EP0488401A1 - Une préparation pharmaceutique à libération contrôlée pour l'implantation intraoculaire - Google Patents
Une préparation pharmaceutique à libération contrôlée pour l'implantation intraoculaire Download PDFInfo
- Publication number
- EP0488401A1 EP0488401A1 EP91120586A EP91120586A EP0488401A1 EP 0488401 A1 EP0488401 A1 EP 0488401A1 EP 91120586 A EP91120586 A EP 91120586A EP 91120586 A EP91120586 A EP 91120586A EP 0488401 A1 EP0488401 A1 EP 0488401A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- intra
- controlled
- pharmaceutical preparation
- polylactic acid
- release pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts or implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
- Y10S623/905—Eye
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP338853/90 | 1990-11-30 | ||
| JP33885390 | 1990-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EP0488401A1 true EP0488401A1 (fr) | 1992-06-03 |
Family
ID=18322023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP91120586A Withdrawn EP0488401A1 (fr) | 1990-11-30 | 1991-11-29 | Une préparation pharmaceutique à libération contrôlée pour l'implantation intraoculaire |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US5501856A (fr) |
| EP (1) | EP0488401A1 (fr) |
| JP (1) | JP3116489B2 (fr) |
| KR (1) | KR0185215B1 (fr) |
| CA (1) | CA2056513A1 (fr) |
Cited By (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0654256A4 (fr) * | 1993-02-26 | 1995-01-04 | Santen Pharmaceutical Co Ltd | Bouchon de sclerotique biodegradable. |
| WO1996013286A3 (fr) * | 1994-10-26 | 1996-06-20 | Houston Biotechnology | Procedes et compositions de modulation de la proliferation cellulaire et de la cicatrisation |
| WO1997028833A1 (fr) * | 1996-02-12 | 1997-08-14 | Houston Biotechnology Incorporated | Procedes et compositions de modulation de la proliferation cellulaire et de cicatrisation de lesions |
| US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| EP0992244A4 (fr) * | 1997-07-02 | 2001-01-17 | Santen Pharmaceutical Co Ltd | Bouchons scleraux d'acide polylactique |
| WO2002002076A3 (fr) * | 2000-07-05 | 2002-07-04 | Oculex Pharm Inc | Procedes servant a traiter des etats inflammatoires de l'oeil |
| WO2002078713A1 (fr) * | 2001-03-28 | 2002-10-10 | Santen Pharmaceutical Co., Ltd. | Medicaments contre les affections retiniennes et choroidiennes contenant des steroides comme principe actif |
| US6699493B2 (en) | 2000-11-29 | 2004-03-02 | Oculex Pharmaceuticals, Inc. | Method for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor |
| WO2004062649A3 (fr) * | 2003-01-09 | 2004-11-04 | Allergan Inc | Implant oculaire biodegradable |
| EP1550471A1 (fr) * | 2000-11-29 | 2005-07-06 | Allergan Inc. | Implants intra-oculaires pour la prévention du rejet de greffe dans l'oeil |
| WO2005110380A1 (fr) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Implants intraoculaires a liberation soutenue contenant un antagoniste du recepteur beta-adrenergique et methodes de traitement de neuropathies oculaires |
| WO2005110366A1 (fr) * | 2004-04-30 | 2005-11-24 | Allergan, Inc. | Derive d'estradiol, derive d'estratopone contenant un implant intra-oculaire a liberation prolongee et leurs procedes de fabrication |
| WO2006017347A2 (fr) | 2004-07-12 | 2006-02-16 | Allergan, Inc. | Compositions ophtalmiques et procédés de traitement de conditions ophtalmiques |
| EP1637164A2 (fr) * | 1995-06-02 | 2006-03-22 | Allergan, Inc. | Amélioration apportée à une formulation destinée à la libération contrôlée des médicaments par combinaison d'agents hydrophiles et hydrophobes |
| WO2008020087A1 (fr) | 2006-08-08 | 2008-02-21 | Fundacion Inasmet | Système optique implantable, son procédé de mise au point et ses applications |
| EP1637126A3 (fr) * | 2000-07-05 | 2009-10-21 | Allergan, Inc. | Méthodes de traitement des inflammations de l'oeil |
| WO2010054403A1 (fr) | 2008-11-10 | 2010-05-14 | Alexion Pharmaceuticals, Inc. | Procédés et compositions pour le traitement de troubles associés au complément |
| EP2218424A1 (fr) | 2006-12-01 | 2010-08-18 | Allergan, Inc. | Dispositif pour l'administration intraoculaire d'un médicament |
| WO2010151526A1 (fr) | 2009-06-23 | 2010-12-29 | Alexion Pharmaceuticals, Inc. | Anticorps bispécifiques se liant aux protéines du complément |
| EP2329811A1 (fr) | 2004-08-13 | 2011-06-08 | Allergan, Inc. | Implant oculaire fabriqué par un procédé d'extrusion multiple |
| WO2011103599A2 (fr) | 2010-02-19 | 2011-08-25 | The Regents Of The Universith Of California | Réactifs de liaison de la protéine membranaire épithéliale 2 (emp2) et leurs utilisations thérapeutiques dans des maladies oculaires |
| WO2011137395A1 (fr) | 2010-04-30 | 2011-11-03 | Rother Russell P | Anticorps anti-c5a et méthodes pour utiliser les anticorps |
| US8119154B2 (en) | 2004-04-30 | 2012-02-21 | Allergan, Inc. | Sustained release intraocular implants and related methods |
| US8147865B2 (en) | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8231892B2 (en) | 2007-05-24 | 2012-07-31 | Allergan, Inc. | Biodegradable drug delivery system |
| WO2012106634A1 (fr) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Utilisation d'un anticorps anti-cd200 pour prolonger la survie d'allogreffes |
| US8580292B2 (en) | 2004-04-30 | 2013-11-12 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| EP2664347A1 (fr) | 2008-07-18 | 2013-11-20 | Allergan, Inc. | Procédé de traitement de la dégénérescence maculaire liée à l'âge atrophique |
| US8609613B2 (en) | 2003-12-05 | 2013-12-17 | Bristol-Myers Squibb Company | Methods of inhibiting type 2 vascular endothelial growth factor receptors using polypeptides |
| US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
| US8728483B2 (en) | 2008-05-22 | 2014-05-20 | Bristol-Myers Squibb Company | Multivalent fibronectin based scaffold domain proteins |
| EP2752427A1 (fr) | 2009-02-24 | 2014-07-09 | Alexion Pharmaceuticals, Inc. | Anticorps contenant des peptides mimétiques TPO/EPO thérapeutiques |
| US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US8846094B2 (en) | 2003-11-12 | 2014-09-30 | Allergan, Inc. | Peripherally administered viscous formulations |
| WO2014160958A1 (fr) | 2013-03-29 | 2014-10-02 | Alexion Pharmaceuticals, Inc. | Compositions et procédés pour augmenter la demi-vie sérique d'un agent thérapeutique ciblant c5 complémentaire |
| US9011857B2 (en) | 2005-04-15 | 2015-04-21 | The Regents Of The University Of California | Methods of treating cancer by administering EMP2 antibodies |
| US9017655B2 (en) | 2008-11-24 | 2015-04-28 | Bristol-Myers Squibb Company | Bispecific EGFR/IGFIR binding molecules |
| US9079949B1 (en) | 2014-03-07 | 2015-07-14 | Alexion Pharmaceuticals, Inc. | Anti-C5 antibodies having improved pharmacokinetics |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| US9110064B2 (en) | 2005-02-28 | 2015-08-18 | The Regents Of The University Of California | Methods for diagnosis and treatment of endometrial cancer |
| US9138480B2 (en) | 2009-11-09 | 2015-09-22 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US9234028B2 (en) | 2008-02-14 | 2016-01-12 | Bristol-Myers Squibb Company | Targeted therapeutics based on engineered proteins that bind EGFR |
| US9259488B2 (en) | 2012-08-17 | 2016-02-16 | The Regents Of The University Of Colorado, A Body Corporate | Anti-C3d antibody conjugates and methods of detecting complement activation |
| US9265775B2 (en) | 2003-11-12 | 2016-02-23 | Allergan, Inc. | Pharmaceutical compositions |
| WO2016054522A1 (fr) | 2014-10-03 | 2016-04-07 | Ntercept, Llc | Compositions et procédés pour inhiber l'activité biologique de biomolécules solubles |
| WO2016123454A1 (fr) | 2015-01-29 | 2016-08-04 | Board Of Trustees Of Miching State University | Polypeptides cryptiques et leurs utilisations |
| AU2013221985B2 (en) * | 2004-07-12 | 2016-09-01 | Allergan, Inc. | Ophthalmic compositions and methods for treating ophthalmic conditions |
| US9464135B2 (en) | 2007-10-08 | 2016-10-11 | The Regents Of The University Of California | Epithelial membrane protein-2 (EMP2) and proliferative vitroretinopathy (PVR) |
| US9562089B2 (en) | 2010-05-26 | 2017-02-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold proteins having improved stability |
| US9572859B2 (en) | 2004-01-20 | 2017-02-21 | Allergan, Inc. | Compositions and methods for localized therapy of the eye |
| US9610246B2 (en) | 2013-02-15 | 2017-04-04 | Allergan, Inc. | Sustained drug delivery implant |
| WO2017176762A1 (fr) | 2016-04-06 | 2017-10-12 | Nanotics, Llc | Particules comprenant des sous-particules ou des échafaudages d'acide nucléique |
| US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
| EP3290922A1 (fr) | 2013-08-07 | 2018-03-07 | Alexion Pharmaceuticals, Inc. | Protéines de bio-marqueurs de syndrome hémolytique et urémique atypique |
| WO2018236904A1 (fr) | 2017-06-19 | 2018-12-27 | Surface Oncology, Inc. | Combinaison d'anticorps anti-cd47 et d'agents induisant la mort cellulaire, et leurs utilisations |
| WO2019014328A2 (fr) | 2017-07-11 | 2019-01-17 | Compass Therapeutics Llc | Anticorps agonistes qui lient cd137 humain et leurs utilisations |
| WO2019023564A1 (fr) | 2017-07-27 | 2019-01-31 | Alexion Pharmaceutical, Inc. | Formules d'anticorps anti-c5 à haute concentration |
| WO2019036605A2 (fr) | 2017-08-17 | 2019-02-21 | Massachusetts Institute Of Technology | Agents de liaison à spécificité multiple de chimiokines cxc et leurs utilisations |
| US10221232B2 (en) | 2006-11-22 | 2019-03-05 | Bristol-Myers Squibb Company | Methods of treating cancer by administering IGF-IR binding molecules |
| WO2019051073A1 (fr) | 2017-09-08 | 2019-03-14 | Bristol-Myers Squibb Company | Facteur de croissance des fibroblastes 21 (fgf-21) modifié destiné à une utilisation dans des méthodes de traitement de la stéatohépatite non alcoolique (nash) |
| WO2019067499A1 (fr) | 2017-09-27 | 2019-04-04 | Alexion Pharmaceuticals, Inc. | Signature de biomarqueur pour la prédiction d'une réponse tumorale vis-à-vis d'une thérapie anti-cd200 |
| WO2019089753A2 (fr) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Anticorps cd137 et antagonistes pd-1 et leurs utilisations |
| WO2019100052A2 (fr) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Anticorps cd137 et anticorps ciblant un antigène tumoral et leurs utilisations |
| WO2019178269A2 (fr) | 2018-03-14 | 2019-09-19 | Surface Oncology, Inc. | Anticorps qui se lient à cd39 et leurs utilisations |
| WO2019200357A1 (fr) | 2018-04-12 | 2019-10-17 | Surface Oncology, Inc. | Biomarqueur pour agents thérapeutiques ciblant cd47 et leurs utilisations |
| WO2019204743A1 (fr) | 2018-04-19 | 2019-10-24 | Checkmate Pharmaceuticals, Inc. | Agonistes de récepteur de type rig-i synthétique |
| WO2019226658A1 (fr) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Compositions multispécifiques de liaison à l'antigène et procédés d'utilisation |
| WO2019226617A1 (fr) | 2018-05-21 | 2019-11-28 | Compass Therapeutics Llc | Compositions et procédés pour améliorer la destruction de cellules cibles par des lymphocytes nk |
| WO2020018715A1 (fr) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Protéines de fusion à base d'échafaudage d'immunoglobuline multimère soluble et leurs utilisations |
| WO2020033925A2 (fr) | 2018-08-09 | 2020-02-13 | Compass Therapeutics Llc | Anticorps qui se lient à cd277 et leurs utilisations |
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| WO2021067526A1 (fr) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Inhibiteurs du complément pour le traitement d'une réponse médiée par le complément induite par un médicament |
| WO2021081353A1 (fr) | 2019-10-23 | 2021-04-29 | Checkmate Pharmaceuticals, Inc. | Agonistes de récepteur du type rig-i synthétiques |
| WO2021080682A1 (fr) | 2019-10-24 | 2021-04-29 | Massachusetts Institute Of Technology | Anticorps monoclonaux qui se lient au cd161 humain et leurs utilisations |
| US11046769B2 (en) | 2018-11-13 | 2021-06-29 | Compass Therapeutics Llc | Multispecific binding constructs against checkpoint molecules and uses thereof |
| WO2021231720A1 (fr) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Méthode d'utilisation de vésicules extracellulaires pour détecter une activation du complément, et leurs utilisations pour l'évaluation et/ou la surveillance du traitement d'une maladie à médiation par le complément |
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| WO2022236134A1 (fr) | 2021-05-07 | 2022-11-10 | Surface Oncology, Inc. | Anticorps anti-il-27 et leurs utilisations |
| WO2022251446A1 (fr) | 2021-05-28 | 2022-12-01 | Alexion Pharmaceuticals, Inc. | Procédés de détection de biomarqueurs cm-tma |
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| WO2023230128A1 (fr) | 2022-05-25 | 2023-11-30 | Surface Oncology, Inc. | Utilisation d'anticorps anti-il-27 |
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| US12128101B2 (en) | 2017-10-26 | 2024-10-29 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) |
| WO2024238422A1 (fr) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Utilisation d'un panel de lectines pour la détection de biomarqueurs du complément dans des vésicules extracellulaires d'urine |
| WO2024238421A1 (fr) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Utilisation de biomarqueurs pour l'identification et le traitement de troubles médiées par le complément |
| US12240893B2 (en) | 2018-10-30 | 2025-03-04 | Alexion Pharmaceuticals, Inc. | Subcutaneous dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) |
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| US12404320B2 (en) | 2018-05-31 | 2025-09-02 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-C5 antibodies for treatment of paroxysmal nocturnal hemoglobinuria (PNH) in pediatric patients |
| US12460012B2 (en) | 2018-06-04 | 2025-11-04 | Alexion Pharmaceuticals, Inc. | Dosage and administration of anti-C5 antibodies for treatment of atypical hemolytic uremic syndrome (aHUS) in pediatric patients |
| US12459992B2 (en) | 2016-05-27 | 2025-11-04 | Alexion Pharmaceuticals, Inc. | Methods for treatment of refractory generalized myasthenia gravis |
| WO2026055168A1 (fr) | 2024-09-06 | 2026-03-12 | Surface Oncology, LLC | Anticorps anti-il-27, leurs utilisations et doses |
| WO2026055167A1 (fr) | 2024-09-05 | 2026-03-12 | Surface Oncology, LLC | Anticorps anti-il-27 et utilisation de biomarqueurs dans leurs utilisations |
| US12577621B2 (en) | 2020-09-08 | 2026-03-17 | Duke University | LRRK2 mutations as biomarkers for the prediction of immune checkpoint response in cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060280774A1 (en) * | 1995-06-02 | 2006-12-14 | Allergan, Inc. | Compositions and methods for treating glaucoma |
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| EP4697024A2 (fr) | 2022-09-06 | 2026-02-18 | Alexion Pharmaceuticals, Inc. | Profils de biomarqueurs de diagnostic et de pronostic chez des patients ayant une microangiopathie thrombotique associée à une greffe de cellules souches hématopoïétiques (hsct-tma) |
| WO2024054436A1 (fr) | 2022-09-06 | 2024-03-14 | Alexion Pharmaceuticals, Inc. | Profils de biomarqueurs de diagnostic et de pronostic chez des patients ayant une microangiopathie thrombotique associée à une greffe de cellules souches hématopoïétiques (hsct-tma) |
| WO2024238421A1 (fr) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Utilisation de biomarqueurs pour l'identification et le traitement de troubles médiées par le complément |
| WO2024238422A1 (fr) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Utilisation d'un panel de lectines pour la détection de biomarqueurs du complément dans des vésicules extracellulaires d'urine |
| WO2026055167A1 (fr) | 2024-09-05 | 2026-03-12 | Surface Oncology, LLC | Anticorps anti-il-27 et utilisation de biomarqueurs dans leurs utilisations |
| WO2026055168A1 (fr) | 2024-09-06 | 2026-03-12 | Surface Oncology, LLC | Anticorps anti-il-27, leurs utilisations et doses |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0517370A (ja) | 1993-01-26 |
| KR0185215B1 (ko) | 1999-05-01 |
| CA2056513A1 (fr) | 1992-05-31 |
| JP3116489B2 (ja) | 2000-12-11 |
| KR920009385A (ko) | 1992-06-25 |
| US5501856A (en) | 1996-03-26 |
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