EP0118528A4 - 5-(bicyclische stickstoffheteroaryl)pyrid-2-one und deren verwendung zum erhöhen des herzzusammenziehungsvermögens. - Google Patents

5-(bicyclische stickstoffheteroaryl)pyrid-2-one und deren verwendung zum erhöhen des herzzusammenziehungsvermögens.

Info

Publication number: EP0118528A4
Authority: EP; European Patent Office
Prior art keywords: pyrid; heteroaryl; ones; cardiac contractility; bicyclic nitrogen
Prior art date: 1982-08-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19830902935

Other languages

English (en)

French (fr)

Other versions

EP0118528A1 (de

Inventor

Henry Flud Campbell

Donald Ernest Kuhla

William Lyon Studt

Stuart Alan Dodson

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rorer International Overseas Inc

Original Assignee

Rorer International Overseas Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-23

Filing date

1983-08-23

Publication date

1985-09-09

1983-08-23 Application filed by Rorer International Overseas Inc filed Critical Rorer International Overseas Inc

1984-09-19 Publication of EP0118528A1 publication Critical patent/EP0118528A1/de

1985-09-09 Publication of EP0118528A4 publication Critical patent/EP0118528A4/de

Status Withdrawn legal-status Critical Current

Links

230000000747 cardiac effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP19830902935 1982-08-23 1983-08-23 5-(bicyclische stickstoffheteroaryl)pyrid-2-one und deren verwendung zum erhöhen des herzzusammenziehungsvermögens. Withdrawn EP0118528A4 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41064682A	1982-08-23	1982-08-23
US410646		1982-08-23

Publications (2)

Publication Number	Publication Date
EP0118528A1 EP0118528A1 (de)	1984-09-19
EP0118528A4 true EP0118528A4 (de)	1985-09-09

Family

ID=23625622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19830902935 Withdrawn EP0118528A4 (de)	1982-08-23	1983-08-23	5-(bicyclische stickstoffheteroaryl)pyrid-2-one und deren verwendung zum erhöhen des herzzusammenziehungsvermögens.

Country Status (5)

Country	Link
EP (1)	EP0118528A4 (de)
JP (1)	JPS59501716A (de)
AU (1)	AU2038683A (de)
IT (1)	IT8367883A0 (de)
WO (1)	WO1984000756A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2568251B1 (fr) *	1984-07-26	1988-05-27	Mitsui Toatsu Chemicals	Nouveaux derives d'isoquinoleine et leurs applications therapeutiques
JPS625963A (ja) *	1985-07-02	1987-01-12	Mitsui Toatsu Chem Inc	イソキノリン誘導体
US4785005A (en) *	1986-06-25	1988-11-15	Rorer Pharmaceutical Corporation	6-(6-alkylpyridone)-carbostyril compounds and their cardiotonic uses
US5002944A (en) *	1986-10-29	1991-03-26	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having cardiotonic activity
US4859672A (en) *	1986-10-29	1989-08-22	Rorer Pharmaceutical Corporation	Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE69108733T2 (de) *	1990-08-21	1995-09-14	Upjohn Co	Bisphosphonsäurederivate als antiarthritische mittel.
US5141931A (en) *	1991-01-03	1992-08-25	Sterling Winthrop Inc.	5-Quinolinylpyridinones, cardiotonic compositions and methods
CZ403592A3 (en) *	1992-02-20	1993-12-15	Hoechst Ag	Arylcarbonylaminoalkyldihydrooxopyridines, process of their preparation and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4271168A (en) *	1979-12-26	1981-06-02	Sterling Drug Inc.	Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones
GB2070606A (en) *	1980-03-03	1981-09-09	Sandoz Ltd	2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3981882A (en) *	1972-08-31	1976-09-21	Bayer Aktiengesellschaft	Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester
DE2242787C2 (de) *	1972-08-31	1982-01-21	Bayer Ag, 5090 Leverkusen	4-Phenyl-6-amino-3,4-dihydropyridon-(2)-3,5-dicarbonsäure-diäthylesterderivate, ein Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

1983
- 1983-08-22 IT IT8367883A patent/IT8367883A0/it unknown
- 1983-08-23 JP JP58502958A patent/JPS59501716A/ja active Pending
- 1983-08-23 AU AU20386/83A patent/AU2038683A/en not_active Abandoned
- 1983-08-23 WO PCT/US1983/001285 patent/WO1984000756A1/en not_active Ceased
- 1983-08-23 EP EP19830902935 patent/EP0118528A4/de not_active Withdrawn

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4072746A (en) *	1975-10-14	1978-02-07	Sterling Drug Inc.	3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4107315A (en) *	1975-10-14	1978-08-15	Sterling Drug Inc.	5-(Pyridinyl)-2(1H)-pyridinones
US4137233A (en) *	1975-10-14	1979-01-30	Sterling Drug Inc.	1,2-Dihydro-2-oxo-5-(pyridinyl)nicotinamides
US4271168A (en) *	1979-12-26	1981-06-02	Sterling Drug Inc.	Selected 3-acylamino-5-[4(or 3)-pyridinyl]-2(1H)-pyridinones
GB2070606A (en) *	1980-03-03	1981-09-09	Sandoz Ltd	2(1h)-pyridinone derivatives their preparation and pharmaceutical compositions containing them

Also Published As

Publication number	Publication date
IT8367883A0 (it)	1983-08-22
WO1984000756A1 (en)	1984-03-01
JPS59501716A (ja)	1984-10-11
AU2038683A (en)	1984-03-07
EP0118528A1 (de)	1984-09-19

Legal Events

Date	Code	Title	Description
1984-07-21	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1984-09-19	AK	Designated contracting states	Designated state(s): AT BE CH DE FR GB LI LU NL SE
1984-11-14	17P	Request for examination filed	Effective date: 19840829
1987-07-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1987-09-09	18D	Application deemed to be withdrawn	Effective date: 19870302
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: CAMPBELL, HENRY, FLUD Inventor name: KUHLA, DONALD, ERNEST Inventor name: DODSON, STUART, ALAN Inventor name: STUDT, WILLIAM, LYON

Publication	Publication Date	Title
JPS56167689A (en)	1981-12-23	Beta-lactam compounds, their manufacture and use
EP0094260A3 (en)	1984-07-18	Herbicidal heterocyclic alkylaminocarbonylsulfonamides
ES507058A0 (es)	1983-03-01	Procedimiento de fabricacion de polvoras propulsivas finas en granos.
GB2121796B (en)	1986-03-12	Amidines
ZA801002B (en)	1981-03-25	Histamine antagonists
JPS57194101A (en)	1982-11-29	Revolving body
EP0118528A4 (de)	1985-09-09	5-(bicyclische stickstoffheteroaryl)pyrid-2-one und deren verwendung zum erhöhen des herzzusammenziehungsvermögens.
GB2121413B (en)	1986-05-08	Oxazolidines
GB2128988B (en)	1985-09-18	Xanthine derivatives
GB8318525D0 (en)	1983-08-10	Heterocyclic derivatives
EP0078839A4 (de)	1984-07-25	Heterozyklische amidinoharnstoffe.
JPS5749447A (en)	1982-03-23	Far infrered body warmer
ZA833967B (en)	1984-02-29	Amidines
JPS5731856A (en)	1982-02-20	Body warmer
ZA802908B (en)	1981-05-27	Penicillins
GB2116178B (en)	1985-10-02	Heterocyclic derivatives
ATA216581A (de)	1982-10-15	Schichtkoerper
PT71856B (en)	1981-07-09	Penicillins
ZA831263B (en)	1984-10-31	Heterocyclic derivatives
ZA833328B (en)	1984-12-24	Herbicidal heterocyclic alkylaminocarbonylsulfonamides
ZA816075B (en)	1982-09-29	Use of embonates of 2,4-diamino-benzyl pyrimidines
GB2072018B (en)	1984-03-21	Body warmer
CS780682A1 (en)	1984-06-18	Zarizeni k mereni polohy stredu polomeru tvoriciho oblouku plaste rotacnich obrobku
IE822680L (en)	1983-05-12	Heterocyclic compounds.
KR820001471Y1 (en)	1982-07-22	Handbags