EP0458845B1 - Granule a additifs detergents et procede de production d'un tel granule - Google Patents

Granule a additifs detergents et procede de production d'un tel granule Download PDF

Info

Publication number
EP0458845B1
EP0458845B1 EP90903319A EP90903319A EP0458845B1 EP 0458845 B1 EP0458845 B1 EP 0458845B1 EP 90903319 A EP90903319 A EP 90903319A EP 90903319 A EP90903319 A EP 90903319A EP 0458845 B1 EP0458845 B1 EP 0458845B1
Authority
EP
European Patent Office
Prior art keywords
core
granulate
shell
detergent additive
granulate according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
EP90903319A
Other languages
German (de)
English (en)
Other versions
EP0458845A1 (fr
Inventor
Erik Kjaer Markussen
Per Falholt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8097473&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0458845(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of EP0458845A1 publication Critical patent/EP0458845A1/fr
Application granted granted Critical
Publication of EP0458845B1 publication Critical patent/EP0458845B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38672—Granulated or coated enzymes

Definitions

  • This invention relates to a detergent additive granulate and a method for production thereof.
  • drum granulator represents a broad category of granulator devices, comprising for instance pan granulators and granulation mixers.
  • the enzyme containing granulate described in EP-A-0304332 comprises a core surrounded by a coating comprising cellulose fibres or artificial fibres in an amount of 1.5 to 40% by weight, based on the dry weight of the granulate except for the core, a binder in an amount of 0 to 15% by weight, based on the dry weight of the granulate, except for the core, a filler, and one or more granulating agents, whereby the core and/or the coating contains an enzyme.
  • the invention is a further development of the special embodiment of the invention described in EP-A-0304332, which comprises an enzyme in either the core or the shell.
  • the shell or the core in the detergent additive granulate according to the invention does not necessarily contain an enzyme; but the core contains one detergent additive (which may be an enzyme, here identified as the primary detergent additive), and the shell contains another detergent additive (which may be another enzyme, here identified as the secondary detergent additive).
  • the primary detergent additive should be protected against the secondary detergent additive and/or environmental factors, e.g. in cases where an enzyme is degraded by a bleaching agent and humidity in the atmosphere, or vice versa
  • there is a need for an effective separation between the primary and secondary detergent additives during storage there is a need for a granulate with high physical strength, and for a corresponding method of production, which is easily controllable and adapted for an industrial scale.
  • the purpose of the invention is the provision of a detergent additive granulate with a high physical strength and which contains a primary and a secondary detergent additive of the above mentioned kind, wherein the primary and secondary detergent additives are effectively separated from each other and/or from harmful environmental factors, and the provision of a corresponding method of production, which is easily controllable and adapted for an industrial scale.
  • the detergent additive granulate according to the invention comprises a core with a primary detergent additive surrounded by a shell comprising a secondary detergent additive, a binder, and granulating agents, and optionally a filler, and a protective coating between the core and the shell, whereby the shell comprises cellulose fibres or artificial fibres, preferably in an amount of between 1.5 and 40% by weight of the shell, more preferably between 5 and 20% by weight of the shell, and whereby the core facultatively comprises cellulose fibres or artificial fibres, preferably in an amount of between 1.5 and 40% by weight of the core, more preferably between 5 and 20% by weight of the core.
  • the detergent additive granulate according to the invention comprises a shell with a secondary detergent additive and cellulose fibres or artificial fibres.
  • EP 0 286 773 describes encapsulated enzymes, which in some regards are similar to the detergent additive granulate according to the invention in its broadest aspect.
  • the prior art encapsulated enzymes do not contain reinforcing cellulose fibres or artificial fibres in the shell and is not described as being produced by means of the above indicated granulator method, but by means of the fluid bed method, which is not well adapted to production on an industrial scale.
  • the protective coating can be any protective coating used in the art, which does not hurt the primary or secondary detergent additives or in other manner disturb the manufacturing process or the application of the granulate.
  • Examples of usable protective coatings are: fatty acid esters, alkoxylated alcohols, polyvinyl alcohols, ethoxylated alkylphenols, polyethylene glycols (MW 1000 to 8000), linear alcohol alkoxylates (MW 1450 to 2670), polyvinyl pyrrolidone (MW 26000 to 33000), polymeric nonylphenyl ethoxylates (MW 1975 to 4315), and dinonylphenyl ethoxylate (average MW 6900), fatty acids, e.g.
  • palmitic acid stearic acid, and arachidonic acid
  • paraffins bee wax, waxes, mono-, di- or triglycerides of single fatty acids or mixed fatty acids, fatty alcohols, methyl cellulose, ethyl cellulose, hydroxypropyl cellulose, and coconut monoethanol amide.
  • pairs of primary and secondary detergent additives are the following: (optical brightener)-(enzyme), (enzyme)-(optical brightener), (enzyme)-(bleach activator), (bleach activator)-(enzyme), (bleach activator)-(optical brightener), (optical brightener)-(bleach activator), (enzyme-chlorine scavenger), (bleach activator-chlorine scavenger), (optical brightener-chlorine scavenger), (bleaching agent)-(enzyme), and (enzyme)-(bleaching agent).
  • the core is of a shape corresponding to a maximum ratio between the largest and the smallest dimension of around 3, preferably around 2, more preferably around 1.5. In this embodiment a satisfactory coating around the core can always be obtained.
  • the amount of the core is between 5 and 85% by weight, preferably between 10 and 50% by weight of the granulate, most preferably between 15 and 40% by weight of the granulate. If the amount of the core is above 85%, the loading of a sufficient amount of secondary detergent additive will be difficult, and if the amount of the core is less than 5%, the loading of a sufficient amount of primary detergent additive will be difficult.
  • the core has a mean particle size between 100 and 100 ⁇ m, preferably 200-700 ⁇ m.These are the particle sizes most often required by the users.
  • the core or the shell contains an enzyme.
  • An enzyme is a typical detergent additive which needs protection from aggressive detergent components.
  • the enzyme is a protease, an amylase, a lipase, an amidase, a cellulase, or an oxidase. These are the most common enzymes for industrial detergent purposes.
  • the filler consists of or comprises inorganic salts.
  • the filler consists of or comprises inorganic salts.
  • the shell is surrounded by a final dust suppressing coating.
  • This final dust suppressing coating can also in certain cases serve as a further protective coating.
  • the protective coating is a mixture of a mono- and diglyceride of a fatty acid. It has been found that in this embodiment a most satisfactory protective action during the storage can be obtained. Advantageously mixtures of the kind described in EP-A-0304332 can be used.
  • the protective coating contains an antioxidant.
  • Suitable examples of antioxidants or reduction agents are thiosulphates, sulfites, bisulfites, ascorbic acid, ascorbates, or butyl hydroxy toluene. In many cases an even better storage stability can be obtained due to the presence of the antioxidant.
  • the invention comprises a method for production of the granulate according to the invention.
  • the method for the production of the detergent additive granulate according to the invention comprises the introduction of the core into a granulating drum, whereafter sequentially the protective coating agent, the shell material and optionally a final dust suppressing coating agent, and furthermore cellulose fibres or artificial fibres in the appropriate amounts and at the appropriate stages, are introduced into the granulating drum.
  • any granulating drum can be used in relation to the method according to the invention. The entire process can be carried out in one of these granulating drums.
  • the core can be coated with the protective coating agent in one granulating drum, whereafter the coated core can be isolated an transferred to another granulating drum for application of the shell, whereafter if wanted application of a dust suppression coating can be performed on the same granulating drum or another granulating drum.
  • the method according to the invention can be performed both batchwise and continuously.
  • the granulate is dried on a fluid bed to a water content below 1% and finally sifted to get a product with particle range 300 ⁇ m to 900 ⁇ m.
  • Example 7 kg of a granulate produced as described in Example 1 with particle size between 300-900 ⁇ m is coated with a layer of glyceryl stearate/palmitate Grindtek MSP 90 (melting point 68°C) and bentonite ASB 350 ECC in the following manner.
  • the granulate is heated to 75-80°C in a 20 l heat jacketed Lödige mixer which temperature is kept during the whole coating process.
  • the heated granulate is mixed and sprayed with 700 g melted MSP90 followed by a powdering with 1000 g bentonite followed by spraying with 210 g MSP90 followed by powdering with 1000 g MSP90 followed by spraying with 210 g MSP90.
  • the granulate is finally cooled to room temperature on a fluid bed and sifted between 300 and 1000 ⁇ m.
  • a granulate with an inner core containing an optical brightener and an outer shell containing a proteolytic enzyme with the core and the shell separated by a protective layer is produced in the following manner.
  • the granulate is finally dried to a water content below 1 % and sifted between 300 and 1000 ⁇ m.
  • the granulate has proteolytic activity of 6.0 KNPU/g.
  • Example 3 7 kg of granulate as produced as described in Example 3 is coated with a layer of sodium thiosulphate and kaolin by a conventional fluid bed coating process.
  • 280 g sodium thiosulphate and 280 g kaolin SPESWHITE ECC are dissolved/dispersed in 1000 g of water and sprayed onto the 7 kg of granulate in a Glatt WSG 5 fluid bed with continuous layering and drying.
  • the granulate has a proteolytic activity of 5.2 KNPU/g.
  • Example 4 7 kg of granulate produced as described in Example 4 is coated with a protective coating of 280 g Grindtek MSP90 followed by 875 g titanium dioxyde: Kaolin (SPESWHITE) 1:1 followed by 140 g Grindtek MSP90 as described in example 2.
  • the granulate is cooled to room temperature on a fluid bed and sifted between 300 and 1000 ⁇ m.
  • the granulate has a proteolytic activity of 4.7 KNPU/g.
  • the stability test is made at a temperature of 37°C and a humidity of 70%.
  • the granulate was dried to a water content below 1 % and finally sifted to obtain a product with particle range 300 ⁇ m to 900 ⁇ m.
  • a granulate with an inner core containing TAED and an outer shell containing a proteolytic enzyme with the core and the shell separated by a protective layer was produced in the following manner.
  • the shell was supplied with 1.4 kg of a 28.5% aqueous solution of a carbohydrate binder in the manner described in Danish patent No. 157937, Example 1, except that in the present example the core contains a perborate activator, TAED, and that a 50 l Lödige mixer was used.
  • the granulate was finally dried to a water content below 1 % and sieved to between 300 ⁇ m and 100 ⁇ m.
  • a TAED containing granulate coated with hydrogenated tallow was produced as described in Example 6, except that 20% kaolin was used in the wax coating step.
  • a granulate with an inner core containing TAED and an outer shell containing an optical brightener and with the core and the shell separated by a protective layer was produced in the following manner.
  • the shell was supplied with a continuous self-regulating loss-in-weight powder dosing system with a powder dosing rate of 20 kg/h. As a total 1.4 kg of an 28.5% aqueous carbohydrate binder solution was sprayed to bind the powder to the surface of the core particles. Otherwise the layering was applied as described in PCT WO 89/08695, Example 1.
  • the granulate was finally dried to a water content below 1 % and sieved to obtain a product with particle range 300 - 900 ⁇ m.
  • the shell was supplied with a continuous self-regulating loss-in-weight powder dosing system with a powder dosing rate of 20 kg/h and with a total of 2.6 kg of an 26.2% aqueous carbohydrate binder solution, and otherwise as described in PCT WO 89/08695, Example 1.
  • the granulate was finally dried to a water content below 1 % and sieved to obtain a product with particle range 300 - 900 ⁇ m.
  • a granulate with an inner core containing the proteolytic enzyme SAVINASE® and an outer shell containing a chlorine scavenger, whereby the core and the shell was separated by a protective layer was produced in the following manner.
  • the granulate was finally dried to a water content below 1 % and sieved to obtain a product with particle range 300 - 1000 ⁇ m.
  • the granulate was finally dried to a water content below 1% and sieved to obtain a product with particle range 300 - 1000 ⁇ m.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Detergent Compositions (AREA)

Claims (17)

  1. Granule à additifs détergents comprenant un noyau avec un additif détergent primaire entouré d'une enveloppe comprenant un second additif détergent secondaire, un liant, et des agents de granulation et un revêtement de protection entre le noyau et l'enveloppe, dans lesquels l'enveloppe comprend des fibres de cellulose.
  2. Granule à additifs détergents selon la revendication 1, dans lesquels l'enveloppe comprend une matière de charge.
  3. Granule à additifs détergents selon les revendications 1-2, dans lesquels les fibres de cellulose dans l'enveloppe sont présentes dans une quantité entre 1,5 et 40 % en poids de l'enveloppe.
  4. Granule à additifs détergents selon la revendication 3, dans lesquels les fibres de cellulose dans l'enveloppe sont présentes dans une quantité entre 5 et 20 % en poids de l'enveloppe.
  5. Granule à additifs détergents selon la revendication 4, dans lesquels le noyau comprend des fibres de cellulose ou des fibres artificielles.
  6. Granule à additifs détergents selon la revendication 5, dans lesquels les fibres de cellulose ou fibres articielles dans le noyau sont présentes dans une quantité entre 1,5 et 40 % en poids du noyau.
  7. Granule à additifs détergents selon la revendication 6, dans lesquels les fibres de cellulose ou fibres artificielles dans le noyau sont présentes dans une quantité entre 5 et 20 % en poids du noyau.
  8. Granule selon les revendications 1-7, dans lesquels le noyau a une forme correspondant à un taux maximum entre la plus grande et la plus petite dimension d'environ 3, de préférence d'environ 2, de façon plus préférée d'environ 1,5.
  9. Granule selon les revendications 1-8, dans lesquels la quantité de noyau se situe entre 5 et 85 % en poids, de préférence entre 10 et 50 % en poids du granule, de façon plus préférée entre 15 et 40 % en poids du granule.
  10. Granule selon les revendications 1-9 dans lesquels le noyau présente une dimension particulaire moyenne entre 100 et 1000 µm, de préférence 200-700 µm.
  11. Granule selon les revendications 1-10, dans lesquels le noyau ou l'enveloppe contient une enzyme.
  12. Granule selon les revendications 1-11, dans lesquels l'enzyme est une protéase, une amylase, une lipase, une amidase, une cellulase et/ou une oxydase.
  13. Granule selon les revendications 1-12, dans lesquels la matière de charge consiste ou comprend des sels inorganiques.
  14. Granule selon les revendications 1-13, dans lesquels l'enveloppe est entourée d'un revêtement supprimant la poussière finale.
  15. Granule selon les revendications 1-14, dans lesquels le revêtement protecteur est un mélange de mono- et diglycéride d'un acide gras.
  16. Granule selon les revendications 1-15, dans lesquels la couche de protection contient un antioxydant.
  17. Procédé pour la production du granule à additifs détergents selon les revendications 1-16, lequel procédé comprend l'introduction du noyau dans un tambour de granulation, après quoi on introduit dans le dispositif de granulation séquentiellement l'agent de revêtement de protection, le matériau d'enveloppe et facultativement un agent de revêtement supprimant la poussière finale et de plus des fibres de cellulose ou des fibres artificielles dans les quantités appropriées et aux étapes appropriées.
EP90903319A 1989-02-20 1990-02-16 Granule a additifs detergents et procede de production d'un tel granule Expired EP0458845B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK078089A DK78089D0 (da) 1989-02-20 1989-02-20 Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
DK780/89 1989-02-20

Publications (2)

Publication Number Publication Date
EP0458845A1 EP0458845A1 (fr) 1991-12-04
EP0458845B1 true EP0458845B1 (fr) 1992-12-23

Family

ID=8097473

Family Applications (1)

Application Number Title Priority Date Filing Date
EP90903319A Expired EP0458845B1 (fr) 1989-02-20 1990-02-16 Granule a additifs detergents et procede de production d'un tel granule

Country Status (7)

Country Link
EP (1) EP0458845B1 (fr)
JP (1) JP2801395B2 (fr)
AT (1) ATE83797T1 (fr)
DE (1) DE69000662T2 (fr)
DK (2) DK78089D0 (fr)
ES (1) ES2036904T3 (fr)
WO (1) WO1990009428A1 (fr)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4322229A1 (de) * 1993-07-05 1995-01-12 Cognis Bio Umwelt Umhüllte Enzymzubereitung für Wasch- und Reinigungsmittel
DK0773984T3 (da) * 1995-05-29 2000-04-10 Kao Corp Enzymholdig granuleret substans og fremgangsmåde til fremstilling heraf
DE19524287A1 (de) * 1995-07-06 1997-01-09 Henkel Kgaa Von Staub- und Feinanteilen freie granulare Wasch- und Reinigungsmittel hoher Schüttdichte
DE19545729A1 (de) 1995-12-08 1997-06-12 Henkel Kgaa Bleich- und Waschmittel mit enzymatischem Bleichsystem
GB2339575A (en) * 1998-07-15 2000-02-02 Procter & Gamble Cellulose disintegrant for detergent compositions
JP4647868B2 (ja) * 1999-07-09 2011-03-09 ノボザイムス アクティーゼルスカブ 酵素含有顆粒の調製方法
US6933141B1 (en) 1999-10-01 2005-08-23 Novozymes A/S Enzyme granulate
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
JP4198996B2 (ja) 2001-01-31 2008-12-17 ノボザイムス アクティーゼルスカブ 酵素含有粒体の製造方法
US20050085406A1 (en) 2001-12-21 2005-04-21 Novozymes A/S Salt coatings
AU2003214037A1 (en) 2002-03-27 2003-10-08 Novozymes A/S Granules with filamentous coatings
WO2004033083A2 (fr) 2002-10-09 2004-04-22 Novozymes A/S Procede destine a ameliorer des compositions particulaires
JP2006517990A (ja) 2003-01-27 2006-08-03 ノボザイムス アクティーゼルスカブ 粒体の安定化
CA2560613C (fr) 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Compositions pharmaceutiques par voie orale a base de lipases, en particulier de pancreatine, contenant des tensioacitfs
CN101056540A (zh) 2004-09-27 2007-10-17 诺维信公司 酶颗粒
WO2006048142A2 (fr) † 2004-11-02 2006-05-11 Henkel Kommanditgesellschaft Auf Aktien Granulats / agglomerats pour detergents ou produits de nettoyage
PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
EP1994130A1 (fr) 2006-03-02 2008-11-26 Novozymes A/S Procédé d'encapsulation haute capacité
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
EP2051590B1 (fr) 2006-08-07 2016-04-20 Novozymes A/S Granules d'enzyme pour alimentation animale
US20080031998A1 (en) 2006-08-07 2008-02-07 Novozymes A/S Enzyme Granules for Animal Feed
PT2079445E (pt) 2007-02-20 2016-02-29 Allergan Pharmaceuticals Internat Ltd Composições de enzimas digestivas estáveis
WO2009109856A2 (fr) 2008-03-07 2009-09-11 Axcan Pharma Inc. Procédé pour détecter un parvovirus infectieux dans des préparations pharmaceutiques
EP2262885B1 (fr) 2008-03-28 2013-05-15 Novozymes A/S Particules comportant un système de libération déclenché par une enzyme
EP2216393B1 (fr) 2009-02-09 2024-04-24 The Procter & Gamble Company Composition de détergent
WO2011000924A1 (fr) 2009-07-03 2011-01-06 Abbott Products Gmbh Amylase séchée par pulvérisation, préparations pharmaceutiques la comprenant et son utilisation
GB2477914B (en) 2010-02-12 2012-01-04 Univ Newcastle Compounds and methods for biofilm disruption and prevention
EA029101B1 (ru) † 2010-10-01 2018-02-28 Апталис Фарма Лимитид Составы с низкой дозой панкрелипазы и кишечнорастворимым покрытием
EP2537918A1 (fr) 2011-06-20 2012-12-26 The Procter & Gamble Company Produits de consommation avec particules enrobées comprenant une lipase
US10711262B2 (en) 2011-07-12 2020-07-14 Novozymes A/S Storage-stable enzyme granules
CA2843556A1 (fr) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Procede de test de dissolution de compositions solides contenant des enzymes digestives
EP2674475A1 (fr) 2012-06-11 2013-12-18 The Procter & Gamble Company Composition détergente
WO2014200658A1 (fr) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase issue de promicromonospora vindobonensis
WO2014200656A1 (fr) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase provenant de streptomyces umbrinus
WO2014200657A1 (fr) 2013-06-13 2014-12-18 Danisco Us Inc. Alpha-amylase provenant destreptomyces xiamenensis
EP3011020A1 (fr) 2013-06-17 2016-04-27 Danisco US Inc. Alpha-amylase issue d'un membre de la famille des bacillaceae
EP3639846B1 (fr) 2013-08-09 2022-09-28 Allergan Pharmaceuticals International Limited Composition d'enzymes digestives appropriée pour une administration entérale
WO2015028567A1 (fr) * 2013-08-28 2015-03-05 Novozymes A/S Granulé enzymatique contenant un agent de blanchiment fluorescent
WO2015050724A1 (fr) 2013-10-03 2015-04-09 Danisco Us Inc. Alpha-amylases faisant partie d'un sous-ensemble d'exiguobacterium, et procédés d'utilisation correspondants
EP3060659B1 (fr) 2013-10-03 2019-05-29 Danisco US Inc. Alpha-amylases de exiguobacterium, methodes et utilisation
JP6560214B2 (ja) 2013-11-20 2019-08-14 ダニスコ・ユーエス・インク プロテアーゼ開裂に対する感受性を低減した変異体α−アミラーゼ、及びその使用方法
EP3157568A1 (fr) 2014-06-19 2017-04-26 Aptalis Pharma Limited Procédés d'élimination de contaminants viraux dans des extraits pancréatiques
EP3181671B1 (fr) 2015-12-17 2024-07-10 The Procter & Gamble Company Composition de detergent de lave-vaisselle automatique
EP3181672A1 (fr) 2015-12-17 2017-06-21 The Procter and Gamble Company Composition de detergent de lave-vaisselle automatique
EP3181679A1 (fr) 2015-12-17 2017-06-21 The Procter and Gamble Company Procédé de fabrication d'un produit pour laver la vaisselle automatiquement
EP3181670B1 (fr) 2015-12-17 2019-01-30 The Procter and Gamble Company Composition de detergent de lave-vaisselle automatique
EP3181675B2 (fr) 2015-12-17 2022-12-07 The Procter & Gamble Company Composition de détergent de lave-vaisselle automatique
EP3181678A1 (fr) 2015-12-17 2017-06-21 The Procter and Gamble Company Procédé de fabrication de détergent
EP3181676B1 (fr) 2015-12-17 2019-03-13 The Procter and Gamble Company Composition de detergent de lave-vaisselle automatique
DE102015225873A1 (de) * 2015-12-18 2017-06-22 Henkel Ag & Co. Kgaa Zweistufiges Waschverfahren
WO2017173190A2 (fr) 2016-04-01 2017-10-05 Danisco Us Inc. Alpha-amylases, compositions et procédés
WO2017173324A2 (fr) 2016-04-01 2017-10-05 Danisco Us Inc. Alpha-amylases, compositions et procédés
CN109312321A (zh) 2016-05-24 2019-02-05 诺维信公司 包含具有半乳聚糖酶活性的多肽和具有β-半乳糖苷酶活性的多肽的组合物
AU2017270269A1 (en) 2016-05-24 2018-11-15 Novozymes A/S Compositions comprising polypeptides having galactanase activity and polypeptides having beta-galactosidase activity
AU2017269498A1 (en) 2016-05-24 2018-11-08 Novozymes A/S Polypeptides having alpha-galactosidase activity and polynucleotides encoding same
ES3014057T3 (en) 2016-05-24 2025-04-16 Novozymes As Gastric stable polypeptides having alpha-galactosidase activity and polynucleotides encoding same
RU2752204C2 (ru) 2016-07-08 2021-07-23 Новозимс А/С Варианты ксиланазы и кодирующие их полинуклеотиды
MX2019000139A (es) 2016-07-08 2019-06-10 Novozymes As Polipeptidos que tienen actividad xilanasa y polinucleotidos que los codifican.
US20190284647A1 (en) 2016-09-29 2019-09-19 Novozymes A/S Spore Containing Granule
US11753605B2 (en) 2016-11-01 2023-09-12 Novozymes A/S Multi-core granules
EP3535279A1 (fr) 2016-11-07 2019-09-11 Lihme Protein Solutions APS Procédé de précipitation pour isoler des composés
AU2017380488B2 (en) 2016-12-21 2023-09-14 Novozymes A/S Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof
EP3642339B1 (fr) 2017-06-22 2025-09-10 Novozymes A/S Variantes de xylanase et polynucléotides les codant
CN111050566A (zh) 2017-09-01 2020-04-21 诺维信公司 包含具有蛋白酶活性的多肽的动物饲料添加剂及其用途
US20200196633A1 (en) 2017-09-01 2020-06-25 Novozymes A/S Animal Feed Additives Comprising Polypeptide Having Protease Activity and Uses Thereof
US11746310B2 (en) 2017-10-02 2023-09-05 Novozymes A/S Polypeptides having mannanase activity and polynucleotides encoding same
CN111373036A (zh) 2017-10-02 2020-07-03 诺维信公司 具有甘露聚糖酶活性的多肽和编码它们的多核苷酸
WO2019076833A1 (fr) 2017-10-16 2019-04-25 Novozymes A/S Granules libérant une faible quantité poussière
EP3701001B1 (fr) 2017-10-24 2026-06-10 Novozymes A/S Compositions comprenant des polypeptides présentant une activité mannanase
CN111315879A (zh) 2017-11-09 2020-06-19 巴斯夫欧洲公司 包含有机白色颜料的酶颗粒涂层
US20210076704A1 (en) 2017-12-20 2021-03-18 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
US20200337337A1 (en) 2017-12-20 2020-10-29 Dsm Ip Assets B.V. Animal feed compositions comprising muramidase and uses thereof
BR112020012438A2 (pt) 2018-01-11 2020-11-24 Novozymes A/S composição, ração animal ou aditivo de ração animal, e, método de melhoria da liberação de xilana a partir de alimento para animais.
EP3749094A2 (fr) 2018-02-06 2020-12-16 Novozymes BioAG A/S Procédés de protection d'une plante vis-à-vis de champignons nuisibles
BR112020021365A2 (pt) 2018-04-25 2021-01-19 Novozymes A/S Ração animal, método para melhoria do fator de eficiência de produção europeu, ganho de peso corporal e/ou razão de conversão de ração de um animal monogástrico, uso de pelo menos um probiótico em combinação com um polipeptídeo tendo atividade de muramidase em uma composição de ração, e, composição de ração ou uma composição de pré-mistura, ou um aditivo de ração para animais.
EP3801017A1 (fr) 2018-06-05 2021-04-14 Novozymes Bioag A/S Procédés de protection d'une plante contre les insectes nuisibles
BR112020024509A2 (pt) 2018-06-05 2021-03-02 Novozymes Bioag A/S métodos de aplicação foliar de uma composição, de controle de pragas de plantas em uma planta ou parte da planta e/ou indução de resistência a uma praga de plantas em uma planta ou parte da planta e de controle ou prevenção de danos por pragas em um material de propagação da planta, uma planta, parte de uma planta e/ou órgão da planta.
US11473076B2 (en) 2018-08-31 2022-10-18 Novozymes A/S Animal feed additives and compositions comprising an S8 serine protease
AU2019339732B2 (en) 2018-09-11 2025-04-03 Novozymes A/S Stable granules for feed compositions
BR112021004826A2 (pt) 2018-09-17 2021-06-08 Dsm Ip Assets B.V. composições de ração animal e usos das mesmas
WO2020058225A1 (fr) 2018-09-17 2020-03-26 Dsm Ip Assets B.V. Compositions d'aliments pour animaux et leurs utilisations
BR112021004817A2 (pt) 2018-09-17 2021-06-08 Dsm Ip Assets B.V. composições de ração animal e usos das mesmas
AU2019341519A1 (en) 2018-09-17 2021-03-18 Dsm Ip Assets B.V. Animal feed compositions and uses thereof
CN113056476A (zh) 2018-10-03 2021-06-29 诺维信公司 具有α-甘露聚糖降解活性的多肽以及编码它们的多核苷酸
WO2020115179A1 (fr) 2018-12-05 2020-06-11 Novozymes A/S Utilisation d'un granule enzymatique
EP4031661A1 (fr) 2019-09-16 2022-07-27 Novozymes A/S Polypeptides dotés d'une activité bêta-glucanase et polynucléotides codant pour ces polypeptides
WO2021078839A1 (fr) 2019-10-22 2021-04-29 Novozymes A/S Composition d'aliment pour animaux
EP4077656A2 (fr) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides présentant une activité protéolytique et leur utilisation
EP4097226A1 (fr) 2020-01-31 2022-12-07 Novozymes A/S Variants de mannanase et polynucléotides codant pour ceux-ci
WO2021152123A1 (fr) 2020-01-31 2021-08-05 Novozymes A/S Variants de mannanase et polynucléotides codant pour ceux-ci
WO2021163030A2 (fr) 2020-02-10 2021-08-19 Novozymes A/S Polypeptides ayant une activité alpha-amylase et polynucléotides codant pour ces derniers
EP4152945A1 (fr) 2020-05-18 2023-03-29 DSM IP Assets B.V. Compositions d'aliments pour animaux
EP4152946A1 (fr) 2020-05-18 2023-03-29 DSM IP Assets B.V. Compositions d'aliments pour animaux
US20230364203A1 (en) 2020-10-07 2023-11-16 Novozymes A/S New Granules for Animal Feed
EP4225048A2 (fr) 2020-10-07 2023-08-16 Novozymes A/S Conservation enzymatique d'aliments
WO2022079238A1 (fr) 2020-10-15 2022-04-21 Dsm Ip Assets B.V. Procédés de modulation de métabolites gastro-intestinaux
AU2021370998A1 (en) 2020-11-02 2023-05-25 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
WO2023225459A2 (fr) 2022-05-14 2023-11-23 Novozymes A/S Compositions et procédés de prévention, de traitement, de suppression et/ou d'élimination d'infestations et d'infections phytopathogènes
WO2023288294A1 (fr) 2021-07-16 2023-01-19 Novozymes A/S Compositions et procédés pour améliorer la résistance à la pluie de protéines sur des surfaces de plantes
US20250075152A1 (en) 2021-02-12 2025-03-06 Novozymes A/S Stabilized biological detergents
EP4206309A1 (fr) 2021-12-30 2023-07-05 Novozymes A/S Particules de protéines à blancheur améliorée
EP4242303A1 (fr) 2022-03-08 2023-09-13 Novozymes A/S Polypeptides de fusion avec inhibiteur de désamidase et domaines de désamidase
JP2025509233A (ja) 2022-03-08 2025-04-11 ノボザイムス アクティーゼルスカブ デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド
AR128995A1 (es) 2022-04-07 2024-07-03 Novozymes As Proteínas de fusión y su uso contra eimeria
EP4544036A1 (fr) 2022-06-21 2025-04-30 Novozymes A/S Variants de mannanase et polynucléotides codant pour ceux-ci
WO2023247664A2 (fr) 2022-06-24 2023-12-28 Novozymes A/S Variants de lipase et compositions comprenant de tels variants de lipase
EP4547210A1 (fr) 2022-06-30 2025-05-07 Novozymes A/S Mutanases et compositions d'hygiène buccale les comprenant
JP2025525309A (ja) 2022-07-15 2025-08-05 ノボザイムス アクティーゼルスカブ デアミダーゼ阻害剤活性を有するポリペプチド
CN120989059A (zh) 2022-12-05 2025-11-21 诺维信公司 蛋白酶变体以及编码其的多核苷酸
EP4629838A1 (fr) 2022-12-08 2025-10-15 Novozymes A/S Polypeptide ayant une activité lysozymique et polynucléotides codant pour celui-ci
EP4634355A1 (fr) 2022-12-14 2025-10-22 Novozymes A/S Variants de lipase gcl1 améliorés
EP4638725A1 (fr) 2022-12-19 2025-10-29 Novozymes A/S Polypeptides de la famille 3 de gludice estérase (ce3) présentant une activité acétyl xylane estérase et polynucléotides codant pour ceux-ci
CN120380140A (zh) 2022-12-19 2025-07-25 诺维信公司 具有阿魏酸酯酶和/或乙酰木聚糖酯酶活性的碳水化合物酯酶家族1（ce1）多肽和编码其的多核苷酸
AU2023410701A1 (en) 2022-12-21 2025-05-22 Novo Nordisk Pharmatech A/S Microbial proteases for cell detachment
EP4389865A1 (fr) 2022-12-21 2024-06-26 Novozymes A/S Protéase recombinante pour le détachement cellulaire
WO2024133497A1 (fr) 2022-12-21 2024-06-27 Novozymes A/S Protéase recombinante pour détachement cellulaire
CN120417880A (zh) 2023-02-22 2025-08-01 诺维信公司 包含转化酶的口腔护理组合物
AU2024325961A1 (en) 2023-08-15 2026-01-29 Novozymes A/S Polypeptides having alkaline phosphatase activity for animal feed
WO2025103765A1 (fr) 2023-11-17 2025-05-22 Novozymes A/S Monooxygénases polysaccharidiques lytiques et leur utilisation dans un détergent
WO2025111274A2 (fr) 2023-11-20 2025-05-30 Novozymes A/S Variants d'épimérase et polynucléotides les codant
CN122270290A (zh) 2023-11-30 2026-06-23 诺维信公司 包含肽酶或内酯酶的口腔护理组合物
WO2025114053A1 (fr) 2023-11-30 2025-06-05 Novozymes A/S Biopolymères destinés à être utilisés dans un détergent
WO2025128568A1 (fr) 2023-12-11 2025-06-19 Novozymes A/S Composition et son utilisation pour augmenter la solubilisation de fibres hémicellulosiques
WO2025191164A2 (fr) 2024-03-12 2025-09-18 Novozymes A/S Utilisation de chymopapaïne dans le détachement de cellules
AU2025239494A1 (en) 2024-03-22 2026-06-25 Novozymes A/S Oral care compositions comprising dnases
WO2025217017A1 (fr) 2024-04-08 2025-10-16 Novozymes A/S Compositions et procédés pour augmenter la disponibilité du phosphore
WO2025257254A1 (fr) 2024-06-12 2025-12-18 Novozymes A/S Lipases et variants de lipase et leur utilisation
WO2026068782A1 (fr) 2024-09-30 2026-04-02 Novozymes A/S Variants de protéase et polynucléotides codant pour ceux-ci
WO2026109480A1 (fr) 2024-11-25 2026-05-28 Novozymes A/S Mannanases gh26 et leur utilisation dans les détergents
WO2026132160A1 (fr) 2024-12-19 2026-06-25 Novozymes A/S Stabilisation d'enzymes dans un aliment pour animaux

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58179492A (ja) * 1982-04-12 1983-10-20 Dainichi Seika Kogyo Kk 洗剤用酵素粒剤およびその製造方法
JPS6192570A (ja) * 1984-10-12 1986-05-10 Showa Denko Kk 酵素造粒法
JPS61168698A (ja) * 1985-01-22 1986-07-30 昭和電工株式会社 洗剤用複合酵素粒剤
AU8317487A (en) * 1987-04-17 1988-10-20 Ecolab Inc. Water insoluble encapsulated enzymes protected against deactivation by halogen bleaches
DK435687D0 (da) * 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf

Also Published As

Publication number Publication date
WO1990009428A1 (fr) 1990-08-23
DK78089D0 (da) 1989-02-20
DE69000662D1 (de) 1993-02-04
JP2801395B2 (ja) 1998-09-21
JPH04503369A (ja) 1992-06-18
EP0458845A1 (fr) 1991-12-04
DK0458845T3 (da) 1993-03-29
ES2036904T3 (es) 1993-06-01
DE69000662T2 (de) 1993-04-22
ATE83797T1 (de) 1993-01-15

Similar Documents

Publication Publication Date Title
WO1990009428A1 (fr) Granule a additifs detergents et procede de production d'un tel granule
US5733763A (en) Enzyme granulate formed of an enzyme-containing core and an enzyme-containing shell
EP0404806B1 (fr) Composition particulaire stabilisee
JP2927540B2 (ja) 酵素含有粒質物および該粒質物の製法
US5254283A (en) Isophthalic polymer coated particles
JP2647695B2 (ja) 酵素含有粒質物
EP2209880B1 (fr) Granulat d'un ingrédient sensible d'un agent de lavage ou de nettoyage
EP2007863B1 (fr) Granulés d'un produit lavant ou nettoyant sensible
CA1285509C (fr) Compose contenant un enzyme stabilise et un agent de blanchiment sec completement enrobe avec un sel de tampon alcalin
US5318714A (en) Stabilized particulate composition
EP2732018B1 (fr) Granules d'enzyme stables au stockage
CA1285508C (fr) Granules contenant un enzyme stabilise et un agent de blanchiment sec
DE69605009T2 (de) Enzymhaltiges granulat und verfahren zu seiner herstellung
EP0478684B1 (fr) Granule d'addition au detergent et detergent
DE69613329T2 (de) Enzym enthaltendes Granulat, Herstellungsmethode und das Granulat enthaltende Zusammensetzungen
US5376288A (en) Detergent additive granulate and detergent
Becker et al. Formulation of detergent enzymes
WO1994016064A1 (fr) Granulat contenant en enzyme, procede de production de ce granulat et son utilisation
EP1807498B1 (fr) Procede de preparation des granules / agglomerats pour compositions detergentes

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19910601

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

17Q First examination report despatched

Effective date: 19920319

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Effective date: 19921223

Ref country code: CH

Effective date: 19921223

Ref country code: LI

Effective date: 19921223

REF Corresponds to:

Ref document number: 83797

Country of ref document: AT

Date of ref document: 19930115

Kind code of ref document: T

REF Corresponds to:

Ref document number: 69000662

Country of ref document: DE

Date of ref document: 19930204

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 19930228

ITF It: translation for a ep patent filed
REG Reference to a national code

Ref country code: DK

Ref legal event code: T3

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

ET Fr: translation filed
REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2036904

Country of ref document: ES

Kind code of ref document: T3

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

26 Opposition filed

Opponent name: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

Effective date: 19930916

NLR1 Nl: opposition has been filed with the epo

Opponent name: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

PLBM Termination of opposition procedure: date of legal effect published

Free format text: ORIGINAL CODE: 0009276

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: OPPOSITION PROCEDURE CLOSED

27C Opposition proceedings terminated

Effective date: 19950922

NLR2 Nl: decision of opposition
REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

REG Reference to a national code

Ref country code: FR

Ref legal event code: TP

NLS Nl: assignments of ep-patents

Owner name: NOVOZYMES A/S

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20020213

Year of fee payment: 13

Ref country code: AT

Payment date: 20020213

Year of fee payment: 13

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DK

Payment date: 20020227

Year of fee payment: 13

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030216

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030228

REG Reference to a national code

Ref country code: DK

Ref legal event code: EBP

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: NL

Payment date: 20040205

Year of fee payment: 15

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20030217

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: BE

Payment date: 20050420

Year of fee payment: 16

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20050901

NLV4 Nl: lapsed or anulled due to non-payment of the annual fee

Effective date: 20050901

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20060209

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20060215

Year of fee payment: 17

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20060220

Year of fee payment: 17

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20060228

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: IT

Payment date: 20060228

Year of fee payment: 17

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20070216

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20071030

BERE Be: lapsed

Owner name: *NOVOZYMES A/S

Effective date: 20060228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070901

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070228

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070216

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20070216