Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

Definitions

• the present invention provides a transfer device for serological diagnosis, to be used in particular in the diagnostic processes for HTLV III virus infections.
• the transfer device allows to interconnect a plurality of opposite vessels, con ⁇ taining each a small ball coated with antigens, so as to allow, by a single operation, to shift the serum under examination from a vessel to the other so quickly that the liquid temperature has no time to diminish, and absolutely avoiding any contaminations and/or possi ⁇ bility of mistakes.
• the taken sample is introduced in a vessel in contact with a solid substrate, for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
• a solid substrate for instance a polystyrene ball covered with antibodies, to which immunoglobulins adhere that are then detected by means of conjugated anti-antibodies .
• the colouring of the ball indicates the presence in blood of the sought for immunoglobulins and, accordingly, the infection state.
• the critical phase of this new process is the elution, that takes place at a temperature oscillating between 50° and 58°C, necessary to cause the specific immunoglo ⁇ bulins of the various classes - caught by the antigens secured to the first substrate - to detach therefrom, which enables the production of an eluate of specific antibodies of the various classes, with few non-speci- fie antibodies .
• the transfer of the eluate from the first to the second vessel takes l ce via suction and force-pumps.
• the present invention provides a transfer device consisting substa tially of a plurality of con ⁇ necting elements, fastened to a common support, and arranged in such a manner as to fit, from either side, to the plates carrying the vessels used at present in laboratories for serological diagnosis.
• a characteristic of the invention is the special shap ⁇ ing of its parts that allows to arrange a pair of opposi ' te plates, so that each vessel of one of these plates communicates with the corresponding vessel of the other plate, the whole being watertight; it is thus possible, by a single operation, to shift serum from the vessels in one plate to those in the second plate, without any decrease in temperature taking place.
• FIG. 1 shows the plane view of the transfer device according to the invention
• FIG. 2 shows the side, partly section view, of a transfer device according to the invention
• FIG. 3 shows a view from above of a detail of the transfer device according to the invention.
• a plate or support 1 comprises a plurality of elements, each of which is referenced as a whole with No. 2, each of them being suitable to allow connection between a pair of opposite vessels.
• elements 2 are located at the vertexes of a square link grid.
• Each element 2 is substantially a hollow cylinder defin ⁇ ed by side walls 3, inside which passes the serum, that shifts from one vessel to the other.
• each element 2 is not of constant size but has a narrowing at the central zone.
• the upper inner part of element 2 comprises a first, substantially cylindrical section 4, linked to a frusto-conical section 5 and to a lower duct 6, of lesser diameter.
• the sizes of the frusto-conical section 5 too are inferior to those of the upper cylindrical section 4, so as to define, on the bottom of the latter, a flat peripheral edge 7.
• the lower duct 6 extends downwards to a certain extent
• Plate 1 comprises further a number of stif ening ribs 12. The utilization takes place as follows:
• the samples of serum to be examined are inside as many vessels 13 (Fig.2) , present on a support plate and arranged in the same way as the elements 2.
• Each of these vessels contains, in addition to serum, a small
• the transfer device according to the invention is put on top o the essels, so that their ' edge fits the
• the transfer device can be inserted between a pair of opposite twin plates, provided each with a plurality of vessels, in such a way as to ensure a continuous link between each vessel of one plate and the corresponding vessel of the other, the said link being direct and watertight.

Landscapes

• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Analytical Chemistry (AREA)
• General Health & Medical Sciences (AREA)
• Hematology (AREA)
• Clinical Laboratory Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Investigating Or Analysing Biological Materials (AREA)
• Devices For Use In Laboratory Experiments (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=11212401

Family Applications (1)

Country Status (9)

Families Citing this family (2)

Family Cites Families (4)

• 1985
  • 1985-12-17 IT IT8524180U patent/IT209360Z2/it active
• 1986
  • 1986-12-16 AU AU68389/87A patent/AU6838987A/en not_active Abandoned
  • 1986-12-16 JP JP62500401A patent/JPS63502774A/ja active Pending
  • 1986-12-16 EP EP87900254A patent/EP0287565A1/de not_active Withdrawn
  • 1986-12-16 WO PCT/IT1986/000092 patent/WO1987003825A1/en not_active Ceased
  • 1986-12-17 PT PT83950A patent/PT83950A/pt not_active Application Discontinuation
  • 1986-12-17 ES ES19868601661U patent/ES1001194Y/es not_active Expired
• 1987
  • 1987-08-13 NO NO873401A patent/NO873401L/no unknown
  • 1987-08-14 DK DK424287A patent/DK424287A/da not_active Application Discontinuation

Non-Patent Citations (1)

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