EP0630372A4 - Heteroalkoxy-benzazepine. - Google Patents

Heteroalkoxy-benzazepine.

Info

Publication number: EP0630372A4
Authority: EP; European Patent Office
Prior art keywords: heteroalcoxy; benzazepines; heteroalcoxy benzazepines
Prior art date: 1991-08-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19920917522

Other languages

English (en)

French (fr)

Other versions

EP0630372A1 (de

Inventor

Robert Michael Demarinis

Francis Richard Pfeiffer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-05

Filing date

1992-08-05

Publication date

1994-07-05

1992-08-05 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1994-07-05 Publication of EP0630372A4 publication Critical patent/EP0630372A4/de

1994-12-28 Publication of EP0630372A1 publication Critical patent/EP0630372A1/de

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

EP92917522A 1991-08-05 1992-08-05 Heteroalkoxy-benzazepine Withdrawn EP0630372A1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB91168245		1991-08-05
GB919116824A GB9116824D0 (en)	1991-08-05	1991-08-05	Chemical compounds
PCT/US1992/006538 WO1993003015A1 (en)	1991-08-05	1992-08-05	Heteroalkoxy benzazepines

Publications (2)

Publication Number	Publication Date
EP0630372A4 true EP0630372A4 (de)	1994-07-05
EP0630372A1 EP0630372A1 (de)	1994-12-28

Family

ID=10699496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP92917522A Withdrawn EP0630372A1 (de)	1991-08-05	1992-08-05	Heteroalkoxy-benzazepine

Country Status (5)

Country	Link
EP (1)	EP0630372A1 (de)
JP (1)	JPH06511239A (de)
AU (1)	AU2433092A (de)
GB (1)	GB9116824D0 (de)
WO (1)	WO1993003015A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4373497B2 (ja)	1996-06-19	2009-11-25	ローン−プーラン・ロレ・リミテツド	置換されたアザビシクロ化合物、ならびにｔｎｆおよびサイクリックａｍｐホスホジエステラーゼ産生の阻害剤としてのそれらの使用
AU2003256793A1 (en) *	2002-08-20	2004-03-11	Eli Lilly And Company	Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) *	2002-10-16	2002-11-27	Glaxo Group Ltd	Novel compounds
KR100897642B1 (ko)	2002-12-20	2009-05-14	글락소 그룹 리미티드	신경 장애 치료용 벤즈아제핀 유도체
CN1805938B (zh)	2003-06-17	2010-06-16	艾尼纳制药公司	用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
US20080009478A1 (en) *	2003-10-22	2008-01-10	Arena Pharmaceuticals, Inc.	Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
SI1720836T1 (sl)	2004-02-25	2014-06-30	Eli Lilly And Company	6-substituirani 2,3,4,5-tetrahidro-1h-benzo (d)azepini kot agonisti 5-ht2c receptorja
BRPI0515862A2 (pt)	2004-12-23	2011-10-11	Arena Pharm Inc	uso de fentermina e agonista seletivo do receptor de 5ht-2c na preparação de composições, composições moduladoras do receptor de 5ht-2c e forma de dosagem unitária compreendendo as mesmas
CA2619450C (en) *	2005-09-01	2013-10-22	Eli Lilly And Company	6-n-linked heterocycle-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists
ATE438627T1 (de)	2005-09-01	2009-08-15	Lilly Co Eli	6-substituierte- 2,3,4,5-tetrahydro-1h- benzoädüazepine als 5-ht2c-rezeptoragonisten
CN101253153A (zh)	2005-09-01	2008-08-27	伊莱利利公司	作为5－HT<sub>2c</sub>受体激动剂的6－取代的2,3,4,5－四氢－1H－苯并[d]氮杂䓬
AU2006287202B2 (en)	2005-09-01	2013-01-24	Eli Lilly And Company	6-arylalkylamino- 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2c receptor agonists
EP2288585A1 (de)	2008-03-04	2011-03-02	Arena Pharmaceuticals, Inc.	Verfahren zur herstellung von mit dem 5-ht2c-agonisten (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin verwandten zwischenprodukten
US9045431B2 (en)	2010-06-02	2015-06-02	Arena Pharmaceuticals, Inc.	Processes for the preparation of 5-HT2C receptor agonists
JP6272695B2 (ja)	2010-09-01	2018-01-31	エーザイ・アール・アンド・ディー・マネジメント株式会社	体重管理のために有用な５−ｈｔ２ｃアゴニストの改変放出剤形
AU2011296015B2 (en)	2010-09-01	2015-11-12	Arena Pharmaceuticals, Inc.	Administration of lorcaserin to individuals with renal impairment
JP2013536859A (ja)	2010-09-01	2013-09-26	アリーナファーマシューティカルズ，インコーポレイテッド	５−ｈｔ２ｃアゴニストの非吸湿性塩
KR20130138770A (ko)	2010-09-01	2013-12-19	아레나 파마슈티칼스, 인크.	광학적으로 활성 산을 갖는 로르카세린의 염
JP2015534563A (ja)	2012-10-09	2015-12-03	アリーナファーマシューティカルズ，インコーポレイテッド	体重管理の方法
JP6582056B2 (ja) *	2014-12-01	2019-09-25	イドーシアファーマシューティカルズリミテッドＩｄｏｒｓｉａＰｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ	Ｃｘｃｒ７受容体調節剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4233217A (en) *	1968-03-11	1980-11-11	Pennwalt Corporation	Substituted 1,2,4,5-tetrahydro-3H, 3 benzazepines
US4265890A (en) *	1978-07-07	1981-05-05	Smithkline Corporation	6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4469634A (en) *	1982-07-29	1984-09-04	Smithkline Beckman Corporation	Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4683229A (en) *	1986-03-17	1987-07-28	Smithkline Beckman Corporation	6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists

1991
- 1991-08-05 GB GB919116824A patent/GB9116824D0/en active Pending
1992
- 1992-08-05 JP JP5503834A patent/JPH06511239A/ja active Pending
- 1992-08-05 AU AU24330/92A patent/AU2433092A/en not_active Abandoned
- 1992-08-05 EP EP92917522A patent/EP0630372A1/de not_active Withdrawn
- 1992-08-05 WO PCT/US1992/006538 patent/WO1993003015A1/en not_active Ceased

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9303015A1 *

Also Published As

Publication number	Publication date
AU2433092A (en)	1993-03-02
EP0630372A1 (de)	1994-12-28
WO1993003015A1 (en)	1993-02-18
GB9116824D0 (en)	1991-09-18
JPH06511239A (ja)	1994-12-15

Legal Events

Date	Code	Title	Description
1994-07-05	A4	Supplementary search report drawn up and despatched
1994-07-05	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): BE CH DE FR GB IT LI NL
1994-11-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-12-28	17P	Request for examination filed	Effective date: 19940208
1994-12-28	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): BE CH DE FR GB IT LI NL
1997-10-01	17Q	First examination report despatched	Effective date: 19970819
1998-02-04	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1998-04-20	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1998-05-20	GRAG	Despatch of communication of intention to grant	Free format text: ORIGINAL CODE: EPIDOS AGRA
1998-05-20	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
1998-06-10	RIN1	Information on inventor provided before grant (corrected)	Inventor name: PFEIFFER, FRANCIS, RICHARD Inventor name: DEMARINIS, ROBERT, MICHAEL
1998-07-01	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: SMITHKLINE BEECHAM CORPORATION
1999-03-03	18D	Application deemed to be withdrawn	Effective date: 19980908

Publication	Publication Date	Title
DE122006000020I1 (de)	2011-12-01	Aerosolpraparate.
DE59201883D1 (de)	1995-05-18	Tilger.
FI910188A0 (fi)	1991-01-14	Styrbar hoegfrekvensdaempare.
EP0630372A4 (de)	1994-07-05	Heteroalkoxy-benzazepine.
FI913321A0 (fi)	1991-07-09	Mobiltelefon.
DE59105384D1 (de)	1995-06-08	Anomaloskop.
FI915864A0 (fi)	1991-12-12	Matningsfoerfarande foer aluminium- elektrolyser.
FI910079A0 (fi)	1991-01-07	Gaongjaern.
ES1017798Y (es)	1992-07-01	Garfio-soporte.
ES1017618Y (es)	1992-07-16	Flexometro-trazador.
ES1016842Y (es)	1992-06-01	Carpeta-agenda.
ES1018067Y (es)	1992-08-16	Tarjeta-puzzle.
ES1018229Y (es)	1993-01-01	Bovedilla.
ES1018322Y (es)	1992-08-01	Hidrocompresor.
ES1018708Y (es)	1992-09-16	Batidora-mezcladora.
ES1018836Y (es)	1992-10-01	Cisterna-remolque.
ES1019520Y (es)	1992-11-16	Lapida funeraria.
FI86243B (fi)	1992-04-30	Foervaringskaerl foer vattendjur saosom fiskar.
ES1016478Y (es)	1992-04-16	Papelera pefeccionada.
ES1015938Y (es)	1992-04-01	Pizarro-calendario.
FI911752A0 (fi)	1991-04-11	Metallstege.
FI910172A0 (fi)	1991-01-14	Foensteralarmapparat.
NO910447D0 (no)	1991-02-06	Stoevbindemiddel.
FI912312A0 (fi)	1991-05-13	Anordning foer begravningsakt.
NO911074D0 (no)	1991-03-19	Skiskjerm.