EP0287565A1 - Dispositif de transfert pour diagnostic serologique - Google Patents

Dispositif de transfert pour diagnostic serologique

Info

Publication number
EP0287565A1
EP0287565A1 EP87900254A EP87900254A EP0287565A1 EP 0287565 A1 EP0287565 A1 EP 0287565A1 EP 87900254 A EP87900254 A EP 87900254A EP 87900254 A EP87900254 A EP 87900254A EP 0287565 A1 EP0287565 A1 EP 0287565A1
Authority
EP
European Patent Office
Prior art keywords
vessels
transfer device
plate
duct
serum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87900254A
Other languages
German (de)
English (en)
Inventor
Guglielmo Bedarida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Technogenetics SRL
Original Assignee
Technogenetics SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technogenetics SRL filed Critical Technogenetics SRL
Publication of EP0287565A1 publication Critical patent/EP0287565A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Definitions

  • the present invention provides a transfer device for serological diagnosis, to be used in particular in the diagnostic processes for HTLV III virus infections.
  • the transfer device allows to interconnect a plurality of opposite vessels, con ⁇ taining each a small ball coated with antigens, so as to allow, by a single operation, to shift the serum under examination from a vessel to the other so quickly that the liquid temperature has no time to diminish, and absolutely avoiding any contaminations and/or possi ⁇ bility of mistakes.
  • the taken sample is introduced in a vessel in contact with a solid substrate, for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
  • a solid substrate for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
  • the colouring of the ball indicates the presence in blood of the sought for immunoglobulins and, accordingly, the infection state.
  • the critical phase of this new process is the elution, that takes place at a temperature oscillating between 50° and 58°C, necessary to cause the specific immunoglo ⁇ bulins of the various classes - caught by the antigens secured to the first substrate - to detach therefrom, which enables the production of an eluate of specific antibodies of the various classes, with few non-speci- fie antibodies .
  • the transfer of the eluate from the first to the second vessel takes l ce via suction and force-pumps.
  • the present invention provides a transfer device consisting substa tially of a plurality of con ⁇ necting elements, fastened to a common support, and arranged in such a manner as to fit, from either side, to the plates carrying the vessels used at present in laboratories for serological diagnosis.
  • a characteristic of the invention is the special shap ⁇ ing of its parts that allows to arrange a pair of opposi ' te plates, so that each vessel of one of these plates communicates with the corresponding vessel of the other plate, the whole being watertight; it is thus possible, by a single operation, to shift serum from the vessels in one plate to those in the second plate, without any decrease in temperature taking place.
  • FIG. 1 shows the plane view of the transfer device according to the invention
  • FIG. 2 shows the side, partly section view, of a transfer device according to the invention
  • FIG. 3 shows a view from above of a detail of the transfer device according to the invention.
  • a plate or support 1 comprises a plurality of elements, each of which is referenced as a whole with No. 2, each of them being suitable to allow connection between a pair of opposite vessels.
  • elements 2 are located at the vertexes of a square link grid.
  • Each element 2 is substantially a hollow cylinder defin ⁇ ed by side walls 3, inside which passes the serum, that shifts from one vessel to the other.
  • each element 2 is not of constant size but has a narrowing at the central zone.
  • the upper inner part of element 2 comprises a first, substantially cylindrical section 4, linked to a frusto-conical section 5 and to a lower duct 6, of lesser diameter.
  • the sizes of the frusto-conical section 5 too are inferior to those of the upper cylindrical section 4, so as to define, on the bottom of the latter, a flat peripheral edge 7.
  • the lower duct 6 extends downwards to a certain extent
  • Plate 1 comprises further a number of stif ening ribs 12. The utilization takes place as follows:
  • the samples of serum to be examined are inside as many vessels 13 (Fig.2) , present on a support plate and arranged in the same way as the elements 2.
  • Each of these vessels contains, in addition to serum, a small
  • the transfer device according to the invention is put on top o the essels, so that their ' edge fits the
  • the transfer device can be inserted between a pair of opposite twin plates, provided each with a plurality of vessels, in such a way as to ensure a continuous link between each vessel of one plate and the corresponding vessel of the other, the said link being direct and watertight.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Devices For Use In Laboratory Experiments (AREA)

Abstract

Dans le dispositif de transfert pour diagnostic sérologique, des moyens (1) sont prévus pour s'adapter entre une paire de plaques opposées chacune d'elles étant équipée de plusieurs conteneurs (13, 14) destinés à contenir le sérum à examiner, lesdits moyens (1) constituant une liaison entre des paires de conteneurs opposés (13, 14) de manière à permettre le transfert du sérum des conteneurs (13) d'une plaque aux conteneurs (14) de l'autre plaque en renversant l'ensemble.
EP87900254A 1985-12-17 1986-12-16 Dispositif de transfert pour diagnostic serologique Withdrawn EP0287565A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2418085U 1985-12-17
IT8524180U IT209360Z2 (it) 1985-12-17 1985-12-17 Trasportatore per diagnosi sierologiche.

Publications (1)

Publication Number Publication Date
EP0287565A1 true EP0287565A1 (fr) 1988-10-26

Family

ID=11212401

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87900254A Withdrawn EP0287565A1 (fr) 1985-12-17 1986-12-16 Dispositif de transfert pour diagnostic serologique

Country Status (9)

Country Link
EP (1) EP0287565A1 (fr)
JP (1) JPS63502774A (fr)
AU (1) AU6838987A (fr)
DK (1) DK424287A (fr)
ES (1) ES1001194Y (fr)
IT (1) IT209360Z2 (fr)
NO (1) NO873401L (fr)
PT (1) PT83950A (fr)
WO (1) WO1987003825A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2829709B1 (fr) * 2001-09-14 2004-01-02 In Cyto Tox Dispositif de transfert de fluide pour essais in vitro
DK3400754T3 (da) * 2016-01-08 2021-11-01 Siemens Healthcare Diagnostics Inc Varmeelement til sensorarray

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4111754A (en) * 1976-11-29 1978-09-05 Hydow Park Immunological testing devices and methods
FR2378283A1 (fr) * 1977-01-21 1978-08-18 Searle & Co Procede et appareil pour des reactions de diagnostic in vitro
FR2404466A1 (fr) * 1977-10-03 1979-04-27 Manudo Support servant de receptacles pour analyses, notamment medicales et biochimiques et son procede de fabrication
EP0154686B1 (fr) * 1982-03-03 1991-10-09 Becton Dickinson and Company Plaque de support et dispositif d'examen à récipients multiples pour les essais immunologiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8703825A1 *

Also Published As

Publication number Publication date
PT83950A (pt) 1987-08-19
ES1001194Y (es) 1988-11-16
NO873401D0 (no) 1987-08-13
DK424287D0 (da) 1987-08-14
DK424287A (da) 1987-08-14
ES1001194U (es) 1988-04-16
IT209360Z2 (it) 1988-10-05
WO1987003825A1 (fr) 1987-07-02
JPS63502774A (ja) 1988-10-13
NO873401L (no) 1987-08-13
IT8524180V0 (it) 1985-12-17
AU6838987A (en) 1987-07-15

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Inventor name: BEDARIDA, GUGLIELMO