
  • the production of blood preparations is becoming increasingly important as part of "hemotherapy made to measure”.
  • Multi-bag systems as they are currently on the market consist of 2 or more bag systems, in which a primary bag generally contains the blood stabilizer solution and serves to absorb the blood.
  • the secondary or satellite bag or the satellite bag system which is connected to the primary bag with a tube system, is used to prepare the blood components, such as plasma, factor VIII concentrate, platelet concentrate, etc.
  • the primary bag carries a connection system which, after opening, allows the preparation to pass from the primary bag into the secondary bag.
  • connection system There are various design options for this connection system.
  • connection system which consists of a ball which is pressed into a flexible hose. A free passage is possible after pushing the ball out of the hose.
  • This system has the disadvantage that under extreme conditions such as overpressure, centrifugation, mechanical change in the tube diameter etc. there is no hermetic seal.
  • US-PS 3110 308 describes a connection system consisting of a membrane which is perforated with a cannula-like mandrel. This system often complains about the complicated and time-consuming manipulation.
  • break-off systems are known in which a free passage is possible by breaking off a plastic part in a hose system.
  • Such systems are located outside a blood bag in the connecting tube between the primary and secondary bags (e.g. WO A-1-81 / 01105).
  • This has the disadvantage that a clean and optimal separation of the blood preparations according to e.g. Centrifugation is not possible and the preparation is contaminated.
  • the manufacture and assembly of such systems is complex and costly.
  • the invention has for its object to provide a blood bag with a connection system; which has the advantages of the generic blood bag with a connection system, but in which blocking of the free passage through the break-off part is largely avoided.
  • break-off part consists of a material that has a lower density than blood.
  • a break-off part which is made of a material that has a lower density than blood, will float on the blood or blood preparation after the separation and will not sink, whereby a blockage of the passage that is possible due to the sinking is largely avoided.
  • Fig. 1 shows the blood bag (1) (primary bag) with the blood collection tube (4), which is connected to the blood bag (2) (secondary bag) by a connecting tube (3).
  • the Blood bag (1) is sealed liquid-tight by the connecting piece (5).
  • the connecting piece (5) When the connecting piece (5) is opened, the preparation can overflow into the secondary bag (2) via the connecting tube (3).
  • part of the connecting piece (5) lies in a recess (1 c).
  • a tube (1 b) is also shown, which according to one embodiment is located between the blood bag (1) and the connecting piece (5).
  • Fig. 2 shows a detailed enlargement of the connector (5) used as a connection system. It consists of a collar (6), connecting part (7), break-off part (8) made of a material with a lower density than blood and predetermined breaking point (9).
  • the collar (6) is connected to the connecting tube (3), the connecting part (7) is hermetically connected to the blood bag (1), and the breaking part (8) is connected to the connecting part (7) via the breaking or predetermined breaking point (9 ) connected.
  • the predetermined breaking point (9) is designed so that when the connection part (7) is broken off it receives a free flow which corresponds to or approximately corresponds to the lumen of the connection part (7). If the transfer hose (3) is glued inside the collar (6), then after breaking off the demolition part (8) there is a free flow through the complete system, which has approximately the lumen of the connecting hose (3).
  • the break-off part (8) After opening the connection system, the break-off part (8) remains in the primary bag (11). If, when the blood flows out of the blood bag, the blood level has dropped so far that it is at the level of the flow, a floating break-off part could also block the flow. In order to prevent the break-off part in the embodiment in which it falls freely into the bag, in the case of transfusion or preparation, when the preparation runs through the tube (3) or any other outlet connection, this prevents the flow from being blocked, the break-off part (8) has a structured surface which allows the liquid to flow past.
  • Fig. 3 shows a cross section of a preferred surface structure of the break-off part (8), which is composed of 4 semicircles in a rosette shape.
  • Fig. 4 shows an embodiment in which the connecting piece (5), consisting of connecting part (7) and break-off part (8), is welded directly into the bag.
  • the connecting hose (3) is glued directly into the open part of the system after the part has been welded in.
  • the connecting piece (5) is connected to the blood bag via connecting part (7) (Fig. 2), the connecting piece (5) being connected to the bag (1) via a tube (1b) (as in Fig. 1) or directly to the bag (as shown in Fig. 4).
  • Hose (3) and connecting part (7) of the connecting system (5) can also be designed such that hose (3) is inserted into the connecting part (7).
  • the hose (3) with the connecting piece (5) and the bag (1) can be connected by gluing or welding or by other known joining techniques, such as ultrasound welding or rotary welding.
  • Connection piece (5) is made of a transparent or colored plastic, which shows optimal properties both in steam sterilization and when breaking off.
  • a slight through pressure on the break-off part (8) results in a free passage, wherein the predetermined breaking point (9) can be structured in such a way that part (8) still adheres to part (7), but preferably breaks off completely.
  • Plastics such as hard polyvinyl chloride or Makrolon (registered trademark) are suitable for this application. It is essential that the materials have a lower density than 1 and thus the break-off part floats on the blood or blood preparation after separation.
  • the connecting piece (5) is that it is almost flush with the upper edge of the blood bag (1) and therefore no contamination of the preparation can take place.
  • the upper edge of the blood bag can also be designed such that the connecting piece (5) is located in a recess (1c) of the bag. This facilitates manipulation of the breaking off, because blood components of the bag (1) are not stirred up.
  • Recess (1c) can also be designed as a bag, so that the break-off part (8) does not fall freely into the bag (1), but is retained in the bag.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (6)

1. Sac à sang avec un système de connexion, contenant une pièce de connexion (5) faite d'une partie de connexion (7), d'une pièce de rupture (8), d'un point destiné à la rupture (9) et le cas échéant d'un col (6), où la pièce de connexion (5) est reliée immédiatement au sac à sang (1), de manière qu'elle se trouve directement au bord supérieur du sac et se termine essentiellement au ras de celui-ci, où la pièce de rupture (8) fait saillie dans le sac, si bien que la pièce de rupture (8) se trouve à l'intérieur du sac après rupture, caractérisé en ce que la pièce de rupture (8) se compose d'une matière qui a une densité plus faible que celle du sang.
2. Sac à sang selon la revendication 1, caractérisé en ce qu'il présente à son bord supérieur un évidement (1 c) et en ce que la pièce de connexion (5) est disposée dans cet évidement.
3. Sac à sang selon la revendication 2, caractérisé en ce que l'évidement (1c) est formé comme une sorte de poche où la pièce de rupture (8) brisée est retenue.
4. Sac à sang selon l'une des revendications précédentes, caractérisé en ce que le système de connexion est introduit directement sans tuyau dans le sac à sang.
5. Sac à sang selon l'une des revendications précédentes, caractérisé en ce que la pièce de rupture (8) est entièrement degagée et en ce qu'elle possède une structure superficielle qui fait que l'écoulement du sang ou des préparations de sang hors du sac à sang n'est pas empêché.
6. Sac à sang selon la revendication 5, caractérisé en ce que la structure superficielle de la pièce de rupture (8) présente une section qui se compose de quatre demi-cercles en forme de rosette.
EP81106885A 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion Expired EP0073847B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT81106885T ATE23271T1 (de) 1981-09-03 1981-09-03 Blutbeutel mit einem verbindungssystem.
EP81106885A EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81106885A EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion

Publications (2)

Publication Number Publication Date
EP0073847A1 EP0073847A1 (fr) 1983-03-16
EP0073847B1 true EP0073847B1 (fr) 1986-11-05

Family

ID=8187893

Family Applications (1)

Application Number Title Priority Date Filing Date
EP81106885A Expired EP0073847B1 (fr) 1981-09-03 1981-09-03 Sac à sang ayant un système de connexion

Country Status (2)

Country Link
EP (1) EP0073847B1 (fr)
AT (1) ATE23271T1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS607833U (ja) * 1983-06-27 1985-01-19 テルモ株式会社 血液バツグ装置
JPS6171064A (ja) * 1984-09-13 1986-04-11 日本赤十字社 血液成分の分離用器具
AU578554B2 (en) * 1986-01-24 1988-10-27 Japanese Red Cross Society Centrifugal method of separating blood components
US6491679B1 (en) 1997-10-20 2002-12-10 Rodney Okamoto System for infusing intravenous nutrition solutions
FR2820029B1 (fr) * 2001-01-26 2003-04-25 Pascal Lecointe Sachet et bande de sachets de conditionnement de substance, a canule et embout integres
DE10244154A1 (de) * 2002-09-23 2004-04-08 Prisma Diagnostika Gmbh Trägerelement für diagnostische Tests

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2098873A5 (fr) * 1970-07-30 1972-03-10 Labaz Laboratoires

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2819805A (en) * 1953-10-05 1958-01-14 Price Battery Corp Battery component assembling machines
AT203145B (de) * 1956-10-30 1959-04-25 Vifor Sa Vorrichtung zur Infusion von Flüssigkeiten
US3158165A (en) * 1961-06-20 1964-11-24 Torrington Co Valve assembly and method of making it
CH401363A (fr) * 1964-05-13 1965-10-31 Vifor Sa Appareil pour l'infusion de liquides dans un corps
US3470893A (en) * 1968-03-04 1969-10-07 Illinois Tool Works Fluid distribution unit
DE7719528U1 (de) * 1977-06-22 1978-03-16 Knoll Ag, 6700 Ludwigshafen Infusionsbeutel
US4181140A (en) * 1978-02-10 1980-01-01 Baxter Travenol Laboratories, Inc. Frangible resealable closure for a flexible tube having hold open means
US4340049A (en) * 1979-10-18 1982-07-20 Baxter Travenol Laboratories, Inc. Breakaway valve

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2098873A5 (fr) * 1970-07-30 1972-03-10 Labaz Laboratoires

Also Published As

Publication number Publication date
ATE23271T1 (de) 1986-11-15
EP0073847A1 (fr) 1983-03-16

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